Review: Elavil and Benadryl drug interactions
This review analyzes the interactions between Elavil and Benadryl. It is created by eHealthMe based on 822 people who have drug interactions while taking the drugs. The review uses reports from FDA and social media, and is updated regularly.
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What are the drugs
Elavil (latest outcomes from 11,844 users) has active ingredients of amitriptyline hydrochloride. It is often used in depression.
Benadryl (latest outcomes from 29,259 users) has active ingredients of diphenhydramine hydrochloride. It is often used in allergies.
On Feb, 10, 2014: 822 people who reported to have interactions when taking Elavil, Benadryl are studied
Drug combinations in study:
- Elavil (amitriptyline hydrochloride)
- Benadryl (diphenhydramine hydrochloride)
Most common interactions experienced by people in the use of Elavil, Benadryl:(click on each outcome to view in-depth analysis, incl. how people recovered)
|Interaction||Number of reports|
|Dyspnoea (difficult or laboured respiration)||255|
|Arthralgia (joint pain)||232|
|Nausea (feeling of having an urge to vomit)||128|
|Headache (pain in head)||114|
Most common interactions experienced by people in long term use of Elavil, Benadryl:(click on each outcome to view in-depth analysis, incl. how people recovered)
|Interaction||Number of reports|
|Decreased Appetite (decreased appetite occurs when you have a reduced desire to eat)||2|
|Cardio-respiratory Arrest (sudden dysfunction of heart and lungs)||2|
|Nasal Ulcer (ulcer of nose)||1|
How effective are the drugs:
|not at all||somewhat||moderate||high||very high|
Top conditions involved for these people * :
Top co-used drugs for these people * :
- Amitriptyline hcl
- Diphenhydramine hcl
- Heparin sodium injection
* Approximation only. Some reports may have incomplete information.
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Complete drug side effects:
On eHealthMe, Elavil (amitriptyline hydrochloride) is often used to treat depression. Benadryl (diphenhydramine hydrochloride) is often used to treat allergen. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.
What is the drug used for and how effective is it:
- Elavil is used in:
- Benadryl is used in:
Other drugs that are used to treat the same conditions:
- Elavil alternatives:
- Benadryl alternatives:
Comments from related studies:
From this study (1 year ago):
From this study (1 year ago):
From this study (1 year ago):
I was admitted to hospital for four days due to the adverse effects from these medications. On the last day, I begged them to let me out even though I was not better, so I could be with my family. I have to walk with a cane to help stabilize me, because I have fallen several times. I still have hallucinations where I see stuff on the walls and floors that are not there. I also suffered double and trouble focusing my eyes, this has for the most part disappeared.
I think my daughter is addicted to these meds. She has muscle severe uncontrolled muscle twitching. Sleeps a lot at times and is fatigued. She is also uninterested in daily responsiblilities at times. Erratic.
Dan L. on Oct, 15, 2012:
the twitching might be tourette symdrome
I have a bactroid (flagilis- aerobic, metal in back, rod from hip to ankle, it may stay in body..2 yrs ago..3 surgeries, now have candida in mouth, vaginal, intestinal?, burning in legs at night, low platelet count, petiechie, abdominal distention, UTI, maybe autoimmune,?drug induced? I have stopped lisinopril and prevastatin ( dr's ok to try to see if these are cause; cut soma from 4 to 3,
Tylenol from 4 to 2,effexor from 2 to 1, have been gluten & wheat free for 3 mos. Now have tried to go yeast free in diet. Total fatigue even though am trying to get down in med count. Overweight and now retaining water in legs though wearing Ted hose.. Am trying to drink alot of water.
Such a mess and seem to be going downhill.. Thank you for listening..Ramona Faust
Ramona on Oct, 13, 2012:
Thank you for your input..I appreciate it!
