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Review: Flexeril and Methotrexate

This review analyzes the effectiveness and drug interactions between Flexeril and Methotrexate. It is created by eHealthMe based on reports of 1,205 people who take the same drugs from FDA and social media, and is updated regularly.

Get connected: join a mobile support group for people who take Flexeril and Methotrexate >>>

What are the drugs

Flexeril (latest outcomes from 16,427 users) has active ingredients of cyclobenzaprine hydrochloride. It is often used in muscle spasms.

Methotrexate (latest outcomes from 131,137 users) has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis.

On Sep, 19, 2014: 1,205 people who take Flexeril, Methotrexate are studied

Flexeril, Methotrexate outcomes

Drug combinations in study:
- Flexeril (cyclobenzaprine hydrochloride)
- Methotrexate (methotrexate sodium)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Flexeril is effective25.00%
(1 of 4 people)
(0 of 3 people)
(0 of 3 people)
(2 of 3 people)
(1 of 4 people)
(3 of 4 people)
(4 of 5 people)
Methotrexate is effectiven/a0.00%
(0 of 3 people)
(0 of 2 people)
(1 of 1 people)
(3 of 10 people)
(0 of 2 people)
(3 of 7 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Muscle SpasmsPneumoniaCellulitisOsteonecrosisDiarrhoeaHypoglycaemiaNauseaPain
RetchingCellulitisHyperkeratosisGraft DysfunctionDehydrationLiver Function Test AbnormalSepsisFatigue
VomitingNauseaHypersensitivityHaematomaColitis CollagenousInterstitial Lung DiseaseRheumatoid ArthritisArthralgia
StomatitisDecreased AppetiteInflammatory Bowel DiseaseHot FlushBlood Amylase IncreasedBlood Lactate Dehydrogenase IncreasedPneumoniaNausea
Abdominal PainVomitingHot FlushHypersensitivityDrug IneffectiveAspartate Aminotransferase IncreasedHypothyroidismOedema Peripheral
CellulitisJaundiceIncontinenceFallLipase IncreasedRespiratory Tract InfectionHysterectomyFall
Acute Lymphocytic Leukaemia RecurrentPyrexiaGraft DysfunctionCerebrovascular AccidentHypoglycaemiaAlanine Aminotransferase IncreasedIntervertebral Disc DegenerationDiarrhoea
Drug IneffectiveRenal ImpairmentDiverticulumDepressionDiplegiaMental DisorderHypertensionAbdominal Pain
Gastrointestinal DisorderPainEar PainDiverticulumWeight DecreasedDyspnoeaIrritable Bowel SyndromePain In Extremity
Feeling AbnormalHaematomaFallEar PainPancreatitisDeep Vein ThrombosisHiatus HerniaDyspnoea

Drug effectiveness by gender :

Flexeril is effective50.00%
(10 of 20 people)
(1 of 6 people)
Methotrexate is effective15.79%
(3 of 19 people)
(4 of 6 people)

Most common drug interactions by gender * :

NauseaOedema Peripheral
ArthralgiaChest Pain
Oedema PeripheralFatigue
DiarrhoeaMuscle Spasms
Abdominal PainPain In Extremity
Bone PainDrug Ineffective

Drug effectiveness by age :

Flexeril is effectiven/an/an/an/a9.09%
(1 of 11 people)
(2 of 10 people)
(7 of 16 people)
(1 of 4 people)
Methotrexate is effectiven/an/an/an/a22.22%
(2 of 9 people)
(1 of 10 people)
(3 of 14 people)
(1 of 4 people)

Most common drug interactions by age * :

n/an/aAmblyopia NosHeadachePainArthralgiaFatiguePain
Asthma AggravatedNauseaDrug IneffectivePainPainArthralgia
Headache NosRheumatoid ArthritisPneumoniaOedema PeripheralAbdominal PainFatigue
Vomiting NosTachycardiaArthralgiaInjection Site PainDiarrhoeaAnaemia
VertigoGallbladder DisorderNauseaNauseaBone PainDyspnoea
DysarthriaDyspnoeaVomitingRheumatoid ArthritisNauseaFall
Tongue Disorder NosAcute Lymphocytic Leukaemia RecurrentInjection Site HaemorrhageVomitingOedema PeripheralOedema Peripheral
HypoaesthesiaSyringomyeliaWeight IncreasedHeadacheSwellingPain In Extremity
TremorVaginal HaemorrhageCoughDyspnoeaOsteoarthritisDeep Vein Thrombosis
Chorea NosParaesthesiaRashHypoaesthesiaArthralgiaHypertension

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Flexeril and Methotrexate?

Comments from related studies:

  • From this study (5 months ago):

  • The abnormal dreams & mild hallucinations came only after starting the methylprednisolone a few days ago. They happen primarily when I am sleeping. I woke up last night with very unusual dreams & head/brain pain, and was quite concerned. I had taken 1 methylprednisolone & 1 cymbalta before bed. Earlier in the day, I had taken 2 methylprednisolone & 2 tramadol before a nap, and had similar, though not as severe issues. Trying to figure out what the interaction problem is. I did not take the muscle relaxant (cyclopenzaprine) before bed since I started the cortico steroid pack.


    britsarmymom on Apr, 26, 2014:

    Mother just survived near brush with respiratory arrest. Hallucinated at night on Tramadol, argumentative with RN who reported her to MD. He planned to ADD Seroquel 25 mg to Tramadol, Neurontin, Remeron and Ativan in rehab facility. She declined Tramadol and Seroquel and was still so sedated her pulse ox went down to 84 with long periods of apnea and need for constant obs with frequent rousing for airway. MAJOR struggle with RN to get 02 and MD agreed to no more Tramodol at night and absolutely no Seroquel. How many elderly are lost this way?


