Review: taking Flexeril and Effexor Xr together
Summary: drug interactions are reported among people who take Flexeril and Effexor Xr together.
This review analyzes the effectiveness and drug interactions between Flexeril and Effexor Xr. It is created by eHealthMe based on reports of 1,532 people who take the same drugs from FDA and social media, and is updated regularly.
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Flexeril has active ingredients of cyclobenzaprine hydrochloride. It is often used in muscle spasms. (latest outcomes from 16,458 Flexeril users) Effexor xr has active ingredients of venlafaxine hydrochloride. It is often used in depression. (latest outcomes from 21,881 Effexor xr users)
What are the drugs
Flexeril has active ingredients of cyclobenzaprine hydrochloride. It is often used in muscle spasms. (latest outcomes from 16,458 Flexeril users)
Effexor xr has active ingredients of venlafaxine hydrochloride. It is often used in depression. (latest outcomes from 21,881 Effexor xr users)
On Feb, 12, 2015: 1,532 people who take Flexeril, Effexor Xr are studied
Drug combinations in study:
- Flexeril (cyclobenzaprine hydrochloride)
- Effexor Xr (venlafaxine hydrochloride)
Drug effectiveness over time :
|< 1 month||1 - 6 months||6 - 12 months||1 - 2 years||2 - 5 years||5 - 10 years||10+ years||not specified|
|Flexeril is effective||7.69%|
(1 of 13 people)
(4 of 12 people)
(0 of 6 people)
(4 of 10 people)
(4 of 14 people)
(2 of 4 people)
(3 of 5 people)
|Effexor Xr is effective||0.00%|
(0 of 1 people)
(4 of 11 people)
(1 of 6 people)
(2 of 10 people)
(6 of 17 people)
(8 of 19 people)
(6 of 6 people)
(1 of 1 people)
Most common drug interactions over time * :
|< 1 month||1 - 6 months||6 - 12 months||1 - 2 years||2 - 5 years||5 - 10 years||10+ years||not specified|
|Confusional State||Nausea||Cerebral Cyst||Anxiety||Suicidal Ideation||Anxiety||Depression||Anxiety|
|Completed Suicide||Gastrooesophageal Reflux Disease||Arthropathy||Oral Herpes||Depression||Constipation||Suicide Attempt||Back Pain|
|Respiratory Failure||Sleep Apnoea Syndrome||Oral Herpes||Cerebral Cyst||Insomnia||Headache Nos||Anxiety||Depression|
|Suicide Attempt||Type 2 Diabetes Mellitus||Temporomandibular Joint Syndrome||Osteonecrosis||Hot Flush||Gastroenteritis Nos||Abnormal Behaviour||Dyspnoea|
|Abnormal Behaviour||Vomiting||Wound||Temporomandibular Joint Syndrome||Aggression||Epistaxis||Paranoia||Fall|
|Delirium||Atrial Septal Defect||Vertigo||Vertigo||Drug Withdrawal Syndrome||Dehydration||Memory Impairment||Nausea|
|Acute Myocardial Infarction||Coarctation Of The Aorta||Osteonecrosis||Wound||Panic Attack||Dizziness (excl Vertigo)||Mood Swings||Headache|
|Nausea||Diabetic Neuropathy||Depression||Arthropathy||Memory Impairment||Hypokalaemia||Aggression||Fatigue|
|Unresponsive To Stimuli||Death||Aphthous Stomatitis||Foreign Body Trauma||Nausea||Fatigue||Extrasystoles||Arthralgia|
Drug effectiveness by gender :
|Flexeril is effective||29.09%|
(16 of 55 people)
(2 of 9 people)
|Effexor Xr is effective||41.67%|
(25 of 60 people)
(3 of 10 people)
Most common drug interactions by gender * :
Drug effectiveness by age :
|Flexeril is effective||n/a||n/a||n/a||22.22%|
(2 of 9 people)
(4 of 19 people)
(6 of 51 people)
(4 of 39 people)
(2 of 8 people)
|Effexor Xr is effective||n/a||n/a||n/a||0.00%|
(0 of 7 people)
(8 of 24 people)
(16 of 61 people)
(3 of 41 people)
(1 of 8 people)
Most common drug interactions by age * :
|Diabetes Mellitus||Nausea||Suicidal Ideation||Oedema Peripheral||Depression||Dyspnoea||Fatigue|
|Pyrexia||Depression||Pain In Extremity||Chest Pain||Hypertension||Back Pain|
|Pain||Drug Withdrawal Syndrome||Pulmonary Embolism||Nausea||Neuropathy Peripheral||Dyspnoea|
|Drug Withdrawal Syndrome||Anxiety||Back Pain||Headache||Headache||Pain|
|Drug Ineffective||Pyrexia||Hypoaesthesia||Dyspnoea||Back Pain||Arthralgia|
|Drug Dependence||Dehydration||Depression||Back Pain||Fatigue||Headache|
|Cough||Weight Decreased||Type 2 Diabetes Mellitus||Fatigue||Depression||Osteonecrosis Of Jaw|
|Papilloedema||Vomiting||Deep Vein Thrombosis||Insomnia||Diarrhoea||Chest Pain|
* Some reports may have incomplete information.
