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Review: Coumadin and Methadone

This review analyzes the effectiveness and drug interactions between Coumadin and Methadone. It is created by eHealthMe based on reports of 534 people who take the same drugs from FDA and social media, and is updated regularly.

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What are the drugs

Coumadin (latest outcomes from 75,061 users) has active ingredients of warfarin sodium. It is often used in blood clots.

Methadone hydrochloride (latest outcomes from 2,796 users) has active ingredients of methadone hydrochloride. It is often used in pain.

On Jul, 20, 2014: 534 people who take Coumadin, Methadone Hydrochloride are studied

Coumadin, Methadone Hydrochloride outcomes

Drug combinations in study:
- Coumadin (warfarin sodium)
- Methadone Hydrochloride (methadone hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Coumadin is effectiven/a0.00%
(0 of 1 people)
(0 of 1 people)
(3 of 4 people)
(2 of 2 people)
(3 of 3 people)
(1 of 1 people)
Methadone Hydrochloride is effective0.00%
(0 of 4 people)
(1 of 3 people)
(3 of 3 people)
(2 of 3 people)
(1 of 1 people)
(1 of 1 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
International Normalised Ratio IncreasedRadiation MucositisRenal ImpairmentRetroperitoneal HaemorrhageMetastatic NeoplasmPemphigoidErectile DysfunctionPain
Radiation MucositisNeutropeniaCalculus UrinaryPneumoniaLymphoedemaAtrial FibrillationDyspnoea
NeuralgiaFebrile NeutropeniaConstipationInternational Normalised Ratio IncreasedLoose ToothAnxiety
MalaiseOropharyngeal PainDiarrhoea NosAtrial FibrillationMultiple MyelomaOsteonecrosis Of Jaw
FlatulenceDepressionDrug IneffectiveNauseaBack Pain
Weight DecreasedWeaknessAbdominal Pain NosOsteoarthritisNausea
Eating DisorderOedemaCellulitis
Erectile DysfunctionObesityOedema Peripheral
Febrile NeutropeniaKyphosisPyrexia

Drug effectiveness by gender :

Coumadin is effective66.67%
(4 of 6 people)
(5 of 6 people)
Methadone Hydrochloride is effective57.14%
(4 of 7 people)
(4 of 8 people)

Most common drug interactions by gender * :

Osteonecrosis Of JawAnxiety
Back PainOsteonecrosis Of Jaw
Oedema PeripheralAnaemia
Weight DecreasedNausea
DepressionBack Pain

Drug effectiveness by age :

Coumadin is effectiven/an/an/an/a100.00%
(1 of 1 people)
(3 of 10 people)
(3 of 4 people)
(2 of 2 people)
Methadone Hydrochloride is effectiven/an/an/an/a66.67%
(2 of 3 people)
(4 of 10 people)
(1 of 4 people)
(1 of 4 people)

Most common drug interactions by age * :

International Normalised Ratio Increasedn/aEncephalopathyPainPainPyrexiaPainPain
PhlebitisPain In ExtremityJoint Range Of Motion DecreasedDyspnoeaAbdominal PainInjury
Depressed Level Of ConsciousnessCellulitisArthralgiaBack PainAnxietyAnxiety
ConvulsionOsteonecrosis Of JawNephrogenic Systemic FibrosisChest PainArthralgiaAnaemia
PancreatitisHeadacheSkin HypertrophyUrinary Tract InfectionDyspnoeaOsteomyelitis
Abdominal Pain UpperAstheniaPruritusNauseaPneumoniaVomiting
Bone DisorderMyalgiaBone DisorderNeuropathy PeripheralNausea
Tooth ExtractionPain In ExtremityAnaemiaBack PainTenderness
ParaesthesiaOedema PeripheralWeight DecreasedHeadacheOsteonecrosis Of Jaw
InsomniaJoint ContractureToothacheOsteonecrosis Of JawObesity

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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Comments from related studies:

  • From this study (2 years ago):

  • after starting axiron Atrial fibrillation started and has continued still for about 1 month. Blood preasure good HR at about 55 per minute


  • From this study (3 years ago):

  • effects of taking these two medicines together. Is is ok?


  • From this study (4 years ago):

  • Vomiting 4-5 hours after taking methadone. Vomiting when driking and eating. Works great for pain


Can you answer these questions (what is this?):

More questions for: Coumadin, Methadone Hydrochloride

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  • Mental or emotional symptoms of warfarin sodium
    Took Coumadin or Warfarin sodium for 18 years it introduced some strange behaviors causing the people around me to think it was caused by the small stroke I had (why I was put on Coumadin). I was switched to Xarelto and within a few days I could remember the things I had been doing and thinking abo ...

More reviews for: Coumadin, Methadone Hydrochloride

Complete drug side effects:

On eHealthMe, Coumadin (warfarin sodium) is often used to treat blood clots. Methadone Hydrochloride (methadone hydrochloride) is often used to treat pain. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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