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Review: Coumadin and Zanaflex

This review analyzes the effectiveness and drug interactions between Coumadin and Zanaflex. It is created by eHealthMe based on reports of 434 people who take the same drugs from FDA and social media, and is updated regularly.

Get connected: join a mobile support group for people who take Coumadin and Zanaflex >>>

What are the drugs

Coumadin (latest outcomes from 75,079 users) has active ingredients of warfarin sodium. It is often used in blood clots.

Zanaflex (latest outcomes from 7,296 users) has active ingredients of tizanidine hydrochloride. It is often used in muscle spasms.

On Sep, 19, 2014: 434 people who take Coumadin, Zanaflex are studied

Coumadin, Zanaflex outcomes

Drug combinations in study:
- Coumadin (warfarin sodium)
- Zanaflex (tizanidine hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Coumadin is effective100.00%
(1 of 1 people)
(0 of 2 people)
(0 of 1 people)
(2 of 3 people)
(0 of 1 people)
(1 of 1 people)
(2 of 2 people)
Zanaflex is effective0.00%
(0 of 1 people)
(0 of 1 people)
(1 of 3 people)
(1 of 4 people)
(1 of 1 people)
(0 of 1 people)
(0 of 1 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
International Normalised Ratio IncreasedCondition AggravatedInfectionInternational Normalised Ratio IncreasedNeutropenian/an/aPain
DehydrationNeutropeniaPyrexiaFatigueNeutropenic SepsisFatigue
WeaknessHypomagnesaemiaRash PruriticExtremity ContracturePericardial EffusionFall
FatigueNeutropenic SepsisGranulocyte Count DecreasedMuscle RigidityHypomagnesaemiaAsthenia
SyncopePericardial EffusionDisseminated Intravascular CoagulationNauseaHypokalaemiaHypotension
SomnolenceCoagulopathyC-reactive Protein IncreasedWeight DecreasedCondition AggravatedAnxiety
Unresponsive To StimuliArthralgiaDiarrhoeaTremorAnaemiaNausea
Retroperitoneal HaemorrhageFungal SepsisDysphagiaFungal SepsisDiarrhoea
Liver Function Test AbnormalInternational Normalised Ratio DecreasedDysarthriaClostridium Difficile ColitisAnaemia

Drug effectiveness by gender :

Coumadin is effective55.56%
(5 of 9 people)
(1 of 2 people)
Zanaflex is effective20.00%
(2 of 10 people)
(1 of 2 people)

Most common drug interactions by gender * :

FatigueOedema Peripheral

Drug effectiveness by age :

Coumadin is effectiven/an/an/a0.00%
(0 of 1 people)
(0 of 1 people)
(1 of 1 people)
(4 of 5 people)
(1 of 4 people)
Zanaflex is effectiven/an/an/a0.00%
(0 of 1 people)
(0 of 1 people)
(0 of 2 people)
(2 of 5 people)
(1 of 4 people)

Most common drug interactions by age * :

Deathn/an/aPulmonary EmbolismDeathPain In ExtremityAnaemiaHypotension
Dementia Alzheimer's TypeNauseaHypertensionPyrexiaAstheniaFall
BradycardiaPalpitationsMultiple SclerosisFallHypotensionAsthenia
HypertensionPressure SoreInfected CystAnxietyPyrexiaPain
Pain In ExtremityDrug IneffectivePulmonary EmbolismDeep Vein ThrombosisNauseaNausea
Atrioventricular Block CompleteDyspnoea NosFatiguePainDrug IneffectiveDiarrhoea
Memory ImpairmentStaphylococcal InfectionVomitingDepressionDyspnoea
Loss Of ConsciousnessHypoaesthesiaAstheniaInternational Normalised Ratio IncreasedAtrial Fibrillation
FatigueMuscle SpasticityUrinary Tract InfectionFallOsteoarthritis

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Coumadin and Zanaflex?

Comments from related studies:

  • From this study (13 months ago):

  • Also take multiple vitamins and minerals


  • From this study (5 years ago):

  • looking for side effects and drug interactions


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Complete drug side effects:

On eHealthMe, Coumadin (warfarin sodium) is often used to treat blood clots. Zanaflex (tizanidine hydrochloride) is often used to treat muscle spasms. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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