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Review: taking Clonidine and Benadryl together

Summary: drug interactions are reported among people who take Clonidine and Benadryl together.

This review analyzes the effectiveness and drug interactions between Clonidine and Benadryl. It is created by eHealthMe based on reports of 358 people who take the same drugs from FDA and social media, and is updated regularly.





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What are the drugs

Clonidine has active ingredients of clonidine. It is often used in high blood pressure. (latest outcomes from 9,684 Clonidine users)

Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in allergies. (latest outcomes from 29,395 Benadryl users)

On Feb, 27, 2015: 358 people who take Clonidine, Benadryl are studied

Clonidine, Benadryl outcomes

Drug combinations in study:
- Clonidine (clonidine)
- Benadryl (diphenhydramine hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Clonidine is effective100.00%
(1 of 1 people)
(0 of 4 people)
(0 of 1 people)
(1 of 1 people)
(1 of 1 people)
Benadryl is effective0.00%
(0 of 3 people)
(0 of 1 people)
(0 of 1 people)
(1 of 2 people)
(0 of 1 people)

Drug effectiveness by gender :

Clonidine is effective60.00%
(3 of 5 people)
(0 of 3 people)
Benadryl is effective20.00%
(1 of 5 people)
(0 of 3 people)

Drug effectiveness by age :

Clonidine is effectiven/a0.00%
(0 of 3 people)
(0 of 1 people)
(2 of 25 people)
(1 of 3 people)
Benadryl is effectiven/a0.00%
(0 of 3 people)
(0 of 1 people)
(1 of 25 people)
(0 of 3 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
DyspnoeaPneumonia Respiratory Syncytial ViralPainCardiac Failure CongestiveSkin Burning SensationShort-term Memory Lossn/aPain
Obsessive-compulsive DisorderAcute Respiratory Distress SyndromeRenal ImpairmentCondition AggravatedDiarrheaMenopausal SymptomsDyspnoea
Muscle SpasmsPneumonitisSleep Apnoea SyndromeErythemaHeadacheNipple Discharge - AbnormalAnxiety
Eyelid PtosisBlood Bilirubin IncreasedInfusion Related ReactionNausea AggravatedAnxiety, Apprehension, Feeling Uptight, Jitters, Stress, Stress And Anxiety, TensionAsthenia
Posture AbnormalHypernatraemiaCondition AggravatedPancreatitis AggravatedConstipationVomiting
SomnolenceSleep Apnoea SyndromeErythemaChronic PancreatitisPancreatitis AggravatedArthralgia
VomitingRenal ImpairmentFabry's DiseaseChronic SinusitisNauseaDepression
Tourette's DisorderPainFoot FractureFabry's DiseaseNausea AggravatedPyrexia
TachypnoeaCondition AggravatedCardiac Failure CongestiveFoot FractureChronic SinusitisHeadache

Most common drug interactions by gender * :

Chest PainGait Disturbance
Pleural EffusionDyspnoea
Oedema PeripheralDehydration

Most common drug interactions by age * :

Application Site DiscolourationEnuresisNeuroleptic Malignant SyndromeVomitingPainDepressionDepressionPain
Eyelid PtosisDrug Administration ErrorBronchitisHeadachePainVomitingDyspnoea
VomitingCompartment SyndromeUrinary Tract InfectionAbdominal PainArthralgiaNauseaAnaemia
CoughRhabdomyolysisInsomniaDepressionDyspnoeaOedema PeripheralAnxiety
HypertensionExtremity NecrosisSinusitisAbdominal DistensionAnxietySuicidal IdeationRenal Failure Chronic
Night SweatsHypotensionCardiac Failure CongestiveBack PainNauseaNephrogenic Systemic FibrosisPleural Effusion
Abdominal DistensionAgitationInfluenza Like IllnessMuscular WeaknessDiabetes MellitusRashAsthenia
Ocular HyperaemiaPneumonia Respiratory Syncytial ViralBack PainArteriosclerosisSwelling FaceFatigueBone Disorder
Blood Pressure DecreasedPneumonitisUpper Respiratory Tract InfectionDiabetes Mellitus Inadequate ControlNephrogenic Systemic FibrosisPainArthralgia
Neuropathy PeripheralHeadachePulmonary OedemaSchizoaffective DisorderDizzinessAstheniaHeadache

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Get connected: join our support group of Clonidine and Benadryl on

Do you take Clonidine and Benadryl?

