Review: Flexeril and Clonazepam
Summary: drug interactions are reported among people who take Flexeril and Clonazepam together.
This review analyzes the effectiveness and drug interactions between Flexeril and Clonazepam. It is created by eHealthMe based on reports of 2,066 people who take the same drugs from FDA and social media, and is updated regularly.
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Flexeril has active ingredients of cyclobenzaprine hydrochloride. It is often used in muscle spasms. (latest outcomes from Flexeril 16,445 users) Clonazepam has active ingredients of clonazepam. It is often used in stress and anxiety. (latest outcomes from Clonazepam 41,283 users)
What are the drugs
Flexeril has active ingredients of cyclobenzaprine hydrochloride. It is often used in muscle spasms. (latest outcomes from Flexeril 16,445 users)
Clonazepam has active ingredients of clonazepam. It is often used in stress and anxiety. (latest outcomes from Clonazepam 41,283 users)
On Nov, 26, 2014: 2,066 people who take Flexeril, Clonazepam are studied
Drug combinations in study:
- Flexeril (cyclobenzaprine hydrochloride)
- Clonazepam (clonazepam)
Drug effectiveness over time :
|< 1 month||1 - 6 months||6 - 12 months||1 - 2 years||2 - 5 years||5 - 10 years||10+ years||not specified|
|Flexeril is effective||32.00%|
(8 of 25 people)
(5 of 16 people)
(3 of 13 people)
(5 of 21 people)
(5 of 22 people)
(4 of 14 people)
(2 of 9 people)
|Clonazepam is effective||50.00%|
(2 of 4 people)
(9 of 15 people)
(7 of 19 people)
(13 of 25 people)
(15 of 29 people)
(10 of 17 people)
(8 of 16 people)
Most common drug interactions over time * :
|< 1 month||1 - 6 months||6 - 12 months||1 - 2 years||2 - 5 years||5 - 10 years||10+ years||not specified|
|Headache||Pain||Nausea In The Morning - Females||Peripheral Ischaemia||Type 2 Diabetes Mellitus||Pain||High Blood Pressure||Anxiety|
|Depression||Emotional Distress||Ejection Fraction Decreased||Cyanosis||Diabetes Mellitus Inadequate Control||Depression||Chest Pain||Depression|
|Fatigue||Fear||Arterial Thrombosis Limb||Pain||Depression||Emotional Distress||Joint Stiffness||Nausea|
|Memory Impairment||Ra||Dyspnoea||Emotional Distress||Diabetic Neuropathy||Peripheral Ischaemia||Dermatitis Allergic||Headache|
|Paraesthesia||Impulse-control Disorder||Sickle Cell Anaemia With Crisis||Arterial Thrombosis||Gallbladder Disorder||Cyanosis||Sleep Disorder Due To General Medical Condition, Insomnia Type||Back Pain|
|Pathological Gambling||Joint Pain||Pulmonary Congestion||Drug Hypersensitivity||Microalbuminuria||Cholecystitis Chronic||Incontinence||Dyspnoea|
|Suicide Attempt||Headache - Migraine With Aura||Ventricular Tachyarrhythmia||Itching||Anxiety||Pancreatitis||Gallbladder Injury||Dizziness|
|Nausea||Dry Skin||Muscle Oedema||Anxiety Disorder||Sphincter Of Oddi Dysfunction||Sphincter Of Oddi Dysfunction||Hypertension||Fatigue|
|Malaise||Lumbar Disc Lesion||Haemoglobin Decreased||Fatigue||Fatigue||Suicide Attempt||Decreased Appetite||Arthralgia|
Drug effectiveness by gender :
|Flexeril is effective||24.74%|
(24 of 97 people)
(8 of 23 people)
|Clonazepam is effective||50.00%|
(51 of 102 people)
(13 of 23 people)
Most common drug interactions by gender * :
Drug effectiveness by age :
|Flexeril is effective||n/a||n/a||100.00%|
(1 of 1 people)
(5 of 19 people)
(13 of 87 people)
(3 of 59 people)
(9 of 67 people)
(1 of 13 people)
|Clonazepam is effective||n/a||n/a||50.00%|
(1 of 2 people)
(7 of 20 people)
(23 of 90 people)
(14 of 63 people)
(14 of 67 people)
(5 of 13 people)
Most common drug interactions by age * :
|Type 2 Diabetes Mellitus||Pancreatitis||Insomnia||Headache||Pain||Headache||Pain In Extremity|
|Obesity||Cholecystitis Chronic||Bronchitis||Pain||Anxiety||Back Pain||Anxiety|
|Pancreatitis||Sphincter Of Oddi Dysfunction||Sinusitis||Anxiety||Nausea||Nausea||Back Pain|
