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Review: Diphenhydramine and Dimenhydrinate

This review analyzes the effectiveness and drug interactions between Diphenhydramine and Dimenhydrinate. It is created by eHealthMe based on 126 people who take the drugs. The review uses reports from FDA and social media, and is updated regularly.

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On Mar, 31, 2014: 126 people who reported to have interactions when taking Diphenhydramine Hydrochloride, Dimenhydrinate are studied

Trend of Diphenhydramine Hydrochloride, Dimenhydrinate's drug interactions, side effects and effectiveness reports (5161230)

Drug combinations in study:
- Diphenhydramine Hydrochloride (diphenhydramine hydrochloride)
- Dimenhydrinate (dimenhydrinate)

eHealthMe real world results:

Most common interactions experienced by people in the use of Diphenhydramine Hydrochloride, Dimenhydrinate:

(click on each outcome to view in-depth analysis, incl. how people recovered)
InteractionNumber of reports
Dyspnoea (difficult or laboured respiration)61
Nausea (feeling of having an urge to vomit)50
Infusion Related Reaction48
Flushing (the warm, red condition of human skin)45
Febrile Neutropenia (fever with reduced white blood cells)36
Neutropenia (an abnormally low number of neutrophils)33
Malaise (a feeling of general discomfort or uneasiness)22

Most common interactions experienced by people in long term use of Diphenhydramine Hydrochloride, Dimenhydrinate:

(click on each outcome to view in-depth analysis, incl. how people recovered)
InteractionNumber of reports
Pyrexia (fever)3
Lethargy (tiredness)3
Acute Myeloid Leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts)3
Cardiac Failure Congestive3
Ejection Fraction Decreased (systolic heart failure)3
Post Procedural Bile Leak3
Oedema (fluid collection in tissue)3
Abdominal Abscess (collection of pus in abdomen)3
Condition Aggravated3
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)3

How effective are the drugs:

not at allsomewhatmoderatehighvery high
Diphenhydramine Hydrochloride0.00%100.00%0.00%0.00%0.00%

Top conditions involved for these people * :

  1. Premedication
  2. Hypertension
  3. Pain
  4. Crohn's disease
  5. Constipation

Top co-used drugs for these people * :

  1. Benadryl
  2. Remicade
  3. Gravol tab
  4. Sodium chloride
  5. Acetaminophen

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Related topic: Dimenhydrinate, Diphenhydramine Hydrochloride

You can also:

Complete drug side effects:

On eHealthMe, Diphenhydramine Hydrochloride (diphenhydramine hydrochloride) is often used to treat insomnia. Dimenhydrinate (dimenhydrinate) is often used to treat nausea. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

Comments from related studies:

  • From this study (1 year ago):

  • Upper abdominal pain, gave me percocet on the Emergency room, very itchy skin and nausea


  • From this study (1 year ago):

  • Overall: Diabetes stays under 120, testosterone levels remain low for age (48, but testosterone levels of 90 year old man). Atypically small penis, testes often recede so that the scrotum is flat and tight. Bi-sexual with periodic gender issues (desire to be feminine). Married, two children and no family issues to include sexual oddities, wife is supportive.

    I am reluctant to bring up sexual and gender issues to Doctor, but have the feeling that gender drift (feelings), small penis and receding testicles and attraction to both sexes (including transgendered males with feminine qualities and penis). I know that all of this makes me rather unusual in terms of societal norms, but this is an honest assessment to the best of my ability. I started becoming sexually active at 13 years old with males first and later (15) with females. I desire only a relationship with a female or shemale (preferable but not realistic so I don't dwell on it).

    Despite gender struggles from 14 to present I joined the US Army and went Airborne and Special Forces, spending a majority of my adult life (even unitl present) as an operator in Special Forces (albeit my age is making that more and more difficult).

    I'm looking for a medical opinion that takes in current health conditions and issues, sexual history and other factors that are tell tale signs of a condition that I am unaware of.


    Me on Jan, 4, 2013:

    Forgot to mention that I have one son who has only one testicle but is not infertile. He was operated on at 3 to determine is it was an undescended testicle, however no trace of a second testicle was found. In his 20s he fathered a female child and still no trace of second testicle.


  • From this study (2 years ago):

  • My insomnia has been severe lately and it was recommended, by a friend, that I try using "Sleep-eze" [Diphenhydramine HCL - 50mg] to help me sleep. As I often take "Novo-Dimenate" [Dimenhydrinate - 50mg] at night for nausea and stomach pain from GERDS, I am concerned about taking both of these drugs at the same time. Is this a problem? Both these conditions are a result of cancer treatment including radiation & 2 chemos.

    Also, I was taking Domperidone Maleate - 10mg 4 times a day to help my stomach empty. As there is a recent warning out regarding this drug causing 'fatal heart attacks' my doctor has reduced my dosage to 3 times a day; this is to get me through to testing being done in May. Unfortunately, your system does not even recognize this drug. Up until last fall I was also taking Pantaprzole twice daily; at that time I was switched to Esomeprazole Magnesium Trihydrate - 40 mg twice daily. This appears to be more effective for my GERDS than the Pantaprazole was. Again, both these conditions are a result of my cancer treatment with radiation & 2 chemos.

    As all of these drugs affect the stomach, I am concerned about interactions. I am also concerned about additiveness of the Diphenhydramine HCL. Can you advise me as to their use together?


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NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

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DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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Related studies

- Dimenhydrinate side effects
- Diphenhydramine Hydrochloride side effects



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