Joe on Oct, 9, 2012:
Have your doctor check your liver. My sister complained about extreme fatigue & it happen to be her liver. It was stage four liver cancer. Hope this is not your case, but if my sister's doctors had been on top of her complaints, she might still be alive today. Best of luck.
rose on Oct, 14, 2012:
Hello, am very sorry you have to go through this. You may want to do some research on "Systemic Capillary Leakage Syndrome or otherwise known as Clarkson's Syndrome named after the doctor who discovered it in 1960". Mayo Clinic.com is a great start. It is a non-hereditary / acquired autoimmune disorder where an apoptosis (biochemical change) happens within the body altering DNA-function. The body goes through a biochemical change which causes plasma to leak out of the capillaries/vessels and causes swelling in soft tissues all over the body.... randomly. It is not as rare as study show I think its under recognized by standard evaluation techniques. There is a leak phase and a reabsorption phase of the condition and can cause All of the symptoms you mentioned...plus an unusual electrolyte imbalance-that's all that usually shows up on standard tests. Unless you check things like Immune G-CSF, protein - albumin(blood and urine), IG KAPPA, Hematocrit is usually high during leak phases and this condition can be misdiagnosed as polycythemia by standard medical doctors...... most(non specialists) are not even aware this exists which is frightening!!!!! - because they can DO MORE harm then good during leak phases by prescribing to much IV fluids or meds that have very serious and deadly results. ******If your doctor is not listening to you and your body... get one that does immediately!! I have found D.O.'s (Osteopathic Doctors) to be great because they treat the body as a unit not just one organ at a time and are not as quick to hand you a pill like most (M.D.'s) medical doctors these days. Naturopathic Medical Doctors (NMD) are also great because they use medical labs results and natural healing sources to put the body back in balance. Hope this was of some help. Good Luck ....Best Wishes!
Ramona on Oct, 15, 2012:
Thank you Rose! I knew about lupus, sjorden syndrome, and have research about them, trying to educate myself in these.
Can you answer these questions (what is this?):
- I have cfs and have been treated for depression for years.will adderall replace the antidepressants ect that i'm taking now?
I have a long history of depression and anxiety disorder.I was recently diagnosed with CFS.Now that I know exactly what this disease entails,everything makes perfect sense.My physical symptoms,with the exception of increased debilitating pain over the last 2 years, I had come to accept as normal! Gl ...
- Have benadryl users ever experienced sudden onset hearing loss in one ear? does i hearing return?
I've been taking Benadryl tablets to control intense itching for the past two months or so. My last tablet was 2 days ago. Today, over the course of 2 hours, I've lost a significant amount of hearing in one ear. Has anyone else experienced this? Was your hearing restored, and if so, with treatmen ...
- Do you see any relationship between insomnia and dehydration?
I cannot fall asleep. Sometimes it takes several hours (4-5). I have been taking Amitriptyline 10 mg for almost a year which helped tremendously and lately has not helped at all.
You may be interested at these reviews (what is this?):
- Leg pain and occasional arm and hand pain
I started having leg pains at night, lower leg felt like the muscle and bone were being pulled causing sharp pain. It was relieved by getting up and walking but would last most of the night. I finally realized after suffering this over and over for months, that it only happened when I had taken be ...
Recent related drug studies:
- A study of drug interactions between Amitriptyline Hydrochloride, Flexeril, Benadryl, Advil for a patient with Fibromyalgia, Muscle Spasms, Sinus Headache, Headache - Migraine With Aura. The patient has Dry Mouth, Dizziness, Hallucination (Hallucinations), Blue Vision
- A study of drug interactions between Ambien - 10MG, Soma, Amitriptyline Hydrochloride, Tylenol, Aspirin, Effexor, Benadryl for a patient with Pain, Insomnia, Muscle Pain, Sleep Disorder Due To A General Medical Condition, Pain, Depression, Allergies.
- A study of drug interactions between Amitriptyline Hydrochloride, Zoloft, Diphenhydramine Hydrochloride, Lortab for a patient with Anxiety, Stress And Anxiety, Sleep Disorder Therapy, Headache - Cluster. The patient has Muscle Twitching
NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.
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