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Review: taking Co-codamol and Ibuprofen together

Summary: drug interactions are reported among people who take Co-codamol and Ibuprofen together. This review analyzes the effectiveness and drug interactions between Co-codamol and Ibuprofen. It is created by eHealthMe based on reports of 1,529 people who take the same drugs from FDA and social media, and is updated regularly.

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What are the drugs

Co-codamol has active ingredients of acetaminophen; codeine phosphate. It is often used in pain. (latest outcomes from 258 Co-codamol users)

Ibuprofen has active ingredients of ibuprofen. It is often used in pain. (latest outcomes from 61,663 Ibuprofen users)

On May, 2, 2015: 1,529 people who take Co-codamol, Ibuprofen are studied

Co-codamol, Ibuprofen outcomes

Drug combinations in study:
- Co-codamol (acetaminophen; codeine phosphate)
- Ibuprofen (ibuprofen)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Co-codamol is effective35.29%
(6 of 17 people)
(1 of 2 people)
(0 of 1 people)
(1 of 2 people)
(1 of 4 people)
(2 of 3 people)
(0 of 4 people)
(1 of 2 people)
Ibuprofen is effective20.00%
(3 of 15 people)
(0 of 1 people)
(1 of 2 people)
(1 of 5 people)
(2 of 3 people)
(2 of 4 people)
(1 of 4 people)
(0 of 1 people)

Drug effectiveness by gender :

Co-codamol is effective35.71%
(10 of 28 people)
(2 of 7 people)
Ibuprofen is effective25.00%
(7 of 28 people)
(3 of 7 people)

Drug effectiveness by age :

Co-codamol is effectiven/an/a0.00%
(0 of 8 people)
(3 of 6 people)
(5 of 19 people)
(3 of 7 people)
(0 of 10 people)
(1 of 3 people)
Ibuprofen is effectiven/an/a0.00%
(0 of 8 people)
(1 of 5 people)
(5 of 20 people)
(3 of 7 people)
(1 of 10 people)
(0 of 3 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
HypotensionCoronary Artery InsufficiencyAnxietyBiliary DyskinesiaPainAnxietyPerforated UlcerPain
Oesophagitis HaemorrhagicGastritisEmotional DistressMultiple InjuriesAnxietyDepressionOedemaAnxiety
Gastrointestinal HaemorrhageArteriosclerosis Coronary ArteryCoronary Artery StenosisStomach DiscomfortMyocardial InfarctionDyspepsiaNeuroendocrine CarcinomaNausea
HaematemesisCoronary Artery StenosisCholelithiasisGastritisDepressionScarHepatic FailureBack Pain
Duodenal UlcerChest PainAbdominal Pain UpperCholecystitis ChronicInjuryFlatulenceAnxiety DisorderFatigue
Gastric UlcerEpistaxisNauseaGallbladder DisorderOedema PeripheralHaematemesisGastrointestinal HaemorrhageVomiting
Swollen TongueMyocardial InfarctionVomitingSmall Intestinal StenosisEmotional DistressInjuryCardiac Function Disturbance PostoperativeDyspnoea
DyspnoeaHyperhidrosisDepressionSmall Intestine UlcerHypertensionAbdominal DistensionCardiac FailureHeadache
Renal Failure AcuteAnxietyGeneral Physical Health DeteriorationPainPulmonary EmbolismConstipationGastric Ulcer PerforationDepression
UrticariaGastrointestinal HaemorrhageEncephalitisDrug IneffectiveMuscular WeaknessPainHaemothoraxDizziness

Most common drug interactions by gender * :

Back PainBone Disorder
FatiguePain In Jaw
Abdominal PainInsomnia

Most common drug interactions by age * :

Psychomotor HyperactivityAsthmaAbdominal Pain UpperDysphagiaPulmonary EmbolismAnxietyFatiguePain
DeliriumVomitingNauseaMemory ImpairmentAnxietyBack PainHeadacheAnxiety
Myocardial InfarctionEpistaxisCholecystitis ChronicHallucinationHeadacheNauseaAnxietyDyspnoea
Skin Disorder NosHepatic Enzyme IncreasedAnxietyCholecystitis ChronicChest PainCoughParaesthesiaGastrointestinal Haemorrhage
Pregnancy NosNasopharyngitisInjuryAbnormal BehaviourDepressionBone DisorderNauseaBack Pain
Ventricular Septal Defect NosUnresponsive To StimuliCompleted SuicideHepatic FailurePainHeadacheHiatus HerniaAbdominal Pain
Multiple Congenital AbnormalitiesArrhythmiaDeep Vein ThrombosisGait DisturbanceAbdominal PainEmotional DistressPlatelet Count DecreasedBone Disorder
Condition AggravatedSudden DeathAbdominal PainAccidental OverdoseDeep Vein ThrombosisTooth ExtractionOedemaMalaise
Gastroenteritis NosAstheniaPainNauseaPyrexiaVomitingDepressionConfusional State

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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Do you take Co-codamol and Ibuprofen?


You are not alone! Join a related support group:
- support group for people who take Co-codamol
- support group for people who take Ibuprofen

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Complete drug side effects:

On eHealthMe, Co-codamol (acetaminophen; codeine phosphate) is often used to treat pain. Ibuprofen (ibuprofen) is often used to treat pain. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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