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Review: Depakote Er and Wellbutrin Xl





Summary: drug interactions are reported among people who take Depakote Er and Wellbutrin Xl together.

This review analyzes the effectiveness and drug interactions between Depakote Er and Wellbutrin Xl. It is created by eHealthMe based on reports of 2,024 people who take the same drugs from FDA and social media, and is updated regularly.

You are not alone: join a mobile support group for people who take Depakote Er and Wellbutrin Xl >>>

What are the drugs

Depakote er has active ingredients of divalproex sodium. It is often used in bipolar disorder. (latest outcomes from Depakote er 3,677 users)

Wellbutrin xl has active ingredients of bupropion hydrochloride. It is often used in depression. (latest outcomes from Wellbutrin xl 13,268 users)

On Nov, 25, 2014: 2,024 people who take Depakote Er, Wellbutrin Xl are studied

Depakote Er, Wellbutrin Xl outcomes

Drug combinations in study:
- Depakote Er (divalproex sodium)
- Wellbutrin Xl (bupropion hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Depakote Er is effective25.00%
(3 of 12 people)
15.38%
(2 of 13 people)
46.15%
(6 of 13 people)
38.46%
(5 of 13 people)
35.71%
(5 of 14 people)
56.25%
(9 of 16 people)
50.00%
(8 of 16 people)
50.00%
(1 of 2 people)
Wellbutrin Xl is effective30.00%
(3 of 10 people)
6.67%
(1 of 15 people)
25.00%
(3 of 12 people)
28.57%
(6 of 21 people)
50.00%
(9 of 18 people)
61.11%
(11 of 18 people)
27.27%
(3 of 11 people)
0.00%
(0 of 1 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
DizzinessTremorType 2 Diabetes MellitusTremorWeight IncreasedWeight IncreasedWeight IncreasedDiabetes Mellitus
AmnesiaDepressionSuicidal IdeationAlopeciaVomitingDiabetes MellitusObesityType 2 Diabetes Mellitus
ConvulsionOverdoseDiabetes MellitusWeight IncreasedDiabetic NeuropathyType 2 Diabetes MellitusBack DisorderWeight Increased
FallFeeling AbnormalBlood Triglycerides IncreasedType 2 Diabetes MellitusProteinuriaErectile DysfunctionAbnormal DreamsDepression
Suicidal IdeationSuicide AttemptTremorErectile DysfunctionRenal DisorderPancreatitisBlood Cholesterol IncreasedSuicidal Ideation
Weight IncreasedDizzinessBlood Cholesterol IncreasedDyspnoeaDiabetes Mellitus Inadequate ControlFatigueAbdominal Pain UpperInsomnia
DyspnoeaCryingObesityDizzinessPneumoniaHypertensionBlood Triglycerides IncreasedSuicide Attempt
ParanoiaAggressionAlopeciaRash PapularCoughAngerIrritable Bowel SyndromeBlood Cholesterol Increased
AgitationManiaNeuropathy PeripheralDrug Exposure During PregnancyType 2 Diabetes MellitusHepatomegalyHyperlipidaemiaDrug Ineffective
DepressionBipolar DisorderHyperglycaemiaBlood Glucose IncreasedConstipationHepatic SteatosisGallbladder DisorderHeadache

Drug effectiveness by gender :

FemaleMale
Depakote Er is effective36.73%
(18 of 49 people)
42.00%
(21 of 50 people)
Wellbutrin Xl is effective31.37%
(16 of 51 people)
36.36%
(20 of 55 people)

Most common drug interactions by gender * :

FemaleMale
Diabetes MellitusDiabetes Mellitus
Type 2 Diabetes MellitusType 2 Diabetes Mellitus
Weight IncreasedWeight Increased
DepressionSuicidal Ideation
Suicidal IdeationDepression
NauseaTremor
DizzinessDrug Ineffective
Blood Cholesterol IncreasedSuicide Attempt
InsomniaInsomnia
Chest PainBlood Cholesterol Increased

Drug effectiveness by age :

0-12-910-1920-2930-3940-4950-5960+
Depakote Er is effectiven/an/a40.00%
(2 of 5 people)
20.59%
(7 of 34 people)
20.59%
(7 of 34 people)
41.67%
(10 of 24 people)
32.43%
(12 of 37 people)
4.76%
(1 of 21 people)
Wellbutrin Xl is effectiven/an/a16.67%
(1 of 6 people)
17.65%
(6 of 34 people)
21.05%
(8 of 38 people)
20.83%
(5 of 24 people)
32.43%
(12 of 37 people)
22.22%
(4 of 18 people)

Most common drug interactions by age * :

