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Review: taking Depakote Er and Keppra together

Summary: drug interactions are reported among people who take Depakote Er and Keppra together. This review analyzes the effectiveness and drug interactions between Depakote Er and Keppra. It is created by eHealthMe based on reports of 860 people who take the same drugs from FDA and social media, and is updated regularly.

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What are the drugs

Depakote er has active ingredients of divalproex sodium. It is often used in bipolar disorder. (latest outcomes from 3,686 Depakote er users)

Keppra has active ingredients of levetiracetam. It is often used in epilepsy. (latest outcomes from 21,262 Keppra users)

On Apr, 30, 2015: 860 people who take Depakote Er, Keppra are studied

Depakote Er, Keppra outcomes

Drug combinations in study:
- Depakote Er (divalproex sodium)
- Keppra (levetiracetam)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Depakote Er is effective100.00%
(1 of 1 people)
25.00%
(1 of 4 people)
0.00%
(0 of 4 people)
50.00%
(3 of 6 people)
14.29%
(1 of 7 people)
87.50%
(7 of 8 people)
66.67%
(6 of 9 people)
0.00%
(0 of 1 people)
Keppra is effective50.00%
(1 of 2 people)
40.00%
(2 of 5 people)
40.00%
(2 of 5 people)
0.00%
(0 of 6 people)
36.36%
(4 of 11 people)
83.33%
(5 of 6 people)
50.00%
(1 of 2 people)
n/a

Drug effectiveness by gender :

FemaleMale
Depakote Er is effective31.25%
(5 of 16 people)
60.87%
(14 of 23 people)
Keppra is effective33.33%
(5 of 15 people)
45.45%
(10 of 22 people)

Drug effectiveness by age :

0-12-910-1920-2930-3940-4950-5960+
Depakote Er is effectiven/a50.00%
(3 of 6 people)
30.00%
(3 of 10 people)
36.84%
(7 of 19 people)
30.00%
(3 of 10 people)
12.50%
(2 of 16 people)
33.33%
(1 of 3 people)
0.00%
(0 of 3 people)
Keppra is effectiven/a50.00%
(2 of 4 people)
10.00%
(1 of 10 people)
29.41%
(5 of 17 people)
20.00%
(2 of 10 people)
25.00%
(4 of 16 people)
33.33%
(1 of 3 people)
0.00%
(0 of 3 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Abnormal BehaviourConvulsionAstheniaSedationConvulsionDiabetes MellitusMemory ImpairmentConvulsion
ConvulsionDrug IneffectiveWeight DecreasedSomnolenceDizzinessDiabetic KetoacidosisHypoglycaemiaSomnolence
Stevens-johnson SyndromeFallAmnesiaEpilepsyGait DisturbanceLeft Ventricular FailureAbnormal Loss Of WeightDizziness
PyrexiaPyrexiaAtaxiaAbnormal BehaviourAstheniaMalaiseSomnolenceTremor
RashConfusional StateConfusional StateDrowningGrand Mal ConvulsionCoronary Artery DiseaseDecreased AppetiteGrand Mal Convulsion
Memory ImpairmentDrug HypersensitivityAppetite DisorderAutismTremorConvulsionVitamin C DeficiencyHeadache
TremorLethargyAbnormal BehaviourSudden Unexplained Death In EpilepsyDrug IneffectiveArteriosclerosis Coronary ArteryAmnesiaDrug Ineffective
Cytolytic HepatitisTremorColitis UlcerativeHypoglycaemiaCognitive DisorderCardiomegalyAbnormal DreamsFall
FatigueSomnolenceComplex Partial SeizuresHyperhidrosisIll-defined DisorderCardiomyopathyAnxietyPneumonia
Hallucination, AuditoryCerebral Arteriovenous Malformation HaemorrhagicDiarrhoea NosSocial PhobiaAmnesiaType 1 Diabetes MellitusAutismMental Status Changes

Most common drug interactions by gender * :

FemaleMale
ConvulsionConvulsion
TremorSomnolence
Mental Status ChangesDrug Ineffective
DizzinessAggression
HeadacheSedation
SomnolenceGrand Mal Convulsion
PneumoniaAbnormal Behaviour
AlopeciaPyrexia
Back PainWeight Increased
MalaiseThrombocytopenia

Most common drug interactions by age * :

