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Review: Depakote and Olanzapine

This review analyzes the effectiveness and drug interactions between Depakote and Olanzapine. It is created by eHealthMe based on reports of 4,479 people who take the same drugs from FDA and social media, and is updated regularly.

Stay connected: join a mobile support group for people who take Depakote and Olanzapine >>>

What are the drugs

Depakote (latest outcomes from 30,907 users) has active ingredients of divalproex sodium. It is used in bipolar disorder.

Olanzapine (latest outcomes from 12,146 users) has active ingredients of olanzapine. It is used in bipolar disorder.

On Aug, 13, 2014: 4,479 people who take Depakote, Olanzapine are studied

Depakote, Olanzapine outcomes

Drug combinations in study:
- Depakote (divalproex sodium)
- Olanzapine (olanzapine)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Depakote is effective0.00%
(0 of 7 people)
(1 of 9 people)
(1 of 4 people)
(0 of 4 people)
(2 of 6 people)
(2 of 5 people)
(1 of 5 people)
Olanzapine is effective28.57%
(2 of 7 people)
(1 of 12 people)
(1 of 6 people)
(0 of 3 people)
(1 of 5 people)
(3 of 3 people)
(2 of 3 people)
(1 of 1 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Diabetes MellitusDiabetes MellitusDiabetes MellitusDiabetes MellitusDiabetes MellitusDiabetes MellitusWeight IncreasedDiabetes Mellitus
ComaType 2 Diabetes MellitusWeight IncreasedWeight IncreasedWeight IncreasedWeight IncreasedType 2 Diabetes MellitusWeight Increased
OverdoseWeight IncreasedHypertensionHypertensionType 2 Diabetes MellitusHypertensionObesityType 2 Diabetes Mellitus
PyrexiaBlood Triglycerides IncreasedBlood Cholesterol IncreasedType 2 Diabetes MellitusHypertensionType 2 Diabetes MellitusThrombosisPancreatitis
NeutropeniaBlood Cholesterol IncreasedPancreatitisHyperglycaemiaPancreatitisBlood Triglycerides IncreasedDiabetes MellitusHypertension
Type 2 Diabetes MellitusConvulsionType 2 Diabetes MellitusBlood Triglycerides IncreasedBlood Cholesterol IncreasedObesityBreast MassHyperglycaemia
Weight IncreasedHyperglycaemiaSomnolenceDiabetic KetoacidosisHyperglycaemiaHyperglycaemiaPerirectal AbscessBlood Cholesterol Increased
Confusional StateDiabetic KetoacidosisConfusional StateBlood Cholesterol IncreasedObesityDiabetic ComaBlood Cholesterol IncreasedDiabetic Ketoacidosis
Blood Triglycerides IncreasedAgitationVision BlurredObesityBlood Triglycerides IncreasedDiabetic KetoacidosisFeeling AbnormalBlood Triglycerides Increased
DisorientationChest PainBlood Triglycerides IncreasedPancreatitisChest PainBlood Cholesterol IncreasedWeight DecreasedObesity

Drug effectiveness by gender :

Depakote is effective15.00%
(3 of 20 people)
(4 of 20 people)
Olanzapine is effective16.67%
(3 of 18 people)
(8 of 22 people)

Most common drug interactions by gender * :

Diabetes MellitusDiabetes Mellitus
Weight IncreasedWeight Increased
Type 2 Diabetes MellitusType 2 Diabetes Mellitus
PancreatitisDiabetic Ketoacidosis
Blood Cholesterol IncreasedHypertension
Blood Triglycerides IncreasedPancreatitis
HyperglycaemiaBlood Cholesterol Increased
Diabetic KetoacidosisOverdose

Drug effectiveness by age :

Depakote is effectiven/a0.00%
(0 of 1 people)
(0 of 3 people)
(2 of 27 people)
(1 of 13 people)
(1 of 15 people)
(2 of 10 people)
(1 of 11 people)
Olanzapine is effectiven/a0.00%
(0 of 1 people)
(1 of 3 people)
(3 of 27 people)
(2 of 11 people)
(1 of 15 people)
(2 of 10 people)
(2 of 9 people)

Most common drug interactions by age * :

Weight IncreasedAggressionWeight IncreasedWeight IncreasedDiabetes MellitusDiabetes MellitusDiabetes MellitusDiabetes Mellitus
Suicidal IdeationWeight IncreasedAgitationDiabetes MellitusType 2 Diabetes MellitusType 2 Diabetes MellitusType 2 Diabetes MellitusTremor
Apgar Score LowBipolar DisorderSuicidal IdeationType 2 Diabetes MellitusWeight IncreasedWeight IncreasedWeight IncreasedConfusional State
Muscular WeaknessConvulsionAggressionDiabetic KetoacidosisObesityBlood Cholesterol IncreasedHypertensionFall
Drug Exposure During PregnancyIntentional Self-injuryAbnormal BehaviourBlood Cholesterol IncreasedPancreatitisBlood Triglycerides IncreasedHyperglycaemiaRenal Failure Acute
Developmental DelayManiaManiaSedationHyperglycaemiaPancreatitisBlood Cholesterol IncreasedType 2 Diabetes Mellitus
AggressionHomicidal IdeationDepressionHyperglycaemiaBlood Cholesterol IncreasedHypertensionPancreatitisHypertension
Type 2 Diabetes MellitusAgitationOverdoseOverdoseDiabetic KetoacidosisHyperglycaemiaBlood Triglycerides IncreasedWeight Increased
DepressionInsomniaSuicide AttemptSuicidal IdeationDiabetes Mellitus Inadequate ControlDiabetic KetoacidosisChest PainUrinary Tract Infection
ConvulsionSuicidal IdeationDiabetes MellitusPancreatitisBlood Triglycerides IncreasedChest PainAnxietyHypotension

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

You can also:

Get connected! Join a mobile support group:
- group for people who take Depakote and Olanzapine
- group for people who take Depakote
- group for people who take Olanzapine

Comments from related studies:

  • From this study (4 months ago):

  • After doubling my Depakote dose, my abdomen is swollen and I am so dizzy and hallucinating so badly I can barely read. My nausea and pain are so severe, very effective drugs at doses that are a significant amount to my system are barely helping. Due to the weather and thus swelling of my previous Chiai Malformation Decompression Brain Surgery site, I have significant and debilitating headache pain and other Chiari symptoms are much worse than usual.


  • From this study (5 months ago):

  • symptoms became pronounced immediately after introduction of olanzapine (5mg), No previous history of paranoia


  • From this study (7 months ago):

  • I had exposer to bath salts


Post a new comment    OR    Read more comments

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Complete drug side effects:

On eHealthMe, Depakote (divalproex sodium) is often used to treat bipolar disorder. Olanzapine (olanzapine) is often used to treat bipolar disorder. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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