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Review: taking Dilantin and Depakote together

Summary: drug interactions are reported among people who take Dilantin and Depakote together.

This review analyzes the effectiveness and drug interactions between Dilantin and Depakote. It is created by eHealthMe based on reports of 115 people who take the same drugs from FDA and social media, and is updated regularly.





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What are the drugs

Dilantin has active ingredients of phenytoin sodium. It is often used in epilepsy. (latest outcomes from 960 Dilantin users)

Depakote has active ingredients of divalproex sodium. It is often used in bipolar disorder. (latest outcomes from 30,936 Depakote users)

On Jan, 15, 2015: 115 people who take Dilantin, Depakote are studied

Dilantin, Depakote outcomes

Drug combinations in study:
- Dilantin (phenytoin sodium)
- Depakote (divalproex sodium)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Dilantin is effectiven/an/an/an/a100.00%
(1 of 1 people)
(2 of 3 people)
(7 of 9 people)
Depakote is effectiven/a0.00%
(0 of 1 people)
(1 of 1 people)
(0 of 2 people)
(2 of 2 people)
(0 of 2 people)
(4 of 6 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
FatigueDrug Level DecreasedUnintended PregnancyEncephalopathyTremorConvulsionDeathConvulsion
ChillsDeliriumPremature Separation Of PlacentaConvulsionFeeling AbnormalDizzinessAmmonia IncreasedDrug Ineffective
PyrexiaAphoniaAmmonia IncreasedAlopeciaIncoherentConvulsionGrand Mal Convulsion
ConvulsionDementia Alzheimer's TypeTirednessMenstruation IrregularAnticonvulsant Drug Level IncreasedHallucinationLoss Of Consciousness
Night SweatsIrritabilityBack PainAphasiaWeight Gain PoorPyrexia
AmnesiaWeight DecreasedDyspepsiaDrug IneffectiveDizzinessUrinary Incontinence
Gingival HyperplasiaAmmonia IncreasedCholelithiasisTirednessShort-term Memory LossSomnolence
HallucinationGrand Mal ConvulsionSpeech DisorderBlood Glucose DecreasedHiccupsDrug Level Decreased
Gingival BleedingAbasiaFatigueTachycardiaDizziness
Epileptic AuraLethargyMuscle SpasmsHaemoglobin Decreased

Drug effectiveness by gender :

Dilantin is effective75.00%
(3 of 4 people)
(7 of 9 people)
Depakote is effective50.00%
(2 of 4 people)
(5 of 10 people)

Most common drug interactions by gender * :

Weight DecreasedConvulsion
Loss Of ConsciousnessGrand Mal Convulsion
DyspepsiaUrinary Incontinence
HeadacheDrug Ineffective
Drug IneffectiveDrug Level Decreased
Burning SensationActivities Of Daily Living Impaired
Ingrowing NailDelusion
CystitisMental Impairment

Drug effectiveness by age :

Dilantin is effectiven/an/an/a100.00%
(2 of 2 people)
(2 of 2 people)
(5 of 6 people)
(0 of 2 people)
(1 of 2 people)
Depakote is effectiven/an/an/a33.33%
(1 of 3 people)
(2 of 3 people)
(3 of 6 people)
(0 of 2 people)
(1 of 2 people)

Most common drug interactions by age * :

n/aDehydrationGrand Mal ConvulsionDrug IneffectivePancreatitis NosConvulsionLoss Of ConsciousnessConvulsion
Appetite DecreasedVomiting NosUnintended PregnancyAppendicitisDrug IneffectiveWeight DecreasedDeath
Haemoglobin IncreasedGingival SwellingPremature Separation Of PlacentaOvarian Cyst RupturedDiabetes MellitusGrand Mal ConvulsionDizziness
Hypertension NosGingival InjuryPyrexiaTachycardiaPlatelet Count DecreasedIngrowing Nail
Hepatic FailureTooth InjuryBlood Glucose DecreasedVomitingIngrowing NailArteriosclerosis Coronary Artery
HypotensionHeadacheGrand Mal ConvulsionSinusitisCystitisAbdominal Distension
Pancreatitis HaemorrhagicPetit Mal EpilepsyAbdominal Pain LowerThroat TightnessGastric DisorderWeight Decreased
Blood In StoolMouth HaemorrhageMouth HaemorrhageAstheniaAnaemiaPalpitations
Ataxia NecJoint SprainPain NosAmnesiaBlood Pressure IncreasedBlood Count Abnormal
Pleural EffusionArthralgiaVomitingPleural EffusionBlood Triglycerides IncreasedBurning Sensation

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Dilantin and Depakote?

You are not alone! Join a related mobile support group:
- support group for people who take Dilantin and Depakote
- support group for people who take Depakote
- support group for people who take Dilantin

Can you answer these questions (Ask a question):

More questions for: Depakote, Dilantin

You may be interested at these reviews (Write a review):

  • Seizure patient was on depakote for 16 years now on keppra 1500 mg.
    I am 28 years old and been off depakote for 5 months. I started keppra to control my seizure disorder, which works great. But for the past year I have developed osteoarthritis in my thoracic, si joints, and lumbar. I get alot of muscle hypersensitivity and pain. Can any of this be due to long term effects of seizure meds?
  • Depakote er affected by grapefruit
    I have taken Depakote ER for since 2005 for epilepsy. Once stabilized many years ago seizures and auras have not been bothering me. Until I recently ate three grapefruits over three days. After a few days, when the grapefruit cleared my system, the seizures and auras ceased. Therefore, grapefruit does affect how Depakote ER acts on your system.
  • Understanding and living with cancer
    After having one treatment of Gemzar, I had a severe reaction, which caused me to have many seizures. This caused me to developed PRES, which in turn has caused me to have brain damage.When I came out of my induced coma I did not know where I was, nor did I know who my family members were. I could not bathe myself, drive, my speech was broken, I could not add two plus two. I was not the woman I was before Gemzar treatment.Now I am unable to work, I am unable to live on my own, I must always be in the company of another person. I have lost my home and car and job due to this condition. I am currently in speech therapy and soon will start occupational therapy (which is VERY costly) This month marks the one year anniversary of this condition for me. I am making progress. I am able to bathe myself, I can do a little cooking, (although the first time I tried I caught the kitchen on fire a little), I am still living with my Mother , as she is my care taker, my nurse, my driver, my chef, my house cleaner. I currently receive disability. My student loans have gone into default. I could go on but I am depressing myself. I am, followed by my Oncologist every two months now.I want to share this information to anyone and everyone who can benefit from this information.

    Thank you, Chelette Williams, BA,MBA.
  • Dilantin and interactions
    I've taken Dilantin for over 40 years..seizure free for over 30 years..became hypothyroid 10 years ago..B12 deficient approximately 3 years ago and have had a benign arrhythmia for over 30 years. I take magnesium because it seems to hep the arrhythmia and vitamin d because mine is low normal.

More reviews for: Depakote, Dilantin

Complete drug side effects:

On eHealthMe, Dilantin (phenytoin sodium) is often used to treat epilepsy. Depakote (divalproex sodium) is often used to treat bipolar disorder. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.


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