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Review: Depakote Er and Keppra





Summary: drug interactions are reported among people who take Depakote Er and Keppra together.

This review analyzes the effectiveness and drug interactions between Depakote Er and Keppra. It is created by eHealthMe based on reports of 859 people who take the same drugs from FDA and social media, and is updated regularly.

You are not alone: join a mobile support group for people who take Depakote Er and Keppra >>>

What are the drugs

Depakote er has active ingredients of divalproex sodium. It is often used in bipolar disorder. (view latest outcomes from 3,677 users)

Keppra has active ingredients of levetiracetam. It is often used in epilepsy. (latest outcomes from Keppra 21,210 users)

On Nov, 25, 2014: 859 people who take Depakote Er, Keppra are studied

Depakote Er, Keppra outcomes

Drug combinations in study:
- Depakote Er (divalproex sodium)
- Keppra (levetiracetam)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Depakote Er is effective100.00%
(1 of 1 people)
25.00%
(1 of 4 people)
0.00%
(0 of 4 people)
50.00%
(3 of 6 people)
14.29%
(1 of 7 people)
85.71%
(6 of 7 people)
66.67%
(6 of 9 people)
0.00%
(0 of 1 people)
Keppra is effective50.00%
(1 of 2 people)
40.00%
(2 of 5 people)
40.00%
(2 of 5 people)
0.00%
(0 of 6 people)
36.36%
(4 of 11 people)
80.00%
(4 of 5 people)
50.00%
(1 of 2 people)
n/a

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Abnormal BehaviourConvulsionAstheniaSedationConvulsionDiabetes MellitusMemory ImpairmentConvulsion
ConvulsionDrug IneffectiveWeight DecreasedSomnolenceDizzinessDiabetic KetoacidosisHypoglycaemiaSomnolence
Stevens-johnson SyndromeFallAmnesiaEpilepsyGait DisturbanceLeft Ventricular FailureAbnormal Loss Of WeightDizziness
PyrexiaPyrexiaAtaxiaAbnormal BehaviourAstheniaMalaiseSomnolenceTremor
RashConfusional StateConfusional StateDrowningGrand Mal ConvulsionCoronary Artery DiseaseDecreased AppetiteGrand Mal Convulsion
Memory ImpairmentDrug HypersensitivityAppetite DisorderAutismTremorConvulsionVitamin C DeficiencyHeadache
TremorLethargyAbnormal BehaviourSudden Unexplained Death In EpilepsyDrug IneffectiveArteriosclerosis Coronary ArteryAmnesiaDrug Ineffective
Cytolytic HepatitisTremorColitis UlcerativeHypoglycaemiaCognitive DisorderCardiomegalyAbnormal DreamsFall
FatigueSomnolenceComplex Partial SeizuresHyperhidrosisIll-defined DisorderCardiomyopathyAnxietyPneumonia
Hallucination, AuditoryCerebral Arteriovenous Malformation HaemorrhagicDiarrhoea NosSocial PhobiaAmnesiaType 2 Diabetes MellitusAutismMental Status Changes

Drug effectiveness by gender :

FemaleMale
Depakote Er is effective31.25%
(5 of 16 people)
59.09%
(13 of 22 people)
Keppra is effective33.33%
(5 of 15 people)
42.86%
(9 of 21 people)

Most common drug interactions by gender * :

FemaleMale
ConvulsionConvulsion
TremorSomnolence
Mental Status ChangesDrug Ineffective
DizzinessSedation
HeadacheAggression
SomnolenceGrand Mal Convulsion
PneumoniaPyrexia
AlopeciaWeight Increased
Back PainAbnormal Behaviour
MalaiseThrombocytopenia

Drug effectiveness by age :

0-12-910-1920-2930-3940-4950-5960+
Depakote Er is effectiven/a66.67%
(2 of 3 people)
30.00%
(3 of 10 people)
36.84%
(7 of 19 people)
30.00%
(3 of 10 people)
12.50%
(2 of 16 people)
33.33%
(1 of 3 people)
0.00%
(0 of 3 people)
Keppra is effectiven/a100.00%
(1 of 1 people)
10.00%
(1 of 10 people)
29.41%
(5 of 17 people)
20.00%
(2 of 10 people)
25.00%
(4 of 16 people)
33.33%
(1 of 3 people)
0.00%
(0 of 3 people)

Most common drug interactions by age * :

