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Review: taking Flexeril and Melatonin together

Summary: drug interactions are reported among people who take Flexeril and Melatonin together.

This review analyzes the effectiveness and drug interactions between Flexeril and Melatonin. It is created by eHealthMe based on reports of 106 people who take the same drugs from FDA and social media, and is updated regularly.

 

 

 

 

You are not alone: join a mobile support group for people who take Flexeril and Melatonin >>>

What are the drugs

Flexeril has active ingredients of cyclobenzaprine hydrochloride. It is often used in muscle spasms. (latest outcomes from 16,458 Flexeril users)

Melatonin has active ingredients of melatonin. It is often used in insomnia. (latest outcomes from 2,685 Melatonin users)

On Feb, 25, 2015: 106 people who take Flexeril, Melatonin are studied

Flexeril, Melatonin outcomes

Drug combinations in study:
- Flexeril (cyclobenzaprine hydrochloride)
- Melatonin (melatonin)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Flexeril is effective0.00%
(0 of 1 people)
50.00%
(2 of 4 people)
n/a40.00%
(2 of 5 people)
75.00%
(3 of 4 people)
0.00%
(0 of 2 people)
0.00%
(0 of 1 people)
n/a
Melatonin is effectiven/a14.29%
(1 of 7 people)
66.67%
(2 of 3 people)
25.00%
(1 of 4 people)
0.00%
(0 of 2 people)
n/an/an/a

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Exhaustion, Fatigue, Lethargy, Tiredness, WearinessNauseaNauseaNauseaCandidiasisFood IntoleranceVaginal SloughingPain
DystoniaExhaustion, Fatigue, Lethargy, Tiredness, WearinessDiarrheaNeck PainFood IntoleranceFood AllergyDepression
Language Disorder - ExpressiveInsomniaPain In JawFatigue - ChronicFood AllergyCandidiasisFatigue
CataplexyDiarrheaPain - BackInsomniaCandidal Infection NosCandidal Infection NosDiarrhoea
Spasm Of The EsophagusParkinsonismInsomniaBack PainFractureAnxiety
SpasticityRestless Legs SyndromeKnee PainAbdominal PainDrug Ineffective
Neuropathy - PeripheralNeuropathy - PeripheralRestless Legs SyndromeBack Pain
Restless Legs SyndromeOrthostatic HypotensionMuscle FatigueInsomnia
Numbness And TinglingNumbness And TinglingSweating - ExcessiveInjury
Musculoskeletal StiffnessDystoniaHigh Blood PressurePain In Extremity

Drug effectiveness by gender :

FemaleMale
Flexeril is effective41.67%
(5 of 12 people)
40.00%
(2 of 5 people)
Melatonin is effective30.77%
(4 of 13 people)
0.00%
(0 of 3 people)

Most common drug interactions by gender * :

FemaleMale
Drug IneffectiveDiarrhoea
PainPain
InsomniaPain In Extremity
DepressionBone Pain
NauseaBack Pain
FatigueCellulitis
Abdominal PainBone Lesion
DyspnoeaBone Disorder
Heart Rate IncreasedOsteonecrosis Of Jaw
ParaesthesiaCystitis

Drug effectiveness by age :

0-12-910-1920-2930-3940-4950-5960+
Flexeril is effectiven/an/an/a8.33%
(1 of 12 people)
4.76%
(1 of 21 people)
15.00%
(3 of 20 people)
100.00%
(2 of 2 people)
0.00%
(0 of 3 people)
Melatonin is effectiven/an/an/a0.00%
(0 of 16 people)
5.00%
(1 of 20 people)
5.00%
(1 of 20 people)
100.00%
(1 of 1 people)
33.33%
(1 of 3 people)

Most common drug interactions by age * :

