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Review: taking Flexeril and Synthroid together

Summary: drug interactions are reported among people who take Flexeril and Synthroid together.

This review analyzes the effectiveness and drug interactions between Flexeril and Synthroid. It is created by eHealthMe based on reports of 2,903 people who take the same drugs from FDA and social media, and is updated regularly.





You are not alone: join a mobile support group for people who take Flexeril and Synthroid >>>

What are the drugs

Flexeril has active ingredients of cyclobenzaprine hydrochloride. It is often used in muscle spasms. (latest outcomes from 16,452 Flexeril users)

Synthroid has active ingredients of levothyroxine sodium. It is often used in hypothyroidism. (latest outcomes from 93,791 Synthroid users)

On Jan, 26, 2015: 2,902 people who take Flexeril, Synthroid are studied

Flexeril, Synthroid outcomes

Drug combinations in study:
- Flexeril (cyclobenzaprine hydrochloride)
- Synthroid (levothyroxine sodium)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Flexeril is effective27.27%
(6 of 22 people)
(3 of 19 people)
(3 of 10 people)
(5 of 20 people)
(7 of 31 people)
(4 of 21 people)
(5 of 16 people)
(1 of 1 people)
Synthroid is effective0.00%
(0 of 2 people)
(3 of 8 people)
(2 of 8 people)
(6 of 10 people)
(13 of 21 people)
(24 of 37 people)
(37 of 53 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
DizzinessPainNeutropeniaAnxietyDepressionDepressionDeep Vein ThrombosisPain
VomitingEmotional DistressFebrile NeutropeniaPainAnxietyAnxietyPulmonary EmbolismNausea
AnxietyInjuryPneumoniaNauseaSuicide AttemptCerebrovascular AccidentAnxietyFall
HeadacheVision BlurredMulti-organ FailureDepressionMemory ImpairmentFatigueSwellingArthralgia
Febrile NeutropeniaRetinal OedemaSeptic ShockPulmonary EmbolismIntentional OverdoseHeadachePost Thrombotic SyndromeBack Pain
NeutropeniaVomitingFatigueSuicide AttemptLoss Of ConsciousnessSuicidal IdeationPainDyspnoea
DiarrhoeaAnxietyHeadacheInjuryNervousnessThyroid DisorderMobility DecreasedFatigue
InjuryAbdominal PainHypothyroidismIntentional OverdoseRoad Traffic AccidentDizzinessImpaired Driving AbilityOedema Peripheral
HypokalaemiaHypothyroidismHypokalaemiaCholecystitis ChronicBipolar DisorderLoss Of ConsciousnessSkin DiscolourationAnxiety
OedemaLeukopeniaDiarrhoeaMental DisorderNeck PainNumbness And TinglingConversion DisorderDepression

Drug effectiveness by gender :

Flexeril is effective24.43%
(32 of 131 people)
(2 of 9 people)
Synthroid is effective60.77%
(79 of 130 people)
(6 of 8 people)

Most common drug interactions by gender * :

Back PainPyrexia
Oedema PeripheralHeadache
DepressionOedema Peripheral

Drug effectiveness by age :

Flexeril is effectiven/an/an/a10.00%
(1 of 10 people)
(4 of 59 people)
(9 of 95 people)
(11 of 101 people)
(9 of 38 people)
Synthroid is effectiven/an/an/a70.00%
(7 of 10 people)
(12 of 48 people)
(26 of 94 people)
(21 of 102 people)
(19 of 39 people)

Most common drug interactions by age * :

n/an/aGastritisPulmonary EmbolismPainNauseaPainOedema Peripheral
InjuryDeep Vein ThrombosisAnxietyPainArthralgiaPain
Cholecystitis ChronicPainPulmonary EmbolismBack PainNauseaFall
Abdominal Pain UpperInjuryDepressionDizzinessHypoaesthesiaAsthenia
VomitingDizzinessWeight IncreasedFatigueDepressionDyspnoea
Abdominal PainAnxietyNauseaDyspnoeaFatigueBack Pain
Lip SwellingHeadacheInjuryVomitingChest PainArthralgia
Rheumatoid ArthritisVomitingDeep Vein ThrombosisChest PainAnxietyPneumonia
Loss Of ConsciousnessDiabetes MellitusType 2 Diabetes MellitusOedema PeripheralFallFatigue
NauseaExtrapyramidal DisorderDizzinessDepressionDyspnoeaNausea

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Flexeril and Synthroid?

You are not alone! Join a related mobile support group:
- support group for people who take Flexeril and Synthroid
- support group for people who take Flexeril
- support group for people who take Synthroid

Can you answer these questions (Ask a question):

More questions for: Flexeril, Synthroid

You may be interested at these reviews (Write a review):

  • Syntroid and pruritus
    I have been on levothyroxine for more than ten years and have had two episodes, each lasting over several months of unbearable itching. Doctors seem to deny any connection but are also unable identify the cause of the itching. None of the tests pick anything. Antihistamines are not much of a help. I am still in the throes of the second episode and life is plain, simple miserable.
  • Thrush while on prograf
    I am a health provider at an emergency room and had a patient come in because of a food bolus and when i examined his oral/pharynx I noticed he had thrush. Patient stated it has been their for a while. Patient also stated he has been having progressive difficulty in swallowing. Pt is a kidney transplant patient and has been worked up for other causes of his thrush (including HIV, as per patient results neg) and everything came back negative. I can only conclude that maybe the prograf which is a immunosupressent can possible be the cause
  • Cardio version caused fingernail abnormalities
    Right hip fracture. When prepping for surgery AFIB was found. Surgery was cancelled and they attempted to get AFIB under control. Finally, cardioversion was performed. When my nails started to grow out they all had two horizontal lines that cause the nail to break when it grows out to that point.
  • Synthroid and breast enlargement
    I have went from a B-C cup size to a D cup in the past 8-9 months.
  • Double vision on levothyroxine
    Diagnosed with under active thyroid in January 2011. Noticed onset of double vision in January 2014. Blurred vision and double vision worsened to such an extent that my glasses prescription has changed three times in less than 7 months. All the symptons I experience are a direct result of taking Levothyrixine and have increased as my dose has been increased.

More reviews for: Flexeril, Synthroid

Comments from related studies:

  • From this study (13 hours ago):

  • I have chronic fatigue syndrome, fibromyalgia, GERD, IBS, Bipolar 2, PTSD. High levels of anxiety and depression, hypomanic states at times. Hospitalization has been required multiple times to alter drugs. Abuse and overuse of drugs, mixing drugs has been ongoing for 9 weeks. Detox program starting.


  • From this study (3 months ago):

  • peanuts on Mar, 31, 2010:

    my friend is suffering from rhumatory arthertis.and is currenty taking cocaine. oxy cotin,prestine, wellbutrim, predisone 10mg what side effects should she expect ?????


    mtntexas on May, 11, 2013:

    Just ask John Belushi


Post a new comment    OR    Read more comments

Complete drug side effects:

On eHealthMe, Flexeril (cyclobenzaprine hydrochloride) is often used to treat muscle spasms. Synthroid (levothyroxine sodium) is often used to treat hypothyroidism. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

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