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Review: Coumadin and Methotrexate

This review analyzes the effectiveness and drug interactions between Coumadin and Methotrexate. It is created by eHealthMe based on reports of 2,170 people who take the same drugs from FDA and social media, and is updated regularly.

Stay connected: join a mobile support group for people who take Coumadin and Methotrexate >>>

What are the drugs

Coumadin (what 75,068 Coumadin users reported?) has active ingredients of warfarin sodium. It is used in blood clots.

Methotrexate (what 131,102 Methotrexate users reported?) has active ingredients of methotrexate sodium. It is used in rheumatoid arthritis.

On Aug, 12, 2014: 2,170 people who take Coumadin, Methotrexate are studied

Coumadin, Methotrexate outcomes

Drug combinations in study:
- Coumadin (warfarin sodium)
- Methotrexate (methotrexate sodium)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Coumadin is effective100.00%
(1 of 1 people)
50.00%
(2 of 4 people)
100.00%
(1 of 1 people)
75.00%
(3 of 4 people)
75.00%
(3 of 4 people)
100.00%
(2 of 2 people)
100.00%
(1 of 1 people)
n/a
Methotrexate is effective0.00%
(0 of 2 people)
0.00%
(0 of 1 people)
100.00%
(2 of 2 people)
40.00%
(2 of 5 people)
0.00%
(0 of 3 people)
25.00%
(1 of 4 people)
100.00%
(1 of 1 people)
n/a

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
FallAnaemiaVomitingPulmonary EmbolismPancytopeniaWeight DecreasedOedema PeripheralAtrial Fibrillation
StomatitisGastrointestinal HaemorrhageDecreased AppetiteDiverticulum Intestinal HaemorrhagicDizzinessPyrexiaDyspnoeaPain
PyrexiaConfusional StateInflammationVomitingInterstitial Lung DiseaseFacial ParesisAtrial FibrillationDyspnoea
International Normalised Ratio IncreasedThrombocytopeniaAtrial FibrillationPneumoniaBalance DisorderCoughAutoimmune HepatitisPneumonia
ConstipationHaemolytic AnaemiaChest PainVulval CellulitisSquamous Cell CarcinomaSquamous Cell CarcinomaHepatic CirrhosisArthralgia
Platelet Count DecreasedHemiparesisLiver DisorderNauseaRheumatoid ArthritisMetastases To Central Nervous SystemPancreatitis AcuteAnaemia
Non-hodgkin's LymphomaCardiac Failure CongestiveNauseaDiarrhoeaDental CariesPneumoniaLactose IntoleranceAsthenia
Deep Vein ThrombosisFallHerpes OesophagitisDeep Vein ThrombosisDeep Vein ThrombosisHiatus HerniaAstheniaFatigue
C-reactive Protein IncreasedInternational Normalised Ratio DecreasedHerpes Virus InfectionCerebrovascular AccidentMyelodysplastic SyndromeLung Cancer MetastaticCardiac Failure ChronicPyrexia
ArrhythmiaPalmar-plantar Erythrodysaesthesia SyndromeViral InfectionAlopeciaSepsis NosBone LesionBlood Alkaline Phosphatase IncreasedFall

Drug effectiveness by gender :

FemaleMale
Coumadin is effective70.00%
(7 of 10 people)
85.71%
(6 of 7 people)
Methotrexate is effective27.27%
(3 of 11 people)
42.86%
(3 of 7 people)

Most common drug interactions by gender * :

FemaleMale
PainPneumonia
Atrial FibrillationAtrial Fibrillation
DyspnoeaAsthenia
AnaemiaPyrexia
ArthralgiaDyspnoea
FallFatigue
PneumoniaPain
Pulmonary EmbolismChest Pain
AstheniaOedema Peripheral
NauseaCough

Drug effectiveness by age :

0-12-910-1920-2930-3940-4950-5960+
Coumadin is effectiven/an/an/an/a100.00%
(1 of 1 people)
100.00%
(1 of 1 people)
20.00%
(3 of 15 people)
53.33%
(8 of 15 people)
Methotrexate is effectiven/an/an/an/a0.00%
(0 of 1 people)
n/a5.13%
(2 of 39 people)
26.67%
(4 of 15 people)