0-12-910-1920-2930-3940-4950-5960+
n/an/aPulmonary EmbolismNauseaPainFatigueDrug IneffectiveDiarrhoea
Deep Vein ThrombosisInsomniaArthralgiaPainDyspnoeaDepression
Fatigue - ChronicDepressionAnxietyRespiratory FailureFall
Deep Vein ThrombosisInsomniaDepressionMental Status ChangesHyperhidrosis
Neck PainFeeling AbnormalBack PainSeptic ShockMyocardial Infarction
Back PainBlood Creatinine IncreasedDiarrhoeaRenal Failure AcuteMuscle Spasms
Abdominal PainAngerPain In ExtremityIschaemic HepatitisWeight Decreased
DiarrheaCervicobrachial SyndromeCellulitisAcute Coronary SyndromeMuscle Strain
Pulmonary EmbolismSkin UlcerBone LesionAbdominal PainDrug Ineffective
Pain In JawDyspepsiaBone DisorderPanic AttackInjury

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Get connected: join our support group of Flexeril and Melatonin on

Do you take Flexeril and Melatonin?

You are not alone! Join a related mobile support group:
- support group for people who take Flexeril and Melatonin
- support group for people who take Flexeril
- support group for people who take Melatonin

Can you answer these questions (Ask a question):

  • Will flexeril help with alcohol withdrawal anxiet????
    I have been suffering with alcohol withdrawals plus the flu the only meds that I have available is one flexor all will this help ease anxiety and let me sleep??
  • I take klonopin and diltiazem (calcium channel blocker blood pressure medicine) and am concerned about side effects. my accupuncturist recommends the ashwagandha. anyone have any issues with this?
    I take these prescription medications but have been going to an accupuncturist since 2012. I have trouble sleeping at night without my clonazepam and take naps during the day and am having trouble losing weight. She thinks that my adrenal glands may be fatigued and told me to try something called Adrenal Response which contains Sensoril Ashwagandha. When I looked up Ashwaganda it said that it could interact with the Clonazepam or Klonopin and also with High blood pressure medication. I am a little concerned. I mentioned this to her and she said they both are metabolized by the liver and it should be ok to take it, just to take it an hour or more after I take the Clonazepam. Has anyone had any issues with interactions with their prescribed meds while taking Ashwagandha? I don't want to have to monitor my blood pressure because my blood pressure medication works good for me. Any help would be appreciated because I want to try it but I am a little scared too. Thanks, Crystal
  • Can nuvigil (vs adderall) be used simultaneously to help wean off 60mg/day of adderall? (1 answer)
    I have been on Adderall 30mg 2x daily for years!! I've had it lowered to 20mg, I've TRIED to go months without it (when not working) however I feel I've built up a tolerance level to the point that it's not as effective as it once was. My personal life has detoured WAY past anything an ADHD medication can possibly help as far as focusing on NEEDED tasks etc. I end up feeling wrapped up in what I'm doing at the moment that my anxiety increases due to all that I haven't been able to accomplish. I take various medications for various reasons, depression, anxiety, bulimia etc., and for the most part the doses have varied based on circumstances and current need at said time of prescription.. MY FAMILY HAS A HISTORY OF HEART DISEASE, And realizing that I'm already on the highest Adderall dosage scares me (and THEN as I think about it, it makes my heart race!). I've also noticed increased muscle spasms as well as extreme and intense pressure on my jaw (TMJ). MY QUESTION IS: does anyone have any experience LOWERING their Adderall dosage AND adding Nuvigil? The research I've done to date gives me impression that it could help balance out the more extreme effects of Adderall (60mg/day) but that the nuvigil would or could potentially help with the EXTREME exhaustion I feel as Adderall wears off. Some days I just crash, some days I sleep fine and others no matter how hard I tryyyy, I just CAN'T fall asleep, therefore making the next day worse! IDEALLY I'D LIKE TO BE MED FREE, right now I need them, but am hoping maybe I can speak with my doctor to lower Adderall and add Nuvigil to help wean me off the amphetamines as well as lower dosage intake. YES, a lot of the anxiety, sleeplessness and depression are related to current circumstances in my life, however, where I am is not where I want to be or where I'm headed.. Life is a journey, and all my meds have become a part of a journey I never thought I'd find myself taking. I don't want life/meds to define me, or create a me I no longer recognize, because scarily enough that seems to be a common pattern. As I overcome each and every daily obstacle, I also don't want to be "hooked" on my meds or needing "more" to wake up/sleep/function.. I'd like to work on finding a solution towards weaning off my meds NOW, and work my way off slowly, primarily the Adderall. I'm hoping by suggesting to my doctor and showing him my research he may agree (IF ITS EVEN A LOGICAL COMBO, CLEARLY IM NOT A DOCTOR) nuvigil could help me. I've already started taking less of my anti depressants, trazadone and xanax without discussing with doc because he is always busy.. My next appt I want to go in fully prepared with a plan and an overall goal to REDUCE my Adderall dose, but overall, I'm clueless!!! I have no idea what other meds other than nuvigil "could" potentially help if at all. I could be entirely wrong, Anyone with any experience using one vs other or both simultaneously, or anyone with constructive input, PLEASE COMMENT/SHARE!!
  • Can i take melatonin if i take prograf?
    I take Prograf to prevent organ rejection in a liver transplant.
  • Why would i get copd since i never smoked?
    I have several autoimmune disorders, I was shocked to get the COPD diagnosis since I have never smoked but I had second hand smoke first 23 years of my life.
    My doctor said my Autoimmune Hepatitis and Primary Biliary Cholingitis set me up for COPD.

