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Review: taking Coumadin and Methotrexate together

Summary: drug interactions are reported among people who take Coumadin and Methotrexate together.

This review analyzes the effectiveness and drug interactions between Coumadin and Methotrexate. It is created by eHealthMe based on reports of 2,171 people who take the same drugs from FDA and social media, and is updated regularly.

 

 

 

 

You are not alone: join a mobile support group for people who take Coumadin and Methotrexate >>>

What are the drugs

Coumadin has active ingredients of warfarin sodium. It is often used in blood clots. (latest outcomes from 75,111 Coumadin users)

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. (latest outcomes from 131,243 Methotrexate users)

On Feb, 25, 2015: 2,171 people who take Coumadin, Methotrexate are studied

Coumadin, Methotrexate outcomes

Drug combinations in study:
- Coumadin (warfarin sodium)
- Methotrexate (methotrexate sodium)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Coumadin is effective100.00%
(1 of 1 people)
50.00%
(2 of 4 people)
100.00%
(1 of 1 people)
75.00%
(3 of 4 people)
75.00%
(3 of 4 people)
100.00%
(3 of 3 people)
100.00%
(1 of 1 people)
n/a
Methotrexate is effective0.00%
(0 of 2 people)
0.00%
(0 of 2 people)
100.00%
(2 of 2 people)
40.00%
(2 of 5 people)
0.00%
(0 of 3 people)
25.00%
(1 of 4 people)
100.00%
(1 of 1 people)
n/a

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
FallAnaemiaVomitingPulmonary EmbolismPancytopeniaWeight DecreasedOedema PeripheralAtrial Fibrillation
StomatitisThrombocytopeniaDecreased AppetiteDiverticulum Intestinal HaemorrhagicDizzinessPyrexiaDyspnoeaPain
PyrexiaGastrointestinal HaemorrhageInflammationVomitingInterstitial Lung DiseaseFacial ParesisAtrial FibrillationDyspnoea
International Normalised Ratio IncreasedConfusional StateAtrial FibrillationPneumoniaBalance DisorderCoughAutoimmune HepatitisPneumonia
ConstipationHaemolytic AnaemiaChest PainVulval CellulitisSquamous Cell CarcinomaSquamous Cell CarcinomaHepatic CirrhosisArthralgia
Platelet Count DecreasedInternational Normalised Ratio DecreasedLiver DisorderNauseaRheumatoid ArthritisHiatus HerniaPancreatitis AcuteAnaemia
Non-hodgkin's LymphomaNeuropathy PeripheralNauseaDiarrhoeaDental CariesPneumoniaLactose IntoleranceAsthenia
Deep Vein ThrombosisFallHerpes OesophagitisDeep Vein ThrombosisDeep Vein ThrombosisMetastases To Central Nervous SystemAstheniaFatigue
C-reactive Protein IncreasedCardiac Failure CongestiveHerpes Virus InfectionCerebrovascular AccidentMyelodysplastic SyndromeLung Cancer MetastaticCardiac Failure ChronicPyrexia
ArrhythmiaPalmar-plantar Erythrodysaesthesia SyndromeViral InfectionAlopeciaSepsis NosMuscle RigidityBlood Alkaline Phosphatase IncreasedFall

Drug effectiveness by gender :

FemaleMale
Coumadin is effective72.73%
(8 of 11 people)
85.71%
(6 of 7 people)
Methotrexate is effective25.00%
(3 of 12 people)
42.86%
(3 of 7 people)

Most common drug interactions by gender * :

FemaleMale
PainPneumonia
Atrial FibrillationAtrial Fibrillation
DyspnoeaAsthenia
AnaemiaPyrexia
ArthralgiaDyspnoea
FallFatigue
PneumoniaPain
Pulmonary EmbolismChest Pain
AstheniaOedema Peripheral
NauseaCough

Drug effectiveness by age :

