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Related topic: Flexeril, Methotrexate

Review: Flexeril and Methotrexate

This review analyzes the effectiveness and drug interactions between Flexeril and Methotrexate. It is created by eHealthMe based on 1,205 people who take the drugs. The review uses reports from FDA and social media, and is updated regularly.

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On Apr, 10, 2014: 1,205 people who take Flexeril, Methotrexate are studied

Flexeril, Methotrexate outcomes

Drug combinations in study:
- Flexeril (cyclobenzaprine hydrochloride)
- Methotrexate (methotrexate sodium)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Flexeril is effective25.00%
(1 of 4 people)
0.00%
(0 of 3 people)
0.00%
(0 of 3 people)
66.67%
(2 of 3 people)
25.00%
(1 of 4 people)
75.00%
(3 of 4 people)
80.00%
(4 of 5 people)
n/a
Methotrexate is effectiven/a0.00%
(0 of 3 people)
0.00%
(0 of 2 people)
100.00%
(1 of 1 people)
30.00%
(3 of 10 people)
0.00%
(0 of 2 people)
42.86%
(3 of 7 people)
n/a

Drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Muscle Spasms
(3 reports)

Retching
(3 reports)

Vomiting
(3 reports)

Stomatitis
(3 reports)

Abdominal Pain
(3 reports)

Cellulitis
(2 reports)

Acute Lymphocytic Leukaemia Recurrent
(2 reports)

Drug Ineffective
(1 report)

Gastrointestinal Disorder
(1 report)

Feeling Abnormal
(1 report)

Pneumonia
(5 reports)

Cellulitis
(4 reports)

Nausea
(4 reports)

Decreased Appetite
(4 reports)

Vomiting
(4 reports)

Jaundice
(4 reports)

Pyrexia
(3 reports)

Renal Impairment
(3 reports)

Pain
(3 reports)

Haematoma
(3 reports)

Cellulitis
(2 reports)

Hyperkeratosis
(1 report)

Hypersensitivity
(1 report)

Inflammatory Bowel Disease
(1 report)

Hot Flush
(1 report)

Incontinence
(1 report)

Graft Dysfunction
(1 report)

Diverticulum
(1 report)

Ear Pain
(1 report)

Fall
(1 report)

Osteonecrosis
(4 reports)

Graft Dysfunction
(3 reports)

Haematoma
(3 reports)

Hot Flush
(3 reports)

Hypersensitivity
(3 reports)

Fall
(3 reports)

Cerebrovascular Accident
(3 reports)

Depression
(3 reports)

Diverticulum
(3 reports)

Ear Pain
(3 reports)

Diarrhoea
(2 reports)

Dehydration
(2 reports)

Colitis Collagenous
(2 reports)

Blood Amylase Increased
(2 reports)

Drug Ineffective
(2 reports)

Lipase Increased
(2 reports)

Hypoglycaemia
(2 reports)

Diplegia
(2 reports)

Weight Decreased
(2 reports)

Pancreatitis
(2 reports)

Hypoglycaemia
(2 reports)

Liver Function Test Abnormal
(1 report)

Interstitial Lung Disease
(1 report)

Blood Lactate Dehydrogenase Increased
(1 report)

Aspartate Aminotransferase Increased
(1 report)

Respiratory Tract Infection
(1 report)

Alanine Aminotransferase Increased
(1 report)

Mental Disorder
(1 report)

Dyspnoea
(1 report)

Deep Vein Thrombosis
(1 report)

Nausea
(2 reports)

Sepsis
(2 reports)

Rheumatoid Arthritis
(2 reports)

Pneumonia
(2 reports)

Hypothyroidism
(1 report)

Hysterectomy
(1 report)

Intervertebral Disc Degeneration
(1 report)

Hypertension
(1 report)

Irritable Bowel Syndrome
(1 report)

Hiatus Hernia
(1 report)

Pain
(113 reports)

Fatigue
(87 reports)

Arthralgia
(79 reports)

Oedema Peripheral
(74 reports)

Nausea
(72 reports)

Abdominal Pain
(67 reports)

Bone Pain
(66 reports)

Diarrhoea
(64 reports)

Fall
(62 reports)

Osteoarthritis
(60 reports)

Drug effectiveness by gender :

FemaleMale
Flexeril is effective50.00%
(10 of 20 people)
16.67%
(1 of 6 people)
Methotrexate is effective15.79%
(3 of 19 people)
66.67%
(4 of 6 people)

Drug interactions by gender * :

FemaleMale
Common drug interactions Pain
(113 reports)

Fatigue
(99 reports)

Nausea
(92 reports)

Arthralgia
(88 reports)

Oedema Peripheral
(79 reports)

Fall
(71 reports)

Diarrhoea
(71 reports)