Most common drug interactions by age * :

0-12-910-1920-2930-3940-4950-5960+
n/an/aVomitingCondition AggravatedArthralgiaPainFatigueAtrial Fibrillation
Infusion Related ReactionWegener's GranulomatosisPneumoniaDepressionDyspnoeaAsthenia
HeadachePancytopeniaNauseaAnxietyArthralgiaPneumonia
PneumoniaInternational Normalised Ratio IncreasedVenous ThrombosisFatigueAtrial FibrillationPain
ScoliosisAbscessVentricular TachycardiaIntervertebral Disc ProtrusionCoughFall
Crohn's DiseaseWeight IncreasedOsteonecrosis Of JawPyrexiaDyspnoea
Drug IneffectiveAcute Right Ventricular FailurePulmonary EmbolismPainAnaemia
Aspartate Aminotransferase IncreasedPharyngeal OedemaPyrexiaAnaemiaArthralgia
Abdominal PainUrticariaFallRheumatoid ArthritisPyrexia
Diarrhoea HaemorrhagicAnaemiaPneumoniaNauseaChest Pain

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

You can also:

Get connected! Join a mobile support group to help out with your experience or learn from others anytime and anywhere:
- group for people who take Coumadin and Methotrexate
- group for people who take Coumadin
- group for people who take Methotrexate

Comments from related studies:

  • From this study (1 month ago):

  • Have also been on the following medications on and off: Tramadol\Acet, Lyrica,
    Vitamin D, and Lanzap.
    Patient also suffers from rheumatoid arthritis.

    Reply

  • From this study (11 months ago):

  • I suffer from UC for 8 years, the past 2 years I have had many flare ups, so I am almost Steroid dependent, as they are the only thing that works. So to get off Steroids, i have tried Azathiopran (didn't work caused severe side-effects) then 6MP, (also failed due to lowering my WBC and caused me to become Neurtaphinic and i caught C-Diff), so I am now trying Methotrexate, but I got a blood clot on the lung (4 weeks ago). After I came out of hospital for a week, I was given Warfarin tablets (3 weeks ago) and ever since I've taken them, I have not passed ANY stools naturally. I went 8 days with no movement, so ended up using Microlex Enema to release some, which works, but I have been using them every day for the past 13 days as its the only thing that gets me 'going', only only some soft stools slide out (look normal and soft), so am I constipated or do I have a blockage, or are these drugs stopping me from having the "urge" to go. My belly is ever so bloated, tight and aches a little.
    I am only 10.5 stone and 36 years old, I have a swollen face too....
    I've only taken 3 doeses (one a week) of Methotrexate, so I think it is too early for any side affects of this drug to kick in yet (I began the Warfarin on the Friday and the Methotrexate on the Monday (3 weeks ago)...
    Help please?.... as all the consultants and doctors say is "Try enemas and water etc bla bla...." but I am now dependent on the Microlex enema to go...

    Reply

  • From this study (1 year ago):

  • have not started cipralex yet - conce4rned about warfarin mix

    Reply

    Joe T on Feb, 26, 2013:

    I am on Methotrexate fir the past year, been taking it as a sub cutaneous 20mg injection once weekly.

    About 3 months ago i started to take cipralex(lexapro) 10mg daily. I seem to tolerate ut very well. Cipralex have improved my axiety/mood swings to a great deal, additionally i havent taken one pill of NSAID for the past 3 months. I used to take about 3-4 pills of Arcoxia every week. I am not sure if Cipralex numbs y joints pain, or if Methotrexate is working better, all i know is thank God i am doing well physically and psychologically things seem to be in a balance!

    I am male, 28 years of age. I do regular blood tests every 6 weeks. These include liver function tests, kidney function test, erythrocyte sedimentation rate, C reactive protein, and Complete blood count. All my reasults have always been in range with the normal limits.

    I hope my answer helps.

    Cheers,

    Joe

    Reply

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Complete drug side effects:

On eHealthMe, Coumadin (warfarin sodium) is often used to treat blood clots. Methotrexate (methotrexate sodium) is often used to treat rheumatoid arthritis. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

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