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Review: Clindamycin and Methotrexate





Summary: drug interactions are reported among people who take Clindamycin and Methotrexate together.

This review analyzes the effectiveness and drug interactions between Clindamycin and Methotrexate. It is created by eHealthMe based on reports of 308 people who take the same drugs from FDA and social media, and is updated regularly.

You are not alone: join a mobile support group for people who take Clindamycin and Methotrexate >>>

What are the drugs

Clindamycin hydrochloride has active ingredients of clindamycin hydrochloride. It is often used in infection. (latest outcomes from Clindamycin hydrochloride 1,318 users)

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. (latest outcomes from Methotrexate 131,201 users)

On Nov, 27, 2014: 308 people who take Clindamycin Hydrochloride, Methotrexate are studied

Clindamycin Hydrochloride, Methotrexate outcomes

Drug combinations in study:
- Clindamycin Hydrochloride (clindamycin phosphate)
- Methotrexate (methotrexate sodium)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Clindamycin Hydrochloride is effective0.00%
(0 of 1 people)
n/an/an/an/an/an/an/a
Methotrexate is effectiven/an/a0.00%
(0 of 1 people)
n/an/an/an/an/a

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Acute Respiratory Distress SyndromeMyopathyBacteraemian/aLeukocytosisArthritis BacterialErythemaPain
PneumonitisMuscular WeaknessKidney RuptureImpaired Gastric EmptyingHypertensionOedema PeripheralAnxiety
Blood Bilirubin IncreasedLiver Function Test AbnormalArthritis BacterialVentilation/perfusion Scan AbnormalCatheter Site InfectionSkin LesionOsteomyelitis
PneumoniaLeukocytosisArthralgiaPleuritic PainOropharyngeal Cancer Stage UnspecifiedIntervertebral DiscitisAnaemia
HypotensionImpaired Gastric EmptyingPostpartum HaemorrhageDysuriaProgressive Multifocal LeukoencephalopathySkin WarmOsteonecrosis Of Jaw
AnaemiaVentilation/perfusion Scan AbnormalDiarrhoeaCholelithiasisPharyngeal InflammationInfective MyositisOedema Peripheral
NeutropeniaPleuritic PainAbortion SpontaneousBlood Culture PositiveStaphylococcal InfectionIntraspinal AbscessOsteoarthritis
Febrile NeutropeniaDysuriaZygomycosisAcute SinusitisAbscessPyrexia
HiccupsCholelithiasisUterine CancerVenous Thrombosis LimbPurulent DischargeBone Disorder
Aspartate Aminotransferase IncreasedZygomycosisJoint EffusionHypertensive CrisisIntervertebral Disc ProtrusionPleural Effusion

Drug effectiveness by gender :

FemaleMale
Clindamycin Hydrochloride is effectiven/a0.00%
(0 of 1 people)
Methotrexate is effectiven/a0.00%
(0 of 1 people)

Most common drug interactions by gender * :

FemaleMale
PainFebrile Neutropenia
AnxietyAscites
OsteomyelitisRenal Failure
AnaemiaNeutropenia
Osteonecrosis Of JawStaphylococcal Infection
Oedema PeripheralSkin Ulcer Nos
OsteoarthritisStridor
PyrexiaStevens Johnson Syndrome
Tooth ExtractionAngioneurotic Oedema
Bone DisorderAsthenia

Drug effectiveness by age :

0-12-910-1920-2930-3940-4950-5960+
Clindamycin Hydrochloride is effectiven/an/an/an/an/an/a0.00%
(0 of 1 people)
n/a
Methotrexate is effectiven/an/an/an/an/an/a0.00%
(0 of 1 people)
n/a

Most common drug interactions by age * :

