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Review: Flexeril and Lyrica

This review analyzes the effectiveness and drug interactions between Flexeril and Lyrica. It is created by eHealthMe based on reports of 1,712 people who take the same drugs from FDA and social media, and is updated regularly.

Stay connected: get help anytime and anywhere for people who take Flexeril and Lyrica >>>

What are the drugs

Flexeril (latest outcomes from 16,398 users) has active ingredients of cyclobenzaprine hydrochloride. It is often used in muscle spasms.

Lyrica (latest outcomes from 66,459 users) has active ingredients of pregabalin. It is often used in fibromyalgia.

On Jul, 14, 2014: 1,712 people who take Flexeril, Lyrica are studied

Flexeril, Lyrica outcomes

Drug combinations in study:
- Flexeril (cyclobenzaprine hydrochloride)
- Lyrica (pregabalin)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Flexeril is effective0.00%
(0 of 9 people)
9.09%
(1 of 11 people)
10.00%
(1 of 10 people)
30.00%
(3 of 10 people)
35.48%
(11 of 31 people)
21.43%
(3 of 14 people)
50.00%
(3 of 6 people)
50.00%
(1 of 2 people)
Lyrica is effective9.09%
(1 of 11 people)
21.74%
(5 of 23 people)
14.29%
(1 of 7 people)
33.33%
(6 of 18 people)
32.00%
(8 of 25 people)
44.44%
(4 of 9 people)
n/a0.00%
(0 of 1 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
DizzinessAnxietyMulti-organ FailurePainDepressionIrritabilityMuscle Contractions InvoluntaryPain
Vision BlurredDepressionHyperhidrosisAnxietyPainDepressionDry MouthAnxiety
Drug IneffectiveDizzinessNeutropeniaDepressionAnxietyBlood Cholesterol IncreasedAnxiety AggravatedOedema Peripheral
SomnolencePainSeptic ShockDizzinessWeight DecreasedDaydreamingIrritable Bowel SyndromeNausea
NauseaDrug IneffectiveAnxietyInsomniaParanoiaErythemaPanic Disorder With AgoraphobiaFatigue
Dry MouthWeight IncreasedWeight DecreasedConstipationDiabetes MellitusBlood Thyroid Stimulating Hormone IncreasedStiffness In A JointBack Pain
Oedema PeripheralNervousnessAmnesiaNauseaWeight IncreasedHypertensionFrequent HeadachesDrug Ineffective
PainConfusional StateDyspepsiaCardiac DisorderHypoaesthesiaWeight IncreasedBody OverheatingWeight Increased
Weight DecreasedNauseaWithdrawal SyndromeTremorMulti-organ FailureOedema PeripheralMeniere's DiseaseHypoaesthesia
Memory ImpairmentHypersensitivityNauseaHeadacheNeutropeniaSleep DisorderDry Eyes AggravatedArthralgia

Drug effectiveness by gender :

FemaleMale
Flexeril is effective25.32%
(20 of 79 people)
21.43%
(3 of 14 people)
Lyrica is effective27.50%
(22 of 80 people)
21.43%
(3 of 14 people)

Most common drug interactions by gender * :

FemaleMale
PainPain
Oedema PeripheralAnxiety
AnxietyNeuropathy Peripheral
NauseaDrug Ineffective
Weight IncreasedDizziness
FatigueFatigue
Drug IneffectiveBack Pain
Back PainDyspnoea
OsteoarthritisConstipation
DyspnoeaHypoaesthesia

Drug effectiveness by age :

0-12-910-1920-2930-3940-4950-5960+
Flexeril is effectiven/an/a100.00%
(1 of 1 people)
0.00%
(0 of 18 people)
15.09%
(8 of 53 people)
20.00%
(8 of 40 people)
5.97%
(4 of 67 people)
12.50%
(2 of 16 people)
Lyrica is effectiven/an/a0.00%
(0 of 1 people)
5.26%
(1 of 19 people)
18.52%
(10 of 54 people)
22.86%
(8 of 35 people)
5.88%
(4 of 68 people)
12.50%
(2 of 16 people)

Most common drug interactions by age * :