|Gastritis||Gallbladder Disorder||Pain||Dyspnoea||Chest Pain||Anxiety||Arthralgia|
|Blood Cholesterol Increased||Accidental Death||Upper Respiratory Tract Infection||Nausea||Fatigue||Depression||Hypoaesthesia|
|Multiple Drug Overdose||Vomiting||Hypertension||Arthralgia||Dyspnoea||Asthenia|
|Pyrexia||Headache||Bronchitis||Back Pain||Hypoaesthesia||Tooth Fracture|
|Arthralgia||Anxiety||Pain In Extremity||Dizziness||Drug Ineffective||Dyspnoea|
* Some reports may have incomplete information.
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- support group for people who take Flexeril and Clonazepam
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- support group for people who take Flexeril
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- Can nuvigil (vs adderall) be used simultaneously to help wean off 60mg/day of adderall? (1 answer)
I have been on Adderall 30mg 2x daily for years!! I've had it lowered to 20mg, I've TRIED to go months without it (when not working) however I feel I've built up a tolerance level to the point that it's not as effective as it once was. My personal life has detoured WAY past anything an ADHD medication can possibly help as far as focusing on NEEDED tasks etc. I end up feeling wrapped up in what I'm doing at the moment that my anxiety increases due to all that I haven't been able to accomplish. I take various medications for various reasons, depression, anxiety, bulimia etc., and for the most part the doses have varied based on circumstances and current need at said time of prescription.. MY FAMILY HAS A HISTORY OF HEART DISEASE, And realizing that I'm already on the highest Adderall dosage scares me (and THEN as I think about it, it makes my heart race!). I've also noticed increased muscle spasms as well as extreme and intense pressure on my jaw (TMJ). MY QUESTION IS: does anyone have any experience LOWERING their Adderall dosage AND adding Nuvigil? The research I've done to date gives me impression that it could help balance out the more extreme effects of Adderall (60mg/day) but that the nuvigil would or could potentially help with the EXTREME exhaustion I feel as Adderall wears off. Some days I just crash, some days I sleep fine and others no matter how hard I tryyyy, I just CAN'T fall asleep, therefore making the next day worse! IDEALLY I'D LIKE TO BE MED FREE, right now I need them, but am hoping maybe I can speak with my doctor to lower Adderall and add Nuvigil to help wean me off the amphetamines as well as lower dosage intake. YES, a lot of the anxiety, sleeplessness and depression are related to current circumstances in my life, however, where I am is not where I want to be or where I'm headed.. Life is a journey, and all my meds have become a part of a journey I never thought I'd find myself taking. I don't want life/meds to define me, or create a me I no longer recognize, because scarily enough that seems to be a common pattern. As I overcome each and every daily obstacle, I also don't want to be "hooked" on my meds or needing "more" to wake up/sleep/function.. I'd like to work on finding a solution towards weaning off my meds NOW, and work my way off slowly, primarily the Adderall. I'm hoping by suggesting to my doctor and showing him my research he may agree (IF ITS EVEN A LOGICAL COMBO, CLEARLY IM NOT A DOCTOR) nuvigil could help me. I've already started taking less of my anti depressants, trazadone and xanax without discussing with doc because he is always busy.. My next appt I want to go in fully prepared with a plan and an overall goal to REDUCE my Adderall dose, but overall, I'm clueless!!! I have no idea what other meds other than nuvigil "could" potentially help if at all. I could be entirely wrong, Anyone with any experience using one vs other or both simultaneously, or anyone with constructive input, PLEASE COMMENT/SHARE!!
