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Review: Enbrel and Plaquenil





Summary: drug interactions are reported among people who take Enbrel and Plaquenil together.

This review analyzes the effectiveness and drug interactions between Enbrel and Plaquenil. It is created by eHealthMe based on reports of 7,668 people who take the same drugs from FDA and social media, and is updated regularly.

You are not alone: join a mobile support group for people who take Enbrel and Plaquenil >>>

What are the drugs

Enbrel has active ingredients of etanercept. It is often used in rheumatoid arthritis. (latest outcomes from Enbrel 175,525 users)

Plaquenil has active ingredients of hydroxychloroquine sulfate. It is often used in rheumatoid arthritis. (latest outcomes from Plaquenil 15,520 users)

On Dec, 13, 2014: 7,668 people who take Enbrel, Plaquenil are studied

Enbrel, Plaquenil outcomes

Drug combinations in study:
- Enbrel (etanercept)
- Plaquenil (hydroxychloroquine sulfate)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Enbrel is effective50.00%
(3 of 6 people)
40.00%
(4 of 10 people)
75.00%
(6 of 8 people)
100.00%
(5 of 5 people)
37.50%
(3 of 8 people)
40.00%
(2 of 5 people)
100.00%
(1 of 1 people)
n/a
Plaquenil is effectiven/a50.00%
(3 of 6 people)
20.00%
(1 of 5 people)
28.57%
(2 of 7 people)
13.33%
(2 of 15 people)
0.00%
(0 of 3 people)
33.33%
(1 of 3 people)
n/a

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Injection Site ErythemaDrug IneffectiveVaginal HaemorrhageFatigueRheumatoid ArthritisRheumatoid ArthritisPneumoniaInjection Site Pain
Rheumatoid ArthritisInjection Site ErythemaPelvic PainRheumatoid ArthritisDrug IneffectiveFatigueLymphadenopathyRheumatoid Arthritis
HeadacheInjection Site PruritusSquamous Cell Carcinoma Of The CervixPneumoniaArthralgiaNauseaLung NeoplasmInjection Site Erythema
HypersensitivityRheumatoid ArthritisPneumoniaCellulitisPyrexiaOsteoporosisAppendicitis PerforatedInjection Site Reaction Nos
Condition AggravatedArthralgiaCellulitisLung NeoplasmFatigueDizzinessOvarian CystArthralgia
Premature LabourOedema PeripheralLung NeoplasmEscherichia InfectionBack PainHeadachePseudomonas InfectionInjection Site Haemorrhage
AstheniaInjection Site PainLymphadenopathyLymphadenopathyCondition AggravatedOedema PeripheralEscherichia InfectionNausea
Injection Site ReactionPneumoniaRheumatoid ArthritisBeta Haemolytic Streptococcal InfectionNight SweatsFallCellulitisInjection Site Swelling
PyrexiaEczemaArthralgiaLupus-like SyndromeBreast CancerCondition AggravatedBeta Haemolytic Streptococcal InfectionInjection Site Pruritus
PruritusPainNauseaHypotensionSystemic Lupus ErythematosusArthropathyArthralgiaFatigue

Drug effectiveness by gender :

FemaleMale
Enbrel is effective55.56%
(20 of 36 people)
57.14%
(4 of 7 people)
Plaquenil is effective21.21%
(7 of 33 people)
33.33%
(2 of 6 people)

Most common drug interactions by gender * :

FemaleMale
Injection Site PainRheumatoid Arthritis
Rheumatoid ArthritisArthralgia
Injection Site ErythemaDrug Ineffective
Injection Site Reaction NosInjection Site Pain
Injection Site HaemorrhageCondition Aggravated
ArthralgiaInjection Site Reaction Nos
NauseaCough
FatiguePyrexia
Injection Site PruritusFatigue
Drug IneffectiveNausea

Drug effectiveness by age :