0-12-910-1920-2930-3940-4950-5960+
Foetal Exposure During Pregnancyn/aConvulsionPain In ExtremityPainPainPainPain
DeathConversion DisorderPulmonary EmbolismWeight IncreasedDrug IneffectiveOedema PeripheralAnxiety
DisorientationChest PainDepressionMuscle SpasmsFatigueAnaemia
Hallucination, AuditoryHypoaesthesiaDyspnoeaArthralgiaAnxietyHypertension
PyrexiaInsomniaDizzinessSomnolenceOsteoarthritisOedema Peripheral
AstheniaPulmonary EmbolismAnxietyNauseaOsteoarthritis
BronchitisNauseaDepressionHypoaesthesiaNausea
Influenza Like IllnessAbdominal Pain UpperVomitingWeight IncreasedArthralgia
CholecystitisFeeling AbnormalDyspnoeaOsteoporosisBack Pain
Cardiac Failure CongestiveAnxietyMemory ImpairmentBone PainDizziness

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

You can also:

Get connected! Join a mobile support group:
- group for people who take Flexeril and Lyrica
- group for people who take Flexeril
- group for people who take Lyrica

Comments from related studies:

  • From this study (2 months ago):

  • nerve twitching in hands and sometimes face. Muscle spasms from head to toe. Severe Migraines

    Reply

  • From this study (3 months ago):

  • Went off ambien cold turkey and started on clonidine, went to arthritis Dr and said fibromyalgia and she put me on lyrics 50 Mg 3 times a day but pain is worse. I have to take 10/325 percoset that only helps a little.

    Reply

  • From this study (6 months ago):

  • I am suffering from severe mood swings and nervousness. Sometimes I am so mad I want to rip something apart, most of the time my poor husband catches the brunt of it. My headaches are coming back, but I really want to get rid of the crazy mood swings before I hurt myself or someone else when i lose my temper maybe in a car driving, I will fly into a rage over little things...Please help me with this.
    What do I need to get OFF of OR ON...
    Thank you, Carolyn

    Reply

Post a new comment    OR    Read more comments

Can you answer these questions (what is this?):

  • I cannot get a direct answer from any of my drs.,is my sciatic pain caused by my interstitail cystitus?
    I have had interstitail cystitus for almost four years now.I have been on every kind of drug,other than pain pills.I will not take them,I don't believe in them they only mask the problem and cause addiction.of course,just my belief.I have had d.s.m.o. repetitively for first year and a half twice a w ...

  • Can droopy eyelid be caused by a bump and/or pregabalin?
    Had a bad bump on my forehead a couple of weeks ago and my whole face went black. Mostly better now but Im let with a badly drooping eyelid (right) which the doctors tell me will go away. No sign of that at the moment but Ive read that pregabalin (which I take in small doses, can cause this. It ...

  • Is anyone else with ms having problems getting off of lyrica?
    I am on 1.5 mg clonazepam and I take Betaseron injectables for my MS. I take 50 mg of Ellaville and one Prilosec that's it. I was on Lyrica for about three months and am having a horrible time trying to come down off of it. I would really like to know if anyone has tried the Lyrica oral suspension. ...

More questions for: Flexeril, Lyrica

You may be interested at these reviews (what is this?):

  • Review: could lyrica cause intracranial pressure increased?
    One dose (75mg) caused severe head pain (increased intracranial pressure) and nausea.

  • Lyrica caused my kidneys to shut down
    I was on Lyrica for 6 weeks and it almost killed me. I was so weak at the end that my daughter had to help me get out of bed go to the bathroom. I gained 22 lbs in 10 days. I gained over 40 lbs in 6 weeks. My ankles and feet were so swollen that the skin was starting to break open. I was in and out ...

  • Sleepwalking while on lyrica
    I have never had issues with sleepwalking until taking Lyrica. I have had some terrifying experiences like walking up in a hotel lobby in my short nightie. After several episodes, I stopped taking lyrica and stopped sleepwalking. Recently my doctor put me back on this drug and the first night I took ...

More reviews for: Flexeril, Lyrica

Complete drug side effects:

On eHealthMe, Flexeril (cyclobenzaprine hydrochloride) is often used to treat muscle spasms. Lyrica (pregabalin) is often used to treat fibromyalgia. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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