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- support group for people who take Flexeril and Effexor Xr
- support group for people who take Effexor Xr
- support group for people who take Flexeril
Recent conversations of related support groups:
- Support group for people who take Effexor Xr
Hi. just started 37.5 dose 3 days ago for anxiety. Sole care giver for 87 year old mom who jave been in hospital for 6 weeks waiting for a retirement home. Having chills and sweats. Also a bit dizzy. Was on Ciprolex before but got weak and severe head pain. Hoping these effexor symptoms will pass.
Can you answer these questions (Ask a question):
- Is there a drug interaction between paxil and flexeril?
What is the drug interaction, if any between paxil and flexeril? I was taken off a low dosage of paxil two weeks or so ago an due to back issues was issued flexeril for spasms and pain. I try to avoid meds like this but really need it and wanted to know if it was safe. I read about major drug interaction between these two medications and that is why I suffered through pain because I was concerned. Please advise if I can take flexeril now.
- Will flexeril help with alcohol withdrawal anxiet????
I have been suffering with alcohol withdrawals plus the flu the only meds that I have available is one flexor all will this help ease anxiety and let me sleep??
- I tested positive for methadone, i have never taken this drug (1 answer)
I tested positive for methadone, I have never taken this drug. My Dr said I had to have taken it because it was there and that a false positive is out of the question. Could my meds cause methadone to show up on a urine drug test
- Does prozosin have interacction with efforr xr? (1 answer)
Can Effexor Xr and Prazosin be taken together safely?
- Can nuvigil (vs adderall) be used simultaneously to help wean off 60mg/day of adderall? (1 answer)
I have been on Adderall 30mg 2x daily for years!! I've had it lowered to 20mg, I've TRIED to go months without it (when not working) however I feel I've built up a tolerance level to the point that it's not as effective as it once was. My personal life has detoured WAY past anything an ADHD medication can possibly help as far as focusing on NEEDED tasks etc. I end up feeling wrapped up in what I'm doing at the moment that my anxiety increases due to all that I haven't been able to accomplish. I take various medications for various reasons, depression, anxiety, bulimia etc., and for the most part the doses have varied based on circumstances and current need at said time of prescription.. MY FAMILY HAS A HISTORY OF HEART DISEASE, And realizing that I'm already on the highest Adderall dosage scares me (and THEN as I think about it, it makes my heart race!). I've also noticed increased muscle spasms as well as extreme and intense pressure on my jaw (TMJ). MY QUESTION IS: does anyone have any experience LOWERING their Adderall dosage AND adding Nuvigil? The research I've done to date gives me impression that it could help balance out the more extreme effects of Adderall (60mg/day) but that the nuvigil would or could potentially help with the EXTREME exhaustion I feel as Adderall wears off. Some days I just crash, some days I sleep fine and others no matter how hard I tryyyy, I just CAN'T fall asleep, therefore making the next day worse! IDEALLY I'D LIKE TO BE MED FREE, right now I need them, but am hoping maybe I can speak with my doctor to lower Adderall and add Nuvigil to help wean me off the amphetamines as well as lower dosage intake. YES, a lot of the anxiety, sleeplessness and depression are related to current circumstances in my life, however, where I am is not where I want to be or where I'm headed.. Life is a journey, and all my meds have become a part of a journey I never thought I'd find myself taking. I don't want life/meds to define me, or create a me I no longer recognize, because scarily enough that seems to be a common pattern. As