Abdominal Pain
(67 reports)

Bone Pain
(65 reports)

Anaemia
(64 reports)

Arthralgia
(19 reports)

Pain
(17 reports)

Oedema Peripheral
(16 reports)

Chest Pain
(14 reports)

Fatigue
(14 reports)

Nausea
(14 reports)

Muscle Spasms
(13 reports)

Pain In Extremity
(13 reports)

Drug Ineffective
(12 reports)

Hypoaesthesia
(12 reports)

Drug effectiveness by age :

0-12-910-1920-2930-3940-4950-5960+
Flexeril is effectiven/an/an/an/a9.09%
(1 of 11 people)
20.00%
(2 of 10 people)
43.75%
(7 of 16 people)
25.00%
(1 of 4 people)
Methotrexate is effectiven/an/an/an/a22.22%
(2 of 9 people)
10.00%
(1 of 10 people)
21.43%
(3 of 14 people)
25.00%
(1 of 4 people)

Drug interactions by age * :

0-12-910-1920-2930-3940-4950-5960+
Common drug interactions n/an/aAsthma Aggravated
(4 reports)

Vertigo
(3 reports)

Dysarthria
(3 reports)

Hypoaesthesia
(3 reports)

Tremor
(3 reports)

Rheumatoid Arthritis Aggravated
(3 reports)

Vision Blurred
(3 reports)

Loss Of Consciousness
(2 reports)

Blood Urea Increased
(2 reports)

Autoimmune Deficiency Syndrome
(2 reports)

Headache
(7 reports)

Nausea
(5 reports)

Rheumatoid Arthritis
(4 reports)

Tachycardia
(3 reports)

Gallbladder Disorder
(3 reports)

Dyspnoea
(3 reports)

Acute Lymphocytic Leukaemia Recurrent
(2 reports)

Syringomyelia
(2 reports)

Vaginal Haemorrhage
(2 reports)

Paraesthesia
(2 reports)

Pain
(8 reports)

Drug Ineffective
(6 reports)

Pneumonia
(5 reports)

Arthralgia
(5 reports)

Nausea
(5 reports)

Vomiting
(5 reports)

Injection Site Haemorrhage
(4 reports)

Weight Increased
(3 reports)

Cough
(3 reports)

Rash
(3 reports)

Arthralgia
(18 reports)

Pain
(17 reports)

Oedema Peripheral
(16 reports)

Injection Site Pain
(16 reports)

Nausea
(16 reports)

Rheumatoid Arthritis
(13 reports)

Vomiting
(13 reports)

Headache
(12 reports)

Dyspnoea
(11 reports)

Hypoaesthesia
(11 reports)

Fatigue
(54 reports)

Pain
(52 reports)

Abdominal Pain
(50 reports)

Diarrhoea
(44 reports)

Bone Pain
(43 reports)

Nausea
(43 reports)

Oedema Peripheral
(43 reports)

Swelling
(40 reports)

Osteoarthritis
(38 reports)

Arthralgia
(34 reports)

Pain
(39 reports)

Arthralgia
(35 reports)

Fatigue
(34 reports)

Anaemia
(31 reports)

Dyspnoea
(31 reports)

Fall
(29 reports)

Oedema Peripheral
(27 reports)

Pain In Extremity
(27 reports)

Deep Vein Thrombosis
(27 reports)

Hypertension
(26 reports)

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

You can also:

Complete drug side effects:

On eHealthMe, Flexeril (cyclobenzaprine hydrochloride) is often used to treat muscle spasms. Methotrexate (methotrexate sodium) is often used to treat rheumatoid arthritis. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

Comments from related studies:

  • From this study (12 months ago):

  • began sweating 10 years ago, while up in New England, but it is worse now that we moved to Florida 10 years ago. I can only tolerate temperatures 72 degrees or less with little humidity - 50 %

    Reply

    Mrs Kathy Houy on Dec, 26, 2012:

    you mean I get to sweat for years!!!!!!!!!!!!! OMG

    Reply

    Jacqueline on Dec, 23, 2012:

    I am very concerned with Enbrel my husband was diagnosed with Glioblastoma Stage 4 brain cancer. My husband has RA and Sjogrens and started to take Enbrel about a 1 1/2years ago. I am concerned that Enbrel might have played a part with his brain tumor. My husband had brain surgery and 2 weeks later chemo and radiation. We completed radiation and chemo just 2 weeks ago, we now have to wait for a scan for about another 3 weeks to see how the treatment is taking for his tumor. This drug makes me wonder if there might be a correlation between the two!

    Reply

    Interested party on Dec, 21, 2012:

    If you need temperatures less than 72 degrees it may be beneficial to move to Ireland. It only gets to 65 degrees in the summertime. Perhaps you would be more comfortable there, Florida is one of the worst places you could live for your condition.