0-12-910-1920-2930-3940-4950-5960+
Enbrel is effectiven/an/an/a50.00%
(1 of 2 people)
30.77%
(4 of 13 people)
30.77%
(8 of 26 people)
40.91%
(9 of 22 people)
33.33%
(2 of 6 people)
Plaquenil is effectiven/an/an/a0.00%
(0 of 1 people)
8.33%
(1 of 12 people)
13.04%
(3 of 23 people)
19.05%
(4 of 21 people)
16.67%
(1 of 6 people)

Most common drug interactions by age * :

0-12-910-1920-2930-3940-4950-5960+
Congenital Cystic Kidney DiseaseUpper Respiratory Tract Infection NosInjection Site PainVaginal HaemorrhageInjection Site Reaction NosInjection Site Reaction NosInjection Site PainRheumatoid Arthritis
Palatal DisorderPsoriasisInjection Site ErythemaInjection Site ErythemaInjection Site ErythemaInjection Site ErythemaRheumatoid ArthritisInjection Site Reaction Nos
Urinary Tract InfectionPyrexiaNauseaPelvic PainInjection Site HaemorrhageRheumatoid ArthritisInjection Site Reaction NosInjection Site Pain
Respiratory Syncytial Virus InfectionInjection Site PainInjection Site PruritusInjection Site SwellingInjection Site PruritusInjection Site HaemorrhageInjection Site ErythemaInjection Site Haemorrhage
Reflux NephropathyInjection Site DiscolourationInjection Site HaematomaInjection Site Reaction NosInjection Site SwellingInjection Site PainInjection Site HaemorrhageDrug Ineffective
Bladder DiverticulumAutoimmune HepatitisDrug IneffectiveSquamous Cell Carcinoma Of The CervixInjection Site HaematomaArthralgiaArthralgiaArthralgia
Renal HypertrophyAbdominal Pain NosInjection Site RashInjection Site PainRheumatoid ArthritisFatigueOedema PeripheralDermatitis Nos
Clostridial InfectionWeight IncreasedVomitingInjection Site HaematomaInjection Site PainNauseaNauseaNausea
Otitis MediaInjection Site ErythemaClostridial InfectionInjection Site PruritusNauseaHeadacheFatigueInjection Site Erythema
Pericardial EffusionMouth UlcerationHospitalisationPremature LabourHeadache NosInjection Site SwellingPainCough

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Enbrel and Plaquenil?

You are not alone! Join a related mobile support group:
- support group for people who take Enbrel and Plaquenil
- support group for people who take Enbrel
- support group for people who take Plaquenil

Recent conversations of related support groups:

Can you answer these questions (Ask a question):

  • Is it safe to take demerol while taking tramadol hydrochloride and hydroxychloroquine (2 answers)
    I am experiencing acute, debilitating pain due to the Chikungunya virus, which has reintroduced all of the previous painful symptoms I have,ongoing and in the past, from Fibromyalgia, Arthritis, tendonitis and severe headaches. It's in its 38th day and I am basically crippled from neck to feet. Have to sleep propped up as arms throb with pain when horizontal. The only thing that has subdued the pain slightly are Oxycocet and Ibuprofen, but the pain never goes away. My hands and feet are so inflammed it's difficult to perform even the smallest tasks of personal hygiene and housekeeping. I have difficulty controlling my bladder and often don't make it to the washroom in time. Just started on Demerol today so will no longer take the Oxycocet, but am concerned of the interactions with Demerol, Hydroxychloroquine and Tramadol Hydrochloride extended release tablets that I take daily for the Fibromyalgia and Arthritis. I have dealt with a great deal of pain through the years, but I now have the pain of every serious illness I have had in my lifetime, all at the same time. I honestly didn't think a person could deal with this much pain at once. I have tried and am still taking several vitamins and herbal supplements as well as drinking tons of water and eating really well. Lots of berries, dark vegetables, apples, yogurt and minimal meat. Taking turmeric, papaya leaf, ginger, cinnamon and boswellia for the inflammation. Taking minimal wheat products, sugar and no alcohol. Also, drinking green, fennel and nettle tea daily. I know this is a lot of information, but I really need help and wonder if anyone has any suggestions! Thanking you in advance!!!
  • Can people with hypothyroidism take garcinia cambogia? (1 answer)
    I have hypothyroidism, ITP, and MCTD. With me having all of these issues and taking all these different medications, I was wondering if it would be safe for me to take a diet pill named garcinia cambogia.
  • So does hydroxychloroquine cause celiac desease?
    Been tested over the years for celiac and always negitive. Only had IBS. Took hydroxychloroquine for a year and it effected my vision. Then retested again for celiac because of authrits pain and now I'm positive for celiac.
  • Is there a heath warning with a person taking enbrel being around a person with histoplasmosis?
    The person taking enbrel is there a risk facator being around a person with histoplasmosis?
  • What causes it? and why is it so painful? (1 answer)
    I can lift my arm out in front of me but not out to the side!! The diclofenac doesn't seem to help. Any suggestions? Has anyone been on benlysta?

