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Review: Diphenhydramine and Alcohol

This review analyzes the effectiveness and drug interactions between Diphenhydramine and Alcohol. It is created by eHealthMe based on reports of 82 people who take the same drugs from FDA and social media, and is updated regularly.

Stay connected: join a mobile support group for people who take Diphenhydramine and Alcohol >>>

What are the drugs

Diphenhydramine hydrochloride (what 2,983 Diphenhydramine Hydrochloride users reported?) has active ingredients of diphenhydramine hydrochloride. It is used in insomnia.

Alcohol (what 5,718 Alcohol users reported?) has active ingredients of alcohol. It is used in stress and anxiety.

On Aug, 11, 2014: 82 people who take Diphenhydramine Hydrochloride, Alcohol are studied

Diphenhydramine Hydrochloride, Alcohol outcomes

Drug combinations in study:
- Diphenhydramine Hydrochloride (diphenhydramine hydrochloride)
- Alcohol (alcohol)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Diphenhydramine Hydrochloride is effective50.00%
(1 of 2 people)
(0 of 2 people)
(0 of 1 people)
(1 of 1 people)
Alcohol is effective100.00%
(1 of 1 people)
(0 of 1 people)
(0 of 1 people)
(1 of 1 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Multiple Drug Overdose Intentionaln/aHypomaniaGender Identity DisorderSerotonin Syndromen/aPruritus AggravatedSuicide Attempt
Suicide AttemptGender Identity DisorderBreathing - Slowed Or StoppedPsychotic BehaviourNight SweatsRoad Traffic Accident
NeutropeniaBreathing - Slowed Or StoppedHypomaniaOverdoseDizziness AggravatedDepression
ShockBipolar Ii DisorderBipolar Ii DisorderRestless Leg SyndromeDysarthria
HypotensionOrgasmic Sensation DecreasedOrgasmic DysfunctionWeight Above NormalBalance Disorder
HyperhidrosisLack Of Strength, Muscle Weakness, WeaknessOrgasmic Sensation DecreasedOcular Hyperaemia
ErythemaOrgasmic DysfunctionTachycardiaSomnambulism
Skin DiscolourationTachycardiaChronic InsomniaCompleted Suicide
Throat IrritationChronic InsomniaGeneralized Anxiety DisorderMemory Impairment
ThrombocytopeniaGeneralized Anxiety DisorderDizzinessImpaired Driving Ability

Drug effectiveness by gender :

Diphenhydramine Hydrochloride is effective0.00%
(0 of 3 people)
(2 of 3 people)
Alcohol is effective50.00%
(1 of 2 people)
(1 of 2 people)

Most common drug interactions by gender * :

Suicide AttemptBalance Disorder
Non-accidental OverdoseRoad Traffic Accident
Completed SuicideDepression
NauseaImpaired Driving Ability
HypersensitivityLacrimation Increased
VomitingOcular Hyperaemia
Colitis IschaemicMemory Impairment
Road Traffic AccidentSpinal X-ray Abnormal

Drug effectiveness by age :

Diphenhydramine Hydrochloride is effectiven/an/a50.00%
(2 of 4 people)
(0 of 34 people)
(0 of 1 people)
(0 of 5 people)
Alcohol is effectiven/an/a25.00%
(1 of 4 people)
(1 of 67 people)

Most common drug interactions by age * :

n/an/aSerotonin SyndromeSuicide AttemptOverdoseRoad Traffic AccidentAreflexiaNausea
Psychotic BehaviourMultiple Drug Overdose IntentionalCaecitisBalance DisorderDepressionAnalgesic Drug Level Increased
OverdoseDizzinessColitis IschaemicImpaired Driving AbilityNauseaCompleted Suicide
Intentional OverdoseHypersensitivityDepressionAnxietyPneumonia Necrotising
Protein Urine PresentSepsisLacrimation IncreasedTardive DyskinesiaDrug Effect Decreased
SedationSuicide AttemptDysarthriaInjuryHeadache
Infusion Site ErythemaNon-accidental OverdoseOcular HyperaemiaHepatic Enzyme IncreasedOsteonecrosis Of Jaw
VomitingRoad Traffic AccidentSuicide AttemptHaemorrhoidsGastrooesophageal Reflux Disease
StressCompleted SuicideSomnambulismMusculoskeletal StiffnessJoint Injury
Skin DiscomfortChest DiscomfortAmnesiaPainMuscle Spasms

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

You can also:

Get connected! Join a mobile support group to help out with your experience or learn from others anytime and anywhere:
- group for people who take Diphenhydramine and Alcohol
- group for people who take Alcohol
- group for people who take Diphenhydramine Hydrochloride

Comments from related studies:

  • From this study (2 years ago):

  • Was feeling ill with headache and stomach upset for several days, then drank about 4 mixed drinks and started vomiting violently and shaking and was losing consciousness, still dizzy and achy and nausea and confusion two days later.


Can you answer these questions (what is this?):

  • I gave up alcohol 4 years ago..ever since i have had pmle really badly. any chance there is a link?
    I was a heavy drinker of alcohol and have travelled the world for years without suffering from PMLE. I am 43, 4 years ago I gave up alcohol. I have not drunk one drop of alcohol since. On my first foreign trip after quitting drink I suffered a severe bout of PMLE after being in the sun. I had never ...

  • Can facial tics be caused by alcoholism
    My hubby will not admit he is a binge drinker and claims his facial tics have nothing to do with alcohol! He jerks his head back all the time and stuck his tongue out at one point or time like a snake and stomps his one foot while they are crossed on the ground. and constantly scrunches his nose up ...

  • Can eczema of scalp cause headaches
    I had had headaches for some weeks with burning sensation of hairline and scalp which has now been diagmpsed as eczema of the scalp. Inflamation markers are up in blood count

More questions for: Alcohol, Diphenhydramine Hydrochloride

You may be interested at these reviews (what is this?):

  • Leg pain and occasional arm and hand pain
    I started having leg pains at night, lower leg felt like the muscle and bone were being pulled causing sharp pain. It was relieved by getting up and walking but would last most of the night. I finally realized after suffering this over and over for months, that it only happened when I had taken be ...

More reviews for: Alcohol, Diphenhydramine Hydrochloride

Complete drug side effects:

On eHealthMe, Diphenhydramine Hydrochloride (diphenhydramine hydrochloride) is often used to treat insomnia. Alcohol (alcohol) is often used to treat stress and anxiety. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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