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Review: taking Flexeril and Effexor Xr together

Summary: drug interactions are reported among people who take Flexeril and Effexor Xr together.

This review analyzes the effectiveness and drug interactions between Flexeril and Effexor Xr. It is created by eHealthMe based on reports of 1,531 people who take the same drugs from FDA and social media, and is updated regularly.

 

 

 

 

You are not alone: join a mobile support group for people who take Flexeril and Effexor Xr >>>

What are the drugs

Flexeril has active ingredients of cyclobenzaprine hydrochloride. It is often used in muscle spasms. (latest outcomes from 16,452 Flexeril users)

Effexor xr has active ingredients of venlafaxine hydrochloride. It is often used in depression. (latest outcomes from 21,869 Effexor xr users)

On Jan, 13, 2015: 1,531 people who take Flexeril, Effexor Xr are studied

Flexeril, Effexor Xr outcomes

Drug combinations in study:
- Flexeril (cyclobenzaprine hydrochloride)
- Effexor Xr (venlafaxine hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Flexeril is effective7.69%
(1 of 13 people)
36.36%
(4 of 11 people)
0.00%
(0 of 6 people)
40.00%
(4 of 10 people)
28.57%
(4 of 14 people)
50.00%
(2 of 4 people)
60.00%
(3 of 5 people)
n/a
Effexor Xr is effective0.00%
(0 of 1 people)
40.00%
(4 of 10 people)
16.67%
(1 of 6 people)
20.00%
(2 of 10 people)
35.29%
(6 of 17 people)
42.11%
(8 of 19 people)
100.00%
(6 of 6 people)
100.00%
(1 of 1 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
InsomniaPainAnxietyDepressionAnxietyNauseaIntentional OverdosePain
Confusional StateNauseaCerebral CystAnxietySuicidal IdeationAnxietyDepressionAnxiety
Completed SuicideGastrooesophageal Reflux DiseaseArthropathyOral HerpesDepressionConstipationSuicide AttemptBack Pain
Respiratory FailureSleep Apnoea SyndromeOral HerpesCerebral CystInsomniaHeadache NosAnxietyDepression
Suicide AttemptType 2 Diabetes MellitusTemporomandibular Joint SyndromeOsteonecrosisHot FlushGastroenteritis NosAbnormal BehaviourDyspnoea
Abnormal BehaviourVomitingWoundTemporomandibular Joint SyndromeAggressionEpistaxisParanoiaFall
DeliriumCardiomegalyVertigoVertigoDrug Withdrawal SyndromeDehydrationMemory ImpairmentNausea
Acute Myocardial InfarctionVentricular Septal DefectOsteonecrosisWoundPanic AttackDizziness (excl Vertigo)Mood SwingsHeadache
NauseaCoarctation Of The AortaDepressionArthropathyMemory ImpairmentHypokalaemiaAggressionFatigue
Unresponsive To StimuliAtrial Septal DefectAphthous StomatitisForeign Body TraumaNauseaFatigueExtrasystolesArthralgia

Drug effectiveness by gender :

FemaleMale
Flexeril is effective29.63%
(16 of 54 people)
22.22%
(2 of 9 people)
Effexor Xr is effective42.37%
(25 of 59 people)
30.00%
(3 of 10 people)

Most common drug interactions by gender * :

FemaleMale
AnxietyBack Pain
PainDepression
DyspnoeaPain
FatigueArthralgia
DepressionInsomnia
NauseaConstipation
FallAnxiety
Back PainOedema Peripheral
HeadachePyrexia
ArthralgiaFall

Drug effectiveness by age :

0-12-910-1920-2930-3940-4950-5960+
Flexeril is effectiven/an/an/a22.22%
(2 of 9 people)
21.05%
(4 of 19 people)
13.04%
(6 of 46 people)
10.26%
(4 of 39 people)
25.00%
(2 of 8 people)
Effexor Xr is effectiven/an/an/a0.00%
(0 of 7 people)
33.33%
(8 of 24 people)
28.57%
(16 of 56 people)
7.32%
(3 of 41 people)
12.50%
(1 of 8 people)