0-12-910-1920-2930-3940-4950-5960+
Coumadin is effectiven/an/an/an/a100.00%
(1 of 1 people)
66.67%
(2 of 3 people)
20.00%
(3 of 15 people)
53.33%
(8 of 15 people)
Methotrexate is effectiven/an/an/an/a0.00%
(0 of 1 people)
0.00%
(0 of 2 people)
5.13%
(2 of 39 people)
26.67%
(4 of 15 people)

Most common drug interactions by age * :

0-12-910-1920-2930-3940-4950-5960+
n/an/aVomitingCondition AggravatedArthralgiaPainFatigueAtrial Fibrillation
Infusion Related ReactionWegener's GranulomatosisPneumoniaDepressionDyspnoeaAsthenia
HeadachePancytopeniaNauseaAnxietyArthralgiaPneumonia
PneumoniaInternational Normalised Ratio IncreasedVenous ThrombosisFatigueAtrial FibrillationPain
ScoliosisAbscessVentricular TachycardiaPulmonary EmbolismCoughFall
Crohn's DiseaseWeight IncreasedPyrexiaPyrexiaDyspnoea
Drug IneffectiveAcute Right Ventricular FailureIntervertebral Disc ProtrusionPainAnaemia
Aspartate Aminotransferase IncreasedPharyngeal OedemaOsteonecrosis Of JawAnaemiaArthralgia
Abdominal PainUrticariaFallRheumatoid ArthritisPyrexia
Diarrhoea HaemorrhagicAnaemiaAnaemiaNauseaChest Pain

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Get connected: join our support group of Coumadin and Methotrexate on

Do you take Coumadin and Methotrexate?

You are not alone! Join a related mobile support group:
- support group for people who take Coumadin and Methotrexate
- support group for people who take Coumadin
- support group for people who take Methotrexate

Recent conversations of related support groups:

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  • Does humira cause excessive sweating?
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  • Would the tinnitus abate with if i discontinue methotrexate?
    I've just begun my 4th year of Methotrexate for Rheumatoid issue, but it also alleviated my psoriasis. I am hesitant to discontinue because the benefits are great. However, the tinnitus is becoming unbearable and almost maddening. I will more likely consider talking to my doctor about changing medications if 1. The tinnitus subsides with the discontinuance of Methotrexate and if 2. Other rheumatoid medication would not have the same issues with tinnitus. Just discovered the possible connection minutes ago and am eager and hopeful. Please help. Thank you. -Celeste

More questions for: Coumadin, Methotrexate

You may be interested at these reviews (Write a review):

  • Muscle weakness from methotrexate
    I'm 61 and have taken methotrexate for 25 yrs. I've always done well with my blood results etc. Lately I've been having problems pushing a grocery cart. My arm muscles are so weak!
  • Having leg cramps after 2 years on enbrel
    Started having leg cramps after using Enbrel for almsot 2 years. They start the day I give the injection and have lasted 1-3 days waking me several time in the middle of the night.
  • Sodium phosphate sensitivity - chlortrimaton helps
    When I eat meat or any product with Sodium Phosphate in it, either in one large dose or cumulatively I get all of these symptoms. It gets worse if I eat it in consecutive meals and/or days. Taking Chlortrimaton eases the symptoms. The Doctor says this is not an allergy but is a sensitivity to Sodium Phosphate. There are other meat tenderizers and preservatives that have one or more of the symptoms listed but I have not been able to identify them.
  • The effect of magnesium citrate on coumadin
    the combination of coumadin and magnesium citrate guarantees too low INR
  • Humira: my experience
    I have had some form of arthritis probably since birth. My father and maternal grandfather had some form of arthritis. I began to realize pain in both ankles if I stood or walked too long.

