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Review: taking Cymbalta and Zoloft together

Summary: drug interactions are reported among people who take Cymbalta and Zoloft together.

This review analyzes the effectiveness and drug interactions between Cymbalta and Zoloft. It is created by eHealthMe based on reports of 1,324 people who take the same drugs from FDA and social media, and is updated regularly.


You are not alone: join a support group for people who take Cymbalta and Zoloft >>>

On Apr, 8, 2015: 1,324 people who take Cymbalta, Zoloft are studied

Cymbalta, Zoloft outcomes

Drug combinations in study:
- Cymbalta (duloxetine hydrochloride)
- Zoloft (sertraline hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Cymbalta is effective33.33%
(3 of 9 people)
(3 of 14 people)
(0 of 7 people)
(1 of 6 people)
(4 of 5 people)
(0 of 1 people)
(0 of 1 people)
Zoloft is effective28.57%
(2 of 7 people)
(2 of 8 people)
(0 of 3 people)
(1 of 9 people)
(2 of 7 people)
(1 of 3 people)
(0 of 4 people)
(0 of 1 people)

Drug effectiveness by gender :

Cymbalta is effective28.57%
(10 of 35 people)
(1 of 7 people)
Zoloft is effective20.00%
(7 of 35 people)
(1 of 7 people)

Drug effectiveness by age :

Cymbalta is effectiven/an/a0.00%
(0 of 2 people)
(0 of 4 people)
(4 of 59 people)
(2 of 20 people)
(5 of 22 people)
(0 of 2 people)
Zoloft is effectiven/an/a0.00%
(0 of 2 people)
(2 of 4 people)
(2 of 71 people)
(2 of 14 people)
(1 of 23 people)
(1 of 2 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
NauseaType 2 Diabetes MellitusStress FractureAngerPainChest PainDrug IneffectivePain
PainDepressionOsteopeniaFeeling AbnormalDepressionGastrooesophageal Reflux DiseaseFatigueAnxiety
DiarrhoeaSuicidal IdeationHip FractureWeight IncreasedPancreatitisAnxietySomnolenceDepression
PruritusAnxietyRib FractureDizzinessAnxietyDepressionKnee ArthroplastyNausea
HypertensionConfusional StatePainLoss Of LibidoRoad Traffic AccidentPainSuicidal BehaviourHeadache
FallBradyphreniaBone Density DecreasedContusionHallucinationPulmonary EmbolismDepressionFall
HypophagiaBradykinesiaSuicidal IdeationFearSleep Apnoea SyndromeInjurySuicidal IdeationDrug Ineffective
AnxietyHallucinationAnxietyBalance DisorderSuicide AttemptArthralgiaOverdoseType 2 Diabetes Mellitus
Abdominal Pain UpperHyperhidrosisDepressed MoodCerebral HaemorrhageTardive DyskinesiaAcute Myocardial InfarctionArthropathyFatigue
Abdominal PainAlanine Aminotransferase IncreasedType 2 Diabetes MellitusOesophageal UlcerWeight DecreasedEmotional DistressSurgeryBack Pain

Most common drug interactions by gender * :

HeadacheWeight Decreased
ArthralgiaBack Pain
Type 2 Diabetes MellitusType 2 Diabetes Mellitus
Drug IneffectiveVomiting
DyspnoeaDrug Ineffective

Most common drug interactions by age * :

Umbilical Cord Around NeckPremature BabyCholecystitis ChronicCholecystitis ChronicType 2 Diabetes MellitusPainAnxietyFall
Neonatal DisorderLow Birth Weight BabyPainNauseaDiabetes MellitusDepressionPainPain
Drug Exposure Via Breast MilkFoetal Exposure During PregnancyGallbladder DisorderAbdominal PainBlood Cholesterol IncreasedType 2 Diabetes MellitusNauseaAnxiety
Cyanosis NeonatalAnxietyDiarrhoeaDiabetic NeuropathyAnxietyPyrexiaPain In Extremity
Body Temperature FluctuationSphincter Of Oddi DysfunctionAbdominal Pain UpperHyperlipidaemiaHeadacheOsteonecrosis Of JawAnaemia
Neonatal HypotensionPancreatitisCholelithiasisAnxietyDrug IneffectiveFallBack Pain
Ischaemic StrokeDrug DependenceBiliary DyskinesiaPainDyspnoeaDepressionDizziness
Drug Exposure During PregnancyDisturbance In AttentionGallbladder DisorderDiabetes Mellitus Inadequate ControlMuscle SpasmsPain In JawFatigue
Convulsion NeonatalCondition AggravatedOcular HyperaemiaObesityBack PainFatigueDrug Ineffective

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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- support group for people who take Cymbalta
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Recent related drug studies (Check your drugs):

Complete drug side effects:

On eHealthMe, Cymbalta (duloxetine hydrochloride) is often used to treat depression. Zoloft (sertraline hydrochloride) is often used to treat depression. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

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