More questions for: Enbrel, Plaquenil

You may be interested at these reviews (Write a review):

  • Hair loss with enbrel
    I have been on Enbrel for 4 months and started seeing significant hair thinning at the second month of treatments (50 mg once per week). My Rhuematologist suggested 800 mcg of folic acid. I am still losing hair although I am feeling so much better.
  • Etanercept and irritability
    I have been on Etanercept for 8 years for Psoriasis. Previous to this I was on
    Methotrexate, Cyclosporine, Retinodes and ACTH injections.Since being on 25mg twice a week I have been 98% clear.The only side effect to date is "Irritability" which lasts about 24hrs.
    This Drug has been my saving grace.
  • Had nms in 2005, will trileptal increase chance of recurrence?
    In 2005 I had NMS, which was not detected by my drs for 4 months. I'd been on Lexapro & Seroquel for 2 yrs, but was weaned from Lexapro & placed on Lamictal 3/05. Began getting low-grade fevers, which I was told were not caused by the Lamictal. I quit taking it anyway, fevers (along with uncontrollable shivering) continued & got higher. By 5/05 my temps were reaching 105 deg F. Husband said I became combative, refused to go to hospital. Early June/05 he came home to find me wrapped in blankets, with a temp over 105 F. He tried to place me in a tub of cold water, said I was rigid & screamed when he tried to move me. I was in the tub, speaking "in tongues" (his description, I have no memory of this). He called 911, took me to hospital. I woke, no idea where I was or why. After a lumbar puncture & 2 days in ICU I went home. The fevers continued...2 weeks later he came home to find me wrapped in sheets, towels, blankets, with the heat on full (it was in the 90's outside) he called ambulance again. I awoke to find myself under an ice blanket with nurses pushing large vials of dantrolene into both arms, several liters. Another LP, a stint in ICU...this time they told me it was NMS. The dr who dxd me said he was surprised I was alive, & not a vegetable, as my temp had peaked at 109 deg F. I suffered brain damage; short-term memory loss, brain can't control my body temp, my blood pressure went up. An arteriogram showed completely healthy heart & arteries, no plaque at all. I lost all body fat as well as some muscle mass. The fevers continued even after stopping the Seroquel. I visited my PCP for a checkup in 9/05, temp was normal. I started shuddering, my temp went up a full degree every 5 minutes. PCP admitted me to ER, my heart rate was over 272 B/M; they stopped my heart 3 times to "reset" it, which didn't work. I spent 3 days in hospital. Several months later my P doc tried me on Lamictal alone; I got Stevens-Johnson syndrome. I stopped the drug as soon as the signs appeared. I've been untreated, except for Neurontin & Primidone, until my manic episodes became unlivable. 3 weeks ago I went 8 days with no sleep, became psychotic. My P doc gave me Trileptal, which has evened my moods, but I've been getting low-grade fevers (highest was 103.6). Would having had NMS in the past make me more prone to falling to it again with the Trileptal? It's the only new med I've taken in over a year.
  • Humira: my experience
    I have had some form of arthritis probably since birth. My father and maternal grandfather had some form of arthritis. I began to realize pain in both ankles if I stood or walked too long.

