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Review: taking Flexeril and Methotrexate together

Summary: drug interactions are reported among people who take Flexeril and Methotrexate together.

This review analyzes the effectiveness and drug interactions between Flexeril and Methotrexate. It is created by eHealthMe based on reports of 1,206 people who take the same drugs from FDA and social media, and is updated regularly.

 

You are not alone: join a support group for people who take Flexeril and Methotrexate >>>

On Apr, 1, 2015: 1,206 people who take Flexeril, Methotrexate are studied

Flexeril, Methotrexate outcomes

Drug combinations in study:
- Flexeril (cyclobenzaprine hydrochloride)
- Methotrexate (methotrexate sodium)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Flexeril is effective25.00%
(1 of 4 people)
0.00%
(0 of 3 people)
0.00%
(0 of 3 people)
66.67%
(2 of 3 people)
40.00%
(2 of 5 people)
75.00%
(3 of 4 people)
80.00%
(4 of 5 people)
n/a
Methotrexate is effectiven/a0.00%
(0 of 4 people)
0.00%
(0 of 2 people)
100.00%
(1 of 1 people)
30.00%
(3 of 10 people)
0.00%
(0 of 2 people)
42.86%
(3 of 7 people)
n/a

Drug effectiveness by gender :

FemaleMale
Flexeril is effective52.38%
(11 of 21 people)
16.67%
(1 of 6 people)
Methotrexate is effective15.00%
(3 of 20 people)
66.67%
(4 of 6 people)

Drug effectiveness by age :

0-12-910-1920-2930-3940-4950-5960+
Flexeril is effectiven/an/an/an/a9.09%
(1 of 11 people)
21.43%
(3 of 14 people)
43.75%
(7 of 16 people)
25.00%
(1 of 4 people)
Methotrexate is effectiven/an/an/an/a22.22%
(2 of 9 people)
7.14%
(1 of 14 people)
21.43%
(3 of 14 people)
25.00%
(1 of 4 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Muscle SpasmsPneumoniaCellulitisOsteonecrosisDiarrhoeaHypoglycaemiaNauseaPain
RetchingCellulitisHyperkeratosisGraft DysfunctionDrug IneffectiveLiver Function Test AbnormalSepsisFatigue
VomitingDecreased AppetiteHypersensitivityHaematomaLipase IncreasedInterstitial Lung DiseaseRheumatoid ArthritisArthralgia
StomatitisNauseaInflammatory Bowel DiseaseHot FlushDehydrationBlood Lactate Dehydrogenase IncreasedPneumoniaNausea
Abdominal PainVomitingHot FlushHypersensitivityColitis CollagenousAspartate Aminotransferase IncreasedHypothyroidismOedema Peripheral
CellulitisJaundiceIncontinenceFallAlanine Aminotransferase IncreasedRespiratory Tract InfectionHysterectomyFall
Acute Lymphocytic Leukaemia RecurrentRenal ImpairmentGraft DysfunctionCerebrovascular AccidentAspartate Aminotransferase IncreasedAlanine Aminotransferase IncreasedIntervertebral Disc DegenerationDiarrhoea
Drug IneffectivePyrexiaDiverticulumDepressionBlood Amylase IncreasedMental DisorderHypertensionAbdominal Pain
Gastrointestinal DisorderHaematomaEar PainDiverticulumPancreatitisDyspnoeaIrritable Bowel SyndromePain In Extremity
Feeling AbnormalBlood Pressure AbnormalFallEar PainHeadachesDeep Vein ThrombosisHiatus HerniaDyspnoea

Most common drug interactions by gender * :

FemaleMale
PainArthralgia
FatiguePain
NauseaOedema Peripheral
ArthralgiaChest Pain
Oedema PeripheralFatigue
FallNausea
DiarrhoeaMuscle Spasms
Abdominal PainPain In Extremity
Bone PainDrug Ineffective
AnaemiaHypoaesthesia

Most common drug interactions by age * :

0-12-910-1920-2930-3940-4950-5960+
n/an/aAmblyopia NosHeadachePainArthralgiaFatiguePain
Asthma AggravatedNauseaDrug IneffectivePainPainArthralgia
Headache NosRheumatoid ArthritisPneumoniaInjection Site PainAbdominal PainFatigue
Vomiting NosTachycardiaArthralgiaNauseaDiarrhoeaAnaemia
VertigoGallbladder DisorderNauseaOedema PeripheralBone PainDyspnoea
DysarthriaDyspnoeaVomitingVomitingNauseaFall
Tongue Disorder NosAcute Lymphocytic Leukaemia RecurrentInjection Site HaemorrhageRheumatoid ArthritisOedema PeripheralOedema Peripheral
HypoaesthesiaSyringomyeliaWeight IncreasedHeadacheSwellingPain In Extremity
TremorVaginal HaemorrhageCoughWeight DecreasedOsteoarthritisDeep Vein Thrombosis
Chorea NosParaesthesiaRashHypoaesthesiaArthralgiaHypertension

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Get connected: join our support group of Flexeril and Methotrexate on

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- support group for people who take Flexeril
- support group for people who take Methotrexate

Recent related drug studies (Check your drugs):

Complete drug side effects:

On eHealthMe, Flexeril (cyclobenzaprine hydrochloride) is often used to treat muscle spasms. Methotrexate (methotrexate sodium) is often used to treat rheumatoid arthritis. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

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