You are not alone! Join a related mobile support group:
- support group for people who take Clonidine and Benadryl
- support group for people who take Benadryl
- support group for people who take Clonidine

Can you answer these questions (Ask a question):

More questions for: Benadryl, Clonidine

You may be interested at these reviews (Write a review):

  • Diphenhydramine and mental acuity
    For at least 10 years, I have taken diphenhydramine 50 mg. at bedtime for insomnia and allergies. The results have been that I sleep well with no hangover or any cognitive impairment. If I experience vertigo from allergies, I may take an additional 50 mg. but never exceeding 100 mg in a 24 hour period.

    After reading the report regarding an Alzheimer's study finding that after taking as little as 4mg diphenhydramine daily for more than 3 years, dementia rates were high.

    I stopped the diphenhydramine one night. I experienced symptoms of deep brain pulsating pain and severe insomnia. After 4 hours, I took 50 mg diphenhydramine and slept very well. The next night I took 37.5 mg. diphenhydramine, slept very well. However, some of my tasks require layers of mental challenges in which I became slower.

    My question is how did the study recipients obtain 4 mg doses of diphenhydramine when the standard over-the-counter (OTC) availability in tablets is 25 mg? How reliable is the information submitted from the study subjects? What manufacturer's diphendramine was used, or were there several?

    I felt sharper mentally when on 50 mg daily than so far on 37.5 mg.
  • High cholesterol since on losartan and clonidine
    I found studies done ( via online reputable journals of medicine) that cholesterol was found to increase with the use of Losartan. Imagine that! The Dr was amazed since my healthy diet has not been changed for years. No statins for me!
  • Respiridone causes hyper activity
    My 7yr old is taking intuniv in the AM and respiridone @ pm but it makes run around crazy like a boost of energy
  • Dyphenhydramine and headaches horrible going one almost 24 hours a day for 4 weeks and cant get them to stop, now looking for cause . think its the dyphenhydramine im taking to help me sleep .
    have been taking 3 dyphenhydramine for some time to help me sleep , just in last few weeks began having severe headache almost all the time.. cant get it to go away. just found out it can cause headache and am going to lower my intake to one per night and see if my headaches get better. am taking migrane meds and that hasnt helped a bit so think its not migranes im having. some other reason.
  • Nightmare on benadryl
    After 5 nights without sleep and not having past bad dreams, the last 2 night's taking walfrin sub, for benadryl has terrified THE WORST OF WORST dream in my 55 years. Peaceful start of a dream then seeing myself or family,friends get slottard.crazy thing is I don't watch scary movies or the news. I think I'm going to pass on this meds, and pass out next time :) thank you,God bless

More reviews for: Benadryl, Clonidine

Comments from related studies:

  • From this study (1 year ago):

  • I took 2 bendryl at about 5 am this morning n two at about 5 today in the after noon my only thing is I take remeron n clodine for sleep will I be ok


  • From this study (1 year ago):

  • Diagnosed with vascular dementia in 2008. Recently elevated blood pressure which is why clonidine was added. HCTZ recently dropped from her drug regimen. She was diagnosed with low sodium levels after going to ER for high blood pressure. Her dementia symptoms, confusion, and disorientation have increased . Also she often looses her balance and has had several falls.
    Decreasing fluid intake is difficult and she is thirsty all the time. She also goes to the bathroom very often. Seeking info for my 82 year old mother


  • From this study (2 years ago):

  • Have had leaking right breast occasionally during peri-menopausal years. Just noticed same clear yellow liquid in same (right) breast. No pain, lumps, swelling, redness, etc., but the liquid is darker. Should I be concerned?


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Complete drug side effects:

On eHealthMe, Clonidine (clonidine) is often used to treat high blood pressure. Benadryl (diphenhydramine hydrochloride) is often used to treat allergies. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.


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