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Review: Elavil and Benadryl





Summary: drug interactions are reported among people who take Elavil and Benadryl together.

This review analyzes the effectiveness and drug interactions between Elavil and Benadryl. It is created by eHealthMe based on reports of 880 people who take the same drugs from FDA and social media, and is updated regularly.

You are not alone: join a mobile support group for people who take Elavil and Benadryl >>>

What are the drugs

Elavil has active ingredients of amitriptyline hydrochloride. It is often used in depression. (latest outcomes from Elavil 11,891 users)

Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in allergies. (latest outcomes from Benadryl 29,367 users)

On Nov, 22, 2014: 880 people who take Elavil, Benadryl are studied

Elavil, Benadryl outcomes

Drug combinations in study:
- Elavil (amitriptyline hydrochloride)
- Benadryl (diphenhydramine hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Elavil is effective0.00%
(0 of 10 people)
40.00%
(2 of 5 people)
0.00%
(0 of 2 people)
0.00%
(0 of 6 people)
50.00%
(1 of 2 people)
100.00%
(2 of 2 people)
66.67%
(2 of 3 people)
n/a
Benadryl is effective28.57%
(2 of 7 people)
0.00%
(0 of 3 people)
33.33%
(1 of 3 people)
66.67%
(2 of 3 people)
12.50%
(1 of 8 people)
0.00%
(0 of 3 people)
33.33%
(1 of 3 people)
n/a

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
PainEndometrial Cancer Stage IiDrug Withdrawal SyndromeMemory ImpairmentLupus-like SyndromeVertigo PositionalCardio-respiratory ArrestPain
BlisterHypoxiaLip SwellingMenstrual DisorderLupus EnteritisHypersensitivityAnxiety
HyperbilirubinaemiaDyspnoeaOverdoseSuicidal IdeationPain In LimbDepression AggravatedNausea
PyrexiaEndometrial CancerUrticariaThinking SlowedKidney InfectionHypersomniaDyspnoea
Skin InfectionPneumoniaRash PruriticEczema ExacerbatedUrinary Tract Infection ViralSuicidal IdeationArthralgia
HypersensitivityRespiratory FailureNasal Septum PerforationDiarrhoeaHypokalaemiaMemory ImpairmentBack Pain
AnxietyPulmonary ToxicityAnxietyIrritable Bowel SyndromeHeadacheFood IntoleranceDepression
NauseaEndometrial Cancer Stage IFeeling AbnormalFatigueFlushingMenstrual DisorderVomiting
DeathNeoplasmDeathDepression AggravatedHigh Blood PressureDecreased AppetitePain In Extremity
Sinus TachycardiaEndometrial AdenomaHypersomniaHypotension NosCoughPyrexia

Drug effectiveness by gender :

FemaleMale
Elavil is effective23.81%
(5 of 21 people)
22.22%
(2 of 9 people)
Benadryl is effective28.57%
(6 of 21 people)
11.11%
(1 of 9 people)

Most common drug interactions by gender * :

FemaleMale
PainPain
AnxietyAnxiety
PyrexiaNausea
DyspnoeaDepression
Pain In JawBack Pain
ArthralgiaArthralgia
NauseaHeadache
DiarrhoeaOedema Peripheral
Back PainVomiting
Chest PainErectile Dysfunction

Drug effectiveness by age :

0-12-910-1920-2930-3940-4950-5960+
Elavil is effectiven/an/a0.00%
(0 of 2 people)
4.00%
(1 of 25 people)
100.00%
(1 of 1 people)
8.57%
(3 of 35 people)
33.33%
(1 of 3 people)
20.00%
(1 of 5 people)
Benadryl is effectiven/an/a0.00%
(0 of 2 people)
16.67%
(4 of 24 people)
100.00%
(1 of 1 people)
0.00%
(0 of 34 people)
25.00%
(1 of 4 people)
20.00%
(1 of 5 people)

Most common drug interactions by age * :

0-12-910-1920-2930-3940-4950-5960+
Pneumonia Nosn/aNephrogenic Systemic FibrosisAbdominal Pain UpperDiarrhoeaBack PainPainNausea
Pain In ExtremityVomitingVomitingAnxietyAnxietyDyspnoea
Cardiac ArrestNauseaPainNauseaChest PainAnxiety
Myocardial FibrosisDiarrhoeaBack PainAstheniaPyrexiaPain
Muscle ContracturePainFatigueHeadachePain In JawPyrexia
MetaplasiaSickle Cell Anaemia With CrisisNauseaPain In ExtremityBone DisorderCondition Aggravated
Mobility DecreasedConvulsionDyspnoeaPainInsomniaPneumonia
Skin IndurationPain In ExtremityWeight IncreasedArthralgiaPain In ExtremityHypertension
XerosisRenal FailurePyrexiaFallDysphagiaRespiratory Failure
Subcutaneous NoduleSerotonin SyndromeArthralgiaComaFallAnaemia

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Elavil and Benadryl?

