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Review: taking Flexeril and Clonazepam together

Summary: drug interactions are reported among people who take Flexeril and Clonazepam together. This review analyzes the effectiveness and drug interactions between Flexeril and Clonazepam. It is created by eHealthMe based on reports of 2,069 people who take the same drugs from FDA and social media, and is updated regularly.

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What are the drugs

Flexeril has active ingredients of cyclobenzaprine hydrochloride. It is often used in muscle spasms. (latest outcomes from 16,463 Flexeril users)

Clonazepam has active ingredients of clonazepam. It is often used in stress and anxiety. (latest outcomes from 41,387 Clonazepam users)

On May, 7, 2015: 2,069 people who take Flexeril, Clonazepam are studied

Flexeril, Clonazepam outcomes

Drug combinations in study:
- Flexeril (cyclobenzaprine hydrochloride)
- Clonazepam (clonazepam)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Flexeril is effective32.00%
(8 of 25 people)
(5 of 17 people)
(3 of 13 people)
(5 of 21 people)
(5 of 22 people)
(4 of 14 people)
(2 of 10 people)
Clonazepam is effective50.00%
(2 of 4 people)
(10 of 16 people)
(7 of 19 people)
(13 of 25 people)
(15 of 29 people)
(11 of 18 people)
(8 of 17 people)

Drug effectiveness by gender :

Flexeril is effective24.24%
(24 of 99 people)
(8 of 23 people)
Clonazepam is effective50.48%
(53 of 105 people)
(13 of 23 people)

Drug effectiveness by age :

Flexeril is effectiven/an/a100.00%
(1 of 1 people)
(5 of 19 people)
(13 of 87 people)
(3 of 61 people)
(9 of 67 people)
(1 of 13 people)
Clonazepam is effectiven/an/a50.00%
(1 of 2 people)
(7 of 20 people)
(23 of 90 people)
(15 of 65 people)
(15 of 68 people)
(5 of 13 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
HeadachePainNausea In The Morning - FemalesPeripheral IschaemiaType 2 Diabetes MellitusPainHigh Blood PressureAnxiety
DepressionEmotional DistressEjection Fraction DecreasedCyanosisDiabetes Mellitus Inadequate ControlDepressionSleep Disorder Due To General Medical Condition, Insomnia TypeDepression
FatigueAnxietyArterial Thrombosis LimbPainDepressionEmotional DistressDermatitis AllergicNausea
Memory ImpairmentRaDyspnoeaEmotional DistressDiabetic NeuropathyPeripheral IschaemiaChest PainHeadache
ParaesthesiaImpulse-control DisorderSickle Cell Anaemia With CrisisArterial ThrombosisGallbladder DisorderCyanosisIncontinenceBack Pain
Pathological GamblingJoint PainPulmonary CongestionDrug HypersensitivityMicroalbuminuriaCholecystitis ChronicDecreased AppetiteDyspnoea
Suicide AttemptHeadache - Migraine With AuraVentricular TachyarrhythmiaItchingAnxietyPancreatitisImpaired Gastric EmptyingDizziness
NauseaDry SkinMuscle OedemaAnxiety DisorderSphincter Of Oddi DysfunctionSphincter Of Oddi DysfunctionGallbladder InjuryFatigue
MalaiseSpinal Cord Injury Cauda EquinaHaemoglobin DecreasedFatigueFatigueSuicide AttemptHypertensionArthralgia

Most common drug interactions by gender * :

Back PainNausea
FatigueBack Pain
DyspnoeaChest Pain

Most common drug interactions by age * :

Diabetes Mellitusn/aPainNauseaDepressionDepressionPainPain
Type 2 Diabetes MellitusPancreatitisInsomniaHeadachePainHeadachePain In Extremity
ObesityCholecystitis ChronicBronchitisPainAnxietyBack PainAnxiety
PancreatitisSphincter Of Oddi DysfunctionSinusitisAnxietyNauseaNauseaBack Pain
GastritisGallbladder DisorderPainDyspnoeaChest PainAnxietyArthralgia
Blood Cholesterol IncreasedAccidental DeathUpper Respiratory Tract InfectionNauseaFatigueDepressionHypoaesthesia
NauseaFatigueDizzinessWeight IncreasedFatigueHeadache
Multiple Drug OverdoseVomitingHypertensionArthralgiaHypoaesthesiaAsthenia
PyrexiaHeadacheBronchitisBack PainDyspnoeaTooth Fracture
ArthralgiaAnxietyPain In ExtremityDizzinessDrug IneffectiveDyspnoea

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Get connected: join our support group of Flexeril and Clonazepam on

Do you take Flexeril and Clonazepam?


You are not alone! Join a related support group:
- support group for people who take Clonazepam
- support group for people who take Flexeril

Recent conversations of related support groups:

Can you answer these questions (Ask a question):

More questions for: Clonazepam, Flexeril

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More reviews for: Clonazepam, Flexeril

Comments from related studies:

  • From this study (4 months ago):

  • I have chronic fatigue syndrome, fibromyalgia, GERD, IBS, Bipolar 2, PTSD. High levels of anxiety and depression, hypomanic states at times. Hospitalization has been required multiple times to alter drugs. Abuse and overuse of drugs, mixing drugs has been ongoing for 9 weeks. Detox program starting.


  • From this study (6 months ago):

  • I am a 48 yr old female diagnosed with PTSD, bipolar 2, BPD, histrionic suicidal idealation and a mess!!!

    Things were going well in therapy and with my Dr. over the past 2 years on the above "cocktail" MINUS the Latuda and Lexapro.

    I have had 3 very serious suicide attempts, all prior to the Tegretol /Prozac regime.

    I do not want to change meds! Prior to the Tegretol, Klonopin , Lamictal , Prozac, Trazodone routine, I had made 3 very serious suicide attempts. The last leaving me with liver and kidney disease.

    I've recently been left with two tragic yet situational on sets. So against my desire, I agreed to omit Prozac and replace with Lexapro and add Latuda, replacing Tegretol.

    I have not been this unbalanced for YEARS! I know my triggers with suicide and believe that is the only reason I'm still alive. I HAD NOT THOUGHT ABOUT suicide for EIGHT YEARS!

    Crying all the time, don't eat or sleep for sometimes, up to four days! I'm so tired, I just cry more from frustration of not being able to sleep.

    I see my therapist tomorrow, but am on the "call" list for my Dr.

    With the holidays among us, I do not nor do I think I can make it on these meds.

    Can you PLEASE TELL ME if you know and I wasn't told, the, if any benefits will come forth? I know we are all different and I do trust my Md. Just not this time. Please, please help. Thank you.


  • From this study (11 months ago):

  • I had two unexplained broken bones within a one year period.
    Weak urine stream with intermittent breaks.
    High potassium level readings. First: 6.2 Second 5.2
    When diagnosed at ER with esophagitis was also suspected to have peptic ulcers due to stress.


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Complete drug side effects:

On eHealthMe, Flexeril (cyclobenzaprine hydrochloride) is often used to treat muscle spasms. Clonazepam (clonazepam) is often used to treat stress and anxiety. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

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