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Review: taking Doxycycline and Azithromycin together

Summary: drug interactions are reported among people who take Doxycycline and Azithromycin together. This review analyzes the effectiveness and drug interactions between Doxycycline and Azithromycin. It is created by eHealthMe based on reports of 734 people who take the same drugs from FDA and social media, and is updated regularly.

Personalized health information: on eHealthMe you can find out what patients like me (same gender, age) reported their drugs and conditions on FDA and social media since 1977. Our tools are free and anonymous. 66 million people have used us. 200+ peer-reviewed medical journals have referenced our original studies. Start now >>>


You are not alone: join a support group for people who take Doxycycline and Azithromycin >>>

What are the drugs

Doxycycline has active ingredients of doxycycline hyclate. It is often used in acne. (latest outcomes from 13,713 Doxycycline users)

Azithromycin has active ingredients of azithromycin. It is often used in sinusitis. (latest outcomes from 12,361 Azithromycin users)

On May, 6, 2015: 734 people who take Doxycycline, Azithromycin are studied

Doxycycline, Azithromycin outcomes

Drug combinations in study:
- Doxycycline (doxycycline hyclate)
- Azithromycin (azithromycin)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Doxycycline is effective25.00%
(1 of 4 people)
(0 of 3 people)
(0 of 2 people)
(1 of 2 people)
(0 of 1 people)
Azithromycin is effective25.00%
(1 of 4 people)
(0 of 2 people)
(1 of 1 people)
(0 of 2 people)
(0 of 1 people)

Drug effectiveness by gender :

Doxycycline is effective50.00%
(2 of 4 people)
(0 of 8 people)
Azithromycin is effective33.33%
(1 of 3 people)
(1 of 7 people)

Drug effectiveness by age :

Doxycycline is effectiven/an/a0.00%
(0 of 1 people)
(0 of 1 people)
(1 of 6 people)
(0 of 2 people)
(1 of 8 people)
Azithromycin is effectiven/an/a0.00%
(0 of 1 people)
(0 of 1 people)
(0 of 4 people)
(0 of 2 people)
(2 of 8 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
DyspnoeaAstheniaExhaustion, Fatigue, Lethargy, Tiredness, WearinessDepressionDepressionDepressionDepressionAnxiety
Glomerulonephritis MembranousDyspnoeaMuscle TwitchingAbnormal BehaviourAnxietyAnxietyAnxietyPain
PainNeuropathy PeripheralMemory ImpairmentSuicide AttemptSuicide AttemptAggressionDizzinessNausea
Drug IneffectivePainMuscle CrampsHypoacusisAggressionNightmareHeadacheDyspnoea
FatigueLimb DiscomfortTinnitusHeadacheSuicidal IdeationIrritabilityPanic AttackPain In Extremity
Respiratory Tract CongestionDysphagiaDvtInjuryNightmareParanoiaPalpitationsBack Pain
Weight DecreasedDehydrationJoint StiffnessPainPsychotic DisorderSuicidal IdeationSuicidal IdeationDepression
HyperhidrosisIll-defined DisorderSinusitisIntentional OverdosePsychotic DisorderVomiting
Drug Level IncreasedHyperprolactinaemiaHeart InjuryIrritabilityPoor Quality SleepDizziness
NauseaRenal FailureMigraineAbnormal BehaviourIntentional OverdoseFatigue

Most common drug interactions by gender * :

NauseaChest Pain
Pain In ExtremityFatigue
DepressionWeight Decreased
AstheniaBack Pain

Most common drug interactions by age * :

Premature Babyn/aNauseaFatigueDepressionAnxietyAnxietyDyspnoea
Maternal Drugs Affecting FoetusEmotional DistressAnaemiaAnxietyDepressionInjuryPain
HaemorrhageAstheniaPain In ExtremityBack PainPainAnxiety
CholelithiasisAbdominal Pain UpperDyspnoeaPainNauseaInjury
AnaemiaNauseaPainNauseaArthralgiaBone Disorder
AnxietyDeep Vein ThrombosisNauseaArthralgiaNeck PainCardiac Failure Congestive
Irritable Bowel SyndromeKeloid ScarHyperhidrosisDysuriaPain In ExtremityNausea
Lip DryNight SweatsMyalgiaEar PainInsomniaTooth Extraction
Intestinal ObstructionPain In ExtremityBronchitisVomitingDyspnoeaOsteoarthritis
Cholecystitis ChronicChest PainFatigueDiarrhoeaDizzinessSinusitis

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Doxycycline and Azithromycin?


You are not alone! Join a related support group:
- support group for people who take Azithromycin
- support group for people who take Doxycycline

Recent conversations of related support groups:

Can you answer these questions (Ask a question):

More questions for: Azithromycin, Doxycycline

You may be interested at these reviews (Write a review):

More reviews for: Azithromycin, Doxycycline

Comments from related studies:

  • From this study (1 day ago):

  • Noticed that when i take doxycycline i have a sever urge to urinate and i leak urine after urination


  • From this study (11 months ago):

  • I have so many side effects that chronic fatigue seems simplistic. Almost every cell in my body has been damaged. I have seen over 20 doctors since my cascade of symptoms started (13years ago). They all play dumb, tell me my problem is not in their specialty, or offer me antidepressants. Yet when I look up actual research, I see that most of the pieces of the physiology of my syndrome have been known for years (some for decades).

    I also note that on this web site, there is no way to report a high number of side effects or simplify them as mitochondrial damage.

    I believe it is the intent of this web site, the AMA, drug companies, and most doctors to deliberately avoid "knowing" about the holocaust of poisoning that is occurring in the name of heath care.

    The logarithmical explosion of cancer, obesity, depression, allergies, auto-immune diseases, "rare genetic diseases," and diabetes (to name just a few) matches exactly the explosion of pharmaceutical consumption.

    It would be appropriate to apply the scientific method instead of the profit motive to further human health.


    Hope22 on Jul, 9, 2014:

    Is doxycyclin among these drugs that have been given a black box warning for anyone with mitochondrial disease?


    noscreenname on Jun, 23, 2014:

    if you have lyme, youre 75% of 100 likely to have either mycoplasma, or serratia. these cause kidney stones, which in turn, cause damage or loss if not surgically removed (struvite type) AND the way the spirochete and other partner bacteria hide from the meds. The lyme docs have known this all along when they said, "it hides where meds cannot get to it". 75% of lymies having myco...= struvite stones that will keep ANY coinfections going on indefinitely via relapse. Its all about meal ticket patients here....sad.


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Complete drug side effects:

On eHealthMe, Doxycycline (doxycycline hyclate) is often used to treat acne. Azithromycin (azithromycin) is often used to treat sinusitis. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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