0-12-910-1920-2930-3940-4950-5960+
Stevens-johnson SyndromeConvulsionConvulsionConvulsionConvulsionConvulsionConvulsionConvulsion
Pneumonia AspirationAggressionSedationAggressionFallMental Status ChangesDizzinessConfusional State
HypersomniaHallucination, AuditoryGrand Mal ConvulsionGranulocytopeniaThrombocytopeniaSomnolenceDrug IneffectiveTremor
Drug Exposure During PregnancyEnuresisWeight DecreasedAngerAnaemia NosBack PainPneumoniaSomnolence
Convulsion NeonatalAbnormal BehaviourAbnormal BehaviourBone Marrow Depression NosSomnolenceAphasiaAstheniaFatigue
Suicidal IdeationDizzinessHeadacheUnresponsive To StimuliMultiple Sclerosis RelapseTremorDeath
AngerSomnolenceInjuryDrug IneffectiveProgressive Multifocal LeukoencephalopathyAtelectasisPneumonia
Weight IncreasedRhinorrhoeaPregnancy NosGrand Mal ConvulsionImmune Reconstitution SyndromeTachycardiaCerebrovascular Accident
Insulin C-peptide DecreasedFallSomnolenceRhabdomyolysisAtaxiaHypotensionFall
Condition AggravatedHypertensionSuicidal IdeationAnxietyNauseaDysstasiaUrinary Tract Infection

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Depakote Er and Keppra?

You are not alone! Join a related mobile support group:
- support group for people who take Depakote Er and Keppra
- support group for people who take Depakote Er
- support group for people who take Keppra

Can you answer these questions (Ask a question):

More questions for: Depakote Er, Keppra

You may be interested at these reviews (Write a review):

  • Seizure patient was on depakote for 16 years now on keppra 1500 mg.
    I am 28 years old and been off depakote for 5 months. I started keppra to control my seizure disorder, which works great. But for the past year I have developed osteoarthritis in my thoracic, si joints, and lumbar. I get alot of muscle hypersensitivity and pain. Can any of this be due to long term effects of seizure meds?
  • Chest pain from keppra xr
    after 6 years developed right side pain near kidneys a few days a month .
    2 inside of eye lid red dry eyes
    took keppra 7 years .
    started to have chest pain left side .after a month of pain . that would start 3 to 6 hours after taking keppra . would have pain thru the day stopped keppra . chest pain went a way 2 days later .
    switched to a new med . a month later no chest pain
    I developed a allergy to Dilantin ten years ago and had chest pain. went away after stopping Dilantin
  • Depakote er affected by grapefruit
    I have taken Depakote ER for since 2005 for epilepsy. Once stabilized many years ago seizures and auras have not been bothering me. Until I recently ate three grapefruits over three days. After a few days, when the grapefruit cleared my system, the seizures and auras ceased. Therefore, grapefruit does affect how Depakote ER acts on your system.
  • Health issues and struggles
    I have numerous health issues. Some I've lived with not realizing they were there. Others are caused by meds I've taken in the past or am still using now.

    Lupus is the most recent and biggest trouble I have right now. It is caused by the one drug that finally gave me control of my seizures

    Some of the worst troubles have been TBI from birth. Epilepsy my entire life. Brain tumor ( surgery to remove it in 1982) Graves Disease. RA and most recently Lupus ( caused by the keppra)
  • Understanding and living with cancer
    After having one treatment of Gemzar, I had a severe reaction, which caused me to have many seizures. This caused me to developed PRES, which in turn has caused me to have brain damage.When I came out of my induced coma I did not know where I was, nor did I know who my family members were. I could not bathe myself, drive, my speech was broken, I could not add two plus two. I was not the woman I was before Gemzar treatment.Now I am unable to work, I am unable to live on my own, I must always be in the company of another person. I have lost my home and car and job due to this condition. I am currently in speech therapy and soon will start occupational therapy (which is VERY costly) This month marks the one year anniversary of this condition for me. I am making progress. I am able to bathe myself, I can do a little cooking, (although the first time I tried I caught the kitchen on fire a little), I am still living with my Mother , as she is my care taker, my nurse, my driver, my chef, my house cleaner. I currently receive disability. My student loans have gone into default. I could go on but I am depressing myself. I am, followed by my Oncologist every two months now.I want to share this information to anyone and everyone who can benefit from this information.

    Thank you, Chelette Williams, BA,MBA.

More reviews for: Depakote Er, Keppra

Comments from related studies:

  • From this study (10 months ago):

  • Person appears fine, very happy, playing with toys, sitting at table eating or sound asleep. Begins to make an "uh" sound. Quickly becomes very upset appearing terrified, moves in general circles reaching for any objects and throwing them with great force. Vocalization increases in volume as person becomes more upset. Will not make eye contact will not tolerate touch. Does not respond to any attempts to comfort. Person is affected with Angelman's Syndrome. Was on Onfi when the "fits" started. No previous history of any poor behaviors. Onfi was discontinued mid-August 2013.

    Reply

  • From this study (10 months ago):

  • Blood in stools.

    Reply

  • From this study (1 year ago):

  • Took phenobarbital from eight years old to about 22 years old. Took Mysoline from 18 to about 22 years old. Took Dilantin from 12 years old to about 32 years old. Took Depakote only from 32 to 51 years old. Took Depakote and Keppra from 51 years old to present.

    Reply

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Complete drug side effects:

On eHealthMe, Depakote Er (divalproex sodium) is often used to treat bipolar disorder. Keppra (levetiracetam) is often used to treat epilepsy. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

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