More questions for: Flexeril, Melatonin

You may be interested at these reviews (Write a review):

  • Melatonin and diarrhrea
    A lifetime of wakefulness during the night, almost never more than 7 hrs sleep and awake 2-4 times a night. Return to sleep easily. Doctors gave sleep aids. Usually somewhat ineffective and sometimes groggy mornings. So I decided to go the more natural route ... melatonin. Worse. It did not work for me. It gave me some if the wateriest and longest lasting diarrhea of my life. The uncontrolled continuous diarrhea was worse than not sleeping at night. Not listed as one of the side affects of Melatonin. More people should be made aware of the dangers of this dehydration.
  • I need advise, badly ckd!! (1 response)
    The orthostatic BP started in mid April, I was only dizzy upon wakening then it would subside. I have never been a big breakfast eater so I started doing that. We were in Disney later in April and I was extremely fatigued, to the point of not wanting to walk, Disney would be the first time I passed out when getting dizzy. I of course said I had gotten too warm and was exhausted from work the previous week. The dizziness continued in the mornings & I passed out several more times. On May 1st, I passed out while putting my make-up on and hit my eye on the faucet and head on the tile floor, despite that I went to work thinking it would subside, it didn't. I went to the ER directly after work. They ran a B-met on me and my GFR was 11 and creatinine 3.95. They admitted me to a larger hospital for evaluation. While in there, they pumped me with fluids continuously, saying I had severe dehydration. My kidney function improved, my creatinine levels went back down to 1.34. After 5 days I was discharged and told to see a cardiologist and endo. The endo doc cancelled my appointment on the basis it was not his area. I had had a cortisol and ACTH testing which I guess was normal. I saw the cardiologist, who said it wasn't cardio. I had had an echocardiogram in the hospital and EKG monitoring. Cardio sent me to neurology, the PNRN did a basic neurological exam and drew blood for disease markers such as Lupus, sjorgens, hepatitis, ect. All disease markers came back negative, but my GFR was at 11 again and creatinine was 4.25, BUN 50 along with an elevated ACE level. They called me and said I sarcoidosis. I really don't have any of the primary S/S of this autoimmune disease. I don't know where to go from here, they are referring me to another neurologist at a bigger hospital. I can't live my normal life, can't walk on my feet due extreme pain and I pass out at least 2x a week, which is not good for my old body. My BP upon laying and sitting runs like 117/72, upon standing it drops to like 70/50-50/30. I am on 0.1 mg of florinef, I tried increasing it but then my legs swelled up for a gain of 23#. I talked to Mayo Clinic today and all there specialists are booked out thru December. I have to be able to work, I can't stay home any longer than September 8th! Please advise me!
  • Melatonin reduces essential tremor of the hand
    After taking Melatonin 1mg as a sleep aid for several nights, I noticed that my essential tremor of the hand was showing improvement. Within a week the tremor was almost unnoticeable, and I could print and write neatly, even when slightly stressed at work. I haven't seen this response reported anywhere else; have other people noticed this effect?
  • I wish i had never taken ambien
    Ambien was prescribed after my sleep study showed severe sleep latency and awakening. In the five hours I slept I woke 85 times and had only 5 minutes of deep sleep. However, the doctors couldn't make a recommendation because they could detect no cause for the poor sleep pattern. My doctor offered Ambien and since I had obviously needed the help sleeping I took it. For the next 10 years I suffered incredible depression. For example I remember laying in bed staring at the ceiling with tears rolling into my ears but I was too tired to wipe them away and realizing that I wanted to die so badly but there was no way I could have done anything about it. The worst effects were the loss of