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Review: taking Depakote Er and Wellbutrin Xl together

Summary: drug interactions are reported among people who take Depakote Er and Wellbutrin Xl together.

This review analyzes the effectiveness and drug interactions between Depakote Er and Wellbutrin Xl. It is created by eHealthMe based on reports of 2,025 people who take the same drugs from FDA and social media, and is updated regularly.





You are not alone: join a mobile support group for people who take Depakote Er and Wellbutrin Xl >>>

What are the drugs

Depakote Er has active ingredients of divalproex sodium. It is often used in bipolar disorder. (latest outcomes from 3,678 Depakote Er users)

Wellbutrin xl has active ingredients of bupropion hydrochloride. It is often used in depression. (latest outcomes from 13,296 Wellbutrin xl users)

On Jan, 30, 2015: 2,025 people who take Depakote Er, Wellbutrin Xl are studied

Depakote Er, Wellbutrin Xl outcomes

Drug combinations in study:
- Depakote Er (divalproex sodium)
- Wellbutrin Xl (bupropion hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Depakote Er is effective25.00%
(3 of 12 people)
(2 of 14 people)
(6 of 13 people)
(5 of 13 people)
(5 of 14 people)
(9 of 16 people)
(8 of 16 people)
(1 of 2 people)
Wellbutrin Xl is effective30.00%
(3 of 10 people)
(1 of 16 people)
(3 of 12 people)
(6 of 21 people)
(9 of 18 people)
(11 of 18 people)
(3 of 11 people)
(0 of 1 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
DizzinessTremorType 2 Diabetes MellitusTremorWeight IncreasedWeight IncreasedWeight IncreasedDiabetes Mellitus
AmnesiaDepressionSuicidal IdeationAlopeciaVomitingDiabetes MellitusObesityType 2 Diabetes Mellitus
ConvulsionOverdoseDiabetes MellitusWeight IncreasedDiabetic NeuropathyType 2 Diabetes MellitusBack DisorderWeight Increased
FallFeeling AbnormalBlood Triglycerides IncreasedType 2 Diabetes MellitusProteinuriaErectile DysfunctionAbnormal DreamsDepression
Suicidal IdeationSuicide AttemptTremorErectile DysfunctionRenal DisorderPancreatitisBlood Cholesterol IncreasedSuicidal Ideation
Weight IncreasedDizzinessBlood Cholesterol IncreasedDyspnoeaDiabetes Mellitus Inadequate ControlFatigueAbdominal Pain UpperInsomnia
DyspnoeaBipolar DisorderObesityDizzinessPneumoniaHypertensionBlood Triglycerides IncreasedSuicide Attempt
ParanoiaAggressionAlopeciaRash PapularCoughAngerIrritable Bowel SyndromeBlood Cholesterol Increased
AgitationManiaNeuropathy PeripheralDrug Exposure During PregnancyType 2 Diabetes MellitusHepatomegalyHyperlipidaemiaDrug Ineffective
DepressionCryingHyperglycaemiaBlood Glucose IncreasedConstipationHepatic SteatosisGallbladder DisorderHeadache

Drug effectiveness by gender :

Depakote Er is effective36.00%
(18 of 50 people)
(21 of 50 people)
Wellbutrin Xl is effective30.77%
(16 of 52 people)
(20 of 55 people)

Most common drug interactions by gender * :

Diabetes MellitusDiabetes Mellitus
Type 2 Diabetes MellitusType 2 Diabetes Mellitus
Weight IncreasedWeight Increased
DepressionSuicidal Ideation
Suicidal IdeationDepression
DizzinessDrug Ineffective
InsomniaSuicide Attempt
Blood Cholesterol IncreasedInsomnia
HeadacheBlood Cholesterol Increased

Drug effectiveness by age :

Depakote Er is effectiven/an/a40.00%
(2 of 5 people)
(7 of 34 people)
(7 of 35 people)
(10 of 24 people)
(12 of 37 people)
(1 of 21 people)
Wellbutrin Xl is effectiven/an/a16.67%
(1 of 6 people)
(6 of 34 people)
(8 of 39 people)
(5 of 24 people)
(12 of 37 people)
(4 of 18 people)

Most common drug interactions by age * :

PancreatitisDrug IneffectiveSuicidal IdeationDiabetes MellitusDiabetes MellitusDiabetes MellitusDiabetes MellitusTremor
HeadacheRespiratory Arrest (excl Neonatal)Suicide AttemptNauseaType 2 Diabetes MellitusType 2 Diabetes MellitusType 2 Diabetes MellitusDiabetes Mellitus
Pyoderma GangrenosumPersonality ChangeWeight IncreasedSuicidal IdeationWeight IncreasedBlood Cholesterol IncreasedDepressionDrug Ineffective
Gastrointestinal HaemorrhageInfection NosSelf MutilationType 2 Diabetes MellitusSuicidal IdeationWeight IncreasedInsomniaFall
Pelvic PainGrand Mal ConvulsionAgitationWeight IncreasedObesityChest PainDizzinessAnxiety
Ovarian CystStatus EpilepticusOverdoseDepressionDiabetes Mellitus Inadequate ControlBlood Triglycerides IncreasedChest PainWeight Increased
Major DepressionBipolar I DisorderHeadacheBlood Cholesterol IncreasedBlood Cholesterol IncreasedObesityNeuropathy PeripheralSuicidal Ideation
Suicidal IdeationPyrexiaFatigueInsomniaBlood Triglycerides IncreasedDepressionSuicide AttemptDepression
HyperventilationManiaFeeling AbnormalDiabetic KetoacidosisDepressionHeadacheWeight IncreasedDiarrhoea
Type 2 Diabetes MellitusHormone Level Nos AbnormalHallucination, AuditorySuicide AttemptPancreatitisPancreatitisSuicidal IdeationBalance Disorder

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Depakote Er and Wellbutrin Xl?

