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Review: taking Depakote Er and Clozaril together

Summary: drug interactions are reported among people who take Depakote Er and Clozaril together.

This review analyzes the effectiveness and drug interactions between Depakote Er and Clozaril. It is created by eHealthMe based on reports of 2,490 people who take the same drugs from FDA and social media, and is updated regularly.





You are not alone: join a mobile support group for people who take Depakote Er and Clozaril >>>

What are the drugs

Depakote er has active ingredients of divalproex sodium. It is often used in bipolar disorder. (latest outcomes from 3,677 Depakote er users)

Clozaril has active ingredients of clozapine. It is often used in schizophrenia. (latest outcomes from 25,619 Clozaril users)

On Jan, 4, 2015: 2,490 people who take Depakote Er, Clozaril are studied

Depakote Er, Clozaril outcomes

Drug combinations in study:
- Depakote Er (divalproex sodium)
- Clozaril (clozapine)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Depakote Er is effectiven/an/a0.00%
(0 of 2 people)
(0 of 2 people)
(3 of 5 people)
(0 of 2 people)
Clozaril is effective100.00%
(1 of 1 people)
(2 of 2 people)
(2 of 2 people)
(0 of 2 people)
(0 of 1 people)
(1 of 2 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
TachycardiaWhite Blood Cell Count IncreasedWhite Blood Cell Count DecreasedWhite Blood Cell Count DecreasedNeutropeniaCardiac ArrestConvulsionPyrexia
Oxygen Saturation DecreasedNeutropeniaLeukopeniaDiarrhoeaConvulsionFallCellulitisWhite Blood Cell Count Decreased
Body Temperature IncreasedPyrexiaDeathAgitationPneumoniaNeutrophil Count DecreasedObesityDiabetes Mellitus
White Blood Cell Count DecreasedWhite Blood Cell Count DecreasedAgitationVomitingPulmonary EmbolismHaemoglobin DecreasedConstipationLeukopenia
LeukopeniaLeukopeniaVomitingLeukopeniaCardiac ArrestLower Respiratory Tract InfectionBone Marrow FailureType 2 Diabetes Mellitus
Confusional StateNeutrophil Count DecreasedAgranulocytosisExtrapyramidal DisorderNeutrophil Count DecreasedDysphagiaPsychotic DisorderDeath
C-reactive Protein IncreasedNeutrophil Count IncreasedDiarrhoeaAgranulocytosisWhite Blood Cell Count DecreasedHypotensionNeutropeniaAgranulocytosis
AgranulocytosisOropharyngeal PainBlood Prolactin IncreasedWhite Blood Cell Count IncreasedConfusional StateWhite Blood Cell Count DecreasedAbdominal Pain UpperConvulsion

Drug effectiveness by gender :

Depakote Er is effective28.57%
(2 of 7 people)
(1 of 4 people)
Clozaril is effective71.43%
(5 of 7 people)
(1 of 3 people)

Most common drug interactions by gender * :

Diabetes MellitusNeutropenia
Type 2 Diabetes MellitusWhite Blood Cell Count Decreased
White Blood Cell Count DecreasedAgitation
DeathDiabetes Mellitus

Drug effectiveness by age :

Depakote Er is effectiven/an/a0.00%
(0 of 1 people)
(3 of 5 people)
(0 of 3 people)
(0 of 2 people)
(0 of 2 people)
Clozaril is effectiven/an/a0.00%
(0 of 1 people)
(3 of 4 people)
(2 of 3 people)
(0 of 2 people)
(1 of 2 people)

Most common drug interactions by age * :

Convulsion NeonatalEmotional DisorderGranulocytopeniaGranulocytopeniaGranulocytopeniaGranulocytopeniaGranulocytopeniaDeath
Drug Exposure During PregnancyFrontotemporal DementiaNeutropeniaPyrexiaConvulsionNeutropeniaAgranulocytosisGranulocytopenia
TremorPetit Mal EpilepsyPyrexiaNeutropeniaType 2 Diabetes MellitusDiabetes MellitusPyrexiaLeukopenia
Neoplasm MalignantHaematomaVomitingDiabetes MellitusNeutropeniaType 2 Diabetes MellitusDeathHaemoglobin Decreased
Muscular WeaknessGranulocytopeniaHyperhidrosisLeukopeniaPyrexiaWhite Blood Cell Count DecreasedLeukopeniaWhite Blood Cell Count Decreased
Cerebrovascular AccidentNeutrophil Percentage DecreasedWhite Blood Cell Count DecreasedAgitationDiabetes MellitusLeukopeniaWhite Blood Cell Count IncreasedPneumonia
White Blood Cell Count DecreasedWeight IncreasedVomitingSedationTachycardiaWhite Blood Cell Count DecreasedConfusional State
Rash ErythematousAgranulocytosisNeutrophil Count DecreasedWeight IncreasedAgranulocytosisDiabetes MellitusNeutropenia
Photosensitivity ReactionWhite Blood Cell Count IncreasedAgranulocytosisPsychotic DisorderPyrexiaNeutrophil Count DecreasedPyrexia
Rash GeneralisedAgitationType 2 Diabetes MellitusConvulsions NosOxygen Saturation DecreasedMyocardial InfarctionHypotension

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Depakote Er and Clozaril?

You are not alone! Join a related mobile support group:
- support group for people who take Depakote Er and Clozaril
- support group for people who take Clozaril
- support group for people who take Depakote Er

Can you answer these questions (Ask a question):

More questions for: Clozaril, Depakote Er

You may be interested at these reviews (Write a review):

  • Seizure patient was on depakote for 16 years now on keppra 1500 mg.
    I am 28 years old and been off depakote for 5 months. I started keppra to control my seizure disorder, which works great. But for the past year I have developed osteoarthritis in my thoracic, si joints, and lumbar. I get alot of muscle hypersensitivity and pain. Can any of this be due to long term effects of seizure meds?
  • Depakote er affected by grapefruit
    I have taken Depakote ER for since 2005 for epilepsy. Once stabilized many years ago seizures and auras have not been bothering me. Until I recently ate three grapefruits over three days. After a few days, when the grapefruit cleared my system, the seizures and auras ceased. Therefore, grapefruit does affect how Depakote ER acts on your system.

More reviews for: Clozaril, Depakote Er

Comments from related studies:

  • From this study (3 months ago):

  • doc moc on Apr, 25, 2013:

    BREAK down FOOL!


    Rhs on Oct, 13, 2012:

    Get your medical records
    and consult w/your doctor


    trust1983 on Dec, 3, 2012:

    Is it true in the states that a psych doc can up and just leave and refuse to treat you because you tried to kill yourself, especially if you didn't have a contact for life with you r doc?


Post a new comment    OR    Read more comments

Complete drug side effects:

On eHealthMe, Depakote Er (divalproex sodium) is often used to treat bipolar disorder. Clozaril (clozapine) is often used to treat schizophrenia. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.


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