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Review: Elavil and Benadryl

This review analyzes the effectiveness and drug interactions between Elavil and Benadryl. It is created by eHealthMe based on reports of 880 people who take the same drugs from FDA and social media, and is updated regularly.

Get connected: join a mobile support group for people who take Elavil and Benadryl >>>

What are the drugs

Elavil (what 11,884 Elavil users reported?) has active ingredients of amitriptyline hydrochloride. It is used in depression.

Benadryl (what 29,330 Benadryl users reported?) has active ingredients of diphenhydramine hydrochloride. It is used in insomnia.

On Aug, 20, 2014: 880 people who take Elavil, Benadryl are studied

Elavil, Benadryl outcomes

Drug combinations in study:
- Elavil (amitriptyline hydrochloride)
- Benadryl (diphenhydramine hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Elavil is effective0.00%
(0 of 10 people)
(2 of 5 people)
(0 of 2 people)
(0 of 6 people)
(1 of 2 people)
(2 of 2 people)
(2 of 3 people)
Benadryl is effective28.57%
(2 of 7 people)
(0 of 3 people)
(1 of 3 people)
(2 of 3 people)
(1 of 8 people)
(0 of 3 people)
(1 of 3 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
PainEndometrial Cancer Stage IiDrug Withdrawal SyndromeMemory ImpairmentLupus-like SyndromeVertigo PositionalCardio-respiratory ArrestPain
BlisterHypoxiaLip SwellingMenstrual DisorderLupus EnteritisHypersensitivityAnxiety
HyperbilirubinaemiaDyspnoeaOverdoseSuicidal IdeationPain In LimbDepression AggravatedNausea
PyrexiaEndometrial CancerUrticariaThinking SlowedKidney InfectionHypersomniaDyspnoea
Skin InfectionPneumoniaRash PruriticEczema ExacerbatedUrinary Tract Infection ViralSuicidal IdeationArthralgia
HypersensitivityRespiratory FailureNasal Septum PerforationDiarrhoeaHypokalaemiaMemory ImpairmentBack Pain
AnxietyPulmonary ToxicityAnxietyIrritable Bowel SyndromeHeadacheFood IntoleranceDepression
NauseaEndometrial Cancer Stage IFeeling AbnormalFatigueFlushingMenstrual DisorderVomiting
DeathNeoplasmDeathDepression AggravatedHigh Blood PressureDecreased AppetitePain In Extremity
Sinus TachycardiaEndometrial AdenomaHypersomniaHypotension NosCoughPyrexia

Drug effectiveness by gender :

Elavil is effective23.81%
(5 of 21 people)
(2 of 9 people)
Benadryl is effective28.57%
(6 of 21 people)
(1 of 9 people)

Most common drug interactions by gender * :

Pain In JawBack Pain
DiarrhoeaOedema Peripheral
Back PainVomiting
Chest PainErectile Dysfunction

Drug effectiveness by age :

Elavil is effectiven/an/a0.00%
(0 of 2 people)
(1 of 25 people)
(1 of 1 people)
(3 of 35 people)
(1 of 3 people)
(1 of 5 people)
Benadryl is effectiven/an/a0.00%
(0 of 2 people)
(4 of 24 people)
(1 of 1 people)
(0 of 34 people)
(1 of 4 people)
(1 of 5 people)

Most common drug interactions by age * :

Pneumonia Nosn/aNephrogenic Systemic FibrosisAbdominal Pain UpperDiarrhoeaBack PainPainNausea
Pain In ExtremityVomitingVomitingAnxietyAnxietyDyspnoea
Cardiac ArrestNauseaPainNauseaChest PainAnxiety
Myocardial FibrosisDiarrhoeaBack PainAstheniaPyrexiaPain
Muscle ContracturePainFatigueHeadachePain In JawPyrexia
MetaplasiaSickle Cell Anaemia With CrisisNauseaPain In ExtremityBone DisorderCondition Aggravated
Mobility DecreasedConvulsionDyspnoeaPainInsomniaPneumonia
Skin IndurationPain In ExtremityWeight IncreasedArthralgiaPain In ExtremityHypertension
XerosisRenal FailurePyrexiaFallDysphagiaRespiratory Failure
Subcutaneous NoduleSerotonin SyndromeArthralgiaComaFallAnaemia

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Elavil and Benadryl?

Get connected! Join a mobile support group:
- group for people who take Elavil and Benadryl
- group for people who take Benadryl
- group for people who take Elavil

Comments from related studies:

  • From this study (4 months ago):

  • Been I'll for 9 months. Just recently found pneumonia. Can't afford dermatologist and do for doesn't know what the hives are. You can write with your finger on my skin and it will show up.


  • From this study (2 years ago):

  • I was admitted to hospital for four days due to the adverse effects from these medications. On the last day, I begged them to let me out even though I was not better, so I could be with my family. I have to walk with a cane to help stabilize me, because I have fallen several times. I still have hallucinations where I see stuff on the walls and floors that are not there. I also suffered double and trouble focusing my eyes, this has for the most part disappeared.


  • From this study (2 years ago):

  • I think my daughter is addicted to these meds. She has muscle severe uncontrolled muscle twitching. Sleeps a lot at times and is fatigued. She is also uninterested in daily responsiblilities at times. Erratic.


    Dan L. on Oct, 15, 2012:

    the twitching might be tourette symdrome


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Complete drug side effects:

On eHealthMe, Elavil (amitriptyline hydrochloride) is often used to treat depression. Benadryl (diphenhydramine hydrochloride) is often used to treat allergies. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

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