0-12-910-1920-2930-3940-4950-5960+
PancreatitisDrug IneffectiveSuicidal IdeationDiabetes MellitusDiabetes MellitusDiabetes MellitusDiabetes MellitusTremor
HeadacheRespiratory Arrest (excl Neonatal)Suicide AttemptNauseaType 2 Diabetes MellitusType 2 Diabetes MellitusType 2 Diabetes MellitusDiabetes Mellitus
Pyoderma GangrenosumPersonality ChangeWeight IncreasedSuicidal IdeationWeight IncreasedBlood Cholesterol IncreasedDepressionDrug Ineffective
Gastrointestinal HaemorrhageInfection NosSelf MutilationType 2 Diabetes MellitusSuicidal IdeationWeight IncreasedInsomniaFall
Pelvic PainGrand Mal ConvulsionAgitationWeight IncreasedDiabetes Mellitus Inadequate ControlChest PainDizzinessAnxiety
Ovarian CystStatus EpilepticusOverdoseDepressionObesityBlood Triglycerides IncreasedChest PainWeight Increased
Major DepressionBipolar I DisorderHeadacheBlood Cholesterol IncreasedBlood Cholesterol IncreasedObesityNeuropathy PeripheralSuicidal Ideation
Suicidal IdeationPyrexiaFatigueInsomniaDepressionDepressionSuicide AttemptDepression
HyperventilationManiaFeeling AbnormalDiabetic KetoacidosisBlood Triglycerides IncreasedHeadacheWeight IncreasedDiarrhoea
Type 2 Diabetes MellitusHormone Level Nos AbnormalHallucination, AuditorySuicide AttemptPancreatitisPancreatitisSuicidal IdeationBalance Disorder

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Depakote Er and Wellbutrin Xl?

You are not alone! Join a related mobile support group:
- support group for people who take Depakote Er and Wellbutrin Xl
- support group for people who take Depakote Er
- support group for people who take Wellbutrin Xl

Can you answer these questions (Ask a question):

  • Can clyndamican cause a seizure while taking depakote
    I am currently taking Depakote Extended Realease 1000mgs at bedtime with Clyndamican an antibiotic. I have been feeling dizzy, fatigue, headaches, body aches, sore throat, and pain and pressure in my chest. I would like to know if these two medications mixed together are causing me these problems, and if it can cause me a seizure.
  • I am on 2 x daily rifampin and 4 x daily cephalixin 500mg and and awake exhausted after 8-9 hours sleep and the fatigue is unbelievable all day every day, is this "normal" or should i investigate ore (1 answer)
    Had total knee replacement 11/12, bad from the start, knee swollen/hot/painful/unstable for most of 2 years before a mechanically successful Revision that found a loose patella and both ends of the prostheses loose. In spite of 10-12 aspirations and almost as many samples sent to labs for testing the result was always "no growth after a week". Following the revision, 10 days after, surgeons office called and says yes you have a staph E infection. Immediate therapy with 6 weeks of 3 X day IV PLUS 2 x per day oral Rifampin.
    IV over but now on the 2 X day Rifampin PLUS 4 X day 500mg cephalexin and the fatigue is unbelievable. Wake up exhausted after 8 hours sleep, daily hour plus mid afternoon naps.
  • Has anyone been helped by taking lexapro and wellbutrin? (1 answer)
    I am the mom of a 22 year old who is trying to get through college and can't seem to find the right meds for depression. She is taking Lexapro and I am wondering if adding Wellbutrin will help.
  • My sister has been taking depakote cogentin and geodon and suffers with great memory loss inability to carry on a conversation and drops things all the time is this the effect of these drugs? (1 answer)
    Sister takes over 16 perscriptions but the ones mentioned are severe.. due to being bi-polar, and severe agoraphobia and anxiety with depression..is this now her life? Not being able to fully comprehend or remember anything? Dropping things and falling when under the full impact of this medication? I either need to get some acceptance or find answers to the effects this medicine is causing..afraid to change up her medicines but needless to say I am worried...
  • I'm on 1 1/12 mg of suboxone. would i have to go off of it if i need major surgery?
    I was taking about 5 to 15 mg of Percocet a day and wanted to get off them. If I don't take suboxone at night I get EXTREME discomfort down my left leg & can not sleep due to pressure on my lower back (that's why I had to take Percocet). I have tried NUMEROUS meds over the past 20 yrs & nothing worked. the actual problem in my lumber spine is not serious enough to have surgery at this time.
    My question is if I need major surgery and need to take an opiate pain med would I have to get off the 1 1/2 mg of suboxone so I don't to go into withdrawal (as a doc once told me)? I'm 72 & the possibility of needing surgery is high, especially since I've had breast, colon & skin cancer. thank you

More questions for: Depakote Er, Wellbutrin Xl

You may be interested at these reviews (Write a review):

