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Review: taking Flexeril and Effexor Xr together

Summary: drug interactions are reported among people who take Flexeril and Effexor Xr together.

This review analyzes the effectiveness and drug interactions between Flexeril and Effexor Xr. It is created by eHealthMe based on reports of 1,532 people who take the same drugs from FDA and social media, and is updated regularly.


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On Mar, 16, 2015: 1,532 people who take Flexeril, Effexor Xr are studied

Flexeril, Effexor Xr outcomes

Drug combinations in study:
- Flexeril (cyclobenzaprine hydrochloride)
- Effexor Xr (venlafaxine hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Flexeril is effective7.69%
(1 of 13 people)
(4 of 12 people)
(0 of 6 people)
(4 of 10 people)
(4 of 14 people)
(2 of 4 people)
(3 of 5 people)
Effexor Xr is effective0.00%
(0 of 1 people)
(4 of 11 people)
(1 of 6 people)
(2 of 10 people)
(6 of 17 people)
(8 of 19 people)
(6 of 6 people)
(1 of 1 people)

Drug effectiveness by gender :

Flexeril is effective29.09%
(16 of 55 people)
(2 of 9 people)
Effexor Xr is effective41.67%
(25 of 60 people)
(3 of 10 people)

Drug effectiveness by age :

Flexeril is effectiven/an/an/a22.22%
(2 of 9 people)
(4 of 19 people)
(6 of 51 people)
(4 of 39 people)
(2 of 8 people)
Effexor Xr is effectiven/an/an/a0.00%
(0 of 7 people)
(8 of 24 people)
(16 of 61 people)
(3 of 41 people)
(1 of 8 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
InsomniaPainAnxietyDepressionAnxietyNauseaIntentional OverdosePain
Confusional StateNauseaCerebral CystAnxietySuicidal IdeationAnxietyDepressionAnxiety
Completed SuicideGastrooesophageal Reflux DiseaseArthropathyOral HerpesDepressionConstipationSuicide AttemptBack Pain
Respiratory FailureSleep Apnoea SyndromeOral HerpesCerebral CystInsomniaHeadache NosAnxietyDepression
Suicide AttemptType 2 Diabetes MellitusTemporomandibular Joint SyndromeOsteonecrosisHot FlushGastroenteritis NosAbnormal BehaviourDyspnoea
Abnormal BehaviourVomitingWoundTemporomandibular Joint SyndromeAggressionEpistaxisParanoiaFall
DeliriumAtrial Septal DefectVertigoVertigoDrug Withdrawal SyndromeDehydrationMemory ImpairmentNausea
Acute Myocardial InfarctionCoarctation Of The AortaOsteonecrosisWoundPanic AttackDizziness (excl Vertigo)Mood SwingsHeadache
NauseaDiabetic NeuropathyDepressionArthropathyMemory ImpairmentHypokalaemiaAggressionFatigue
Unresponsive To StimuliDeathAphthous StomatitisForeign Body TraumaNauseaFatigueExtrasystolesArthralgia

Most common drug interactions by gender * :

AnxietyBack Pain
HeadacheOedema Peripheral
Back PainPyrexia

Most common drug interactions by age * :

Pancreatitisn/aDepressionCholelithiasisDiabetes MellitusPainPainFall
Diabetes MellitusNauseaSuicidal IdeationOedema PeripheralDepressionDyspnoeaFatigue
PyrexiaDepressionPain In ExtremityChest PainHypertensionBack Pain
PainDrug Withdrawal SyndromePulmonary EmbolismNauseaNeuropathy PeripheralDyspnoea
Drug Withdrawal SyndromeAnxietyBack PainHeadacheHeadachePain
Drug IneffectivePyrexiaHypoaesthesiaDyspnoeaBack PainArthralgia
Drug DependenceDehydrationDepressionBack PainFatigueHeadache
CoughWeight DecreasedType 2 Diabetes MellitusFatigueDepressionOsteonecrosis Of Jaw
PapilloedemaVomitingDeep Vein ThrombosisInsomniaDiarrhoeaChest Pain

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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- support group for people who take Effexor Xr
- support group for people who take Flexeril

Recent related drug studies (Check your drugs):

Complete drug side effects:

On eHealthMe, Flexeril (cyclobenzaprine hydrochloride) is often used to treat muscle spasms. Effexor Xr (venlafaxine hydrochloride) is often used to treat depression. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

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