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Review: taking Flexeril and Methotrexate together

Summary: drug interactions are reported among people who take Flexeril and Methotrexate together.

This review analyzes the effectiveness and drug interactions between Flexeril and Methotrexate. It is created by eHealthMe based on reports of 1,206 people who take the same drugs from FDA and social media, and is updated regularly.

 

 

 

 

You are not alone: join a mobile support group for people who take Flexeril and Methotrexate >>>

What are the drugs

Flexeril has active ingredients of cyclobenzaprine hydrochloride. It is often used in muscle spasms. (latest outcomes from 16,458 Flexeril users)

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. (latest outcomes from 131,243 Methotrexate users)

On Feb, 28, 2015: 1,206 people who take Flexeril, Methotrexate are studied

Flexeril, Methotrexate outcomes

Drug combinations in study:
- Flexeril (cyclobenzaprine hydrochloride)
- Methotrexate (methotrexate sodium)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Flexeril is effective25.00%
(1 of 4 people)
0.00%
(0 of 3 people)
0.00%
(0 of 3 people)
66.67%
(2 of 3 people)
40.00%
(2 of 5 people)
75.00%
(3 of 4 people)
80.00%
(4 of 5 people)
n/a
Methotrexate is effectiven/a0.00%
(0 of 4 people)
0.00%
(0 of 2 people)
100.00%
(1 of 1 people)
30.00%
(3 of 10 people)
0.00%
(0 of 2 people)
42.86%
(3 of 7 people)
n/a

Drug effectiveness by gender :

FemaleMale
Flexeril is effective52.38%
(11 of 21 people)
16.67%
(1 of 6 people)
Methotrexate is effective15.00%
(3 of 20 people)
66.67%
(4 of 6 people)

Drug effectiveness by age :

0-12-910-1920-2930-3940-4950-5960+
Flexeril is effectiven/an/an/an/a9.09%
(1 of 11 people)
21.43%
(3 of 14 people)
43.75%
(7 of 16 people)
25.00%
(1 of 4 people)
Methotrexate is effectiven/an/an/an/a22.22%
(2 of 9 people)
7.14%
(1 of 14 people)
21.43%
(3 of 14 people)
25.00%
(1 of 4 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Muscle SpasmsPneumoniaCellulitisOsteonecrosisDiarrhoeaHypoglycaemiaNauseaPain
RetchingCellulitisHyperkeratosisGraft DysfunctionDrug IneffectiveLiver Function Test AbnormalSepsisFatigue
VomitingDecreased AppetiteHypersensitivityHaematomaLipase IncreasedInterstitial Lung DiseaseRheumatoid ArthritisArthralgia
StomatitisNauseaInflammatory Bowel DiseaseHot FlushDehydrationBlood Lactate Dehydrogenase IncreasedPneumoniaNausea
Abdominal PainVomitingHot FlushHypersensitivityColitis CollagenousAspartate Aminotransferase IncreasedHypothyroidismOedema Peripheral
CellulitisJaundiceIncontinenceFallAlanine Aminotransferase IncreasedRespiratory Tract InfectionHysterectomyFall
Acute Lymphocytic Leukaemia RecurrentRenal ImpairmentGraft DysfunctionCerebrovascular AccidentAspartate Aminotransferase IncreasedAlanine Aminotransferase IncreasedIntervertebral Disc DegenerationDiarrhoea
Drug IneffectivePyrexiaDiverticulumDepressionBlood Amylase IncreasedMental DisorderHypertensionAbdominal Pain
Gastrointestinal DisorderHaematomaEar PainDiverticulumPancreatitisDyspnoeaIrritable Bowel SyndromePain In Extremity
Feeling AbnormalBlood Pressure AbnormalFallEar PainHeadachesDeep Vein ThrombosisHiatus HerniaDyspnoea

Most common drug interactions by gender * :

FemaleMale
PainArthralgia
FatiguePain
NauseaOedema Peripheral
ArthralgiaChest Pain
Oedema PeripheralFatigue
FallNausea
DiarrhoeaMuscle Spasms
Abdominal PainPain In Extremity
Bone PainDrug Ineffective
AnaemiaHypoaesthesia

Most common drug interactions by age * :

0-12-910-1920-2930-3940-4950-5960+
n/an/aAmblyopia NosHeadachePainArthralgiaFatiguePain
Asthma AggravatedNauseaDrug IneffectivePainPainArthralgia
Headache NosRheumatoid ArthritisPneumoniaInjection Site PainAbdominal PainFatigue
Vomiting NosTachycardiaArthralgiaNauseaDiarrhoeaAnaemia
VertigoGallbladder DisorderNauseaOedema PeripheralBone PainDyspnoea
DysarthriaDyspnoeaVomitingVomitingNauseaFall
Tongue Disorder NosAcute Lymphocytic Leukaemia RecurrentInjection Site HaemorrhageRheumatoid ArthritisOedema PeripheralOedema Peripheral
HypoaesthesiaSyringomyeliaWeight IncreasedHeadacheSwellingPain In Extremity
TremorVaginal HaemorrhageCoughWeight DecreasedOsteoarthritisDeep Vein Thrombosis
Chorea NosParaesthesiaRashHypoaesthesiaArthralgiaHypertension

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Get connected: join our support group of Flexeril and Methotrexate on

Do you take Flexeril and Methotrexate?