0-12-910-1920-2930-3940-4950-5960+
Renal HypertrophyAscitesPneumonitisNeutropeniaPyrexiaPainPleural EffusionAnxiety
Bladder DiverticulumStevens Johnson SyndromeAcute Respiratory Distress SyndromePneumonia BacterialDermatitis NosAnaemiaPainPain
Clostridial InfectionStridorHypotensionPseudomembranous ColitisAcute Circulatory FailureOedema PeripheralLung DisorderTooth Extraction
Reflux NephropathySkin Ulcer NosBlood Bilirubin IncreasedThrombocytopeniaBlisterAnxietyRenal FailureAnaemia
Palatal DisorderAngioneurotic OedemaLung InfectionHypokalaemiaPruritusOsteonecrosis Of JawOsteopeniaOsteomyelitis
Respiratory Syncytial Virus InfectionBlisterFebrile NeutropeniaRenal ImpairmentStevens Johnson SyndromeBronchitisSinusitisMetastases To Bone
Urinary Tract InfectionStomatitisScedosporium InfectionHiccupsEpidermal NecrolysisHeadacheEnterococcal InfectionOsteoarthritis
Oedema NosEncephalitis FungalAnaemiaWhite Blood Cell Count DecreasedSinusitisSepsisDeep Vein Thrombosis
Mucosal Inflammation NosHypernatraemiaDeep Vein ThrombosisBlood Pressure IncreasedOsteomyelitisOedema PeripheralOsteonecrosis Of Jaw
PyrexiaPneumonia Respiratory Syncytial ViralPneumoniaChest PainInjurySwellingFibromyalgia

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Clindamycin and Methotrexate?

You are not alone! Join a related mobile support group:
- support group for people who take Clindamycin and Methotrexate
- support group for people who take Clindamycin Hydrochloride
- support group for people who take Methotrexate

Recent conversations of related support groups:

Can you answer these questions (Ask a question):

  • Can clindamycin irritate a hi hernia?
    Since I have been taking for 4 days my hi hernia has been acting up. Should I stop taking the medication?
  • Hlab27 antigen and unexplained scratches caused by accutane
    Guinea pig user of Accutane 1982. Experimental drug (told at that time) when a woman hits menopause we are not sure what will happen. I have hit early menopause 42 to be exact. Conjunctivitis, unexplained swelling in fingers, toes, kness, pseudogout (not normal according to my rheumatologist) unexplained scratches in same location, forearms, lower thigh (by knee) fingers. Scratches always are in a line with a break in the line. When a woman hits menopause hormones cease and when this happens the path that Accutane takes to cease sebaceous gland function, skin proliferation ceases. Therefore, my friends the HLA B27 (abnormal antigen targeted for skin proliferation does not know where to go so it randomly attacks whatever organ it chooses. Accutane if I remember correctly and I do have proof, permanently alters DNA. There is no other way orally ingesting a retinolic acid it could control skin, hormonal cesessation. I have only been diagnosed thus far with psoriatic arthritis with no other explanations for these other symptoms. I wonder why this is and I also wonder why dermatologists refuse to take a biopsy of my skin to rule out cell skin proliferation dysfunction. What will this damaging drug attack next. Do no be fooled by Dr.s who tell you that you took this drug so long ago how could this be. Well folks, it is because it has already changed your DNA to the HLAB27 antigen. My question also is, what was supposed to be where this abnormal DNA antigen is and how come this antigen only shows up at menopause. My disease (autoimmune) is progressive) and has already attacked nervous, muscle, skin, joints etc. Interesting
  • How long did the hives/itching eyes last?
    had back to back allergic reactions to iv abx - after clinda (april 2014) developed sjs - still having hives around my eyes, watering, and severe itching. have been on 4x dose zyrtec, prn benadryl. when will this go away?
  • Has anybody had multi lobar pneumonia from reaction to methotrexate?
    Bilateral multilobar pneumonia - rheumatologist considers it was caused by a reaction to methotrexate I was taking for ankylosing spondylitis and I was lucky to survive. Anyone have this and later shown to have scarring of the lungs?
  • I am a 56 year old female with rheumatoid arthritis. i also have found out i have osteoporosis. i keep getting right breast sensitivity also tingling and tenderness in right scapula area... (2 answers)
    I am a 56 year old female with tingling in my right shoulder blade and some tenderness. I have occasional breast discomfort in the same side and sometimes my rt. nipple feels sensitive. If I touch the area, the symptom on the nipple vanishes. at times the tingling travels into my neck and symptoms seem more noticeable in the evening. If I shower in a warm shower the symptoms will vanish for a time.. All my mammograms have been normal and never miss any but it has me very worried. I check my breasts often for lumps. From time to time it also seems like I have tenderness along the sternum on that side. I have rhematoid arthritis as well as was recently told I have osteoporosis. I had a thoracic x-ray and they can see loss of bone density and some vertebrae degeneration. Take methotrexate each week and folic acid every day....Any ideas out there???? Thanks

More questions for: Clindamycin Hydrochloride, Methotrexate

You may be interested at these reviews (Write a review):

  • Humira: my experience
    I have had some form of arthritis probably since birth. My father and maternal grandfather had some form of arthritis. I began to realize pain in both ankles if I stood or walked too long.

