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Review: taking Depakote and Olanzapine together

Summary: drug interactions are reported among people who take Depakote and Olanzapine together.

This review analyzes the effectiveness and drug interactions between Depakote and Olanzapine. It is created by eHealthMe based on reports of 4,480 people who take the same drugs from FDA and social media, and is updated regularly.





You are not alone: join a mobile support group for people who take Depakote and Olanzapine >>>

What are the drugs

Depakote has active ingredients of divalproex sodium. It is often used in bipolar disorder. (latest outcomes from 30,947 Depakote users)

Olanzapine has active ingredients of olanzapine. It is often used in depression. (latest outcomes from 12,164 Olanzapine users)

On Feb, 24, 2015: 4,480 people who take Depakote, Olanzapine are studied

Depakote, Olanzapine outcomes

Drug combinations in study:
- Depakote (divalproex sodium)
- Olanzapine (olanzapine)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Depakote is effective0.00%
(0 of 7 people)
(1 of 9 people)
(1 of 4 people)
(0 of 5 people)
(2 of 6 people)
(2 of 5 people)
(1 of 5 people)
Olanzapine is effective28.57%
(2 of 7 people)
(1 of 12 people)
(1 of 7 people)
(0 of 3 people)
(1 of 5 people)
(3 of 3 people)
(2 of 3 people)
(1 of 1 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Diabetes MellitusDiabetes MellitusDiabetes MellitusDiabetes MellitusDiabetes MellitusDiabetes MellitusWeight IncreasedDiabetes Mellitus
ComaType 2 Diabetes MellitusWeight IncreasedWeight IncreasedWeight IncreasedWeight IncreasedType 2 Diabetes MellitusWeight Increased
OverdoseWeight IncreasedHypertensionHypertensionType 2 Diabetes MellitusHypertensionObesityType 2 Diabetes Mellitus
PyrexiaBlood Triglycerides IncreasedBlood Cholesterol IncreasedHyperglycaemiaHypertensionType 2 Diabetes MellitusThrombosisPancreatitis
NeutropeniaBlood Cholesterol IncreasedPancreatitisType 2 Diabetes MellitusPancreatitisBlood Triglycerides IncreasedDiabetes MellitusHypertension
Type 2 Diabetes MellitusConvulsionType 2 Diabetes MellitusBlood Triglycerides IncreasedBlood Cholesterol IncreasedObesityBreast MassHyperglycaemia
Weight IncreasedHyperglycaemiaVision BlurredDiabetic KetoacidosisHyperglycaemiaHyperglycaemiaPerirectal AbscessBlood Cholesterol Increased
Confusional StateDiabetic KetoacidosisConfusional StateBlood Cholesterol IncreasedObesityDiabetic ComaBlood Cholesterol IncreasedDiabetic Ketoacidosis
Blood Triglycerides IncreasedAgitationSomnolenceObesityBlood Triglycerides IncreasedDiabetic KetoacidosisFeeling AbnormalBlood Triglycerides Increased
DisorientationChest PainBlood Triglycerides IncreasedPancreatitisChest PainBlood Cholesterol IncreasedWeight DecreasedObesity

Drug effectiveness by gender :

Depakote is effective15.00%
(3 of 20 people)
(4 of 21 people)
Olanzapine is effective16.67%
(3 of 18 people)
(8 of 23 people)

Most common drug interactions by gender * :

Diabetes MellitusDiabetes Mellitus
Weight IncreasedWeight Increased
Type 2 Diabetes MellitusType 2 Diabetes Mellitus
PancreatitisDiabetic Ketoacidosis
Blood Cholesterol IncreasedHypertension
Blood Triglycerides IncreasedPancreatitis
HyperglycaemiaBlood Cholesterol Increased
Diabetic KetoacidosisOverdose

Drug effectiveness by age :

Depakote is effectiven/a0.00%
(0 of 1 people)
(0 of 5 people)
(2 of 27 people)
(1 of 13 people)
(1 of 15 people)
(2 of 10 people)
(1 of 11 people)
Olanzapine is effectiven/a0.00%
(0 of 1 people)
(1 of 5 people)
(3 of 27 people)
(2 of 11 people)
(1 of 15 people)
(2 of 10 people)
(2 of 9 people)

Most common drug interactions by age * :