Most common drug interactions by age * :

0-12-910-1920-2930-3940-4950-5960+
Pancreatitisn/aDepressionCholelithiasisDiabetes MellitusPainPainFall
GastritisAnxietyNauseaArthralgiaAnxietyAnxietyAnxiety
Diabetes MellitusNauseaSuicidal IdeationOedema PeripheralDepressionDyspnoeaFatigue
PyrexiaDepressionPain In ExtremityChest PainHypertensionBack Pain
PainDrug Withdrawal SyndromePulmonary EmbolismNauseaNeuropathy PeripheralDyspnoea
Drug Withdrawal SyndromeAnxietyBack PainHeadacheHeadachePain
Drug IneffectivePyrexiaHypoaesthesiaDyspnoeaBack PainArthralgia
Drug DependenceDehydrationDepressionBack PainFatigueHeadache
CoughWeight DecreasedType 2 Diabetes MellitusFatigueDepressionOsteonecrosis Of Jaw
PapilloedemaVomitingDeep Vein ThrombosisInsomniaDiarrhoeaChest Pain

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Flexeril and Effexor Xr?

You are not alone! Join a related mobile support group:
- support group for people who take Flexeril and Effexor Xr
- support group for people who take Effexor Xr
- support group for people who take Flexeril

Recent conversations of related support groups:

  • Support group for people who take Effexor Xr
    Hi. just started 37.5 dose 3 days ago for anxiety. Sole care giver for 87 year old mom who jave been in hospital for 6 weeks waiting for a retirement home. Having chills and sweats. Also a bit dizzy. Was on Ciprolex before but got weak and severe head pain. Hoping these effexor symptoms will pass.

Can you answer these questions (Ask a question):

  • I tested positive for methadone, i have never taken this drug (1 answer)
    I tested positive for methadone, I have never taken this drug. My Dr said I had to have taken it because it was there and that a false positive is out of the question. Could my meds cause methadone to show up on a urine drug test
  • Does prozosin have interacction with efforr xr? (1 answer)
    Can Effexor Xr and Prazosin be taken together safely?
  • Can nuvigil (vs adderall) be used simultaneously to help wean off 60mg/day of adderall? (1 answer)
    I have been on Adderall 30mg 2x daily for years!! I've had it lowered to 20mg, I've TRIED to go months without it (when not working) however I feel I've built up a tolerance level to the point that it's not as effective as it once was. My personal life has detoured WAY past anything an ADHD medication can possibly help as far as focusing on NEEDED tasks etc. I end up feeling wrapped up in what I'm doing at the moment that my anxiety increases due to all that I haven't been able to accomplish. I take various medications for various reasons, depression, anxiety, bulimia etc., and for the most part the doses have varied based on circumstances and current need at said time of prescription.. MY FAMILY HAS A HISTORY OF HEART DISEASE, And realizing that I'm already on the highest Adderall dosage scares me (and THEN as I think about it, it makes my heart race!). I've also noticed increased muscle spasms as well as extreme and intense pressure on my jaw (TMJ). MY QUESTION IS: does anyone have any experience LOWERING their Adderall dosage AND adding Nuvigil? The research I've done to date gives me impression that it could help balance out the more extreme effects of Adderall (60mg/day) but that the nuvigil would or could potentially help with the EXTREME exhaustion I feel as Adderall wears off. Some days I just crash, some days I sleep fine and others no matter how hard I tryyyy, I just CAN'T fall asleep, therefore making the next day worse! IDEALLY I'D LIKE TO BE MED FREE, right now I need them, but am hoping maybe I can speak with my doctor to lower Adderall and add Nuvigil to help wean me off the amphetamines as well as lower dosage intake. YES, a lot of the anxiety, sleeplessness and depression are related to current circumstances in my life, however, where I am is not where I want to be or where I'm headed.. Life is a journey, and all my meds have become a part of a journey I never thought I'd find myself taking. I don't want life/meds to define me, or create a me I no longer recognize, because scarily enough that seems to be a common pattern. As I overcome each and every daily obstacle, I also don't want to be "hooked" on my meds or needing "more" to wake up/sleep/function.. I'd like to work on finding a solution towards weaning off my meds NOW, and work my way off slowly, primarily the Adderall. I'm hoping by suggesting to my doctor and showing him my research he may agree (IF ITS EVEN A LOGICAL COMBO, CLEARLY IM NOT A DOCTOR) nuvigil could help me. I've already started taking less of my anti depressants, trazadone and xanax without discussing with doc because he is always busy.. My next appt I want to go in fully prepared with a plan and an overall goal to REDUCE my Adderall dose, but overall, I'm clueless!!! I have no idea what other meds other than nuvigil "could" potentially help if at all. I could be entirely wrong, Anyone with any experience using one vs other or both simultaneously, or anyone with constructive input, PLEASE COMMENT/SHARE!!
  • Is effexor xr induce paraphillia
    I am a hypocondriasis patient and taking medication last 3 year dose effexor xr 75 mg extendd release.. nw i heard some drug can induced paraphillia..then onwards i am fearing this effexor xr is coming under the category of paraphillia inducing drugs and ? And paraphillic nature vll get to me in future due to this effexor xe medication..about my history, there have no paraphilic nature to me at any point of time... so kindly give a reply soon
  • Why would i get copd since i never smoked?
    I have several autoimmune disorders, I was shocked to get the COPD diagnosis since I have never smoked but I had second hand smoke first 23 years of my life.
    My doctor said my Autoimmune Hepatitis and Primary Biliary Cholingitis set me up for COPD.