    Hope this helps.

    Reply

    Karen on Dec, 24, 2012:

    Sorry. I travel to Ireland quite frequently and it often gets much warmer than 65 degrees in the summer. It IS infinitely cooler than Florida but the humidity is just as high, if not higher.

    Reply

    Mrs. Kathy Houy on Dec, 26, 2012:

    I'm so sorry about your husband God bless you both I cried when I read your post Kathy

    Reply

    subregret on Feb, 23, 2013:

    suboxone is a nightmare and should never be used unless you are a hopeless heroin addict. People who call it a miracle drug are either ignorant or have not been on it long. I say this becuase when you stop suboxone YOU WILL SUFFER!! not only will you suffer but you will suffer for a long long time. Regualar opiate withdrawal lasts 7-10 days. Suboxone withdrawal lasts 60-90 days. I would honestly pick methadone if I had the choice to do it again. Because I quit 80 mg methadone before and it sucked but have been trying to stop suboxone now for years at only 1/2 milligram. My doctor is of no help and tells me he dosent know what to do as he hands me another prescription. YOU ALL HAVE BEEN WARNED..this crap is poison!!

    Reply

    Robert on Feb, 26, 2013:

    Can you tell me if you or your husband did any kind of experimenting with hallucinogens?

    Reply

    Robert on Feb, 26, 2013:

    I had the exact opposite with the us of Soboxone vs. Methadone.
    When I tried Methadone it was just like taking heroin. Then we all learned that we could also get the Meth off the street from people selling there take homes. My friends and I just replaced the Heroin for the Methadone. At this time all the people that got on the Methadone program are still taking there methadone or they are now dead. When I got off the Meth it was just like getting off heroin all the physical symptoms and mental ones.
    I then went to try the Suboxone. I started with the full 8mg then dropping down to the 4mg and ending up being very happy with 2 mg for the rest of my life.This time I wanted to be clean so getting off the 2 mg of suboxone was 90% mental and 10% physical withdrawal. Had 3 days physical pain everyday got much better after the 3rd day. Then there was the depression and the lack of energy that does come back.

    Reply

    Krakow on Apr, 30, 2013:

    The suboxone I believe will be impossible to get off. The withdrawals last 8 months over, and then comes the post acute phase which can last all your life. The suboxone damages seronitin and dopamine permanently, this is a fact. So many have said its a death sentence coming off it as well as staying on it. I promise you there is no way out.

    Reply

    Goku on May, 4, 2013:

    Actually suboxone withdrawals does not at all last 8 months, i know everyone is different, but the actual withdrawals,(the real bad ones) will not last but around 17 gruesome days, then some time after that you will feel a little weak. I was on opiates for at least 2-3 years before getting on suboxone, then was on suboxone for 3 whole entire years, (not missing 1 dose the whole time) once i stopped, cold turkey, i felt awful for about 17 days, then weak for 2 weeks, then started getting my energy back, i believe suboxone is a great drug to "trade" for multiple drugs you've been taking, once you feel though you have had enough of the suboxone, or subutex, i encourage anyone that wants to quit (i advise talking to your Dr. but i wouldn't agree with tapering down, that's just me) and just have the will to KNOW you can do it, and go play golf, run, swim, try to work out(lightly), watch movies/shows you love, have some music (a perfect circle - the 13th step helped me more than ANYTHING) and drink and eat healthy, and keep you some chocolate milk handy (chocolate releases endorphins in your brain) and just fight through it, i know you can do it, just do it for you and only you, and have faith in yourself, also i recommend some isolation, i really hope this helps someone, i seen this comment on here, and had to reply, god bless the addicts

    Reply

    Kristie on May, 25, 2013:

    My 25 year old male cousin committed suicide two weeks ago today. He had just stopped taking suboxin. I wish we had read all this stuff before then :( I had no idea that this could happen. It's a nightmare now.

    Reply

    finally on May, 29, 2013:

    The key to quitting sub is tapering over a very long period of time. I finally jumped about 10 days ago after taking 1mg for a month, i feel pretty good today. I was on sub for almost two years and started off on 20mg a day. Yes I had terrible insomnia for about 5 nights, but it was manageable because I knew they wouldn't last forever. This experience was nothing like how i felt during my past attempts to quit opiates so don't even compare the two. go slow and u will be pleasantly surprised how mild your withdrawals will be. Just knowing you are closing the chapter to your opiate addiction will get you through. It is such a relief to have this behind me. Every day will get easier, I promise.

    Reply

  • From this study (1 year ago):

  • Looking for effect on blood sugar

    Reply

  • From this study (1 year ago):

  • Insomnia with lyrica. It's 5:30 am. 1 week on the drug. It's getting worse.

    Reply

Post a new comment    OR    Read more comments

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