consciousness and the verbal abuse that I heaped on my husband and son. An example of each : I actually had sex with my husband that I could not remember amd hundreds of other actions and discussions. My husband started asking every morning what I remembered of the night before. He could usually tell when I was Ambien-awake (his name for it) he said my eyes would get glassy and my voice cadence would be off. Unfortunately my oldest son was going from infant to 8 years old at this time and any ifraction or even without provocation I would scream horrible things in his face. I don't remember much of it but what I do remember causes me enormous regret. He went from a happy and active toddler to a terrified amd anxious pre-teen. We are still working through the effects of this behavior. Finally, after a surprise pregnancy (see example above) My baby was placed in NICU and I stayed at the Ronald McDonald House and my son and husband visited when they could. Somehow my Ambien prescription was stopped and so I began going through withdrawal but I had no idea what was going on. My vision became so blurred thqt I couldn't identify items unless they were very large and then only by colors. When I visited my son those several days in the NICU I couldn't walk straight and would try to aim myself toward my goal until I hit a wall and I would correct course. These things didn't bother me at all but the nurses in the NICU were with me nearly the entire day because they were afraid I would have a stroke or who knew. Finally, after discussing these symptoms we decided to gradually stop the medication. Thankfully, i didn't have any withdrawal symptoms then. I did feel like an incredibly heavy and black blanket had been lifted away. Ever since I have had very little trouble with depression despite the continuation of sleep disturbance and pain. On a scale from one to 10 for depression with 10 being committing suicide I think my 10 years on the medicine was probably an 8.5 (I desperately wanted to die) and since stopping the medication I don't think it has gone above a 4 and is usually a 2 or 3. I will spend the rest of my life trying to repair the damage my verbal abuse caused my oldest son and my husband. For 10 years they lived in fear of my rages if I had a bad episode with Ambien.
  • Melatonin and diarrhea (1 response)
    I have had difficulty sleeping most of my life. Difficulty going to sleep and waking up multiple times during the night were a usual pattern for me. Testing for sleep apnea did not show a positive result. A friend said to try Melatonin that for him it worked fine. I tried it and the diarrhea started almost immediately. Within days it was full blown water diarrhea. For fear of dehydration I stopped using Melatonin before two weeks time. And the hoped for results of helping my sleep problems were not solved with the Melatonin.

More reviews for: Flexeril, Melatonin

Comments from related studies:

  • From this study (2 years ago):

  • Can any one of these medications, or any combination of them, cause ataxia?

    Reply

  • From this study (3 years ago):

  • Actonel: After approx 2 years of usage developed spontaneous left hip stress fracture and subsequent complete fracture of the hip. After workup by endocrinologist Actonel was stopped due to suspicion of this being contributing to cause of fracture.

    Reply

  • From this study (45 years ago):

  • I have had issues with high blood pressure for years & lost 60 pounds & still have to take 3 different medications for it. I have Candida severely & need to get rid of it & am wondering if any or all of these medications I am taking is cuasing any of these issues. I also have gluten issues, wheat issues, starch issues, peanut butter, chocolate, peanuts, nuts, white rice, potato issues, I can't eat a lot of foods & am struggling with my health. Please help!

    Reply

Complete drug side effects:

On eHealthMe, Flexeril (cyclobenzaprine hydrochloride) is often used to treat muscle spasms. Melatonin (melatonin) is often used to treat insomnia. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

   

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