You are not alone! Join a related mobile support group:
- support group for people who take Flexeril and Methotrexate
- support group for people who take Flexeril
- support group for people who take Methotrexate

Recent conversations of related support groups:

Can you answer these questions (Ask a question):

  • Is there a drug interaction between paxil and flexeril?
    What is the drug interaction, if any between paxil and flexeril? I was taken off a low dosage of paxil two weeks or so ago an due to back issues was issued flexeril for spasms and pain. I try to avoid meds like this but really need it and wanted to know if it was safe. I read about major drug interaction between these two medications and that is why I suffered through pain because I was concerned. Please advise if I can take flexeril now.
  • Will flexeril help with alcohol withdrawal anxiet????
    I have been suffering with alcohol withdrawals plus the flu the only meds that I have available is one flexor all will this help ease anxiety and let me sleep??
  • Does humira cause excessive sweating?
    Having psoriaticarthritis,fibromyalgia,psoriais,restless leg syndrome,roseacea and high blood pressure means complex health issues and a complex list of medication to go with it. Iam suffering extreme sweating,flushing and now a tickled cough. Now it could be due to going through the change (menopause) but that started a year ago and although I was getting the flushes and sweating,it was nothing like it is now! To me,it seems the excessive sweating started roughly a month after taking Humira. Having so many health issues I'm in tune with any changes and note and monitor them. I started Humira 10 months ago now. My Psoriasis has cleared completely so I'm really pleased. Usually,there's a trade off and you end up with something else! Could the issues I have be down to a single drug on the list,or a combination?
  • Would the tinnitus abate with if i discontinue methotrexate?
    I've just begun my 4th year of Methotrexate for Rheumatoid issue, but it also alleviated my psoriasis. I am hesitant to discontinue because the benefits are great. However, the tinnitus is becoming unbearable and almost maddening. I will more likely consider talking to my doctor about changing medications if 1. The tinnitus subsides with the discontinuance of Methotrexate and if 2. Other rheumatoid medication would not have the same issues with tinnitus. Just discovered the possible connection minutes ago and am eager and hopeful. Please help. Thank you. -Celeste
  • Can i take humira while i still have pinpoint red spots on my skin? i have been told to stop the methotrextrate and they started me on prednisone to clear it up, i am scheduled to start humira.
    I have been diagnosed with R/A and started taking Methotrextate and Folic Acid. I began to break out like I had the measles. Was told it was a reaction to the methotrextate. I was taken off of it and given a large dose of prednisone. My question is I am scheduled to start taking Humira injections and I have been off of the methotrextate 24 days and it has not cleared up yet. Is is safe to start the Humira injections?

More questions for: Flexeril, Methotrexate

You may be interested at these reviews (Write a review):

  • Muscle weakness from methotrexate
    I'm 61 and have taken methotrexate for 25 yrs. I've always done well with my blood results etc. Lately I've been having problems pushing a grocery cart. My arm muscles are so weak!
  • Having leg cramps after 2 years on enbrel
    Started having leg cramps after using Enbrel for almsot 2 years. They start the day I give the injection and have lasted 1-3 days waking me several time in the middle of the night.
  • Humira: my experience
    I have had some form of arthritis probably since birth. My father and maternal grandfather had some form of arthritis. I began to realize pain in both ankles if I stood or walked too long.

    I began taking many NSAIDs when I was around 22. I've done gold, prednisone (twice), plaquenil, butazoidin, sulfasalazine, etc. My best results came with methotrexate after I got cellulitis in my knee (scratch it while kayaking in the summer, fiberglass boat). It dropped my sed rate from over 100 to 35 or so within a few months. I continued with MTX from 1977 to 2000 when my MD suggested Enbrel and stopping MTX. That was a VERY bad decision. Enbrel appeared to mask the disease for a few years. I had my left MCP replaced in 2004, my right heel debrided in 2010, and both my TMJs replaced in 2012. I strongly believe that if I had kept with the MTX it would have delayed those changes. Additionally, in 2011 I was in a bus crash returning from RAGBRAI. I got knocked out from three to six minutes. I had a nasty concussion that lasted 2+ years. Towards the end of the third year post accident I started exercising more aggressively. After doing several 40, 50, and 60 miles rides, I took a leisurely 50 mile ride around Boston at night. Two days later I had a spinal edema. So much for biking and other active sports! :-(

    I have continued with MTX. Late 2013 my MD increased my MTX to .8/week. I had been taking .6/week. I stopped taking Enbrel and switched to Humira in early 2014. I took it for a few months before my doc and I realized it was not doing any better than Enbrel. I tried Humira for three months but it did not seem to work any better than Enbrel. In early June I stopped Humira and waited a few weeks before I started Otezla. I stopped Oterzla on 9/15/14 because it made me depressed and allowed my morning stiffness to get much worse.