You are not alone! Join a related mobile support group:
- support group for people who take Elavil and Benadryl
- support group for people who take Benadryl
- support group for people who take Elavil

Can you answer these questions (Ask a question):

More questions for: Benadryl, Elavil

You may be interested at these reviews (Write a review):

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  • Dyphenhydramine and headaches horrible going one almost 24 hours a day for 4 weeks and cant get them to stop, now looking for cause . think its the dyphenhydramine im taking to help me sleep .
    have been taking 3 dyphenhydramine for some time to help me sleep , just in last few weeks began having severe headache almost all the time.. cant get it to go away. just found out it can cause headache and am going to lower my intake to one per night and see if my headaches get better. am taking migrane meds and that hasnt helped a bit so think its not migranes im having. some other reason.
  • Nightmare on benadryl
    After 5 nights without sleep and not having past bad dreams, the last 2 night's taking walfrin sub, for benadryl has terrified THE WORST OF WORST dream in my 55 years. Peaceful start of a dream then seeing myself or family,friends get slottard.crazy thing is I don't watch scary movies or the news. I think I'm going to pass on this meds, and pass out next time :) thank you,God bless
  • Benadryl completed suicide 50 year old
    My mother comitted suicide by taking a bottle of Benadryl. She also had been drinking, she had taken xanax and drank beer, she also took 300 Benadryl pills and started having seizures and went to the hospital was brain dead and her heart stopped the next morning.
  • Had nms in 2005, will trileptal increase chance of recurrence?
    In 2005 I had NMS, which was not detected by my drs for 4 months. I'd been on Lexapro & Seroquel for 2 yrs, but was weaned from Lexapro & placed on Lamictal 3/05. Began getting low-grade fevers, which I was told were not caused by the Lamictal. I quit taking it anyway, fevers (along with uncontrollable shivering) continued & got higher. By 5/05 my temps were reaching 105 deg F. Husband said I became combative, refused to go to hospital. Early June/05 he came home to find me wrapped in blankets, with a temp over 105 F. He tried to place me in a tub of cold water, said I was rigid & screamed when he tried to move me. I was in the tub, speaking "in tongues" (his description, I have no memory of this). He called 911, took me to hospital. I woke, no idea where I was or why. After a lumbar puncture & 2 days in ICU I went home. The fevers continued...2 weeks later he came home to find me wrapped in sheets, towels, blankets, with the heat on full (it was in the 90's outside) he called ambulance again. I awoke to find myself under an ice blanket with nurses pushing large vials of dantrolene into both arms, several liters. Another LP, a stint in ICU...this time they told me it was NMS. The dr who dxd me said he was surprised I was alive, & not a vegetable, as my temp had peaked at 109 deg F. I suffered brain damage; short-term memory loss, brain can't control my body temp, my blood pressure went up. An arteriogram showed completely healthy heart & arteries, no plaque at all. I lost all body fat as well as some muscle mass. The fevers continued even after stopping the Seroquel. I visited my PCP for a checkup in 9/05, temp was normal. I started shuddering, my temp went up a full degree every 5 minutes. PCP admitted me to ER, my heart rate was over 272 B/M; they stopped my heart 3 times to "reset" it, which didn't work. I spent 3 days in hospital. Several months later my P doc tried me on Lamictal alone; I got Stevens-Johnson syndrome. I stopped the drug as soon as the signs appeared. I've been untreated, except for Neurontin & Primidone, until my manic episodes became unlivable. 3 weeks ago I went 8 days with no sleep, became psychotic. My P doc gave me Trileptal, which has evened my moods, but I've been getting low-grade fevers (highest was 103.6). Would having had NMS in the past make me more prone to falling to it again with the Trileptal? It's the only new med I've taken in over a year.

More reviews for: Benadryl, Elavil

Comments from related studies:

  • From this study (9 months ago):

  • Been I'll for 9 months. Just recently found pneumonia. Can't afford dermatologist and do for doesn't know what the hives are. You can write with your finger on my skin and it will show up.

    Reply

  • From this study (2 years ago):

  • I was admitted to hospital for four days due to the adverse effects from these medications. On the last day, I begged them to let me out even though I was not better, so I could be with my family. I have to walk with a cane to help stabilize me, because I have fallen several times. I still have hallucinations where I see stuff on the walls and floors that are not there. I also suffered double and trouble focusing my eyes, this has for the most part disappeared.

    Reply

  • From this study (2 years ago):

  • I think my daughter is addicted to these meds. She has muscle severe uncontrolled muscle twitching. Sleeps a lot at times and is fatigued. She is also uninterested in daily responsiblilities at times. Erratic.

    Reply

    Dan L. on Oct, 15, 2012:

    the twitching might be tourette symdrome

    Reply

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Complete drug side effects:

On eHealthMe, Elavil (amitriptyline hydrochloride) is often used to treat depression. Benadryl (diphenhydramine hydrochloride) is often used to treat allergies. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

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You may report adverse side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

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