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Review: Diphenhydramine and Dimenhydrinate

This review analyzes the effectiveness and drug interactions between Diphenhydramine and Dimenhydrinate. It is created by eHealthMe based on reports of 144 people who take the same drugs from FDA and social media, and is updated regularly.

Stay connected: join a mobile support group for people who take Diphenhydramine and Dimenhydrinate >>>

What are the drugs

Diphenhydramine hydrochloride (latest outcomes from 2,976 users) has active ingredients of diphenhydramine hydrochloride. It is often used in insomnia.

Dimenhydrinate (latest outcomes from 1,030 users) has active ingredients of dimenhydrinate. It is often used in nausea.

On Jul, 20, 2014: 144 people who take Diphenhydramine Hydrochloride, Dimenhydrinate are studied

Diphenhydramine Hydrochloride, Dimenhydrinate outcomes

Drug combinations in study:
- Diphenhydramine Hydrochloride (diphenhydramine hydrochloride)
- Dimenhydrinate (dimenhydrinate)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Diphenhydramine Hydrochloride is effective20.00%
(1 of 5 people)
0.00%
(0 of 1 people)
n/a0.00%
(0 of 1 people)
100.00%
(1 of 1 people)
50.00%
(1 of 2 people)
n/an/a
Dimenhydrinate is effective60.00%
(3 of 5 people)
n/a100.00%
(1 of 1 people)
100.00%
(2 of 2 people)
100.00%
(1 of 1 people)
n/a0.00%
(0 of 1 people)
0.00%
(0 of 1 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
NeutropeniaDrowsinessErectile DysfunctionMucosal Inflammationn/aPyrexiaDemerol OverdoseNausea
DiarrhoeaNauseaSleep Disorder Due To General Medical Condition, Insomnia TypeLethargyAbdominal AbscessInfusion Related Reaction
Febrile NeutropeniaVertigoCardiac Failure CongestiveConvulsionDyspnoea
Rash MacularDisease ProgressionPost Procedural Bile LeakVomiting
Septic ShockAcute Myeloid LeukaemiaErectile DysfunctionFlushing
PneumoniaOedemaDemerol OverdoseNeutropenia
Kidney Transplant RejectionEjection Fraction DecreasedSleep Disorder Due To General Medical Condition, Insomnia TypeDiarrhoea
Renal FailureCondition AggravatedPleural Effusion
Multi-organ FailureFebrile Neutropenia
OedemaHypotension

Drug effectiveness by gender :

FemaleMale
Diphenhydramine Hydrochloride is effective20.00%
(1 of 5 people)
40.00%
(2 of 5 people)
Dimenhydrinate is effective60.00%
(3 of 5 people)
66.67%
(4 of 6 people)

Most common drug interactions by gender * :

FemaleMale
NauseaDiarrhoea
Infusion Related ReactionNeutropenia
DyspnoeaInfusion Related Reaction
Febrile NeutropeniaFlushing
HypersensitivityVomiting
VomitingRash Macular
Vision BlurredDyspnoea
Pleural EffusionNausea
PruritusRenal Failure
MalaiseSeptic Shock

Drug effectiveness by age :

0-12-910-1920-2930-3940-4950-5960+
Diphenhydramine Hydrochloride is effectiven/an/a0.00%
(0 of 4 people)
0.00%
(0 of 2 people)
n/a40.00%
(2 of 5 people)
n/a50.00%
(1 of 2 people)
Dimenhydrinate is effectiven/an/a25.00%
(1 of 4 people)
66.67%
(2 of 3 people)
n/a60.00%
(3 of 5 people)
n/a50.00%
(1 of 2 people)

Most common drug interactions by age * :

