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Review: taking Clonidine and Benadryl together

Summary: drug interactions are reported among people who take Clonidine and Benadryl together.

This review analyzes the effectiveness and drug interactions between Clonidine and Benadryl. It is created by eHealthMe based on reports of 358 people who take the same drugs from FDA and social media, and is updated regularly.


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On Mar, 29, 2015: 358 people who take Clonidine, Benadryl are studied

Clonidine, Benadryl outcomes

Drug combinations in study:
- Clonidine (clonidine)
- Benadryl (diphenhydramine hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Clonidine is effective100.00%
(1 of 1 people)
(0 of 4 people)
(0 of 1 people)
(1 of 1 people)
(1 of 1 people)
Benadryl is effective0.00%
(0 of 3 people)
(0 of 1 people)
(0 of 1 people)
(1 of 2 people)
(0 of 1 people)

Drug effectiveness by gender :

Clonidine is effective60.00%
(3 of 5 people)
(0 of 3 people)
Benadryl is effective20.00%
(1 of 5 people)
(0 of 3 people)

Drug effectiveness by age :

Clonidine is effectiven/a0.00%
(0 of 3 people)
(0 of 1 people)
(2 of 25 people)
(1 of 3 people)
Benadryl is effectiven/a0.00%
(0 of 3 people)
(0 of 1 people)
(1 of 25 people)
(0 of 3 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
DyspnoeaPneumonia Respiratory Syncytial ViralPainCardiac Failure CongestiveSkin Burning SensationShort-term Memory Lossn/aPain
Obsessive-compulsive DisorderAcute Respiratory Distress SyndromeRenal ImpairmentCondition AggravatedDiarrheaMenopausal SymptomsDyspnoea
Muscle SpasmsPneumonitisSleep Apnoea SyndromeErythemaHeadacheNipple Discharge - AbnormalAnxiety
Eyelid PtosisBlood Bilirubin IncreasedInfusion Related ReactionNausea AggravatedAnxiety, Apprehension, Feeling Uptight, Jitters, Stress, Stress And Anxiety, TensionAsthenia
Posture AbnormalHypernatraemiaCondition AggravatedPancreatitis AggravatedConstipationVomiting
SomnolenceSleep Apnoea SyndromeErythemaChronic PancreatitisPancreatitis AggravatedArthralgia
VomitingRenal ImpairmentFabry's DiseaseChronic SinusitisNauseaDepression
Tourette's DisorderPainFoot FractureFabry's DiseaseNausea AggravatedPyrexia
TachypnoeaCondition AggravatedCardiac Failure CongestiveFoot FractureChronic SinusitisHeadache

Most common drug interactions by gender * :

Chest PainGait Disturbance
Pleural EffusionDyspnoea
Oedema PeripheralDehydration

Most common drug interactions by age * :

Application Site DiscolourationEnuresisNeuroleptic Malignant SyndromeVomitingPainDepressionDepressionPain
Eyelid PtosisDrug Administration ErrorBronchitisHeadachePainVomitingDyspnoea
VomitingCompartment SyndromeUrinary Tract InfectionAbdominal PainArthralgiaNauseaAnaemia
CoughRhabdomyolysisInsomniaDepressionDyspnoeaOedema PeripheralAnxiety
HypertensionExtremity NecrosisSinusitisAbdominal DistensionAnxietySuicidal IdeationRenal Failure Chronic
Night SweatsHypotensionCardiac Failure CongestiveBack PainNauseaNephrogenic Systemic FibrosisPleural Effusion
Abdominal DistensionAgitationInfluenza Like IllnessMuscular WeaknessDiabetes MellitusRashAsthenia
Ocular HyperaemiaPneumonia Respiratory Syncytial ViralBack PainArteriosclerosisSwelling FaceFatigueBone Disorder
Blood Pressure DecreasedPneumonitisUpper Respiratory Tract InfectionDiabetes Mellitus Inadequate ControlNephrogenic Systemic FibrosisPainArthralgia
Neuropathy PeripheralHeadachePulmonary OedemaSchizoaffective DisorderDizzinessAstheniaHeadache

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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You are not alone! Join a related support group:
- support group for people who take Benadryl
- support group for people who take Clonidine

Recent related drug studies (Check your drugs):

Complete drug side effects:

On eHealthMe, Clonidine (clonidine) is often used to treat high blood pressure. Benadryl (diphenhydramine hydrochloride) is often used to treat allergies. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

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