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Review: taking Depakote Er and Prevacid together

Summary: drug interactions are reported among people who take Depakote Er and Prevacid together.

This review analyzes the effectiveness and drug interactions between Depakote Er and Prevacid. It is created by eHealthMe based on reports of 755 people who take the same drugs from FDA and social media, and is updated regularly.





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What are the drugs

Depakote er has active ingredients of divalproex sodium. It is often used in bipolar disorder. (latest outcomes from 3,677 Depakote er users)

Prevacid has active ingredients of lansoprazole. It is often used in gastroesophageal reflux disease. (latest outcomes from 40,813 Prevacid users)

On Jan, 20, 2015: 755 people who take Depakote Er, Prevacid are studied

Depakote Er, Prevacid outcomes

Drug combinations in study:
- Depakote Er (divalproex sodium)
- Prevacid (lansoprazole)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Depakote Er is effectiven/a0.00%
(0 of 1 people)
(1 of 1 people)
(2 of 3 people)
(2 of 3 people)
(0 of 1 people)
(1 of 1 people)
Prevacid is effective100.00%
(1 of 1 people)
(0 of 1 people)
(1 of 2 people)
(1 of 3 people)
(2 of 2 people)
(1 of 1 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
TremorDiarrhoeaCatatoniaDiabetic NeuropathyDrug Level DecreasedVomiting NosObesityType 2 Diabetes Mellitus
Renal FailureBlood Cholesterol IncreasedObesityAbortion SpontaneousAmmonia IncreasedPancreatitis NosType 2 Diabetes MellitusDiabetes Mellitus
Liver Function Test AbnormalDehydrationType 2 Diabetes MellitusDrug Exposure During PregnancyWeight DecreasedNauseaWeight IncreasedDepression
JaundiceColitisAggressionType 2 Diabetes MellitusDiarrhoeaDepression NosThrombosisAnxiety
Hepatocellular InjuryVomitingAgitationConvulsionDepressionAbdominal DiscomfortPerirectal AbscessNausea
Confusional StateThrombocytopeniaStereotypyDrug IneffectiveInsomniaBreast MassInsomnia
Ammonia IncreasedDisseminated Intravascular CoagulationAmmonia IncreasedPlatelet Count DecreasedDeliriumDiabetes Mellitus Inadequate ControlDrug Ineffective
Chest PainPancreatitisBlood Triglycerides IncreasedMajor DepressionDyspepsiaDiabetic KetoacidosisHeadache
Heart Rate IncreasedPseudocystBlood Cholesterol IncreasedHeart Rate IncreasedFlatulenceThrombophlebitis SuperficialFatigue
Stomach PainPyrexiaEpistaxisHeart PoundingCholecystitis ChronicAnticoagulation Drug Level Above TherapeuticFall

Drug effectiveness by gender :

Depakote Er is effective57.14%
(4 of 7 people)
(2 of 3 people)
Prevacid is effective57.14%
(4 of 7 people)
(2 of 3 people)

Most common drug interactions by gender * :

Type 2 Diabetes MellitusDepression
Diabetes MellitusDiabetes Mellitus
HeadacheDrug Ineffective
Back PainWeight Decreased
Gastrooesophageal Reflux DiseaseAgitation
DepressionSuicide Attempt

Drug effectiveness by age :

Depakote Er is effectiven/an/an/a25.00%
(2 of 8 people)
(0 of 1 people)
(1 of 1 people)
(0 of 3 people)
(3 of 8 people)
Prevacid is effectiven/an/an/a25.00%
(2 of 8 people)
(0 of 1 people)
(1 of 1 people)
(1 of 2 people)
(2 of 7 people)

Most common drug interactions by age * :

PalpitationsLethargyPancreatitisDrug IneffectiveType 2 Diabetes MellitusGastrooesophageal Reflux DiseaseDizzinessFall
OsteoporosisHypoventilationVomitingSuicide AttemptDiabetes MellitusType 2 Diabetes MellitusAnxietyFatigue
ArthritisPalpitationsDehydrationAnxietyBack PainDiabetes MellitusHeadacheAnaemia
Rash GeneralisedConvulsionAbdominal PainAgitationPain In ExtremityDyspnoeaType 2 Diabetes MellitusBlood Glucose Increased
TachycardiaDrug IneffectiveDiarrhoeaDiabetes MellitusPancreatitisAnxietyDepressionOedema Peripheral
Type 2 Diabetes MellitusDeathContusionDepressionWeight IncreasedHyperhidrosisSomnolenceInjury
Transient Ischaemic AttackUrine Ketone Body PresentInfusion Related ReactionInsomniaDiabetes Mellitus Inadequate ControlInsomniaNauseaDeep Vein Thrombosis
HypertensionPyrexiaType 2 Diabetes MellitusInsomniaRoad Traffic AccidentManiaContusion
Menstrual DisorderTongue DryPancreatitisThrombosisFallDrug IneffectiveNausea
ConvulsionConfusional StateBlood Cholesterol IncreasedDeep Vein ThrombosisBack PainGastrooesophageal Reflux DiseaseCardiomegaly

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Depakote Er and Prevacid?

You are not alone! Join a related mobile support group:
- support group for people who take Depakote Er and Prevacid
- support group for people who take Depakote Er
- support group for people who take Prevacid

Can you answer these questions (Ask a question):

More questions for: Depakote Er, Prevacid

You may be interested at these reviews (Write a review):

  • Seizure patient was on depakote for 16 years now on keppra 1500 mg.
    I am 28 years old and been off depakote for 5 months. I started keppra to control my seizure disorder, which works great. But for the past year I have developed osteoarthritis in my thoracic, si joints, and lumbar. I get alot of muscle hypersensitivity and pain. Can any of this be due to long term effects of seizure meds?
  • Lansoprazole and vitamin c drug interactions (1 response)
    Whenever I use a gastric ulcer or gastric acid treatment drug and eat any food that contains vitamine C, like lemon, orange, etc. I get a strong skin allergy with swollen insecbyte type itching redness, that lasts about two days for each one.
  • Depakote er affected by grapefruit
    I have taken Depakote ER for since 2005 for epilepsy. Once stabilized many years ago seizures and auras have not been bothering me. Until I recently ate three grapefruits over three days. After a few days, when the grapefruit cleared my system, the seizures and auras ceased. Therefore, grapefruit does affect how Depakote ER acts on your system.
  • Choking on fluid in my throat
    I have taken 2 pills, in the last 48 hour period. I have never taken Prevacid 24hr before, and was told it would be safe to use while pregnant. I woke up, the second night, to either mucus or some fluid, in my throat. When I tried it "clear" my throat, the fluid moved to block my breathing. I started choking and vomited. I had to "suck" air into my lungs for a few minutes, while also trying to "clear" my throat, which caused my to vomit again. I felt as if I were choking on my own spit. It was scary, and I will never take Prevacid 24hr again. I think I'll stick to Tums.

More reviews for: Depakote Er, Prevacid

Comments from related studies:

  • From this study (3 months ago):

  • doc moc on Apr, 25, 2013:

    BREAK down FOOL!


    Rhs on Oct, 13, 2012:

    Get your medical records
    and consult w/your doctor


    trust1983 on Dec, 3, 2012:

    Is it true in the states that a psych doc can up and just leave and refuse to treat you because you tried to kill yourself, especially if you didn't have a contact for life with you r doc?


Post a new comment    OR    Read more comments

Complete drug side effects:

On eHealthMe, Depakote Er (divalproex sodium) is often used to treat bipolar disorder. Prevacid (lansoprazole) is often used to treat gastroesophageal reflux disease. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.


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