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Review: Dilantin and Depakote

This review analyzes the effectiveness and drug interactions between Dilantin and Depakote. It is created by eHealthMe based on reports of 115 people who take the same drugs from FDA and social media, and is updated regularly.

Get connected: join a mobile support group for people who take Dilantin and Depakote >>>

What are the drugs

Dilantin (what 950 Dilantin users reported?) has active ingredients of phenytoin sodium. It is used in epilepsy.

Depakote (what 30,913 Depakote users reported?) has active ingredients of divalproex sodium. It is used in bipolar disorder.

On Sep, 18, 2014: 115 people who take Dilantin, Depakote are studied

Dilantin, Depakote outcomes

Drug combinations in study:
- Dilantin (phenytoin sodium)
- Depakote (divalproex sodium)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Dilantin is effectiven/an/an/an/a100.00%
(1 of 1 people)
(2 of 3 people)
(7 of 9 people)
Depakote is effectiven/a0.00%
(0 of 1 people)
(1 of 1 people)
(0 of 2 people)
(2 of 2 people)
(0 of 2 people)
(4 of 6 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
FatigueDrug Level DecreasedUnintended PregnancyEncephalopathyTremorConvulsionDeathConvulsion
ChillsDeliriumPremature Separation Of PlacentaConvulsionFeeling AbnormalDizzinessAmmonia IncreasedDrug Ineffective
PyrexiaAphoniaAmmonia IncreasedAlopeciaIncoherentConvulsionGrand Mal Convulsion
ConvulsionDementia Alzheimer's TypeTirednessMenstruation IrregularAnticonvulsant Drug Level IncreasedHallucinationLoss Of Consciousness
Night SweatsIrritabilityBack PainAphasiaWeight Gain PoorPyrexia
AmnesiaWeight DecreasedDyspepsiaDrug IneffectiveDizzinessUrinary Incontinence
Gingival HyperplasiaAmmonia IncreasedCholelithiasisTirednessShort-term Memory LossSomnolence
HallucinationGrand Mal ConvulsionSpeech DisorderBlood Glucose DecreasedHiccupsDrug Level Decreased
Gingival BleedingAbasiaFatigueTachycardiaDizziness
Epileptic AuraLethargyMuscle SpasmsHaemoglobin Decreased

Drug effectiveness by gender :

Dilantin is effective75.00%
(3 of 4 people)
(7 of 9 people)
Depakote is effective50.00%
(2 of 4 people)
(5 of 10 people)

Most common drug interactions by gender * :

Weight DecreasedConvulsion
Loss Of ConsciousnessGrand Mal Convulsion
DyspepsiaUrinary Incontinence
HeadacheDrug Ineffective
Drug IneffectiveDrug Level Decreased
Burning SensationActivities Of Daily Living Impaired
Ingrowing NailDelusion
CystitisMental Impairment

Drug effectiveness by age :

Dilantin is effectiven/an/an/a100.00%
(2 of 2 people)
(2 of 2 people)
(5 of 6 people)
(0 of 2 people)
(1 of 2 people)
Depakote is effectiven/an/an/a33.33%
(1 of 3 people)
(2 of 3 people)
(3 of 6 people)
(0 of 2 people)
(1 of 2 people)

Most common drug interactions by age * :

n/aDehydrationGrand Mal ConvulsionDrug IneffectivePancreatitis NosConvulsionLoss Of ConsciousnessConvulsion
Appetite DecreasedVomiting NosUnintended PregnancyAppendicitisDrug IneffectiveWeight DecreasedDeath
Haemoglobin IncreasedGingival SwellingPremature Separation Of PlacentaOvarian Cyst RupturedDiabetes MellitusGrand Mal ConvulsionDizziness
Hypertension NosGingival InjuryPyrexiaTachycardiaPlatelet Count DecreasedIngrowing Nail
Hepatic FailureTooth InjuryBlood Glucose DecreasedVomitingIngrowing NailArteriosclerosis Coronary Artery
HypotensionHeadacheGrand Mal ConvulsionSinusitisCystitisAbdominal Distension
Pancreatitis HaemorrhagicPetit Mal EpilepsyAbdominal Pain LowerThroat TightnessGastric DisorderWeight Decreased
Blood In StoolMouth HaemorrhageMouth HaemorrhageAstheniaAnaemiaPalpitations
Ataxia NecJoint SprainPain NosAmnesiaBlood Pressure IncreasedBlood Count Abnormal
Pleural EffusionArthralgiaVomitingPleural EffusionBlood Triglycerides IncreasedBurning Sensation

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Dilantin and Depakote?

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Can you answer these questions (what is this?):

More questions for: Depakote, Dilantin

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More reviews for: Depakote, Dilantin

Complete drug side effects:

On eHealthMe, Dilantin (phenytoin sodium) is often used to treat epilepsy. Depakote (divalproex sodium) is often used to treat bipolar disorder. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.


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