    I started prednisone again from the start of July. By mid-August I told my MD that I was screaming louder than I ever had; my dog was very startled. I stopped it gradually over the next two weeks. Meanwhile, the Otezla made me feel awful.

    My MD is going to get me onto another injectable that I take monthly. I forget its name.
  • I wish i had never taken ambien
    Ambien was prescribed after my sleep study showed severe sleep latency and awakening. In the five hours I slept I woke 85 times and had only 5 minutes of deep sleep. However, the doctors couldn't make a recommendation because they could detect no cause for the poor sleep pattern. My doctor offered Ambien and since I had obviously needed the help sleeping I took it. For the next 10 years I suffered incredible depression. For example I remember laying in bed staring at the ceiling with tears rolling into my ears but I was too tired to wipe them away and realizing that I wanted to die so badly but there was no way I could have done anything about it. The worst effects were the loss of consciousness and the verbal abuse that I heaped on my husband and son. An example of each : I actually had sex with my husband that I could not remember amd hundreds of other actions and discussions. My husband started asking every morning what I remembered of the night before. He could usually tell when I was Ambien-awake (his name for it) he said my eyes would get glassy and my voice cadence would be off. Unfortunately my oldest son was going from infant to 8 years old at this time and any ifraction or even without provocation I would scream horrible things in his face. I don't remember much of it but what I do remember causes me enormous regret. He went from a happy and active toddler to a terrified amd anxious pre-teen. We are still working through the effects of this behavior. Finally, after a surprise pregnancy (see example above) My baby was placed in NICU and I stayed at the Ronald McDonald House and my son and husband visited when they could. Somehow my Ambien prescription was stopped and so I began going through withdrawal but I had no idea what was going on. My vision became so blurred thqt I couldn't identify items unless they were very large and then only by colors. When I visited my son those several days in the NICU I couldn't walk straight and would try to aim myself toward my goal until I hit a wall and I would correct course. These things didn't bother me at all but the nurses in the NICU were with me nearly the entire day because they were afraid I would have a stroke or who knew. Finally, after discussing these symptoms we decided to gradually stop the medication. Thankfully, i didn't have any withdrawal symptoms then. I did feel like an incredibly heavy and black blanket had been lifted away. Ever since I have had very little trouble with depression despite the continuation of sleep disturbance and pain. On a scale from one to 10 for depression with 10 being committing suicide I think my 10 years on the medicine was probably an 8.5 (I desperately wanted to die) and since stopping the medication I don't think it has gone above a 4 and is usually a 2 or 3. I will spend the rest of my life trying to repair the damage my verbal abuse caused my oldest son and my husband. For 10 years they lived in fear of my rages if I had a bad episode with Ambien.
  • Psoratic arthritis and trigeminal neuralgia
    hi i suffer from psorisis and psoratic athritis i was just diagnosed with trigeminal neuralgia i was looking for the connection between the two and i see that there is one from your study
    the thing is all 13 people in the study said to have psoriatic arthropathy yet only one said to have psoratic arthritis yet to the best of my knowledge it is the same condition just a diffrent name which means all those studied have psoratic arthritis like me
    also i have not been taking those medicines in the study yet i have the same condition so if you take me into account could be the oly conecction between all of us is the psorisis and psoratic arthritis and not the medicine

More reviews for: Flexeril, Methotrexate

Comments from related studies:

  • From this study (11 months ago):

  • The abnormal dreams & mild hallucinations came only after starting the methylprednisolone a few days ago. They happen primarily when I am sleeping. I woke up last night with very unusual dreams & head/brain pain, and was quite concerned. I had taken 1 methylprednisolone & 1 cymbalta before bed. Earlier in the day, I had taken 2 methylprednisolone & 2 tramadol before a nap, and had similar, though not as severe issues. Trying to figure out what the interaction problem is. I did not take the muscle relaxant (cyclopenzaprine) before bed since I started the cortico steroid pack.

    Reply

    britsarmymom on Apr, 26, 2014:

    Mother just survived near brush with respiratory arrest. Hallucinated at night on Tramadol, argumentative with RN who reported her to MD. He planned to ADD Seroquel 25 mg to Tramadol, Neurontin, Remeron and Ativan in rehab facility. She declined Tramadol and Seroquel and was still so sedated her pulse ox went down to 84 with long periods of apnea and need for constant obs with frequent rousing for airway. MAJOR struggle with RN to get 02 and MD agreed to no more Tramodol at night and absolutely no Seroquel. How many elderly are lost this way?

    Reply

  • From this study (2 years ago):

  • began sweating 10 years ago, while up in New England, but it is worse now that we moved to Florida 10 years ago. I can only tolerate temperatures 72 degrees or less with little humidity - 50 %

    Reply

    Mrs Kathy Houy on Dec, 26, 2012:

    you mean I get to sweat for years!!!!!!!!!!!!! OMG

    Reply

Post a new comment    OR    Read more comments

Complete drug side effects:

On eHealthMe, Flexeril (cyclobenzaprine hydrochloride) is often used to treat muscle spasms. Methotrexate (methotrexate sodium) is often used to treat rheumatoid arthritis. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

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