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Review: Elavil and Savella

This review analyzes the effectiveness and drug interactions between Elavil and Savella. It is created by eHealthMe based on reports of 130 people who take the same drugs from FDA and social media, and is updated regularly.

Stay connected: join a mobile support group for people who take Elavil and Savella >>>

What are the drugs

Elavil (latest outcomes from 11,881 users) has active ingredients of amitriptyline hydrochloride. It is used in depression.

Savella (latest outcomes from 3,377 users) has active ingredients of milnacipran hydrochloride. It is used in fibromyalgia.

On Aug, 15, 2014: 130 people who take Elavil, Savella are studied

Elavil, Savella outcomes

Drug combinations in study:
- Elavil (amitriptyline hydrochloride)
- Savella (milnacipran hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Elavil is effectiven/a0.00%
(0 of 2 people)
(2 of 4 people)
(1 of 2 people)
(0 of 2 people)
(0 of 1 people)
(2 of 4 people)
Savella is effective0.00%
(0 of 1 people)
(3 of 7 people)
(0 of 1 people)
(2 of 3 people)
(0 of 2 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
DyspnoeaDrug AbuseMental Status ChangesMigraineMigrainen/aDry Eyes AggravatedNausea
PalpitationsSomnolenceConfusional StateDiscolored TeethGerdNauseaPain
Blood Glucose IncreasedNauseaBlood Pressure IncreasedJob ChangeFacet Joint SyndromeVision BlurredTremor
DiarrhoeaSerotonin SyndromeHallucination, VisualTeeth GrindingFibromyalgiaTeeth ClinchingSomnolence
Anaphylactic ShockDepressionAggressionTeeth ClinchingBack Pain - LowTeeth GrindingHeadache
Dermatitis ExfoliativeFeeling AbnormalDrug IneffectiveDry Eyes AggravatedMyofascial Pain SyndromeUrinary Tract InfectionInjection Site Pain
Protein Total DecreasedActivities Of Daily Living ImpairedWeight GainEagles SyndromeBlood UrinePainful Red EyesDrug Ineffective
Non-cardiac Chest PainHallucinationDepression AggravatedPainful Red EyesMood SwingsEagles SyndromeMalaise
Adverse Drug ReactionVision BlurredAlexiaFibromyalgiaWeight Gain - UnintentionalJob ChangeDepression
MigraineAstheniaSweating - ExcessiveBack Pain - LowAbdominal PainDiscolored TeethMigraine

Drug effectiveness by gender :

Elavil is effective33.33%
(5 of 15 people)
Savella is effective38.46%
(5 of 13 people)
(0 of 1 people)

Most common drug interactions by gender * :

NauseaSerotonin Syndrome
PainDrug Abuse
Mental Status Changes
Injection Site Pain
Drug Ineffective

Drug effectiveness by age :

Elavil is effectiven/an/an/a12.50%
(1 of 8 people)
(1 of 2 people)
(0 of 1 people)
(3 of 44 people)
Savella is effectiven/an/an/a22.22%
(2 of 9 people)
(0 of 1 people)
(3 of 44 people)

Most common drug interactions by age * :

n/an/an/aMigraineAbnormal Loss Of WeightInjection Site PainNauseaMental Status Changes
Poor Quality SleepDrug IneffectivePainPainHeadache
Suicidal IdeationScratchDermatitis ExfoliativePalpitationsConfusional State
DizzinessRash MacularAnaphylactic ShockDizzinessPain
TremorLymph Node PainIntestinal ObstructionSerotonin SyndromeDyspnoea
DepressionFatigueAbdominal DistensionDyspnoeaMemory Impairment
Blood Pressure IncreasedLymphadenitisFallMalaiseAggression
GerdPainAdverse Drug ReactionTremorGait Disturbance
Myofascial Pain SyndromeDysuriaApplication Site ErythemaConstipationDrug Abuse

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

You can also:

Get connected! Join a mobile support group:
- group for people who take Elavil and Savella
- group for people who take Elavil
- group for people who take Savella

Comments from related studies:

  • From this study (2 months ago):

  • Well as I said im taking
    savella and elatrol for fibromyalgia and depression.
    I have witnessed breast pain in my right breast someyimes left. Mostly itchy and the nipple hurts to a touch


  • From this study (1 year ago):

  • Profuse Sweating


Post a new comment    OR    Read more comments

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More reviews for: Elavil, Savella

Complete drug side effects:

On eHealthMe, Elavil (amitriptyline hydrochloride) is often used to treat depression. Savella (milnacipran hydrochloride) is often used to treat fibromyalgia. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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