You are not alone! Join a related mobile support group:
- support group for people who take Depakote Er and Wellbutrin Xl
- support group for people who take Depakote Er
- support group for people who take Wellbutrin Xl

Can you answer these questions (Ask a question):

More questions for: Depakote Er, Wellbutrin Xl

You may be interested at these reviews (Write a review):

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    I started taking 100mg of Teva-Lamotrigine Nov 22 once daily. I got a refill on Dec 5 that was Mylan-Lamotrigine. Two days later I woke up with an odd hot feeling rash all over my body and severe fatigue. I went back to bed 1/2 hour later after taking my regular Wellbutrin and the Lamotrigine. I woke up late morning. It got progressively worse during the day and I had a headache,fever and chills. I took the anti-histimine Aerius later that day which didn't help. The next day I went to a walk in clinic and they said it wasn't the Lamotrigine and thought it was a virus and did a throat swab. The fever and chills went away after a few days but I still have the rash. Finally after a week I saw a doctor that agreed it was the drug and I am now on the second week of Prednisone steroid treatment and prescription Reactin which is helping slowly. I have reported it to the Mylan drug company.
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    I was given a prescription for Wellbutrin in approximately 1998. I had has my ocular pressure checked a year prior to this and it was okay. At the time, I only needed to wear reading glasses, common in people over 45. I took the drug at the full prescribed dosage for two weeks. Immediately prior to the narrow angle glaucoma episode, my vision had actually seemed to improve. For one day, prior, I could read without reading glasses. The following night, I was watching tv, and things suddenly became foggy. It was actually as if a fog had enveloped the room. I could not see anything except to discern between light and dark areas. I had to have emergency laser surgery the next morning. I mentioned to the doctor that Iwas taking Wellbutrin to stop smoking, and asked if it could have caused the ocular pressure increase. he consulted the PDR, and said there was no mention of it causing increases in ocular pressure. One year later my primary care doctor again insisted that I stop smoking, and again I mentioned that I thought it might increase ocular pressure. She told me to take a half dose, I did, and I took it one week, at which time I again experienced another episode of narrow angle glaucoma. When I go to the doctor's office my pressure in my left eye was 72, and 68 in my right eye. I was then referred on a triage basis to another doctor. I spent the rest of the day in his office having drops administered every fifteen minutes(extremely painful). I had extensive laser surgery the next morning.It required over fifty shots from the laser machine into each eye, (also extremely painful). I had lost considerable peripheral AND CENTRAL VISION in my left eye, and a good deal in my right. As a result of having to have such extensive laser surgery I also had cataracts that began at 50% maturity. I was advised by the surgeon that I should wait to have the cataracts removed "until my vision and quality of life was so poor that I was ready to commit suicide" because having the cataracts removed would cause the pressure in my eyes to become very difficult to control, and that more than likely I would end up being black blind. I would never use Wellbutrin under any circumstances, and I always check to make sure that any new meds I may be put on don't have anything to do with an increase in ocular pressure. If they do, I refuse to take them. The surgeon said he was surprised that I didn't lose more vision than I did, and I am grateful that I didn't, and that he was a good surgen. He wrote an article concerning this case for a medical journal since he said he had been seeing a recent increase of narrow angle glaucoma.
  • Librium 25mg and wellbutrin 300mg for >1 month
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  • Bedwetting with paxil and wellbutrin
    I have been using both of these drugs and now have bedwetting issues 5 times a week on average. I would rate the bedwetting as moderate about a6/10 but my wife and I can live with this as she had made the comment " you are back to the man I married ". I started taking these due to depression about work and anxiety about work. We both think we can live with the bedwetting as no one needs to know about it
  • Wellbutrin caused my trigeminal neurlagia
    So I'm writing this to hopefully shed light to other users in the same position I was in. I had taken Wellbutrin for about 4 years. The pain experienced in my face was excruciatingly painful. It was just on one side of my face between my temple and upper lip. All the symptoms reflected Trigeminal Neuralgia. But even with an MRI nothing could be found. I suffered for 3 of those years with pain coming and going, not understanding what was going on. Finally one day I decided hell with Wellbutrin and just stopped taking it. It's been 6 months now and I have yet to have a single shred of pain. Coincidence? I doubt it.

More reviews for: Depakote Er, Wellbutrin Xl

Comments from related studies:

  • From this study (2 weeks ago):

  • Can't remember last week events. Sometimes it's like a blackout. I remember bits and pieces.


  • From this study (3 months ago):

  • doc moc on Apr, 25, 2013:

    BREAK down FOOL!


    Rhs on Oct, 13, 2012:

    Get your medical records
    and consult w/your doctor


Post a new comment    OR    Read more comments

Complete drug side effects:

On eHealthMe, Depakote Er (divalproex sodium) is often used to treat bipolar disorder. Wellbutrin Xl (bupropion hydrochloride) is often used to treat depression. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

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