    I began taking many NSAIDs when I was around 22. I've done gold, prednisone (twice), plaquenil, butazoidin, sulfasalazine, etc. My best results came with methotrexate after I got cellulitis in my knee (scratch it while kayaking in the summer, fiberglass boat). It dropped my sed rate from over 100 to 35 or so within a few months. I continued with MTX from 1977 to 2000 when my MD suggested Enbrel and stopping MTX. That was a VERY bad decision. Enbrel appeared to mask the disease for a few years. I had my left MCP replaced in 2004, my right heel debrided in 2010, and both my TMJs replaced in 2012. I strongly believe that if I had kept with the MTX it would have delayed those changes. Additionally, in 2011 I was in a bus crash returning from RAGBRAI. I got knocked out from three to six minutes. I had a nasty concussion that lasted 2+ years. Towards the end of the third year post accident I started exercising more aggressively. After doing several 40, 50, and 60 miles rides, I took a leisurely 50 mile ride around Boston at night. Two days later I had a spinal edema. So much for biking and other active sports! :-(

    I have continued with MTX. Late 2013 my MD increased my MTX to .8/week. I had been taking .6/week. I stopped taking Enbrel and switched to Humira in early 2014. I took it for a few months before my doc and I realized it was not doing any better than Enbrel. I tried Humira for three months but it did not seem to work any better than Enbrel. In early June I stopped Humira and waited a few weeks before I started Otezla. I stopped Oterzla on 9/15/14 because it made me depressed and allowed my morning stiffness to get much worse.

    I started prednisone again from the start of July. By mid-August I told my MD that I was screaming louder than I ever had; my dog was very startled. I stopped it gradually over the next two weeks. Meanwhile, the Otezla made me feel awful.

    My MD is going to get me onto another injectable that I take monthly. I forget its name.

More reviews for: Coumadin, Methotrexate

Comments from related studies:

  • From this study (8 months ago):

  • Have also been on the following medications on and off: Tramadol\Acet, Lyrica,
    Vitamin D, and Lanzap.
    Patient also suffers from rheumatoid arthritis.

    Reply

  • From this study (1 year ago):

  • I suffer from UC for 8 years, the past 2 years I have had many flare ups, so I am almost Steroid dependent, as they are the only thing that works. So to get off Steroids, i have tried Azathiopran (didn't work caused severe side-effects) then 6MP, (also failed due to lowering my WBC and caused me to become Neurtaphinic and i caught C-Diff), so I am now trying Methotrexate, but I got a blood clot on the lung (4 weeks ago). After I came out of hospital for a week, I was given Warfarin tablets (3 weeks ago) and ever since I've taken them, I have not passed ANY stools naturally. I went 8 days with no movement, so ended up using Microlex Enema to release some, which works, but I have been using them every day for the past 13 days as its the only thing that gets me 'going', only only some soft stools slide out (look normal and soft), so am I constipated or do I have a blockage, or are these drugs stopping me from having the "urge" to go. My belly is ever so bloated, tight and aches a little.
    I am only 10.5 stone and 36 years old, I have a swollen face too....
    I've only taken 3 doeses (one a week) of Methotrexate, so I think it is too early for any side affects of this drug to kick in yet (I began the Warfarin on the Friday and the Methotrexate on the Monday (3 weeks ago)...
    Help please?.... as all the consultants and doctors say is "Try enemas and water etc bla bla...." but I am now dependent on the Microlex enema to go...

    Reply

  • From this study (2 years ago):

  • have not started cipralex yet - conce4rned about warfarin mix

    Reply

    Joe T on Feb, 26, 2013:

    I am on Methotrexate fir the past year, been taking it as a sub cutaneous 20mg injection once weekly.

    About 3 months ago i started to take cipralex(lexapro) 10mg daily. I seem to tolerate ut very well. Cipralex have improved my axiety/mood swings to a great deal, additionally i havent taken one pill of NSAID for the past 3 months. I used to take about 3-4 pills of Arcoxia every week. I am not sure if Cipralex numbs y joints pain, or if Methotrexate is working better, all i know is thank God i am doing well physically and psychologically things seem to be in a balance!

    I am male, 28 years of age. I do regular blood tests every 6 weeks. These include liver function tests, kidney function test, erythrocyte sedimentation rate, C reactive protein, and Complete blood count. All my reasults have always been in range with the normal limits.

    I hope my answer helps.

    Cheers,

    Joe

    Reply

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Complete drug side effects:

On eHealthMe, Coumadin (warfarin sodium) is often used to treat blood clots. Methotrexate (methotrexate sodium) is often used to treat rheumatoid arthritis. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

   

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