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- Can my eye twitch be because of lexapro?
So I have had symptoms of anxiety and depression due to a lot of stressors and disasters that happened in my life over the past two years. As my anxiety got worse after a breast biopsy, I started freaking out and thinking I may have MS because my sister has MS. So I went to my GP and she decided my symptoms do not follow the symptoms of MS or any similar problem and it should most likely be anxiety. She put me on Lexapro and Clonazepam. At first I was very hesitant to take medication but as my symptoms got worse I decided to give it a try. I was on Lexopro 5 mg for about two months and then I went to 10 mg, and I would take 1 or 2 Clonazepam a day. And this all started 5 months ago. And things seemed to be working just fine.Until about two months ago I started having this freaking annoying eye twitch on my upper left eyelid. I have had eye twitches before but they always go away after a couple of days or a week top. This one has been lasting for 2 months now and seems to be just getting worse. I went to the GP and my eye doctor and they still found no cause and said it's probably stress and anxiety. I have not been overly stressed and I get plenty of sleep, 10 hrs or more! and I stopped taking caffeine and alcohol after the twitch started. Any idea? Could it be because of medication? I also need to add I have had thumb twitching and severe spasms in my muscles around my right thumb starting in May (before taking any medication).
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- A life of depression and fatigue
1) Family history of depression, 2) Diagnosed depression 1964-not treated until 1973, 3) Worked in medical field 35 years, 4) Emergency on-call 24/7, 5) Hospital 15 times major depression, 6) Tried nearly all MAOI, TCA, SSRI, SNRI, and ECT. 7) 100% Disability in 1998 for depression. Now at age 70 I have dysthymia, chronic fatigue, COPD, and PTSD. My recommendation to younger people - do not over stress,
do not smoke, avoid horrific or traumatic situations and try to find some enjoyment in life. If you have symptoms like mine seek early treatment put balance in your life. The often heard recommendations - get plenty of sleep, eat properly, learn to relax and avoid bad habits should not be ignored, they are critical to good physical and mental health.
- 3 strong drugs together against neuropathic pain
Neuropathic pain debuted when I was 24, now I'm 50. Received diagnosed with Ehler-Danlos syndrome (EDS), joint hypermobility type, when I was 35 years old. So it can take some time to get a diagnose. And as EDS-patient I do not belong to any clinic. Orthopedics says that EDS is not orthopedic, rheumatology says that EDS is not an autoimmune disease, GPs say that EDS is too difficult, and so on. Sooner or later we all end up at Psychiatry, even if we are not depressed.
The first kind of pain I got when I was 24 came from low back, but I experienced as pelvic pain and leg pain. It was clearly a neuropathic pain, but it took years to find out. Later it was treated by a pain clinic with cortisone around the genitofemoral nerves (both sides). Since this treatment didn't result in lasting freedom from pain, the pain clinic started to give me RF (radio frequency) treatment. This made the pain disappeared after one year, and I was 80% free from it between 2002 and 2014, 12 years. The pain doctors said pain could return after 10 years.
The other kind of neuropathic pain started 2003 with intense stomach pain. During 6 months I could hardly eat nothing due to nausea and vomiting. After this 6 months, stomach pain changed to almost unbearable pain in upper back.
What happened 2003, and what all the doctors missed, was that the right lowest ribs slid up over the sternum. This rib dislocation is till there today, but now with a lot of cartilage formed around the rib where it is stuck in the lower end of the sternum. The dislocation is clearly visible on X-ray. This has greatly affected the thoracic spine. I have a scoliosis which I had not before 2003. And I still have severe pain in the thoracic spine.