    I began taking many NSAIDs when I was around 22. I've done gold, prednisone (twice), plaquenil, butazoidin, sulfasalazine, etc. My best results came with methotrexate after I got cellulitis in my knee (scratch it while kayaking in the summer, fiberglass boat). It dropped my sed rate from over 100 to 35 or so within a few months. I continued with MTX from 1977 to 2000 when my MD suggested Enbrel and stopping MTX. That was a VERY bad decision. Enbrel appeared to mask the disease for a few years. I had my left MCP replaced in 2004, my right heel debrided in 2010, and both my TMJs replaced in 2012. I strongly believe that if I had kept with the MTX it would have delayed those changes. Additionally, in 2011 I was in a bus crash returning from RAGBRAI. I got knocked out from three to six minutes. I had a nasty concussion that lasted 2+ years. Towards the end of the third year post accident I started exercising more aggressively. After doing several 40, 50, and 60 miles rides, I took a leisurely 50 mile ride around Boston at night. Two days later I had a spinal edema. So much for biking and other active sports! :-(

    I have continued with MTX. Late 2013 my MD increased my MTX to .8/week. I had been taking .6/week. I stopped taking Enbrel and switched to Humira in early 2014. I took it for a few months before my doc and I realized it was not doing any better than Enbrel. I tried Humira for three months but it did not seem to work any better than Enbrel. In early June I stopped Humira and waited a few weeks before I started Otezla. I stopped Oterzla on 9/15/14 because it made me depressed and allowed my morning stiffness to get much worse.

    I started prednisone again from the start of July. By mid-August I told my MD that I was screaming louder than I ever had; my dog was very startled. I stopped it gradually over the next two weeks. Meanwhile, the Otezla made me feel awful.

    My MD is going to get me onto another injectable that I take monthly. I forget its name.
  • Psoratic arthritis and trigeminal neuralgia
    hi i suffer from psorisis and psoratic athritis i was just diagnosed with trigeminal neuralgia i was looking for the connection between the two and i see that there is one from your study
    the thing is all 13 people in the study said to have psoriatic arthropathy yet only one said to have psoratic arthritis yet to the best of my knowledge it is the same condition just a diffrent name which means all those studied have psoratic arthritis like me
    also i have not been taking those medicines in the study yet i have the same condition so if you take me into account could be the oly conecction between all of us is the psorisis and psoratic arthritis and not the medicine
  • Clindamycin - vertigo and nausea
    2 days in after starting on clendamycin for tooth infection I began having slight vertigo which steadily increased the next day. Nausea present with vomiting. I saw primary doc & I mentioned I was on this antibiotic which was told this could be the source of my problem and to stop taking medicine & consult w/my dentist. I have had 2 slight incidences with vertigo in the last 6 mos. which I assumed was happening not realizing it could be the clendamycin. I do not remember reading this interaction in the enclosed directions. Symptoms have pretty much resolved by today. I believe it was the clendamycin that caused this but have not hard proof
  • Spiriva caused me to swell up like a hippo.
    My Doctor prescribed spiriva to help me breathe due to asthma/cold. I never smoked but my parents and friends were heavy smokers. I used the spiriva 3 times. Once a day for 3 days then I started swelling in my ankles and the swelling continued until my face, hands arms... basically I was so swollen I gained 29 pounds in two days. My doctor put me on lasix and potassium for several weeks. I quit using the spiriva when my other doctor asked if I was on any new meds. Spiriva was the only new medicine. When I stopped using it the swelling went away.
  • Clindamycin induced clostridium difficile colitis (1 response)
    Dentist prescribed 10 day prescription of Clindamycin for tooth ache, where a week after completing it, a near fatal CDiff infection developed. Renal failure and 3 weeks in hospital followed by 2 months of rehab. No probiotics were taken with the antibiotic. Vancomycin and Flagyl cured the CDiff infection.



    Advice: DO NOT TAKE THIS DRUG, IT IS TOO DESTRUCTIVE!

More reviews for: Clindamycin Hydrochloride, Methotrexate

Comments from related studies:

Complete drug side effects:

On eHealthMe, Clindamycin Hydrochloride (clindamycin phosphate) is often used to treat infection. Methotrexate (methotrexate sodium) is often used to treat rheumatoid arthritis. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

   

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