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Review: Depakote Er and Keppra

This review analyzes the effectiveness and drug interactions between Depakote Er and Keppra. It is created by eHealthMe based on reports of 857 people who take the same drugs from FDA and social media, and is updated regularly.

Stay connected: join a mobile support group for people who take Depakote Er and Keppra >>>

What are the drugs

Depakote er (latest outcomes from 3,668 users) has active ingredients of divalproex sodium. It is often used in bipolar disorder.

Keppra (latest outcomes from 21,163 users) has active ingredients of levetiracetam. It is often used in epilepsy.

On Jul, 12, 2014: 857 people who take Depakote Er, Keppra are studied

Depakote Er, Keppra outcomes

Drug combinations in study:
- Depakote Er (divalproex sodium)
- Keppra (levetiracetam)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Depakote Er is effective100.00%
(1 of 1 people)
33.33%
(1 of 3 people)
0.00%
(0 of 4 people)
50.00%
(3 of 6 people)
16.67%
(1 of 6 people)
85.71%
(6 of 7 people)
66.67%
(6 of 9 people)
0.00%
(0 of 1 people)
Keppra is effective50.00%
(1 of 2 people)
40.00%
(2 of 5 people)
50.00%
(2 of 4 people)
0.00%
(0 of 6 people)
40.00%
(4 of 10 people)
80.00%
(4 of 5 people)
50.00%
(1 of 2 people)
n/a

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Abnormal BehaviourConvulsionAstheniaSedationConvulsionDiabetes MellitusMemory ImpairmentConvulsion
ConvulsionDrug IneffectiveWeight DecreasedSomnolenceDizzinessDiabetic KetoacidosisHypoglycaemiaSomnolence
Stevens-johnson SyndromeFallAppetite DisorderEpilepsyAstheniaLeft Ventricular FailureAbnormal Loss Of WeightDizziness
PyrexiaPyrexiaConfusional StateAbnormal BehaviourGait DisturbanceMalaiseSomnolenceTremor
RashConfusional StateAmnesiaDrowningTremorCoronary Artery DiseaseDecreased AppetiteGrand Mal Convulsion
Memory ImpairmentLethargyAtaxiaAutismGrand Mal ConvulsionConvulsionVitamin C DeficiencyHeadache
TremorDrug HypersensitivityAggressionSudden Unexplained Death In EpilepsyIll-defined DisorderArteriosclerosis Coronary ArteryAmnesiaDrug Ineffective
Cytolytic HepatitisSomnolenceComplex Partial SeizuresHypoglycaemiaDrug IneffectiveCardiomegalyAbnormal DreamsFall
FatigueTremorDiarrhoea NosHyperhidrosisDepressionCardiomyopathyAnxietyPneumonia
Hallucination, AuditoryCerebral Arteriovenous Malformation HaemorrhagicAbasiaSocial PhobiaAmnesiaType 2 Diabetes MellitusAutismMental Status Changes

Drug effectiveness by gender :

FemaleMale
Depakote Er is effective33.33%
(5 of 15 people)
61.90%
(13 of 21 people)
Keppra is effective35.71%
(5 of 14 people)
45.00%
(9 of 20 people)

Most common drug interactions by gender * :

FemaleMale
ConvulsionConvulsion
TremorSomnolence
Mental Status ChangesDrug Ineffective
DizzinessAggression
HeadacheSedation
SomnolenceGrand Mal Convulsion
PneumoniaPyrexia
AlopeciaAbnormal Behaviour
Back PainWeight Increased
MalaiseThrombocytopenia

Drug effectiveness by age :

0-12-910-1920-2930-3940-4950-5960+
Depakote Er is effectiven/a66.67%
(2 of 3 people)
37.50%
(3 of 8 people)
36.84%
(7 of 19 people)
33.33%
(3 of 9 people)
12.50%
(2 of 16 people)
33.33%
(1 of 3 people)
0.00%
(0 of 3 people)
Keppra is effectiven/a100.00%
(1 of 1 people)
12.50%
(1 of 8 people)
29.41%
(5 of 17 people)
22.22%
(2 of 9 people)
25.00%
(4 of 16 people)
33.33%
(1 of 3 people)
0.00%
(0 of 3 people)

Most common drug interactions by age * :

0-12-910-1920-2930-3940-4950-5960+
Stevens-johnson SyndromeConvulsionConvulsionConvulsionConvulsionConvulsionConvulsionConvulsion
Pneumonia AspirationAggressionWeight DecreasedAggressionThrombocytopeniaMental Status ChangesDizzinessConfusional State
HypersomniaHallucination, AuditorySedationGranulocytopeniaFallSomnolenceDrug IneffectiveTremor
Drug Exposure During PregnancyEnuresisGrand Mal ConvulsionAngerAnaemia NosBack PainPneumoniaSomnolence
Convulsion NeonatalAbnormal BehaviourAbnormal BehaviourBone Marrow Depression NosSomnolenceAphasiaAstheniaFatigue
Suicidal IdeationDizzinessHeadacheGrand Mal ConvulsionMultiple Sclerosis RelapseTremorDeath
AngerRhinorrhoeaInjuryDrug IneffectiveProgressive Multifocal LeukoencephalopathyAtelectasisPneumonia
Weight IncreasedSomnolencePregnancy NosUnresponsive To StimuliImmune Reconstitution SyndromeTachycardiaCerebrovascular Accident
Insulin C-peptide DecreasedFallSomnolenceMalaiseAtaxiaHypotensionFall
Condition AggravatedDiabetes MellitusSuicidal IdeationNeuroleptic Malignant SyndromeNauseaDysstasiaUrinary Tract Infection

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

You can also:

Get connected! Join a mobile support group:
- group for people who take Depakote Er and Keppra
- group for people who take Depakote Er
- group for people who take Keppra

Comments from related studies:

  • From this study (4 months ago):

  • Person appears fine, very happy, playing with toys, sitting at table eating or sound asleep. Begins to make an "uh" sound. Quickly becomes very upset appearing terrified, moves in general circles reaching for any objects and throwing them with great force. Vocalization increases in volume as person becomes more upset. Will not make eye contact will not tolerate touch. Does not respond to any attempts to comfort. Person is affected with Angelman's Syndrome. Was on Onfi when the "fits" started. No previous history of any poor behaviors. Onfi was discontinued mid-August 2013.

    Reply

  • From this study (8 months ago):

  • Took phenobarbital from eight years old to about 22 years old. Took Mysoline from 18 to about 22 years old. Took Dilantin from 12 years old to about 32 years old. Took Depakote only from 32 to 51 years old. Took Depakote and Keppra from 51 years old to present.

    Reply

Post a new comment    OR    Read more comments

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Complete drug side effects:

On eHealthMe, Depakote Er (divalproex sodium) is often used to treat bipolar disorder. Keppra (levetiracetam) is often used to treat epilepsy. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

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