It was initially treated with morphine daily, and later with Durogesic (fentanyl), but this didn't help much. 2005 I was hospitalized because I had too much pain to take care of myself and my hygiene. After some months the doctors started to give me clonazepam because the muscles along the spine was in a chronic seizures. Clonazepam helped, but I could still have a lot of pain in two vertebrae in the thoracic spine. It felt as if someone drilled into the vertebrae without anesthesia. After a few months, doctors also prescribed me methadone. Then the pain disappeared almost completely. Since 2006, I have eaten clonazepam and methadone every day, and I need to sleep in an armchair to not get more pain because of moving during sleep.
There are side effects. After 1,5 years with clonazepam and methadone I started to have panic attacks. Or rather one long panic attack which didn't stop before I got treatment with amitryptilin and pregabalin (Lyrica). These 2 medicines stopped the panic disorder completely after some hours, and the panic was then gone. Then I got side effects of these 2 medicines, amitryptilin & Lyrica, too. I gained a lot of weight (from 83 to 148 kg) and got much water (edema) in both my legs under the knees and in both feet. The feet could swallow to the double size. 2012 I stopped with amitryptilin and started to loose weight again (in Aug 2014 below 80 kg) and get less water in my legs. Today I eat as little medicines I can, but I have to take methadone, clonazepam and Lyrica every day, twice. If I try to take away one of these 3 medicines, I got pain problems at once. Lyrica is the most painful one to take away. In Sept-Dec 2013 I lowered Lyrica from 300 mg daily, to 150, then to 75 and finally 0 mg. The pain I had was extremely difficult to handle. It didn't help to take more methadone or anything else. I have checked on Internet and found that many people got pain from quitting with Lyrica. Most people start eating it again. So did I. But 2006 and 2007 it was enough to treat the pain with methadone and clonazepam, I got the Lyrica against anxiety not pain. But today I take Lyrica against pain.
Beside weight gain and leg edema, clonazepam and Lyrica significantly affect the sexual desire. And Lyrica alone makes it almost impossible to ejaculate. All four drugs together (clonazepam, methadone, amitryptiline and Lyrica), make one forget all about sex life. You don't even miss it. When I stopped with amitryptiline and lowered Lyrica (still taking clonazepam and methadone), I could suddenly easily get erections again, feel desire, but not getting orgasms. This is quite difficult to deal with.
The pain pattern is greatly affected, by pain and by the medicines. So is the mood. I get something which feels like heavy depression, especially if I take the medicines late that day. I should take a medicine like methadone 3 times a day, because the effects of the tablet lasts around 8 hours. But I take them every 12 hours, to have a low consumption in case doctors prescribe them too late (which happens, and then it's good to have a spouse going to the pharmacy buying them for you, because you have too much pain to go yourself).
Since methadone is also used for treating heroine addicts, medical staff treat you with disrespect when they see that it says "methadone" in your health record. I need to show a certificate that says that I deal with chronic neuropathic pain, that I never have had problems with drug addiction, to get normal respect.
I wanted to share this because I think I am alone in the world with these medicines in combination against neuropathic pain caused by hypermobile joints, joint dislocation and muscle spasms. After trying almost everything else, including surgery cutting nerves, methadone, clonazepam and Lyrica seems to be the only way to kill my pain. But it's a life where you always is questioned, because of the use of methadone. I can guarantee that everybody in the world should accept these medicines if they had experienced the unbearable pain I had in upper back before they started to give me clonazepam and methadone.
