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Review: Flexeril and Lyrica

This review analyzes the effectiveness and drug interactions between Flexeril and Lyrica. It is created by eHealthMe based on 1,627 people who take the drugs. The review uses reports from FDA and social media, and is updated regularly.

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On Apr, 2, 2014: 1,627 people who reported to have interactions when taking Flexeril, Lyrica are studied

Trend of Flexeril, Lyrica's drug interactions, side effects and effectiveness reports (4276328)

Drug combinations in study:
- Flexeril (cyclobenzaprine hydrochloride)
- Lyrica (pregabalin)

eHealthMe real world results:

Most common interactions experienced by people in the use of Flexeril, Lyrica:

(click on each outcome to view in-depth analysis, incl. how people recovered)
InteractionNumber of reports
Pain1,031
Anxiety924
Arthralgia (joint pain)654
Dyspnoea (difficult or laboured respiration)619
Fatigue (feeling of tiredness)510
Nausea (feeling of having an urge to vomit)508
Oedema Peripheral (superficial swelling)504
Back Pain501
Drug Ineffective440
Hypoaesthesia (reduced sense of touch or sensation)434

Most common interactions experienced by people in long term use of Flexeril, Lyrica:

(click on each outcome to view in-depth analysis, incl. how people recovered)
InteractionNumber of reports
Anxiety49
Pain46
Depression46
Memory Impairment31
Weight Increased27
Hypertension (high blood pressure)26
Drug Ineffective22
Weight Decreased20
Insomnia (sleeplessness)20
Withdrawal Syndrome (a discontinuation syndrome is a set of symptoms occurred due to discontinuation of substance)16

How effective are the drugs:

not at allsomewhatmoderatehighvery high
Flexeril0.00%50.00%42.86%7.14%0.00%
Lyrica4.17%37.50%33.33%20.83%4.17%

Top conditions involved for these people * :

  1. Fibromyalgia
  2. Pain
  3. Hypertension
  4. Depression
  5. Rheumatoid arthritis

Top co-used drugs for these people * :

  1. Cymbalta
  2. Nexium
  3. Aspirin
  4. Ambien
  5. Lasix

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Related topic: Flexeril, Lyrica

You can also:

Complete drug side effects:

On eHealthMe, Flexeril (cyclobenzaprine hydrochloride) is often used to treat muscle spasms. Lyrica (pregabalin) is often used to treat fibromyalgia. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

Comments from related studies:

  • From this study (3 months ago):

  • I am suffering from severe mood swings and nervousness. Sometimes I am so mad I want to rip something apart, most of the time my poor husband catches the brunt of it. My headaches are coming back, but I really want to get rid of the crazy mood swings before I hurt myself or someone else when i lose my temper maybe in a car driving, I will fly into a rage over little things...Please help me with this.
    What do I need to get OFF of OR ON...
    Thank you, Carolyn

    Reply

  • From this study (3 months ago):

  • Diagnosed with non-diabetic small fiber neuropathy. Also moderate to severe stenosis lumbar spine. Cyst in lumbar spine. Also fusion c3-c4 and c6-c7 02 2013 with mylemacia.

    Constipation managed with high fiber diet until 08 2013. Then chronic constipation, treated with high volume enema, then Miralax pm, sennacot pm and am, colase am and Relistor injection every other day.

    Reply

  • From this study (7 months ago):

  • Night sweats constantly and once I get hot and start sweating I can't cool down. I just sweat more and more until I do something like blast a fan on me for a long time and I have to keep my a/c down really low. Any activity causes the sweating to start which begins at my head, face and neck and down my back.

    Reply

Post a new comment    OR    Read more comments

Can you answer these questions (what is this?):

  • Can trileptal cause a-fib
    I had an ablation. I got irregular hr on lyrica for neuropathy peripheral.md changed to oxcarbazepine. do these drugs cause a-fib. what is best pain med that does not cause a-fib or tachycardia.cymbalta,paxil Prozac caused atrial tachy and a-fib.?

  • Can i take ibuprophen while i'm taking lyrica
    I'm taking Lyrica for shingles. Although it has greatly helped with the pain, I still have considerable itchiness and pain upon touching the affected area. Can I take ibuprophen along with the lyrica? Any suggestions for the itch?

  • Can flexiral withdraw cause angina? also notice when it's time for a bowel movement
    I've had a resent (2 weeks ago) stress and nucular scan with no sign of heart attack. Also I get this feeling occasionally before a bowel movement

More questions for: Flexeril, Lyrica

You may be interested at these reviews (what is this?):

  • Lyrica caused my kidneys to shut down
    I was on Lyrica for 6 weeks and it almost killed me. I was so weak at the end that my daughter had to help me get out of bed go to the bathroom. I gained 22 lbs in 10 days. I gained over 40 lbs in 6 weeks. My ankles and feet were so swollen that the skin was starting to break open. I was in and out ...

  • Sleepwalking while on lyrica
    I have never had issues with sleepwalking until taking Lyrica. I have had some terrifying experiences like walking up in a hotel lobby in my short nightie. After several episodes, I stopped taking lyrica and stopped sleepwalking. Recently my doctor put me back on this drug and the first night I took ...

  • Off label use of drugs for peripheral neuropathy causing memory loss
    I have peripheral neuropathy with standard symptoms of burning, tingling, stabbing pain on the tops of my feet. I have had this condition for over 15 years getting worse over time. The last 5 years I have seen a couple of doctors and through trial and error we settled on a combination of Savella and ...

More reviews for: Flexeril, Lyrica

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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