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Review: taking Cymbalta and Phentermine together

Summary: drug interactions are reported among people who take Cymbalta and Phentermine together.

This review analyzes the effectiveness and drug interactions between Cymbalta and Phentermine. It is created by eHealthMe based on reports of 112 people who take the same drugs from FDA and social media, and is updated regularly.


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On Apr, 3, 2015: 112 people who take Cymbalta, Phentermine are studied

Cymbalta, Phentermine outcomes

Drug combinations in study:
- Cymbalta (duloxetine hydrochloride)
- Phentermine (phentermine hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Cymbalta is effective16.67%
(1 of 6 people)
(6 of 13 people)
(2 of 6 people)
(3 of 5 people)
(7 of 12 people)
(3 of 3 people)
(1 of 2 people)
Phentermine is effective12.50%
(1 of 8 people)
(5 of 16 people)
(3 of 10 people)
(2 of 6 people)
(1 of 2 people)

Drug effectiveness by gender :

Cymbalta is effective51.16%
(22 of 43 people)
(0 of 3 people)
Phentermine is effective27.50%
(11 of 40 people)
(1 of 2 people)

Drug effectiveness by age :

Cymbalta is effectiven/an/an/a25.00%
(1 of 4 people)
(4 of 20 people)
(11 of 25 people)
(4 of 18 people)
(2 of 2 people)
Phentermine is effectiven/an/an/a33.33%
(1 of 3 people)
(2 of 18 people)
(6 of 23 people)
(2 of 18 people)
(1 of 2 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
NauseaNauseaHigh Blood PressureSerotonin SyndromeHeadacheType 2 Diabetes MellitusDepressionArthralgia
Drug IneffectiveAnxietyHeadacheDizzinessConfusionRheumatoid ArthritisHair LossDrug Ineffective
DizzinessDeep Vein ThrombosisHair LossFeverJittersNeuropathy PeripheralWeight Increased
InsomniaArthralgiaAdipsiaExhaustion, Fatigue, Lethargy, Tiredness, WearinessNauseaSomnolence
IrritabilityDepressionDizzinessJaundiceInsomnia ExacerbatedPain
HostilityOedema PeripheralLoss Of LibidoRashBlurred VisionFatigue
NightmarePainNauseaNauseaShaking PalsyOedema Peripheral
ParaesthesiaDelusions, MixedItchingManiaNausea
PalpitationsConfusional StateLiver Function Test AbnormalGeneralised Anxiety DisorderDrug Withdrawal Syndrome
Blood Pressure IncreasedAphasiaHigh Blood PressureDepressionAmnesia

Most common drug interactions by gender * :

NauseaOrgasm Abnormal
Drug IneffectiveSomnolence
Weight IncreasedFoot Fracture
PainFeeling Hot
FatigueCarpal Tunnel Syndrome
Oedema PeripheralErectile Dysfunction
Drug Withdrawal SyndromeIrritability

Most common drug interactions by age * :

n/an/an/aArthralgiaType 2 Diabetes MellitusDrug IneffectiveSomnolenceArthralgia
Deep Vein ThrombosisRheumatoid ArthritisNauseaNauseaFibromyalgia
Oedema PeripheralHypertensionWeight IncreasedJoint SwellingHip Arthroplasty
Pulmonary EmbolismType 1 Diabetes MellitusAmnesiaOrgasm AbnormalHypertension
YawningNeuropathy PeripheralLigament SprainErectile DysfunctionHepatic Enzyme Increased
SyncopeJoint InjuryWound Infection StaphylococcalWeight Decreased
HyperlipidaemiaPainCarpal Tunnel SyndromeHair Loss
AphasiaMeniscus LesionDepression
Weight IncreasedMuscle InjuryFoot Fracture
AstheniaImpaired Driving AbilityRash Generalised

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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- support group for people who take Cymbalta
- support group for people who take Phentermine

Recent related drug studies (Check your drugs):

Complete drug side effects:

On eHealthMe, Cymbalta (duloxetine hydrochloride) is often used to treat depression. Phentermine (phentermine hydrochloride) is often used to treat weight abnormal. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.


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