0-12-910-1920-2930-3940-4950-5960+
Stevens-johnson SyndromeConvulsionConvulsionConvulsionConvulsionConvulsionConvulsionConvulsion
Pneumonia AspirationAggressionSedationAggressionFallMental Status ChangesDizzinessConfusional State
HypersomniaHallucination, AuditoryGrand Mal ConvulsionGranulocytopeniaThrombocytopeniaSomnolenceDrug IneffectiveTremor
Drug Exposure During PregnancyEnuresisWeight DecreasedAngerAnaemia NosBack PainPneumoniaSomnolence
Convulsion NeonatalAbnormal BehaviourAbnormal BehaviourBone Marrow Depression NosSomnolenceAphasiaAstheniaFatigue
Condition AggravatedDizzinessHeadacheUnresponsive To StimuliMultiple Sclerosis RelapseTremorDeath
AngerSomnolenceInjuryDrug IneffectiveProgressive Multifocal LeukoencephalopathyAtelectasisPneumonia
Insulin C-peptide DecreasedRhinorrhoeaPregnancy NosGrand Mal ConvulsionImmune Reconstitution SyndromeTachycardiaCerebrovascular Accident
SomnolenceFallSomnolenceRhabdomyolysisAtaxiaHypotensionFall
Abnormal Behaviour NosHypertensionSuicidal IdeationAnxietyNauseaDysstasiaUrinary Tract Infection

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Get connected: join our support group of Depakote Er and Keppra on

Do you take Depakote Er and Keppra?

 

You are not alone! Join a related support group:
- support group for people who take Depakote Er
- support group for people who take Keppra

Recent conversations of related support groups:

Can you answer these questions (Ask a question):

More questions for: Depakote Er, Keppra

You may be interested at these reviews (Write a review):

  • Advice on where to turn?
    Please Help.
    My sister was diagnosed with a boarderline personality disorder 13 years ago. She has took so many overdoses i have lost count.
    She has a son of 16 who my parents brought up due to my sister only being 16 when she gave birth. At that time she could not cope.
    She has ...
  • Keppra side effects , nasal congestion, coughing, no taste and smell, latyngitis
    I have been on this drug for 4 months and have never felt so awful. I lost my sense of smell and taste right away. My nose is always congested. This past weekend I lost my voice.
    I can not sleep due to either my nose totally blocked or running like a tap.
    Some days I ache like I have a ...
  • Seizure patient was on depakote for 16 years now on keppra 1500 mg.
    I am 28 years old and been off depakote for 5 months. I started keppra to control my seizure disorder, which works great. But for the past year I have developed osteoarthritis in my thoracic, si joints, and lumbar. I get alot of muscle hypersensitivity and pain. Can any of this be due to long term ...
  • Chest pain from keppra xr
    after 6 years developed right side pain near kidneys a few days a month .
    2 inside of eye lid red dry eyes
    took keppra 7 years .
    started to have chest pain left side .after a month of pain . that would start 3 to 6 hours after taking keppra . would have pain thru the d ...
  • Depakote er affected by grapefruit
    I have taken Depakote ER for since 2005 for epilepsy. Once stabilized many years ago seizures and auras have not been bothering me. Until I recently ate three grapefruits over three days. After a few days, when the grapefruit cleared my system, the seizures and auras ceased. Therefore, grapefrui ...

More reviews for: Depakote Er, Keppra

Comments from related studies:

  • From this study (1 year ago):

  • Person appears fine, very happy, playing with toys, sitting at table eating or sound asleep. Begins to make an "uh" sound. Quickly becomes very upset appearing terrified, moves in general circles reaching for any objects and throwing them with great force. Vocalization increases in volume as person becomes more upset. Will not make eye contact will not tolerate touch. Does not respond to any attempts to comfort. Person is affected with Angelman's Syndrome. Was on Onfi when the "fits" started. No previous history of any poor behaviors. Onfi was discontinued mid-August 2013.

    Reply

  • From this study (1 year ago):

  • Blood in stools.

    Reply

  • From this study (1 year ago):

  • Took phenobarbital from eight years old to about 22 years old. Took Mysoline from 18 to about 22 years old. Took Dilantin from 12 years old to about 32 years old. Took Depakote only from 32 to 51 years old. Took Depakote and Keppra from 51 years old to present.

    Reply

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Complete drug side effects:

On eHealthMe, Depakote Er (divalproex sodium) is often used to treat bipolar disorder. Keppra (levetiracetam) is often used to treat epilepsy. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

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You may report adverse side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

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