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Review: taking Coumadin and Methadone together

Summary: drug interactions are reported among people who take Coumadin and Methadone together.

This review analyzes the effectiveness and drug interactions between Coumadin and Methadone. It is created by eHealthMe based on reports of 534 people who take the same drugs from FDA and social media, and is updated regularly.


You are not alone: join a support group for people who take Coumadin and Methadone >>>

On Apr, 17, 2015: 534 people who take Coumadin, Methadone Hydrochloride are studied

Coumadin, Methadone Hydrochloride outcomes

Drug combinations in study:
- Coumadin (warfarin sodium)
- Methadone Hydrochloride (methadone hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Coumadin is effectiven/a0.00%
(0 of 1 people)
(0 of 1 people)
(3 of 4 people)
(2 of 2 people)
(3 of 3 people)
(1 of 1 people)
Methadone Hydrochloride is effective0.00%
(0 of 4 people)
(1 of 3 people)
(3 of 3 people)
(2 of 3 people)
(1 of 1 people)
(1 of 1 people)

Drug effectiveness by gender :

Coumadin is effective66.67%
(4 of 6 people)
(5 of 6 people)
Methadone Hydrochloride is effective57.14%
(4 of 7 people)
(4 of 8 people)

Drug effectiveness by age :

Coumadin is effectiven/an/an/an/a100.00%
(1 of 1 people)
(3 of 10 people)
(3 of 4 people)
(2 of 2 people)
Methadone Hydrochloride is effectiven/an/an/an/a66.67%
(2 of 3 people)
(4 of 10 people)
(1 of 4 people)
(1 of 4 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
International Normalised Ratio IncreasedRadiation MucositisRenal ImpairmentRetroperitoneal HaemorrhageMetastatic NeoplasmPemphigoidErectile DysfunctionPain
Radiation MucositisNeutropeniaCalculus UrinaryPneumoniaLymphoedemaAtrial FibrillationDyspnoea
NeuralgiaFebrile NeutropeniaConstipationInternational Normalised Ratio IncreasedLoose ToothAnxiety
MalaiseOropharyngeal PainDiarrhoea NosAtrial FibrillationMultiple MyelomaOsteonecrosis Of Jaw
FlatulenceDepressionDrug IneffectiveNauseaBack Pain
Weight DecreasedWeaknessAbdominal Pain NosOsteoarthritisNausea
Eating DisorderOedemaCellulitis
Erectile DysfunctionObesityOedema Peripheral
Febrile NeutropeniaKyphosisPyrexia

Most common drug interactions by gender * :

Osteonecrosis Of JawAnxiety
Back PainOsteonecrosis Of Jaw
Oedema PeripheralAnaemia
Weight DecreasedNausea
DepressionBack Pain

Most common drug interactions by age * :

International Normalised Ratio Increasedn/aEncephalopathyPainPainPyrexiaPainPain
PhlebitisPain In ExtremityJoint Range Of Motion DecreasedDyspnoeaAbdominal PainInjury
Depressed Level Of ConsciousnessCellulitisArthralgiaBack PainAnxietyAnxiety
ConvulsionOsteonecrosis Of JawNephrogenic Systemic FibrosisChest PainArthralgiaAnaemia
PancreatitisHeadacheSkin HypertrophyUrinary Tract InfectionDyspnoeaOsteomyelitis
Abdominal Pain UpperAstheniaPruritusNauseaPneumoniaVomiting
Bone DisorderMyalgiaBone DisorderNeuropathy PeripheralNausea
Tooth ExtractionPain In ExtremityAnaemiaBack PainTenderness
ParaesthesiaOedema PeripheralWeight DecreasedHeadacheOsteonecrosis Of Jaw
InsomniaJoint ContractureToothacheOsteonecrosis Of JawObesity

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Coumadin and Methadone?




You are not alone! Join a related support group:
- support group for people who take Coumadin
- support group for people who take Methadone Hydrochloride

Recent related drug studies (Check your drugs):

Complete drug side effects:

On eHealthMe, Coumadin (warfarin sodium) is often used to treat blood clots. Methadone Hydrochloride (methadone hydrochloride) is often used to treat pain. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

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