I overcome each and every daily obstacle, I also don't want to be "hooked" on my meds or needing "more" to wake up/sleep/function.. I'd like to work on finding a solution towards weaning off my meds NOW, and work my way off slowly, primarily the Adderall. I'm hoping by suggesting to my doctor and showing him my research he may agree (IF ITS EVEN A LOGICAL COMBO, CLEARLY IM NOT A DOCTOR) nuvigil could help me. I've already started taking less of my anti depressants, trazadone and xanax without discussing with doc because he is always busy.. My next appt I want to go in fully prepared with a plan and an overall goal to REDUCE my Adderall dose, but overall, I'm clueless!!! I have no idea what other meds other than nuvigil "could" potentially help if at all. I could be entirely wrong, Anyone with any experience using one vs other or both simultaneously, or anyone with constructive input, PLEASE COMMENT/SHARE!!
You may be interested at these reviews (Write a review):
- Joint pain/depression/thinking unclear
I've been on Effexor 75mg. for 8 month's and recently have been decreasing this amount so that I can safely stop taking this all together. I believe that in the beginning month's of taking it, it had helped with my hot-flashes and anxiety. A few month's ago I've noticed that it isn't helping my anxiety but has added a few more problem's as well. I now have bad swelling in my finger's with bumps on top of the joints. Also, crying, depressing, and lack of interest. The muscle's in my arm's ache. I can't concentrate at work which is very embarrassing.
My plan is to decrease amount of this medicine and go completley off. So far, I've been taking 37.5 mg. for a week and seem's withdrawal symptom's are not so bad as of yet. Hopefully, in a few more wks. I will be completely off of it.
I have decided to invest in Herbal remedie's instead. I have never had a problem with all-natural before. As for the hot flashes I will use Black Cohosh. I will also use natural herb's for anxiety. I am really doing my research. I believe that the all-natural route is better than the synthetic med. because there are way too many bad side effect's.
Another thing I didn't mention was the weight gain from Effexor. I sure hope I lose the weight that I gained! That also add's to the depression.
- Effexor lets me down after 20 years
I dropped Effexor for 5 months. Had a depressive episode and went back to it. It blew me away this time around. I'd lost 20 pounds and was exercising a lot. I went back to 37 g and was doing okay although I hated taking it. The side effects: food tasting bad, no sleep, and no sexual desire was making me sad. Anyway, I accidently took 150 and it was very hard. I felt like a zombie and couldn't eat. The next day I took 37 and was okay. I have experienced a lot of anxiety and that seemed to help a little. The next day I took 75, and went hypomaniac. I had to walk around the block 5 times to calm down. The next day without anything I had to take a spinning class, swim, and lift weights to calm down. Followed was 3 horrible days of drug withdrawal. Today, I've been hanging in for most of the day although I had some bad anxiety this morning and afternoon. I am sitting her forcing myself to watch TV. My life has been a living hell for 3 weeks, and all the doctor told me to do is take more of this poison, but at a lower dose.
- Fructose malabsorption symptoms become wore with effexor
I took Venlafaxine for several years. During that time I was diagnosed with Fructose Malabsorption (FM), something I suspect that I have had for years already. For a period of two years I switched medication and took some other SSRIs instead of Venlafaxine and then returned to Venlafaxine and found that my FM symptoms right away increased/returned. When I came off of Venlafaxine I noticed that my FM symptoms became easier to manage but going back on Venlafaxine has confirm that it does indeed cause greater IBS and FM symptoms.
