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Review: Flexeril and Melatonin

This review analyzes the effectiveness and drug interactions between Flexeril and Melatonin. It is created by eHealthMe based on reports of 103 people who take the same drugs from FDA and social media, and is updated regularly.

Stay connected: join a mobile support group for people who take Flexeril and Melatonin >>>

What are the drugs

Flexeril (latest outcomes from 16,403 users) has active ingredients of cyclobenzaprine hydrochloride. It is often used in muscle spasms.

Melatonin (latest outcomes from 2,615 users) has active ingredients of melatonin. It is often used in insomnia.

On Jul, 27, 2014: 103 people who take Flexeril, Melatonin are studied

Flexeril, Melatonin outcomes

Drug combinations in study:
- Flexeril (cyclobenzaprine hydrochloride)
- Melatonin (melatonin)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Flexeril is effective0.00%
(0 of 1 people)
0.00%
(0 of 2 people)
n/a50.00%
(2 of 4 people)
75.00%
(3 of 4 people)
0.00%
(0 of 2 people)
0.00%
(0 of 1 people)
n/a
Melatonin is effectiven/a16.67%
(1 of 6 people)
100.00%
(1 of 1 people)
25.00%
(1 of 4 people)
0.00%
(0 of 2 people)
n/an/an/a

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Exhaustion, Fatigue, Lethargy, Tiredness, WearinessExhaustion, Fatigue, Lethargy, Tiredness, Wearinessn/aRestless Legs SyndromeCandidiasisFood IntoleranceVaginal SloughingPain
DystoniaVertigoMuscle FatigueFood IntoleranceFood AllergyDepression
Language Disorder - ExpressiveOrthostatic HypotensionPresyncopeFood AllergyCandidiasisFatigue
CataplexyPain - JointsDiarrheaCandidal Infection NosCandidal Infection NosDiarrhoea
Spasm Of The EsophagusNumbness And TinglingNauseaFractureAnxiety
SpasticityMusculoskeletal StiffnessHigh Blood PressureDrug Ineffective
Neuropathy - PeripheralParkinsonismSweating - ExcessiveBack Pain
Restless Legs SyndromeRestless Legs SyndromeUrinary FrequencyInsomnia
Numbness And TinglingSpasticityHeadachesInjury
Musculoskeletal StiffnessSpasm Of The EsophagusLoss Of Sensation, Numbness And Tingling, Paresthesias, Sensory Loss, Tingling And NumbnessPain In Extremity

Drug effectiveness by gender :

FemaleMale
Flexeril is effective40.00%
(4 of 10 people)
25.00%
(1 of 4 people)
Melatonin is effective27.27%
(3 of 11 people)
0.00%
(0 of 2 people)

Most common drug interactions by gender * :

FemaleMale
Drug IneffectiveDiarrhoea
PainPain
InsomniaPain In Extremity
DepressionDepression
FatigueGingival Ulceration
NauseaFatigue
Abdominal PainCellulitis
Heart Rate IncreasedBone Lesion
ParaesthesiaSinus Disorder
DyspnoeaInfection

Drug effectiveness by age :

0-12-910-1920-2930-3940-4950-5960+
Flexeril is effectiven/an/an/an/a4.76%
(1 of 21 people)
15.00%
(3 of 20 people)
100.00%
(1 of 1 people)
0.00%
(0 of 3 people)
Melatonin is effectiven/an/an/a0.00%
(0 of 4 people)
5.00%
(1 of 20 people)
5.00%
(1 of 20 people)
n/a33.33%
(1 of 3 people)

Most common drug interactions by age * :

0-12-910-1920-2930-3940-4950-5960+
n/an/aPulmonary EmbolismPulmonary EmbolismPainFatigueDrug IneffectiveDiarrhoea
Deep Vein ThrombosisDeep Vein ThrombosisArthralgiaPainDyspnoeaDepression
DepressionAnxietyHyperglycaemiaFall
InsomniaDepressionRhabdomyolysisHyperhidrosis
Feeling AbnormalBack PainAcute Coronary SyndromeMyocardial Infarction
Blood Creatinine IncreasedDiarrhoeaRespiratory FailureMuscle Spasms
AngerPain In ExtremityIschaemic HepatitisWeight Decreased
Cervicobrachial SyndromeCellulitisSeptic ShockMuscle Strain
Skin UlcerBone LesionMental Status ChangesDrug Ineffective
DyspepsiaBone DisorderRenal Failure AcuteInjury

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

You can also:

Get connected! Join a mobile support group:
- group for people who take Flexeril and Melatonin
- group for people who take Flexeril
- group for people who take Melatonin

Comments from related studies:

  • From this study (1 year ago):

  • I have had issues with high blood pressure for years & lost 60 pounds & still have to take 3 different medications for it. I have Candida severely & need to get rid of it & am wondering if any or all of these medications I am taking is cuasing any of these issues. I also have gluten issues, wheat issues, starch issues, peanut butter, chocolate, peanuts, nuts, white rice, potato issues, I can't eat a lot of foods & am struggling with my health. Please help!

    Reply

  • From this study (2 years ago):

  • Can any one of these medications, or any combination of them, cause ataxia?

    Reply

  • From this study (2 years ago):

  • Actonel: After approx 2 years of usage developed spontaneous left hip stress fracture and subsequent complete fracture of the hip. After workup by endocrinologist Actonel was stopped due to suspicion of this being contributing to cause of fracture.

    Reply

Can you answer these questions (what is this?):

More questions for: Flexeril, Melatonin

You may be interested at these reviews (what is this?):

  • Melatonin and diarrhea
    I have had difficulty sleeping most of my life. Difficulty going to sleep and waking up multiple times during the night were a usual pattern for me. Testing for sleep apnea did not show a positive result. A friend said to try Melatonin that for him it worked fine. I tried it and the diarrhea st ...

  • Melatonin and skin dryness
    I've been having hard time to sleep, so I started taking Melatonin. It is OTC sleep aid with melatonin and herbal treatment (lemon balm and camomile). about three days after started taking the drug, my back of hands started showing red rashes, then neck and around lips. a week after taking medica ...

  • Bad side effect of melatonin/imitrex use together
    I have taken melatonin for insomnia I've been experiencing recently (not a chronic condition). I haven't had any problems or interactions with my other regular medications while using the melatonin, other than drowsiness in the morning. Last night I had a migraine at bedtime, so took 50 mg. of imi ...

More reviews for: Flexeril, Melatonin

Complete drug side effects:

On eHealthMe, Flexeril (cyclobenzaprine hydrochloride) is often used to treat muscle spasms. Melatonin (melatonin) is often used to treat insomnia. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

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