More questions for: Effexor Xr, Flexeril

You may be interested at these reviews (Write a review):

  • Effexor lets me down after 20 years
    I dropped Effexor for 5 months. Had a depressive episode and went back to it. It blew me away this time around. I'd lost 20 pounds and was exercising a lot. I went back to 37 g and was doing okay although I hated taking it. The side effects: food tasting bad, no sleep, and no sexual desire was making me sad. Anyway, I accidently took 150 and it was very hard. I felt like a zombie and couldn't eat. The next day I took 37 and was okay. I have experienced a lot of anxiety and that seemed to help a little. The next day I took 75, and went hypomaniac. I had to walk around the block 5 times to calm down. The next day without anything I had to take a spinning class, swim, and lift weights to calm down. Followed was 3 horrible days of drug withdrawal. Today, I've been hanging in for most of the day although I had some bad anxiety this morning and afternoon. I am sitting her forcing myself to watch TV. My life has been a living hell for 3 weeks, and all the doctor told me to do is take more of this poison, but at a lower dose.
  • Fructose malabsorption symptoms become wore with effexor
    I took Venlafaxine for several years. During that time I was diagnosed with Fructose Malabsorption (FM), something I suspect that I have had for years already. For a period of two years I switched medication and took some other SSRIs instead of Venlafaxine and then returned to Venlafaxine and found that my FM symptoms right away increased/returned. When I came off of Venlafaxine I noticed that my FM symptoms became easier to manage but going back on Venlafaxine has confirm that it does indeed cause greater IBS and FM symptoms.
  • Effexor near death experience
    In 1999 I was prescribed 75mg time release Effexor. I took one pill and 4 hours later I became dizzy and it felt like a cold patch in the middle of my head. I ckecked my eyes as i started seeing too much light, my puples were dilated, all black. I managed to get up stairs and asked my mom to get me to hospital. I passed out, and as crazy as it sounds I had a vision of my nana. I knew I was gone.she told me to wake up. I wasn't breathing. I could hear my mom talking on the phone to 911saying I had no pulse. (She is an RN) the ambulance came and they couldn't find my blood pressure. I couldn't see very well. The ER doctors said to continue taking the meds and sent my home. I stopped taking the Effexor. I had the side effects for many months. I get aura migraines now and have extreme sensitivity to other drugs.
  • I wish i had never taken ambien
    Ambien was prescribed after my sleep study showed severe sleep latency and awakening. In the five hours I slept I woke 85 times and had only 5 minutes of deep sleep. However, the doctors couldn't make a recommendation because they could detect no cause for the poor sleep pattern. My doctor offered Ambien and since I had obviously needed the help sleeping I took it. For the next 10 years I suffered incredible depression. For example I remember laying in bed staring at the ceiling with tears rolling into my ears but I was too tired to wipe them away and realizing that I wanted to die so badly but there was no way I could have done anything about it. The worst effects were the loss of consciousness and the verbal abuse that I heaped on my husband and son. An example of each : I actually had sex with my husband that I could not remember amd hundreds of other actions and discussions. My husband started asking every morning what I remembered of the night before. He could usually tell when I was Ambien-awake (his name for it) he said my eyes