- Sepsis hallucinations misdiagnosed
I was admitted to the hospital at 10 p.m., with a total bowel blockage caused by scar-tissue adhesions. I had first gone to the ER at 3 a.m. that morning, but the ER doc misdiagnosed my condition as constipation. I was in extreme pain and also too weak to tell my husband when he first came home that I needed to return to the ER. By the time I returned, I became violently nauseated, and vomited repeatedly. Then a gastro-nasal tube was forced down my nose and into my stomach. I began hallucinating at approximately 5 p.m. the following day. I did not realize I was hallucinating, and thought my experiences were real. Some were quite coherent, such as believing there was a book sitting on table at home with a photo on the front showing a sculpture in white marble of a woman's hands holding the Bible, with barbed wire wrapped around her hands. I thought the sculpture had won the Nobel prize, and the book was the biography of the sculptor, whose mother had gone to extraordinary lengths to keep him safe from the Nazis. Some may actually have occurred during dreams, and were wildly improbable, but I don't recall ever going to sleep. At one point, I thought I was at a rest stop on the NJ turnpike, and saw the Nobel-winning sculptor there, working on a wood sculpture. The sculptor turned out to be the maintenance man on the hospital floor. I pulled out the naso-gastral tube three times, but was unaware that I had done so, although I do remember believing that I was buried beneath peat moss and feeling suffocated as I clawed my way out. I also thought I was at a party being given by a law firm which had sold its building to a school for gifted children, but I (also a lawyer) had been deposited there by my nurse and her boyfriend, who were supposed to have taken me to the OR. Some scenes from a book I had been reading made their way into my delusions, which were so real to me that I actually called some of the people involved later on and asked if the events had really happened. The hallucinations began before surgery and continued afterward. When I awoke from anesthesia, I thought the hospital staff was painting the doors to my upstairs bathroom, a project I'd been involved with before the blockage struck. I asked them how they knew what colors to use. They thought I was joking, and confirmed that they had gotten the colors right. Finally a neurologist was summoned, and I told her I was on the passenger ramp at La Guardia airport (instead of in a hospital in NC), and that I'd been born in Havana, Cuba (instead of Baltimore, MD.) I believed myself to be a member of the ruling party in Cuba (pre-Castro) and during an outdoor ceremony, an earthquake had struck, causing ancient monuments to come tumbling down. Later, I was bobbing in harbor waters near a huge ocean liner, with plastic bottles and other detritus floating by. The foregoing are only a small sample of the multitude of hallucinations. Occasionally, I was only an observer of astonishing events, but usually I was a participant. I recognized my husband and friends, but told them about many of these events, believing they had happened. The neurologist diagnosed clonazepam withdrawal. My other doctors later said this was unlikely, as I took clonazepam in small amounts on an erratic schedule, and was not dependent on the drug, although my prescription called for 3 mg. daily. Physician friends said my symptoms were more likely the result of sepsis. I did contract a urinary-tract infection from the catheter, and was being given antibiotics. Additionally, the nature of my underlying condition, and the delay in diagnosis and treatment, may have contributed to the sepsis. Hallucinations occur in only a very small percentage of sepsis sufferers, and in only a small percentage of those withdrawing suddenly from clonazepam. However, I do fit the profile of those who do experience hallucinations with sepsis, being female and aged 62 at the time of this description. After the three-day period, I returned to normal, although believing that my hallucinations had been real persisted for some days afterward. I recovered quickly from the surgery, although the pain persisted for a while, and I was walking easily (dragging my IV with me) through the hospital halls. This was the ONLY symptom I had. Not all the hallucinations were unpleasant -- in fact, they were highly interesting -- but they were incredibly complex. I still remember all the details, better than I remember what actually happened yesterday. Except for the urinary-tract infection, I had no other adverse effects from hospitalization -- no fever, chills, nausea, sweating, headaches, trembling or anything of that kind. The bowel blockage and the surgery were of course not fun, but in a way the hallucinations were fascinating. My own feeling, and that of the doctors who know me and my medical issues, is that my experiences were caused by sepsis, not clonazepam withdrawal, and the antibiotics I was given are probably what saved me.