  • Intrsoccular pressure increase associated with wellbutrin
    I was given a prescription for Wellbutrin in approximately 1998. I had has my ocular pressure checked a year prior to this and it was okay. At the time, I only needed to wear reading glasses, common in people over 45. I took the drug at the full prescribed dosage for two weeks. Immediately prior to the narrow angle glaucoma episode, my vision had actually seemed to improve. For one day, prior, I could read without reading glasses. The following night, I was watching tv, and things suddenly became foggy. It was actually as if a fog had enveloped the room. I could not see anything except to discern between light and dark areas. I had to have emergency laser surgery the next morning. I mentioned to the doctor that Iwas taking Wellbutrin to stop smoking, and asked if it could have caused the ocular pressure increase. he consulted the PDR, and said there was no mention of it causing increases in ocular pressure. One year later my primary care doctor again insisted that I stop smoking, and again I mentioned that I thought it might increase ocular pressure. She told me to take a half dose, I did, and I took it one week, at which time I again experienced another episode of narrow angle glaucoma. When I go to the doctor's office my pressure in my left eye was 72, and 68 in my right eye. I was then referred on a triage basis to another doctor. I spent the rest of the day in his office having drops administered every fifteen minutes(extremely painful). I had extensive laser surgery the next morning.It required over fifty shots from the laser machine into each eye, (also extremely painful). I had lost considerable peripheral AND CENTRAL VISION in my left eye, and a good deal in my right. As a result of having to have such extensive laser surgery I also had cataracts that began at 50% maturity. I was advised by the surgeon that I should wait to have the cataracts removed "until my vision and quality of life was so poor that I was ready to commit suicide" because having the cataracts removed would cause the pressure in my eyes to become very difficult to control, and that more than likely I would end up being black blind. I would never use Wellbutrin under any circumstances, and I always check to make sure that any new meds I may be put on don't have anything to do with an increase in ocular pressure. If they do, I refuse to take them. The surgeon said he was surprised that I didn't lose more vision than I did, and I am grateful that I didn't, and that he was a good surgen. He wrote an article concerning this case for a medical journal since he said he had been seeing a recent increase of narrow angle glaucoma.
  • Librium 25mg and wellbutrin 300mg for >1 month
    I've been taking librium twice daily, morning and night, for about 3 months now along with wellbutrin XL in the morning. I've basically had the mood of "I don't care" and a great boost in confidence.
  • Bedwetting with paxil and wellbutrin
    I have been using both of these drugs and now have bedwetting issues 5 times a week on average. I would rate the bedwetting as moderate about a6/10 but my wife and I can live with this as she had made the comment " you are back to the man I married ". I started taking these due to depression about work and anxiety about work. We both think we can live with the bedwetting as no one needs to know about it
  • Wellbutrin caused my trigeminal neurlagia
    So I'm writing this to hopefully shed light to other users in the same position I was in. I had taken Wellbutrin for about 4 years. The pain experienced in my face was excruciatingly painful. It was just on one side of my face between my temple and upper lip. All the symptoms reflected Trigeminal Neuralgia. But even with an MRI nothing could be found. I suffered for 3 of those years with pain coming and going, not understanding what was going on. Finally one day I decided hell with Wellbutrin and just stopped taking it. It's been 6 months now and I have yet to have a single shred of pain. Coincidence? I doubt it.
  • Lorazepam nearly killed me during cancer treatment
    Day 31 of cold turkey and I want to die. It is a roller coaster from body tics and sweats to rage and crying in one day. I felt so good the 4h day of c/t. It was like before my cancer diagnosis. My bowels are better off Lorazepam. I threw up during bowel movements from the pain. Off Lorazepam first normal bowel movement in over 2 years. Stomach so damaged by Lorazepam that I have absolutely no appetite. I force myself to eat. Neuropathy in hands nearly gone. Feet are better but slower. Lymphedema that appeared after one year on Lorazepam is now gone. I have full range of motion.

More reviews for: Depakote Er, Wellbutrin Xl

Comments from related studies:

  • From this study (2 months ago):

  • doc moc on Apr, 25, 2013:

    BREAK down FOOL!

    Reply

    Rhs on Oct, 13, 2012:

    Get your medical records
    and consult w/your doctor

    Reply

    trust1983 on Dec, 3, 2012:

    Is it true in the states that a psych doc can up and just leave and refuse to treat you because you tried to kill yourself, especially if you didn't have a contact for life with you r doc?

    Reply

Post a new comment    OR    Read more comments

Complete drug side effects:

On eHealthMe, Depakote Er (divalproex sodium) is often used to treat bipolar disorder. Wellbutrin Xl (bupropion hydrochloride) is often used to treat depression. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

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You may report adverse side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

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