Drug interactions between Co-codamol and Ibuprofen
This is a real world study of Co-codamol and Ibuprofen drug interactions. The study is created by eHealthMe based on 1,427 reports from FDA.
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What are the drugs
Co-codamol has active ingredients of acetaminophen; codeine phosphate. It is used in pain, back pain - low.
Ibuprofen has active ingredients of ibuprofen. It is used in pain, headache, back pain - low, inflammation, arthritis, fever.
On May, 16, 2013: 1,427 people who reported to have interactions when taking Co-codamol, Ibuprofen are studied

Drug combinations in study:
- Co-codamol (acetaminophen; codeine phosphate)
- Ibuprofen (ibuprofen)
Most common interactions experienced by people in the use of Co-codamol, Ibuprofen:
(click on each outcome to view in-depth analysis, incl. how people recovered)| Interaction | Number of reports | |
| 1 | Anxiety | 330 |
| 2 | Vomiting | 232 |
| 3 | Dyspnoea | 219 |
| 4 | Pain | 178 |
| 5 | Nausea | 135 |
| 6 | Fatigue | 124 |
| 7 | Headache | 121 |
| 8 | Back Pain | 108 |
| 9 | Depression | 101 |
| 10 | Dizziness | 98 |
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Most common interactions experienced by people in long term use of Co-codamol, Ibuprofen:
(click on each outcome to view in-depth analysis, incl. how people recovered)| Interaction | Number of reports | |
| 1 | Perforated Ulcer | 10 |
| 2 | Anxiety | 10 |
| 3 | Myocardial Infarction | 8 |
| 4 | Pain | 7 |
| 5 | Depression | 4 |
| 6 | Emotional Distress | 3 |
| 7 | Injury | 3 |
| 8 | Oedema Peripheral | 3 |
| 9 | Gallbladder Disorder | 3 |
| 10 | Constipation | 2 |
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Top conditions involved for these people * :
- Pain
- Hypertension
- Rheumatoid arthritis
- Back pain
- Foetal exposure during pregnancy
Top co-used drugs for these people * :
- Motrin
- Aspirin
- Acetaminophen and codeine phosphate
- Advil
- Prednisone
* Approximation only. Some reports may have incomplete information.
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Side effects in real world:
On eHealthMe, Co-codamol (acetaminophen; codeine phosphate) is often used to treat pain. Ibuprofen (ibuprofen) is often used to treat pain. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.
What is the drug used for and how effective is it:
Other drugs that are used to treat the same conditions:
Comments from related studies:
From this study (2 weeks ago):
From this study (4 months ago):
From this study (7 months ago):
From this study (1 year ago):
sensitivity to light and sudden onset ptosis
I want to check interaction of all these drugs together, with dosage taken
modafinil 800mg daily
XYREM 4.5g x 2 daily
Co-codamol 30/500mg upto 8 daily
Ibuprofen 400mg x 3 daily
I also want to check interaction/side effect of XYREM after anaesthetic and when it's safe to restart after micro vascular decompression operation.
sudden onset chest pain with dizziness, some blurred vision, ketones in urine, and recent weight loss over past 2mths
Robert Honey on May, 7, 2012:
At this time I take 1200mg of Ibuprofen 400mg, 240mg of Tramadol 50mg, 240mg of Codeine Phosphate 30mg and 4000mg of Paracetamol 500mg a day, Plus Omeprazole 20 mg x1, Levothyroxine 100mg,and Citalopram 30mg per day. My question, as I have been taking some of this pills (codeine and paracetamol and citalopram) for a year, is how well do they get on with each other? I am 58 years old, and suffer from a few problems, but at this time I get new problems, and when I ask my Doctor he says not to worry, everything is ok! Please if you could help me? Thank you.
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NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.
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