would get glassy and my voice cadence would be off. Unfortunately my oldest son was going from infant to 8 years old at this time and any ifraction or even without provocation I would scream horrible things in his face. I don't remember much of it but what I do remember causes me enormous regret. He went from a happy and active toddler to a terrified amd anxious pre-teen. We are still working through the effects of this behavior. Finally, after a surprise pregnancy (see example above) My baby was placed in NICU and I stayed at the Ronald McDonald House and my son and husband visited when they could. Somehow my Ambien prescription was stopped and so I began going through withdrawal but I had no idea what was going on. My vision became so blurred thqt I couldn't identify items unless they were very large and then only by colors. When I visited my son those several days in the NICU I couldn't walk straight and would try to aim myself toward my goal until I hit a wall and I would correct course. These things didn't bother me at all but the nurses in the NICU were with me nearly the entire day because they were afraid I would have a stroke or who knew. Finally, after discussing these symptoms we decided to gradually stop the medication. Thankfully, i didn't have any withdrawal symptoms then. I did feel like an incredibly heavy and black blanket had been lifted away. Ever since I have had very little trouble with depression despite the continuation of sleep disturbance and pain. On a scale from one to 10 for depression with 10 being committing suicide I think my 10 years on the medicine was probably an 8.5 (I desperately wanted to die) and since stopping the medication I don't think it has gone above a 4 and is usually a 2 or 3. I will spend the rest of my life trying to repair the damage my verbal abuse caused my oldest son and my husband. For 10 years they lived in fear of my rages if I had a bad episode with Ambien.
  • My ex-boyfriend's effexor effects (1 response)
    In my fifth year of living with my ex-boyfriend, he began taking Effexor and soon developed urinary incontinence, kidney failure and nightmares or night terrors so severe that he frequently screamed for prolonged periods, flailed and threw punches in his sleep. Upon ceasing to take Effexor, his sleep returned to normal. His kidneys also recovered, and he regained the ability to control urination. About a year after that, he was arrested for downloading child pornography, and I haven't spoken to him since. I'm not suggesting that Effexor caused him to become a pedophile, but it has been noted to produce personality changes in some users. It would be hard to ascertain whether any or all of these side effects resulted from the drug, but I would NEVER take it or allow anyone I cared about to do so. He had never exhibited any such symptoms before taking it, and I feel it ruined his life on many levels.

More reviews for: Effexor Xr, Flexeril

Comments from related studies:

  • From this study (3 months ago):

  • peanuts on Mar, 31, 2010:

    my friend is suffering from rhumatory arthertis.and is currenty taking cocaine. oxy cotin,prestine, wellbutrim, predisone 10mg what side effects should she expect ?????

    Reply

    mtntexas on May, 11, 2013:

    Just ask John Belushi

    Reply

    2cents on Mar, 6, 2013:

    I'll second that!

    Reply

Post a new comment    OR    Read more comments

Complete drug side effects:

On eHealthMe, Flexeril (cyclobenzaprine hydrochloride) is often used to treat muscle spasms. Effexor Xr (venlafaxine hydrochloride) is often used to treat depression. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

   

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