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Review: taking Coumadin and Phenytoin together

Summary: drug interactions are reported among people who take Coumadin and Phenytoin together. This review analyzes the effectiveness and drug interactions between Coumadin and Phenytoin. It is created by eHealthMe based on reports of 1,438 people who take the same drugs from FDA and social media, and is updated regularly.

Personalized health information: on eHealthMe you can find out what patients like me (same gender, age) reported their drugs and conditions on FDA and social media since 1977. Our tools are free and anonymous. 66 million people have used us. 200+ peer-reviewed medical journals have referenced our original studies. Start now >>>


You are not alone: join a support group for people who take Coumadin and Phenytoin >>>

What are the drugs

Coumadin has active ingredients of warfarin sodium. It is often used in blood clots. (latest outcomes from 75,118 Coumadin users)

Phenytoin has active ingredients of phenytoin. It is often used in epilepsy. (latest outcomes from 11,105 Phenytoin users)

On Apr, 23, 2015: 1,438 people who take Coumadin, Phenytoin are studied

Coumadin, Phenytoin outcomes

Drug combinations in study:
- Coumadin (warfarin sodium)
- Phenytoin (phenytoin)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Coumadin is effectiven/a100.00%
(1 of 1 people)
Phenytoin is effectiven/a100.00%
(1 of 1 people)

Drug effectiveness by gender :

Coumadin is effective100.00%
(1 of 1 people)
Phenytoin is effective100.00%
(1 of 1 people)

Drug effectiveness by age :

Coumadin is effectiven/an/an/an/an/an/a33.33%
(1 of 3 people)
Phenytoin is effectiven/an/an/an/an/an/a33.33%
(1 of 3 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
International Normalised Ratio IncreasedStevens-johnson SyndromeBrain HerniationStress SymptomsConfusional StateConvulsionLupus-like SyndromeConvulsion
Transaminases IncreasedInternational Normalised Ratio IncreasedDrug Level IncreasedHepatitis NosHaemorrhagic StrokeAnticonvulsant Drug Level DecreasedArthritisInternational Normalised Ratio Increased
Hereditary AngioedemaHepatic FailureFallBlood Viscosity IncreasedHeadachePleural EffusionDrug IneffectivePain
Urinary Tract InfectionDeliriumSubdural HaematomaCerebral Artery EmbolismPulmonary HypertensionStatus EpilepticusFall
PancreatitisRashDeathCerebral HaemorrhagePost Procedural ComplicationGrand Mal ConvulsionAsthenia
ConvulsionHepatorenal SyndromeSpeech DisorderAphasiaPhlebothrombosisMalaiseDyspnoea
Status EpilepticusConvulsionAnaemia NosScreamingLimb InjuryNormal Pressure HydrocephalusAnxiety
Stevens-johnson SyndromePruritusWeight DecreasedTardive DyskinesiaPacemaker ComplicationOedema PeripheralPneumonia
Anticonvulsant Drug Level DecreasedCardiomegalyHaemorrhagic StrokeUrine Calcium IncreasedPulmonary ThrombosisCardiac FibrillationHeadache
Ear InfectionHyperthyroidismPalpitationsDelusion NosSleep Apnoea SyndromeBlood Cholesterol IncreasedOedema Peripheral

Most common drug interactions by gender * :

AstheniaInternational Normalised Ratio Increased
ConvulsionOedema Peripheral
Bone DisorderConfusional State
AnxietyDeep Vein Thrombosis
International Normalised Ratio IncreasedRenal Failure

Most common drug interactions by age * :

WeaknessThrombocytopeniaInternational Normalised Ratio IncreasedNephrogenic Systemic FibrosisPainDeep Vein ThrombosisInternational Normalised Ratio IncreasedConvulsion
SedationMucosal HaemorrhageStevens-johnson SyndromeSkin DepigmentationOedema PeripheralConfusional StatePainInternational Normalised Ratio Increased
InjuryThrombosisPeroneal Nerve PalsySkin HypertrophyCytokine StormArthralgiaFall
DeathConvulsionMobility DecreasedMyocardial InfarctionDeliriumBronchitisPain
Megakaryocytes IncreasedSuperior Sagittal Sinus ThrombosisSkin TightnessNephrogenic Systemic FibrosisPetechiaeAnxietyDepression
PetechiaeThalamic InfarctionPainSkin TightnessImpetigoFallAsthenia
Multi-organ FailureThrombosis NosDry SkinJoint ContractureBody Temperature IncreasedConvulsionHeadache
Platelet Destruction IncreasedPhantom Limb PainSubcutaneous NoduleJoint Range Of Motion DecreasedConvulsionOedema PeripheralDyspnoea
DepressionHaematemesisSkin WarmPruritusInternational Normalised Ratio IncreasedBack PainAnxiety
AnxietyCondition AggravatedHyperkeratosisAnxietyChest PainRenal FailureSwelling

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Coumadin and Phenytoin?


You are not alone! Join a related support group:
- support group for people who take Coumadin
- support group for people who take Phenytoin

Recent conversations of related support groups:

Can you answer these questions (Ask a question):

More questions for: Coumadin, Phenytoin

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Comments from related studies:

  • From this study (4 months ago):

  • Had a a fid ablation 2 weeks ago. Family Dr. Wanted blood sugar lower so added januvia. After the first day heart rate was up about 20 bears per minute, from 65 to 85. Second day woke up with afib. Went away within the first half hour. Returned about 12:30 and back to normal at 1:40pm. Back at 2:10 and ok by 3:18. Had instances of heart skipping a beat and pounding till about 8:30p.m. Went to bed about 9:30 no more afib or palpitations through the night and morning. Skipped my januvia so far today and am ok.


  • From this study (1 year ago):

  • Three months status post craniotomy for clot evacuation and subsequent refractory seizures and deep vein thrombosis. History of laminectomy and fusion 30 years ago of L4-5-S1. Symptoms of leg weakness increasing in the last few days.


Complete drug side effects:

On eHealthMe, Coumadin (warfarin sodium) is often used to treat blood clots. Phenytoin (phenytoin) is often used to treat epilepsy. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

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