    I began taking many NSAIDs when I was around 22. I've done gold, prednisone (twice), plaquenil, butazoidin, sulfasalazine, etc. My best results came with methotrexate after I got cellulitis in my knee (scratch it while kayaking in the summer, fiberglass boat). It dropped my sed rate from over 100 to 35 or so within a few months. I continued with MTX from 1977 to 2000 when my MD suggested Enbrel and stopping MTX. That was a VERY bad decision. Enbrel appeared to mask the disease for a few years. I had my left MCP replaced in 2004, my right heel debrided in 2010, and both my TMJs replaced in 2012. I strongly believe that if I had kept with the MTX it would have delayed those changes. Additionally, in 2011 I was in a bus crash returning from RAGBRAI. I got knocked out from three to six minutes. I had a nasty concussion that lasted 2+ years. Towards the end of the third year post accident I started exercising more aggressively. After doing several 40, 50, and 60 miles rides, I took a leisurely 50 mile ride around Boston at night. Two days later I had a spinal edema. So much for biking and other active sports! :-(

    I have continued with MTX. Late 2013 my MD increased my MTX to .8/week. I had been taking .6/week. I stopped taking Enbrel and switched to Humira in early 2014. I took it for a few months before my doc and I realized it was not doing any better than Enbrel. I tried Humira for three months but it did not seem to work any better than Enbrel. In early June I stopped Humira and waited a few weeks before I started Otezla. I stopped Oterzla on 9/15/14 because it made me depressed and allowed my morning stiffness to get much worse.

    I started prednisone again from the start of July. By mid-August I told my MD that I was screaming louder than I ever had; my dog was very startled. I stopped it gradually over the next two weeks. Meanwhile, the Otezla made me feel awful.

    My MD is going to get me onto another injectable that I take monthly. I forget its name.
  • Vasculitis from enbrel
    I have deep scars on my legs from vasculitis. This was caused by Enbrel. Initially no one would connect the two: per my rheumatologist 'no one has ever reported vasculitis as a side effect of enbrel.' (2003)

    I had to suspend the enbrel for 8 weeks in preparation for complex abdominal surgery. The vasculitis started to heal. Several weeks after the surgery I resumed enbrel and the vasculitis returned by the second or third enbrel shot. The Dr was reluctantly willing to concede that 'it may have been the enbrel.'

    The vasculitis was horrific. I've never felt so much pain, pain that wasn't abated in the least by pain medicine. My dermatologist describe it as being equivalent to a third degree burn: the skin dies, nerves start to regenerate but aren't protected by the dermis.

    The scars look like I had flesh torn from my legs that didn't quite 'fill in.'

    Rheumatologists are too pushy about these biological medicines. They brush past even the most serious side effects. Anything for mobility... I'd prefer not to skip to dialysis sessions or treatment for other organ failure!

More reviews for: Enbrel, Plaquenil

Comments from related studies:

  • From this study (11 months ago):

  • Severe Sleep Apnea

    Reply

  • From this study (1 year ago):

  • Incidence of peripheral neuropathy of the 2 drugs interacting resulting in severe "burning feet".

    Reply

  • From this study (1 year ago):

  • 50 mg weekly. symptoms increasing each week for 6 weeks.

    Reply

Post a new comment    OR    Read more comments

Complete drug side effects:

On eHealthMe, Enbrel (etanercept) is often used to treat rheumatoid arthritis. Plaquenil (hydroxychloroquine sulfate) is often used to treat systemic lupus erythematosus. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

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