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Review: taking Depakote Er and Wellbutrin Xl together

Summary: drug interactions are reported among people who take Depakote Er and Wellbutrin Xl together.

This review analyzes the effectiveness and drug interactions between Depakote Er and Wellbutrin Xl. It is created by eHealthMe based on reports of 2,025 people who take the same drugs from FDA and social media, and is updated regularly.


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On Mar, 31, 2015: 2,025 people who take Depakote Er, Wellbutrin Xl are studied

Depakote Er, Wellbutrin Xl outcomes

Drug combinations in study:
- Depakote Er (divalproex sodium)
- Wellbutrin Xl (bupropion hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Depakote Er is effective25.00%
(3 of 12 people)
(2 of 14 people)
(6 of 13 people)
(5 of 13 people)
(5 of 14 people)
(9 of 16 people)
(8 of 16 people)
(1 of 2 people)
Wellbutrin Xl is effective30.00%
(3 of 10 people)
(1 of 16 people)
(3 of 12 people)
(6 of 21 people)
(9 of 18 people)
(11 of 18 people)
(3 of 11 people)
(0 of 1 people)

Drug effectiveness by gender :

Depakote Er is effective36.00%
(18 of 50 people)
(21 of 50 people)
Wellbutrin Xl is effective30.77%
(16 of 52 people)
(20 of 55 people)

Drug effectiveness by age :

Depakote Er is effectiven/an/a40.00%
(2 of 5 people)
(7 of 34 people)
(7 of 35 people)
(10 of 24 people)
(12 of 37 people)
(1 of 21 people)
Wellbutrin Xl is effectiven/an/a16.67%
(1 of 6 people)
(6 of 34 people)
(8 of 39 people)
(5 of 24 people)
(12 of 37 people)
(4 of 18 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
DizzinessTremorType 2 Diabetes MellitusTremorWeight IncreasedWeight IncreasedWeight IncreasedDiabetes Mellitus
AmnesiaDepressionSuicidal IdeationAlopeciaVomitingDiabetes MellitusObesityType 2 Diabetes Mellitus
ConvulsionOverdoseDiabetes MellitusWeight IncreasedDiabetic NeuropathyType 2 Diabetes MellitusBack DisorderWeight Increased
FallFeeling AbnormalBlood Triglycerides IncreasedType 2 Diabetes MellitusProteinuriaErectile DysfunctionAbnormal DreamsDepression
Suicidal IdeationSuicide AttemptTremorErectile DysfunctionRenal DisorderPancreatitisBlood Cholesterol IncreasedSuicidal Ideation
Weight IncreasedDizzinessBlood Cholesterol IncreasedDyspnoeaDiabetes Mellitus Inadequate ControlFatigueAbdominal Pain UpperInsomnia
DyspnoeaBipolar DisorderObesityDizzinessPneumoniaHypertensionBlood Triglycerides IncreasedSuicide Attempt
ParanoiaAggressionAlopeciaRash PapularCoughAngerIrritable Bowel SyndromeBlood Cholesterol Increased
AgitationManiaNeuropathy PeripheralDrug Exposure During PregnancyType 2 Diabetes MellitusHepatomegalyHyperlipidaemiaDrug Ineffective
DepressionCryingHyperglycaemiaBlood Glucose IncreasedConstipationHepatic SteatosisGallbladder DisorderHeadache

Most common drug interactions by gender * :

Diabetes MellitusDiabetes Mellitus
Type 2 Diabetes MellitusType 2 Diabetes Mellitus
Weight IncreasedWeight Increased
DepressionSuicidal Ideation
Suicidal IdeationDepression
DizzinessDrug Ineffective
InsomniaSuicide Attempt
Blood Cholesterol IncreasedInsomnia
HeadacheBlood Cholesterol Increased

Most common drug interactions by age * :

PancreatitisDrug IneffectiveSuicidal IdeationDiabetes MellitusDiabetes MellitusDiabetes MellitusDiabetes MellitusTremor
HeadacheRespiratory Arrest (excl Neonatal)Suicide AttemptNauseaType 2 Diabetes MellitusType 2 Diabetes MellitusType 2 Diabetes MellitusDiabetes Mellitus
Pyoderma GangrenosumPersonality ChangeWeight IncreasedSuicidal IdeationWeight IncreasedBlood Cholesterol IncreasedDepressionDrug Ineffective
Gastrointestinal HaemorrhageInfection NosSelf MutilationType 2 Diabetes MellitusSuicidal IdeationWeight IncreasedInsomniaFall
Pelvic PainGrand Mal ConvulsionAgitationWeight IncreasedObesityChest PainDizzinessAnxiety
Ovarian CystStatus EpilepticusOverdoseDepressionDiabetes Mellitus Inadequate ControlBlood Triglycerides IncreasedChest PainWeight Increased
Major DepressionBipolar I DisorderHeadacheBlood Cholesterol IncreasedBlood Cholesterol IncreasedObesityNeuropathy PeripheralSuicidal Ideation
Suicidal IdeationPyrexiaFatigueInsomniaBlood Triglycerides IncreasedDepressionSuicide AttemptDepression
HyperventilationManiaFeeling AbnormalDiabetic KetoacidosisDepressionHeadacheWeight IncreasedDiarrhoea
Type 2 Diabetes MellitusHormone Level Nos AbnormalHallucination, AuditorySuicide AttemptPancreatitisPancreatitisSuicidal IdeationBalance Disorder

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Depakote Er and Wellbutrin Xl?




You are not alone! Join a related support group:
- support group for people who take Depakote Er
- support group for people who take Wellbutrin Xl

Recent related drug studies (Check your drugs):

Complete drug side effects:

On eHealthMe, Depakote Er (divalproex sodium) is often used to treat bipolar disorder. Wellbutrin Xl (bupropion hydrochloride) is often used to treat depression. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

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