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Home > Depakote Er > Wellbutrin Xl > Depakote Er and Wellbutrin Xl

Review: Depakote Er and Wellbutrin Xl

This review analyzes the effectiveness and drug interactions between Depakote Er and Wellbutrin Xl. It is created by eHealthMe based on reports of 2,023 people who take the same drugs from FDA and social media, and is updated regularly.

You are not alone: join a mobile support group for people who take Depakote Er and Wellbutrin Xl >>>

What are the drugs

Depakote er (latest outcomes from 3,677 users) has active ingredients of divalproex sodium. It is often used in bipolar disorder.

Wellbutrin xl (latest outcomes from 13,250 users) has active ingredients of bupropion hydrochloride. It is often used in depression.

On Oct, 26, 2014: 2,023 people who take Depakote Er, Wellbutrin Xl are studied

Depakote Er, Wellbutrin Xl outcomes

Drug combinations in study:
- Depakote Er (divalproex sodium)
- Wellbutrin Xl (bupropion hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Depakote Er is effective25.00%
(3 of 12 people)
(2 of 13 people)
(6 of 13 people)
(5 of 13 people)
(5 of 13 people)
(9 of 16 people)
(8 of 16 people)
(1 of 2 people)
Wellbutrin Xl is effective30.00%
(3 of 10 people)
(1 of 15 people)
(3 of 12 people)
(6 of 21 people)
(9 of 17 people)
(11 of 18 people)
(3 of 11 people)
(0 of 1 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
DizzinessTremorType 2 Diabetes MellitusTremorWeight IncreasedWeight IncreasedWeight IncreasedDiabetes Mellitus
AmnesiaDepressionSuicidal IdeationAlopeciaVomitingDiabetes MellitusObesityType 2 Diabetes Mellitus
ConvulsionOverdoseDiabetes MellitusWeight IncreasedRenal DisorderType 2 Diabetes MellitusBack DisorderWeight Increased
FallFeeling AbnormalBlood Triglycerides IncreasedType 2 Diabetes MellitusProteinuriaErectile DysfunctionAbnormal DreamsDepression
Suicidal IdeationSuicide AttemptTremorErectile DysfunctionDiabetes Mellitus Inadequate ControlPancreatitisBlood Cholesterol IncreasedSuicidal Ideation
Weight IncreasedDizzinessBlood Cholesterol IncreasedDyspnoeaDiabetic NeuropathyFatigueAbdominal Pain UpperInsomnia
DyspnoeaCryingObesityDizzinessCoughHypertensionBlood Triglycerides IncreasedSuicide Attempt
ParanoiaAggressionAlopeciaRash PapularDiabetes MellitusAngerIrritable Bowel SyndromeBlood Cholesterol Increased
AgitationManiaNeuropathy PeripheralDrug Exposure During PregnancyDiabetic RetinopathyHepatomegalyHyperlipidaemiaDrug Ineffective
DepressionBipolar DisorderHyperglycaemiaBlood Glucose IncreasedPneumoniaHepatic SteatosisGallbladder DisorderHeadache

Drug effectiveness by gender :

Depakote Er is effective36.73%
(18 of 49 people)
(21 of 49 people)
Wellbutrin Xl is effective31.37%
(16 of 51 people)
(20 of 54 people)

Most common drug interactions by gender * :

Diabetes MellitusDiabetes Mellitus
Type 2 Diabetes MellitusType 2 Diabetes Mellitus
Weight IncreasedSuicidal Ideation
DepressionWeight Increased
Suicidal IdeationDepression
DizzinessDrug Ineffective
Blood Cholesterol IncreasedSuicide Attempt
Chest PainBlood Cholesterol Increased

Drug effectiveness by age :

Depakote Er is effectiven/an/a40.00%
(2 of 5 people)
(7 of 34 people)
(7 of 34 people)
(10 of 24 people)
(12 of 35 people)
(1 of 21 people)
Wellbutrin Xl is effectiven/an/a16.67%
(1 of 6 people)
(6 of 34 people)
(8 of 38 people)
(5 of 24 people)
(12 of 35 people)
(4 of 18 people)

Most common drug interactions by age * :

PancreatitisDrug IneffectiveSuicidal IdeationDiabetes MellitusDiabetes MellitusDiabetes MellitusDiabetes MellitusTremor
HeadacheRespiratory Arrest (excl Neonatal)Suicide AttemptNauseaType 2 Diabetes MellitusType 2 Diabetes MellitusType 2 Diabetes MellitusDiabetes Mellitus
Pyoderma GangrenosumPersonality ChangeWeight IncreasedSuicidal IdeationWeight IncreasedBlood Cholesterol IncreasedDepressionDrug Ineffective
Gastrointestinal HaemorrhageInfection NosSelf MutilationType 2 Diabetes MellitusSuicidal IdeationWeight IncreasedInsomniaFall
Pelvic PainGrand Mal ConvulsionAgitationWeight IncreasedDiabetes Mellitus Inadequate ControlChest PainDizzinessAnxiety
Ovarian CystStatus EpilepticusOverdoseDepressionObesityBlood Triglycerides IncreasedChest PainWeight Increased
Major DepressionBipolar I DisorderHeadacheBlood Cholesterol IncreasedBlood Cholesterol IncreasedObesityNeuropathy PeripheralSuicidal Ideation
Suicidal IdeationPyrexiaFatigueInsomniaDepressionDepressionSuicide AttemptDepression
HyperventilationManiaFeeling AbnormalDiabetic KetoacidosisBlood Triglycerides IncreasedHeadacheWeight IncreasedDiarrhoea
Type 2 Diabetes MellitusHormone Level Nos AbnormalHallucination, AuditorySuicide AttemptPancreatitisPancreatitisDiabetic NeuropathyBalance Disorder

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Depakote Er and Wellbutrin Xl?

You are not alone! Join a related mobile support group:
- support group for people who take Depakote Er and Wellbutrin Xl
- support group for people who take Depakote Er
- support group for people who take Wellbutrin Xl

Can you answer these questions (Ask a question):

More questions for: Depakote Er, Wellbutrin Xl

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Complete drug side effects:

On eHealthMe, Depakote Er (divalproex sodium) is often used to treat bipolar disorder. Wellbutrin Xl (bupropion hydrochloride) is often used to treat depression. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

Recent related drug studies (Check your drugs):

More related studies for: Depakote Er, Wellbutrin Xl

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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