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Review: taking Depakote Er and Clozaril together

Summary: drug interactions are reported among people who take Depakote Er and Clozaril together.

This review analyzes the effectiveness and drug interactions between Depakote Er and Clozaril. It is created by eHealthMe based on reports of 2,490 people who take the same drugs from FDA and social media, and is updated regularly.

 

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On Mar, 18, 2015: 2,490 people who take Depakote Er, Clozaril are studied

Depakote Er, Clozaril outcomes

Drug combinations in study:
- Depakote Er (divalproex sodium)
- Clozaril (clozapine)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Depakote Er is effectiven/an/a0.00%
(0 of 2 people)
n/a0.00%
(0 of 2 people)
60.00%
(3 of 5 people)
0.00%
(0 of 2 people)
n/a
Clozaril is effective100.00%
(1 of 1 people)
100.00%
(2 of 2 people)
100.00%
(2 of 2 people)
n/a0.00%
(0 of 2 people)
0.00%
(0 of 1 people)
50.00%
(1 of 2 people)
n/a

Drug effectiveness by gender :

FemaleMale
Depakote Er is effective28.57%
(2 of 7 people)
25.00%
(1 of 4 people)
Clozaril is effective71.43%
(5 of 7 people)
33.33%
(1 of 3 people)

Drug effectiveness by age :

0-12-910-1920-2930-3940-4950-5960+
Depakote Er is effectiven/an/a0.00%
(0 of 1 people)
60.00%
(3 of 5 people)
0.00%
(0 of 3 people)
0.00%
(0 of 2 people)
0.00%
(0 of 2 people)
n/a
Clozaril is effectiven/an/a0.00%
(0 of 1 people)
75.00%
(3 of 4 people)
66.67%
(2 of 3 people)
0.00%
(0 of 2 people)
50.00%
(1 of 2 people)
n/a

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
GranulocytopeniaGranulocytopeniaGranulocytopeniaGranulocytopeniaGranulocytopeniaGranulocytopeniaAgranulocytosisGranulocytopenia
PyrexiaAgranulocytosisNeutropeniaNeutropeniaLeukopeniaLeukopeniaPneumoniaNeutropenia
TachycardiaWhite Blood Cell Count IncreasedWhite Blood Cell Count DecreasedWhite Blood Cell Count DecreasedNeutropeniaCardiac ArrestConvulsionPyrexia
Oxygen Saturation DecreasedNeutropeniaLeukopeniaDiarrhoeaConvulsionFallCellulitisWhite Blood Cell Count Decreased
Body Temperature IncreasedPyrexiaDeathAgitationPneumoniaNeutrophil Count DecreasedObesityDiabetes Mellitus
White Blood Cell Count DecreasedWhite Blood Cell Count DecreasedAgitationVomitingPulmonary EmbolismHaemoglobin DecreasedConstipationLeukopenia
LeukopeniaLeukopeniaVomitingLeukopeniaCardiac ArrestLower Respiratory Tract InfectionBone Marrow FailureType 2 Diabetes Mellitus
Confusional StateNeutrophil Count DecreasedAgranulocytosisExtrapyramidal DisorderNeutrophil Count DecreasedDysphagiaPsychotic DisorderDeath
C-reactive Protein IncreasedNeutrophil Count IncreasedDiarrhoeaAgranulocytosisWhite Blood Cell Count DecreasedHypotensionNeutropeniaAgranulocytosis
AgranulocytosisOropharyngeal PainBlood Prolactin IncreasedWhite Blood Cell Count IncreasedConfusional StateWhite Blood Cell Count DecreasedAbdominal Pain UpperConvulsion

Most common drug interactions by gender * :

FemaleMale
GranulocytopeniaGranulocytopenia
Diabetes MellitusNeutropenia
PyrexiaPyrexia
Type 2 Diabetes MellitusWhite Blood Cell Count Decreased
NeutropeniaConvulsion
AgranulocytosisLeukopenia
LeukopeniaDeath
White Blood Cell Count DecreasedAgitation
SedationPneumonia
DeathDiabetes Mellitus

Most common drug interactions by age * :

0-12-910-1920-2930-3940-4950-5960+
Convulsion NeonatalEmotional DisorderGranulocytopeniaGranulocytopeniaGranulocytopeniaGranulocytopeniaGranulocytopeniaDeath
Drug Exposure During PregnancyFrontotemporal DementiaNeutropeniaPyrexiaConvulsionNeutropeniaAgranulocytosisGranulocytopenia
TremorPetit Mal EpilepsyPyrexiaNeutropeniaType 2 Diabetes MellitusDiabetes MellitusPyrexiaLeukopenia
Neoplasm MalignantHaematomaVomitingDiabetes MellitusNeutropeniaType 2 Diabetes MellitusDeathHaemoglobin Decreased
Muscular WeaknessGranulocytopeniaHyperhidrosisLeukopeniaPyrexiaWhite Blood Cell Count DecreasedLeukopeniaWhite Blood Cell Count Decreased
Cerebrovascular AccidentNeutrophil Percentage DecreasedWhite Blood Cell Count DecreasedAgitationDiabetes MellitusLeukopeniaWhite Blood Cell Count IncreasedPneumonia
White Blood Cell Count DecreasedWeight IncreasedVomitingSedationTachycardiaWhite Blood Cell Count DecreasedConfusional State
Rash ErythematousAgranulocytosisNeutrophil Count DecreasedWeight IncreasedAgranulocytosisDiabetes MellitusNeutropenia
Photosensitivity ReactionWhite Blood Cell Count IncreasedAgranulocytosisPsychotic DisorderPyrexiaNeutrophil Count DecreasedPyrexia
Rash GeneralisedAgitationType 2 Diabetes MellitusConvulsions NosOxygen Saturation DecreasedMyocardial InfarctionHypotension

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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- support group for people who take Clozaril
- support group for people who take Depakote Er

Recent related drug studies (Check your drugs):

Complete drug side effects:

On eHealthMe, Depakote Er (divalproex sodium) is often used to treat bipolar disorder. Clozaril (clozapine) is often used to treat schizophrenia. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

   

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