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Review: taking Flexeril and Synthroid together

Summary: drug interactions are reported among people who take Flexeril and Synthroid together.

This review analyzes the effectiveness and drug interactions between Flexeril and Synthroid. It is created by eHealthMe based on reports of 2,905 people who take the same drugs from FDA and social media, and is updated regularly.


You are not alone: join a support group for people who take Flexeril and Synthroid >>>

On Mar, 29, 2015: 2,904 people who take Flexeril, Synthroid are studied

Flexeril, Synthroid outcomes

Drug combinations in study:
- Flexeril (cyclobenzaprine hydrochloride)
- Synthroid (levothyroxine sodium)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Flexeril is effective27.27%
(6 of 22 people)
(3 of 19 people)
(3 of 10 people)
(5 of 20 people)
(7 of 31 people)
(4 of 21 people)
(5 of 16 people)
(1 of 1 people)
Synthroid is effective0.00%
(0 of 2 people)
(3 of 8 people)
(2 of 8 people)
(6 of 10 people)
(13 of 21 people)
(24 of 37 people)
(37 of 53 people)

Drug effectiveness by gender :

Flexeril is effective24.43%
(32 of 131 people)
(2 of 9 people)
Synthroid is effective60.77%
(79 of 130 people)
(6 of 8 people)

Drug effectiveness by age :

Flexeril is effectiven/an/an/a10.00%
(1 of 10 people)
(4 of 59 people)
(9 of 95 people)
(11 of 101 people)
(9 of 38 people)
Synthroid is effectiven/an/an/a70.00%
(7 of 10 people)
(12 of 48 people)
(26 of 94 people)
(21 of 102 people)
(19 of 39 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
DizzinessPainNeutropeniaAnxietyDepressionDepressionDeep Vein ThrombosisPain
VomitingEmotional DistressFebrile NeutropeniaPainAnxietyAnxietyPulmonary EmbolismNausea
AnxietyInjuryPneumoniaNauseaSuicide AttemptCerebrovascular AccidentAnxietyFall
HeadacheVision BlurredMulti-organ FailureDepressionMemory ImpairmentFatigueSwellingArthralgia
Febrile NeutropeniaRetinal OedemaSeptic ShockPulmonary EmbolismWeight GainSuicidal IdeationPost Thrombotic SyndromeBack Pain
NeutropeniaVomitingFatigueSuicide AttemptIntentional OverdoseThyroid DisorderPainDyspnoea
DiarrhoeaAnxietyHeadacheInjuryLoss Of ConsciousnessLoss Of ConsciousnessMobility DecreasedOedema Peripheral
InjuryAbdominal PainHypothyroidismIntentional OverdoseNeck PainHeadacheImpaired Driving AbilityFatigue
HypokalaemiaHypothyroidismHypokalaemiaCholecystitis ChronicBipolar DisorderDizzinessSkin DiscolourationAnxiety
OedemaLeukopeniaDiarrhoeaMental DisorderAstheniaComplex Partial SeizuresConversion DisorderDepression

Most common drug interactions by gender * :

Back PainFall
Oedema PeripheralAsthenia
DepressionOedema Peripheral

Most common drug interactions by age * :

n/an/aGastritisPulmonary EmbolismPainNauseaPainOedema Peripheral
InjuryDeep Vein ThrombosisAnxietyPainArthralgiaFall
Cholecystitis ChronicPainPulmonary EmbolismBack PainNauseaPain
Abdominal Pain UpperInjuryDepressionDizzinessHypoaesthesiaAsthenia
VomitingDizzinessWeight IncreasedFatigueDepressionDyspnoea
Abdominal PainAnxietyNauseaDyspnoeaFatigueBack Pain
Lip SwellingHeadacheInjuryVomitingChest PainArthralgia
Rheumatoid ArthritisVomitingDeep Vein ThrombosisChest PainAnxietyPneumonia
Loss Of ConsciousnessDiabetes MellitusType 2 Diabetes MellitusOedema PeripheralFallFatigue
NauseaExtrapyramidal DisorderDizzinessDepressionDyspnoeaNausea

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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Do you take Flexeril and Synthroid?




You are not alone! Join a related support group:
- support group for people who take Flexeril
- support group for people who take Synthroid

Recent related drug studies (Check your drugs):

Complete drug side effects:

On eHealthMe, Flexeril (cyclobenzaprine hydrochloride) is often used to treat muscle spasms. Synthroid (levothyroxine sodium) is often used to treat hypothyroidism. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.


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