- I wish i had never taken ambien
Ambien was prescribed after my sleep study showed severe sleep latency and awakening. In the five hours I slept I woke 85 times and had only 5 minutes of deep sleep. However, the doctors couldn't make a recommendation because they could detect no cause for the poor sleep pattern. My doctor offered Ambien and since I had obviously needed the help sleeping I took it. For the next 10 years I suffered incredible depression. For example I remember laying in bed staring at the ceiling with tears rolling into my ears but I was too tired to wipe them away and realizing that I wanted to die so badly but there was no way I could have done anything about it. The worst effects were the loss of consciousness and the verbal abuse that I heaped on my husband and son. An example of each : I actually had sex with my husband that I could not remember amd hundreds of other actions and discussions. My husband started asking every morning what I remembered of the night before. He could usually tell when I was Ambien-awake (his name for it) he said my eyes would get glassy and my voice cadence would be off. Unfortunately my oldest son was going from infant to 8 years old at this time and any ifraction or even without provocation I would scream horrible things in his face. I don't remember much of it but what I do remember causes me enormous regret. He went from a happy and active toddler to a terrified amd anxious pre-teen. We are still working through the effects of this behavior. Finally, after a surprise pregnancy (see example above) My baby was placed in NICU and I stayed at the Ronald McDonald House and my son and husband visited when they could. Somehow my Ambien prescription was stopped and so I began going through withdrawal but I had no idea what was going on. My vision became so blurred thqt I couldn't identify items unless they were very large and then only by colors. When I visited my son those several days in the NICU I couldn't walk straight and would try to aim myself toward my goal until I hit a wall and I would correct course. These things didn't bother me at all but the nurses in the NICU were with me nearly the entire day because they were afraid I would have a stroke or who knew. Finally, after discussing these symptoms we decided to gradually stop the medication. Thankfully, i didn't have any withdrawal symptoms then. I did feel like an incredibly heavy and black blanket had been lifted away. Ever since I have had very little trouble with depression despite the continuation of sleep disturbance and pain. On a scale from one to 10 for depression with 10 being committing suicide I think my 10 years on the medicine was probably an 8.5 (I desperately wanted to die) and since stopping the medication I don't think it has gone above a 4 and is usually a 2 or 3. I will spend the rest of my life trying to repair the damage my verbal abuse caused my oldest son and my husband. For 10 years they lived in fear of my rages if I had a bad episode with Ambien.
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I am a 48 yr old female diagnosed with PTSD, bipolar 2, BPD, histrionic suicidal idealation and a mess!!!
Things were going well in therapy and with my Dr. over the past 2 years on the above "cocktail" MINUS the Latuda and Lexapro.
I have had 3 very serious suicide attempts, all prior to the Tegretol /Prozac regime.
I do not want to change meds! Prior to the Tegretol, Klonopin , Lamictal , Prozac, Trazodone routine, I had made 3 very serious suicide attempts. The last leaving me with liver and kidney disease.
I've recently been left with two tragic yet situational on sets. So against my desire, I agreed to omit Prozac and replace with Lexapro and add Latuda, replacing Tegretol.
I have not been this unbalanced for YEARS! I know my triggers with suicide and believe that is the only reason I'm still alive. I HAD NOT THOUGHT ABOUT suicide for EIGHT YEARS!
Crying all the time, don't eat or sleep for sometimes, up to four days! I'm so tired, I just cry more from frustration of not being able to sleep.
I see my therapist tomorrow, but am on the "call" list for my Dr.
With the holidays among us, I do not nor do I think I can make it on these meds.
Can you PLEASE TELL ME if you know and I wasn't told, the, if any benefits will come forth? I know we are all different and I do trust my Md. Just not this time. Please, please help. Thank you.
I had two unexplained broken bones within a one year period.
Weak urine stream with intermittent breaks.
High potassium level readings. First: 6.2 Second 5.2
When diagnosed at ER with esophagitis was also suspected to have peptic ulcers due to stress.
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Complete drug side effects:
On eHealthMe, Flexeril (cyclobenzaprine hydrochloride) is often used to treat muscle spasms. Clonazepam (clonazepam) is often used to treat stress and anxiety. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.
What is the drug used for and how effective is it:
- Flexeril is used in:
- Clonazepam is used in:
Other drugs that are used to treat the same conditions:
- Flexeril alternatives:
- Clonazepam alternatives:
NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
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