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Review: Clonidine and Benadryl

This review analyzes the effectiveness and drug interactions between Clonidine and Benadryl. It is created by eHealthMe based on reports of 357 people who take the same drugs from FDA and social media, and is updated regularly.

You are not alone: join a mobile support group for people who take Clonidine and Benadryl >>>

What are the drugs

Clonidine (latest outcomes from 9,631 users) has active ingredients of clonidine. It is often used in high blood pressure.

Benadryl (latest outcomes from 29,348 users) has active ingredients of diphenhydramine hydrochloride. It is often used in allergies.

On Oct, 25, 2014: 357 people who take Clonidine, Benadryl are studied

Clonidine, Benadryl outcomes

Drug combinations in study:
- Clonidine (clonidine)
- Benadryl (diphenhydramine hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Clonidine is effective100.00%
(1 of 1 people)
(0 of 4 people)
(0 of 1 people)
(1 of 1 people)
Benadryl is effective0.00%
(0 of 3 people)
(0 of 1 people)
(0 of 1 people)
(1 of 1 people)
(0 of 1 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
DyspnoeaPneumonia Respiratory Syncytial ViralPainRenal ImpairmentNipple Discharge - AbnormalShort-term Memory Lossn/aPain
Obsessive-compulsive DisorderAcute Respiratory Distress SyndromeRenal ImpairmentPainMenopausal SymptomsDyspnoea
Muscle SpasmsPneumonitisSleep Apnoea SyndromeSleep Apnoea SyndromeNipple Discharge - AbnormalAnxiety
Eyelid PtosisBlood Bilirubin IncreasedInfusion Related ReactionLymphoedemaAsthenia
Posture AbnormalHypernatraemiaCondition AggravatedInfusion Related ReactionVomiting
SomnolenceSleep Apnoea SyndromeErythemaCondition AggravatedArthralgia
VomitingRenal ImpairmentFabry's DiseaseErythemaDepression
Tourette's DisorderPainFoot FractureFabry's DiseasePyrexia
TachypnoeaCondition AggravatedCardiac Failure CongestiveFoot FractureHeadache

Drug effectiveness by gender :

Clonidine is effective50.00%
(2 of 4 people)
(0 of 3 people)
Benadryl is effective25.00%
(1 of 4 people)
(0 of 3 people)

Most common drug interactions by gender * :

Chest PainGait Disturbance
Pleural EffusionDyspnoea
Oedema PeripheralDehydration

Drug effectiveness by age :

Clonidine is effectiven/a0.00%
(0 of 3 people)
(0 of 1 people)
(1 of 1 people)
(1 of 3 people)
Benadryl is effectiven/a0.00%
(0 of 3 people)
(0 of 1 people)
(1 of 1 people)
(0 of 3 people)

Most common drug interactions by age * :

Application Site DiscolourationEnuresisNeuroleptic Malignant SyndromeVomitingPainDepressionDepressionPain
Eyelid PtosisDrug Administration ErrorBronchitisHeadachePainSuicidal IdeationDyspnoea
VomitingCompartment SyndromeUrinary Tract InfectionAbdominal PainArthralgiaVomitingAnaemia
CoughRhabdomyolysisInsomniaDepressionDyspnoeaNephrogenic Systemic FibrosisAnxiety
HypertensionExtremity NecrosisSinusitisAbdominal DistensionAnxietyOedema PeripheralRenal Failure Chronic
Night SweatsHypotensionCardiac Failure CongestiveBack PainNauseaNauseaPleural Effusion
Abdominal DistensionAgitationInfluenza Like IllnessMuscular WeaknessDiabetes MellitusFatigueAsthenia
Ocular HyperaemiaPneumonia Respiratory Syncytial ViralBack PainArteriosclerosisSwelling FaceRashBone Disorder
Blood Pressure DecreasedPneumonitisUpper Respiratory Tract InfectionDiabetes Mellitus Inadequate ControlNephrogenic Systemic FibrosisAstheniaArthralgia
Neuropathy PeripheralHeadachePulmonary OedemaSchizoaffective DisorderDizzinessPainHeadache

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Clonidine and Benadryl?

Get connected! Join a related mobile support group:
- support group for people who take Clonidine and Benadryl
- support group for people who take Benadryl
- support group for people who take Clonidine

Comments from related studies:

  • From this study (10 months ago):

  • I took 2 bendryl at about 5 am this morning n two at about 5 today in the after noon my only thing is I take remeron n clodine for sleep will I be ok


  • From this study (11 months ago):

  • Diagnosed with vascular dementia in 2008. Recently elevated blood pressure which is why clonidine was added. HCTZ recently dropped from her drug regimen. She was diagnosed with low sodium levels after going to ER for high blood pressure. Her dementia symptoms, confusion, and disorientation have increased . Also she often looses her balance and has had several falls.
    Decreasing fluid intake is difficult and she is thirsty all the time. She also goes to the bathroom very often. Seeking info for my 82 year old mother


  • From this study (1 year ago):

  • Have had leaking right breast occasionally during peri-menopausal years. Just noticed same clear yellow liquid in same (right) breast. No pain, lumps, swelling, redness, etc., but the liquid is darker. Should I be concerned?


Post a new comment    OR    Read more comments

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Complete drug side effects:

On eHealthMe, Clonidine (clonidine) is often used to treat high blood pressure. Benadryl (diphenhydramine hydrochloride) is often used to treat allergies. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.


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