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Review: Coumadin and Phenytoin

Summary: drug interactions are reported among people who take Coumadin and Phenytoin together.

This review analyzes the effectiveness and drug interactions between Coumadin and Phenytoin. It is created by eHealthMe based on reports of 1,437 people who take the same drugs from FDA and social media, and is updated regularly.

You are not alone: join a mobile support group for people who take Coumadin and Phenytoin >>>

What are the drugs

Coumadin has active ingredients of warfarin sodium. It is often used in blood clots. (latest outcomes from Coumadin 75,095 users)

Phenytoin has active ingredients of phenytoin. It is often used in epilepsy. (latest outcomes from Phenytoin 11,104 users)

On Dec, 6, 2014: 1,437 people who take Coumadin, Phenytoin are studied

Coumadin, Phenytoin outcomes

Drug combinations in study:
- Coumadin (warfarin sodium)
- Phenytoin (phenytoin)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Coumadin is effectiven/a100.00%
(1 of 1 people)
Phenytoin is effectiven/a100.00%
(1 of 1 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
International Normalised Ratio IncreasedStevens-johnson SyndromeBrain HerniationStress SymptomsConfusional StateConvulsionLupus-like SyndromeConvulsion
Transaminases IncreasedInternational Normalised Ratio IncreasedDrug Level IncreasedHepatitis NosHaemorrhagic StrokeAnticonvulsant Drug Level DecreasedArthritisInternational Normalised Ratio Increased
Urinary Tract InfectionHepatic FailureFallBlood Viscosity IncreasedHeadachePleural EffusionDrug IneffectivePain
Hereditary AngioedemaDeliriumSubdural HaematomaCerebral Artery EmbolismPulmonary HypertensionStatus EpilepticusFall
PancreatitisRashDeathCerebral HaemorrhagePost Procedural ComplicationGrand Mal ConvulsionAsthenia
Status EpilepticusHepatorenal SyndromeSpeech DisorderAphasiaPhlebothrombosisMalaiseDyspnoea
ConvulsionConvulsionWeight DecreasedScreamingLimb InjuryNormal Pressure HydrocephalusAnxiety
Stevens-johnson SyndromePruritusHaemorrhagic StrokeTardive DyskinesiaPacemaker ComplicationOedema PeripheralPneumonia
Anticonvulsant Drug Level DecreasedCardiomegalyAnaemia NosUrine Calcium IncreasedPulmonary ThrombosisCardiac FibrillationHeadache
Condition AggravatedHyperthyroidismDelusion NosSleep Apnoea SyndromeBlood Cholesterol IncreasedOedema Peripheral

Drug effectiveness by gender :

Coumadin is effective100.00%
(1 of 1 people)
Phenytoin is effective100.00%
(1 of 1 people)

Most common drug interactions by gender * :

AstheniaInternational Normalised Ratio Increased
ConvulsionConfusional State
Bone DisorderOedema Peripheral
International Normalised Ratio IncreasedRenal Failure
FatigueDeep Vein Thrombosis

Drug effectiveness by age :

Coumadin is effectiven/an/an/an/an/an/a33.33%
(1 of 3 people)
Phenytoin is effectiven/an/an/an/an/an/a33.33%
(1 of 3 people)

Most common drug interactions by age * :

WeaknessThrombocytopeniaInternational Normalised Ratio IncreasedNephrogenic Systemic FibrosisPainDeep Vein ThrombosisInternational Normalised Ratio IncreasedConvulsion
SedationMucosal HaemorrhageStevens-johnson SyndromeSkin DepigmentationOedema PeripheralConfusional StatePainInternational Normalised Ratio Increased
InjuryThrombosisPeroneal Nerve PalsySkin HypertrophyCytokine StormArthralgiaFall
DeathConvulsionMobility DecreasedMyocardial InfarctionDeliriumBronchitisPain
Megakaryocytes IncreasedSuperior Sagittal Sinus ThrombosisSkin TightnessNephrogenic Systemic FibrosisPetechiaeAnxietyDepression
PetechiaeThalamic InfarctionPainSkin TightnessImpetigoFallAsthenia
Multi-organ FailureThrombosis NosDry SkinJoint ContractureBody Temperature IncreasedConvulsionHeadache
Platelet Destruction IncreasedPhantom Limb PainSubcutaneous NoduleJoint Range Of Motion DecreasedConvulsionOedema PeripheralDyspnoea
DepressionHaematemesisSkin WarmPruritusInternational Normalised Ratio IncreasedBack PainSwelling
AnxietyCondition AggravatedHyperkeratosisAnxietyChest PainRenal FailureAnxiety

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Coumadin and Phenytoin?

You are not alone! Join a related mobile support group:
- support group for people who take Coumadin and Phenytoin
- support group for people who take Coumadin
- support group for people who take Phenytoin

Can you answer these questions (Ask a question):

More questions for: Coumadin, Phenytoin

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    Took Coumadin or Warfarin sodium for 18 years it introduced some strange behaviors causing the people around me to think it was caused by the small stroke I had (why I was put on Coumadin). I was switched to Xarelto and within a few days I could remember the things I had been doing and thinking about, I was aghast and ashamed. The sad thing is now I have to break some habits I started over that long period. If anyone knows of a person on these drugs and thinks their mood change is caused by a stroke you may want to think again. There were many physical side effects also caused by these drugs.

More reviews for: Coumadin, Phenytoin

Comments from related studies:

  • From this study (8 months ago):

  • Three months status post craniotomy for clot evacuation and subsequent refractory seizures and deep vein thrombosis. History of laminectomy and fusion 30 years ago of L4-5-S1. Symptoms of leg weakness increasing in the last few days.


Complete drug side effects:

On eHealthMe, Coumadin (warfarin sodium) is often used to treat blood clots. Phenytoin (phenytoin) is often used to treat epilepsy. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

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