Apgar Score LowAggressionWeight IncreasedWeight IncreasedDiabetes MellitusDiabetes MellitusDiabetes MellitusDiabetes Mellitus
Muscular WeaknessWeight IncreasedAgitationDiabetes MellitusType 2 Diabetes MellitusType 2 Diabetes MellitusType 2 Diabetes MellitusTremor
Developmental DelayBipolar DisorderSuicidal IdeationType 2 Diabetes MellitusWeight IncreasedWeight IncreasedWeight IncreasedConfusional State
Drug Exposure During PregnancyConvulsionAggressionDiabetic KetoacidosisObesityBlood Cholesterol IncreasedHypertensionFall
ConvulsionIntentional Self-injuryAbnormal BehaviourBlood Cholesterol IncreasedPancreatitisBlood Triglycerides IncreasedHyperglycaemiaRenal Failure Acute
Type 2 Diabetes MellitusManiaDepressionSedationHyperglycaemiaPancreatitisBlood Cholesterol IncreasedType 2 Diabetes Mellitus
Neonatal Apnoeic AttackHomicidal IdeationManiaHyperglycaemiaBlood Cholesterol IncreasedHypertensionPancreatitisHypertension
Premature BabyAgitationSuicide AttemptOverdoseDiabetic KetoacidosisHyperglycaemiaBlood Triglycerides IncreasedWeight Increased
Suicidal IdeationInsomniaOverdoseSuicidal IdeationDiabetes Mellitus Inadequate ControlDiabetic KetoacidosisChest PainUrinary Tract Infection
Neonatal Respiratory Distress SyndromeSuicidal IdeationDiabetes MellitusPancreatitisBlood Triglycerides IncreasedChest PainAnxietyHypotension

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Depakote and Olanzapine?

You are not alone! Join a related mobile support group:
- support group for people who take Depakote and Olanzapine
- support group for people who take Depakote
- support group for people who take Olanzapine

Can you answer these questions (Ask a question):

More questions for: Depakote, Olanzapine

You may be interested at these reviews (Write a review):

  • Seizure patient was on depakote for 16 years now on keppra 1500 mg.
    I am 28 years old and been off depakote for 5 months. I started keppra to control my seizure disorder, which works great. But for the past year I have developed osteoarthritis in my thoracic, si joints, and lumbar. I get alot of muscle hypersensitivity and pain. Can any of this be due to long term effects of seizure meds?
  • I have less pain from my trigeminal neuralgia when i'm manic.
    Has anyone had a relief of pain when they are manic?
  • Depakote er affected by grapefruit
    I have taken Depakote ER for since 2005 for epilepsy. Once stabilized many years ago seizures and auras have not been bothering me. Until I recently ate three grapefruits over three days. After a few days, when the grapefruit cleared my system, the seizures and auras ceased. Therefore, grapefruit does affect how Depakote ER acts on your system.
  • Olanzepine withdrawal (1 response)
    Has been taking Zyprexa 2.5-5mg daily for 10 yrs.Developed metabolic syndrome and subsequently diabetes after 3 years on zyprexa.Has since tried multiple times but unsuccessfully to discontinue zyprexa.Apparent withdrawal sxs include severely depressed moods ,inability to get out of bed,severe weakness and general malaise.Sxs begin 36-48hrs after last dose of Zyprexa.Sxs begin to improve a few hrs after resuming Zyprexa.Using alternative atypical antipsychotic meds have been ineffective.

More reviews for: Depakote, Olanzapine

Comments from related studies:

  • From this study (11 months ago):

  • After doubling my Depakote dose, my abdomen is swollen and I am so dizzy and hallucinating so badly I can barely read. My nausea and pain are so severe, very effective drugs at doses that are a significant amount to my system are barely helping. Due to the weather and thus swelling of my previous Chiai Malformation Decompression Brain Surgery site, I have significant and debilitating headache pain and other Chiari symptoms are much worse than usual.


  • From this study (12 months ago):

  • symptoms became pronounced immediately after introduction of olanzapine (5mg), No previous history of paranoia


  • From this study (1 year ago):

  • I had exposer to bath salts


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Complete drug side effects:

On eHealthMe, Depakote (divalproex sodium) is often used to treat bipolar disorder. Olanzapine (olanzapine) is often used to treat depression. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

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