- Effexor near death experience
In 1999 I was prescribed 75mg time release Effexor. I took one pill and 4 hours later I became dizzy and it felt like a cold patch in the middle of my head. I ckecked my eyes as i started seeing too much light, my puples were dilated, all black. I managed to get up stairs and asked my mom to get me to hospital. I passed out, and as crazy as it sounds I had a vision of my nana. I knew I was gone.she told me to wake up. I wasn't breathing. I could hear my mom talking on the phone to 911saying I had no pulse. (She is an RN) the ambulance came and they couldn't find my blood pressure. I couldn't see very well. The ER doctors said to continue taking the meds and sent my home. I stopped taking the Effexor. I had the side effects for many months. I get aura migraines now and have extreme sensitivity to other drugs.
- I wish i had never taken ambien
Ambien was prescribed after my sleep study showed severe sleep latency and awakening. In the five hours I slept I woke 85 times and had only 5 minutes of deep sleep. However, the doctors couldn't make a recommendation because they could detect no cause for the poor sleep pattern. My doctor offered Ambien and since I had obviously needed the help sleeping I took it. For the next 10 years I suffered incredible depression. For example I remember laying in bed staring at the ceiling with tears rolling into my ears but I was too tired to wipe them away and realizing that I wanted to die so badly but there was no way I could have done anything about it. The worst effects were the loss of consciousness and the verbal abuse that I heaped on my husband and son. An example of each : I actually had sex with my husband that I could not remember amd hundreds of other actions and discussions. My husband started asking every morning what I remembered of the night before. He could usually tell when I was Ambien-awake (his name for it) he said my eyes would get glassy and my voice cadence would be off. Unfortunately my oldest son was going from infant to 8 years old at this time and any ifraction or even without provocation I would scream horrible things in his face. I don't remember much of it but what I do remember causes me enormous regret. He went from a happy and active toddler to a terrified amd anxious pre-teen. We are still working through the effects of this behavior. Finally, after a surprise pregnancy (see example above) My baby was placed in NICU and I stayed at the Ronald McDonald House and my son and husband visited when they could. Somehow my Ambien prescription was stopped and so I began going through withdrawal but I had no idea what was going on. My vision became so blurred thqt I couldn't identify items unless they were very large and then only by colors. When I visited my son those several days in the NICU I couldn't walk straight and would try to aim myself toward my goal until I hit a wall and I would correct course. These things didn't bother me at all but the nurses in the NICU were with me nearly the entire day because they were afraid I would have a stroke or who knew. Finally, after discussing these symptoms we decided to gradually stop the medication. Thankfully, i didn't have any withdrawal symptoms then. I did feel like an incredibly heavy and black blanket had been lifted away. Ever since I have had very little trouble with depression despite the continuation of sleep disturbance and pain. On a scale from one to 10 for depression with 10 being committing suicide I think my 10 years on the medicine was probably an 8.5 (I desperately wanted to die) and since stopping the medication I don't think it has gone above a 4 and is usually a 2 or 3. I will spend the rest of my life trying to repair the damage my verbal abuse caused my oldest son and my husband. For 10 years they lived in fear of my rages if I had a bad episode with Ambien.
Comments from related studies:
From this study (2 weeks ago):
coolaero on Feb, 7, 2015:
there wont be side effect other that DEATH
peanuts on Mar, 31, 2010:
my friend is suffering from rhumatory arthertis.and is currenty taking cocaine. oxy cotin,prestine, wellbutrim, predisone 10mg what side effects should she expect ?????
mtntexas on May, 11, 2013:
Just ask John Belushi
Complete drug side effects:
On eHealthMe, Flexeril (cyclobenzaprine hydrochloride) is often used to treat muscle spasms. Effexor Xr (venlafaxine hydrochloride) is often used to treat depression. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.
What is the drug used for and how effective is it:
- Flexeril is used in:
- Effexor xr is used in:
Other drugs that are used to treat the same conditions:
- Flexeril alternatives:
- Effexor xr alternatives:
NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.
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