0-12-910-1920-2930-3940-4950-5960+
Overdose NosUrinary IncontinenceHypomagnesaemiaInfusion Related ReactionPruritusFebrile NeutropeniaVomitingNeutropenia
Tachycardia NosElectrocardiogram AbnormalHypokalaemiaVomitingLip SwellingLung InfiltrationNauseaDiarrhoea
Inappropriate Adh SecretionVentricular DysfunctionHypertensionFlushingHypersensitivityPericardial EffusionHypersensitivityRash Macular
HyponatraemiaUnresponsive To StimuliHepatitisNauseaEye PainEngraftment SyndromeParaesthesiaFebrile Neutropenia
Hypertension NosStaringDisseminated Intravascular CoagulationCompleted SuicidePhotophobiaPleural EffusionInfusion Related ReactionSeptic Shock
Convulsions NosDepressed Level Of ConsciousnessPalmar-plantar Erythrodysaesthesia SyndromeMalaiseNauseaBlood Lactate Dehydrogenase IncreasedCardiomyopathyRenal Failure
Excessive Eye BlinkingTumour Lysis SyndromeAbdominal PainVision BlurredRespiratory DistressVentricular TachycardiaPneumonia
NeurotoxicityStevens-johnson SyndromeChest PainEyelid OedemaSubcutaneous EmphysemaCardiac Failure CongestiveMulti-organ Failure
AphasiaPancytopeniaWhite Blood Cell Count IncreasedBlindnessKidney Transplant RejectionMyocarditisHypotension
HaematemesisNephrolithiasisPalpitationsDysphagiaOxygen Saturation DecreasedMalaise

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

You can also:

Get connected! Join a mobile support group:
- group for people who take Diphenhydramine and Dimenhydrinate
- group for people who take Dimenhydrinate
- group for people who take Diphenhydramine Hydrochloride

Comments from related studies:

  • From this study (1 year ago):

  • Upper abdominal pain, gave me percocet on the Emergency room, very itchy skin and nausea

    Reply

  • From this study (2 years ago):

  • Overall: Diabetes stays under 120, testosterone levels remain low for age (48, but testosterone levels of 90 year old man). Atypically small penis, testes often recede so that the scrotum is flat and tight. Bi-sexual with periodic gender issues (desire to be feminine). Married, two children and no family issues to include sexual oddities, wife is supportive.

    I am reluctant to bring up sexual and gender issues to Doctor, but have the feeling that gender drift (feelings), small penis and receding testicles and attraction to both sexes (including transgendered males with feminine qualities and penis). I know that all of this makes me rather unusual in terms of societal norms, but this is an honest assessment to the best of my ability. I started becoming sexually active at 13 years old with males first and later (15) with females. I desire only a relationship with a female or shemale (preferable but not realistic so I don't dwell on it).

    Despite gender struggles from 14 to present I joined the US Army and went Airborne and Special Forces, spending a majority of my adult life (even unitl present) as an operator in Special Forces (albeit my age is making that more and more difficult).

    I'm looking for a medical opinion that takes in current health conditions and issues, sexual history and other factors that are tell tale signs of a condition that I am unaware of.

    Reply

    Me on Jan, 4, 2013:

    Forgot to mention that I have one son who has only one testicle but is not infertile. He was operated on at 3 to determine is it was an undescended testicle, however no trace of a second testicle was found. In his 20s he fathered a female child and still no trace of second testicle.

    Reply

  • From this study (2 years ago):

  • My insomnia has been severe lately and it was recommended, by a friend, that I try using "Sleep-eze" [Diphenhydramine HCL - 50mg] to help me sleep. As I often take "Novo-Dimenate" [Dimenhydrinate - 50mg] at night for nausea and stomach pain from GERDS, I am concerned about taking both of these drugs at the same time. Is this a problem? Both these conditions are a result of cancer treatment including radiation & 2 chemos.

    Also, I was taking Domperidone Maleate - 10mg 4 times a day to help my stomach empty. As there is a recent warning out regarding this drug causing 'fatal heart attacks' my doctor has reduced my dosage to 3 times a day; this is to get me through to testing being done in May. Unfortunately, your system does not even recognize this drug. Up until last fall I was also taking Pantaprzole twice daily; at that time I was switched to Esomeprazole Magnesium Trihydrate - 40 mg twice daily. This appears to be more effective for my GERDS than the Pantaprazole was. Again, both these conditions are a result of my cancer treatment with radiation & 2 chemos.

    As all of these drugs affect the stomach, I am concerned about interactions. I am also concerned about additiveness of the Diphenhydramine HCL. Can you advise me as to their use together?

    Reply

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Can you answer these questions (what is this?):

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More reviews for: Dimenhydrinate, Diphenhydramine Hydrochloride

Complete drug side effects:

On eHealthMe, Diphenhydramine Hydrochloride (diphenhydramine hydrochloride) is often used to treat insomnia. Dimenhydrinate (dimenhydrinate) is often used to treat nausea. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

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