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Review: taking Flexeril and Melatonin together

Summary: drug interactions are reported among people who take Flexeril and Melatonin together.

This review analyzes the effectiveness and drug interactions between Flexeril and Melatonin. It is created by eHealthMe based on reports of 106 people who take the same drugs from FDA and social media, and is updated regularly.


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On Mar, 27, 2015: 106 people who take Flexeril, Melatonin are studied

Flexeril, Melatonin outcomes

Drug combinations in study:
- Flexeril (cyclobenzaprine hydrochloride)
- Melatonin (melatonin)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Flexeril is effective0.00%
(0 of 1 people)
(2 of 4 people)
(2 of 5 people)
(3 of 4 people)
(0 of 2 people)
(0 of 1 people)
Melatonin is effectiven/a14.29%
(1 of 7 people)
(2 of 3 people)
(1 of 4 people)
(0 of 2 people)

Drug effectiveness by gender :

Flexeril is effective41.67%
(5 of 12 people)
(2 of 5 people)
Melatonin is effective30.77%
(4 of 13 people)
(0 of 3 people)

Drug effectiveness by age :

Flexeril is effectiven/an/an/a8.33%
(1 of 12 people)
(1 of 21 people)
(3 of 20 people)
(2 of 2 people)
(0 of 3 people)
Melatonin is effectiven/an/an/a0.00%
(0 of 16 people)
(1 of 20 people)
(1 of 20 people)
(1 of 1 people)
(1 of 3 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Exhaustion, Fatigue, Lethargy, Tiredness, WearinessNauseaNauseaNauseaCandidiasisFood IntoleranceVaginal SloughingPain
DystoniaExhaustion, Fatigue, Lethargy, Tiredness, WearinessDiarrheaNeck PainFood IntoleranceFood AllergyDepression
Language Disorder - ExpressiveInsomniaPain In JawFatigue - ChronicFood AllergyCandidiasisFatigue
CataplexyDiarrheaPain - BackInsomniaCandidal Infection NosCandidal Infection NosDiarrhoea
Spasm Of The EsophagusParkinsonismInsomniaBack PainFractureAnxiety
SpasticityRestless Legs SyndromeKnee PainAbdominal PainDrug Ineffective
Neuropathy - PeripheralNeuropathy - PeripheralRestless Legs SyndromeBack Pain
Restless Legs SyndromeOrthostatic HypotensionMuscle FatigueInsomnia
Numbness And TinglingNumbness And TinglingSweating - ExcessiveInjury
Musculoskeletal StiffnessDystoniaHigh Blood PressurePain In Extremity

Most common drug interactions by gender * :

Drug IneffectiveDiarrhoea
InsomniaPain In Extremity
DepressionBone Pain
NauseaBack Pain
Abdominal PainBone Lesion
DyspnoeaBone Disorder
Heart Rate IncreasedOsteonecrosis Of Jaw

Most common drug interactions by age * :

n/an/aPulmonary EmbolismNauseaPainFatigueDrug IneffectiveDiarrhoea
Deep Vein ThrombosisInsomniaArthralgiaPainDyspnoeaDepression
Fatigue - ChronicDepressionAnxietyRespiratory FailureFall
Deep Vein ThrombosisInsomniaDepressionMental Status ChangesHyperhidrosis
Neck PainFeeling AbnormalBack PainSeptic ShockMyocardial Infarction
Back PainBlood Creatinine IncreasedDiarrhoeaRenal Failure AcuteMuscle Spasms
Abdominal PainAngerPain In ExtremityIschaemic HepatitisWeight Decreased
DiarrheaCervicobrachial SyndromeCellulitisAcute Coronary SyndromeMuscle Strain
Pulmonary EmbolismSkin UlcerBone LesionAbdominal PainDrug Ineffective
Pain In JawDyspepsiaBone DisorderPanic AttackInjury

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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- support group for people who take Flexeril
- support group for people who take Melatonin

Recent related drug studies (Check your drugs):

Complete drug side effects:

On eHealthMe, Flexeril (cyclobenzaprine hydrochloride) is often used to treat muscle spasms. Melatonin (melatonin) is often used to treat insomnia. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.


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