  • From this study (1 year ago):

  • began sweating 10 years ago, while up in New England, but it is worse now that we moved to Florida 10 years ago. I can only tolerate temperatures 72 degrees or less with little humidity - 50 %


    Mrs Kathy Houy on Dec, 26, 2012:

    you mean I get to sweat for years!!!!!!!!!!!!! OMG


    Jacqueline on Dec, 23, 2012:

    I am very concerned with Enbrel my husband was diagnosed with Glioblastoma Stage 4 brain cancer. My husband has RA and Sjogrens and started to take Enbrel about a 1 1/2years ago. I am concerned that Enbrel might have played a part with his brain tumor. My husband had brain surgery and 2 weeks later chemo and radiation. We completed radiation and chemo just 2 weeks ago, we now have to wait for a scan for about another 3 weeks to see how the treatment is taking for his tumor. This drug makes me wonder if there might be a correlation between the two!


    Interested party on Dec, 21, 2012:

    If you need temperatures less than 72 degrees it may be beneficial to move to Ireland. It only gets to 65 degrees in the summertime. Perhaps you would be more comfortable there, Florida is one of the worst places you could live for your condition.

    Hope this helps.


    Karen on Dec, 24, 2012:

    Sorry. I travel to Ireland quite frequently and it often gets much warmer than 65 degrees in the summer. It IS infinitely cooler than Florida but the humidity is just as high, if not higher.


    Mrs. Kathy Houy on Dec, 26, 2012:

    I'm so sorry about your husband God bless you both I cried when I read your post Kathy


    subregret on Feb, 23, 2013:

    suboxone is a nightmare and should never be used unless you are a hopeless heroin addict. People who call it a miracle drug are either ignorant or have not been on it long. I say this becuase when you stop suboxone YOU WILL SUFFER!! not only will you suffer but you will suffer for a long long time. Regualar opiate withdrawal lasts 7-10 days. Suboxone withdrawal lasts 60-90 days. I would honestly pick methadone if I had the choice to do it again. Because I quit 80 mg methadone before and it sucked but have been trying to stop suboxone now for years at only 1/2 milligram. My doctor is of no help and tells me he dosent know what to do as he hands me another prescription. YOU ALL HAVE BEEN WARNED..this crap is poison!!


    Robert on Feb, 26, 2013:

    Can you tell me if you or your husband did any kind of experimenting with hallucinogens?


    Robert on Feb, 26, 2013:

    I had the exact opposite with the us of Soboxone vs. Methadone.
    When I tried Methadone it was just like taking heroin. Then we all learned that we could also get the Meth off the street from people selling there take homes. My friends and I just replaced the Heroin for the Methadone. At this time all the people that got on the Methadone program are still taking there methadone or they are now dead. When I got off the Meth it was just like getting off heroin all the physical symptoms and mental ones.
    I then went to try the Suboxone. I started with the full 8mg then dropping down to the 4mg and ending up being very happy with 2 mg for the rest of my life.This time I wanted to be clean so getting off the 2 mg of suboxone was 90% mental and 10% physical withdrawal. Had 3 days physical pain everyday got much better after the 3rd day. Then there was the depression and the lack of energy that does come back.


    Krakow on Apr, 30, 2013:

    The suboxone I believe will be impossible to get off. The withdrawals last 8 months over, and then comes the post acute phase which can last all your life. The suboxone damages seronitin and dopamine permanently, this is a fact. So many have said its a death sentence coming off it as well as staying on it. I promise you there is no way out.


    Goku on May, 4, 2013:

    Actually suboxone withdrawals does not at all last 8 months, i know everyone is different, but the actual withdrawals,(the real bad ones) will not last but around 17 gruesome days, then some time after that you will feel a little weak. I was on opiates for at least 2-3 years before getting on suboxone, then was on suboxone for 3 whole entire years, (not missing 1 dose the whole time) once i stopped, cold turkey, i felt awful for about 17 days, then weak for 2 weeks, then started getting my energy back, i believe suboxone is a great drug to "trade" for multiple drugs you've been taking, once you feel though you have had enough of the suboxone, or subutex, i encourage anyone that wants to quit (i advise talking to your Dr. but i wouldn't agree with tapering down, that's just me) and just have the will to KNOW you can do it, and go play golf, run, swim, try to work out(lightly), watch movies/shows you love, have some music (a perfect circle - the 13th step helped me more than ANYTHING) and drink and eat healthy, and keep you some chocolate milk handy (chocolate releases endorphins in your brain) and just fight through it, i know you can do it, just do it for you and only you, and have faith in yourself, also i recommend some isolation, i really hope this helps someone, i seen this comment on here, and had to reply, god bless the addicts


    Kristie on May, 25, 2013:

    My 25 year old male cousin committed suicide two weeks ago today. He had just stopped taking suboxin. I wish we had read all this stuff before then :( I had no idea that this could happen. It's a nightmare now.


    finally on May, 29, 2013:

    The key to quitting sub is tapering over a very long period of time. I finally jumped about 10 days ago after taking 1mg for a month, i feel pretty good today. I was on sub for almost two years and started off on 20mg a day. Yes I had terrible insomnia for about 5 nights, but it was manageable because I knew they wouldn't last forever. This experience was nothing like how i felt during my past attempts to quit opiates so don't even compare the two. go slow and u will be pleasantly surprised how mild your withdrawals will be. Just knowing you are closing the chapter to your opiate addiction will get you through. It is such a relief to have this behind me. Every day will get easier, I promise.


  • From this study (2 years ago):

  • Looking for effect on blood sugar


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Complete drug side effects:

On eHealthMe, Flexeril (cyclobenzaprine hydrochloride) is often used to treat muscle spasms. Methotrexate (methotrexate sodium) is often used to treat rheumatoid arthritis. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.


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