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Review: Flexeril and Tramadol





Summary: drug interactions are reported among people who take Flexeril and Tramadol together.

This review analyzes the effectiveness and drug interactions between Flexeril and Tramadol. It is created by eHealthMe based on reports of 2,679 people who take the same drugs from FDA and social media, and is updated regularly.

You are not alone: join a mobile support group for people who take Flexeril and Tramadol >>>

What are the drugs

Flexeril has active ingredients of cyclobenzaprine hydrochloride. It is often used in muscle spasms. (view latest outcomes from 16,445 users)

Tramadol has active ingredients of tramadol hydrochloride. It is often used in pain. (view latest outcomes from 41,501 users)

On Nov, 26, 2014: 2,679 people who take Flexeril, Tramadol are studied

Flexeril, Tramadol outcomes

Drug combinations in study:
- Flexeril (cyclobenzaprine hydrochloride)
- Tramadol (tramadol hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Flexeril is effective18.18%
(6 of 33 people)
10.00%
(3 of 30 people)
15.38%
(2 of 13 people)
30.30%
(10 of 33 people)
34.21%
(13 of 38 people)
27.27%
(3 of 11 people)
71.43%
(5 of 7 people)
50.00%
(2 of 4 people)
Tramadol is effective20.69%
(6 of 29 people)
22.58%
(7 of 31 people)
5.88%
(1 of 17 people)
19.35%
(6 of 31 people)
39.02%
(16 of 41 people)
41.67%
(5 of 12 people)
50.00%
(4 of 8 people)
20.00%
(1 of 5 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Myocardial InfarctionPainAcute Myocardial InfarctionDepressionDepressionPainAnxietyPain
NauseaParaesthesiaTherapeutic Response DecreasedPainAnxietyAnxietyDepressionNausea
Deep Vein ThrombosisSyncopeInfluenzaInsomniaSuicidal IdeationEmotional DistressSuicidal IdeationDepression
Completed SuicideAnxietyIntervertebral Disc DegenerationAbnormal BehaviourLoss Of ConsciousnessCyanosisAbnormal DreamsBack Pain
AnxietyFrequent HeadachesConvulsionMyocardial InfarctionBipolar DisorderGallbladder DisorderPhysiologic Ovarian CystsAnxiety
PainDrug IneffectivePalpitationsRenal Failure AcutePainPeripheral IschaemiaKnee PainArthralgia
DizzinessDetoxificationConstipationFrequent HeadachesNauseaDepressionMiddle InsomniaHeadache
Blood Cholesterol IncreasedCompleted SuicideDepressionDeep Vein ThrombosisConvulsionCholecystitis ChronicFunctional Ovarian CystsFatigue
DyspnoeaPeripheral IschaemiaMyocardial InfarctionJoint SwellingPulmonary EmbolismPancreatitisLoss Of ConsciousnessFall
Heart Rate IncreasedDizzinessNauseaLower Extremity MassMuscle WeaknessSphincter Of Oddi DysfunctionEye FloatersDyspnoea

Drug effectiveness by gender :

FemaleMale
Flexeril is effective26.77%
(34 of 127 people)
24.39%
(10 of 41 people)
Tramadol is effective27.82%
(37 of 133 people)
21.95%
(9 of 41 people)

Most common drug interactions by gender * :

FemaleMale
PainAnxiety
NauseaBack Pain
HeadachePain
ArthralgiaDepression
FatiguePain In Extremity
DepressionNausea
AnxietyDyspnoea
Back PainInsomnia
FallMyocardial Infarction
DyspnoeaHeadache

Drug effectiveness by age :

0-12-910-1920-2930-3940-4950-5960+
Flexeril is effectiven/an/a0.00%
(0 of 1 people)
12.82%
(5 of 39 people)
15.60%
(17 of 109 people)
14.29%
(9 of 63 people)
10.42%
(5 of 48 people)
32.00%
(8 of 25 people)
Tramadol is effectiven/an/a0.00%
(0 of 1 people)
12.20%
(5 of 41 people)
12.50%
(13 of 104 people)
14.52%
(9 of 62 people)
20.75%
(11 of 53 people)
32.00%
(8 of 25 people)

Most common drug interactions by age * :

0-12-910-1920-2930-3940-4950-5960+
DeathSomnolencePainPainPainPainPainBack Pain
Foetal Exposure During PregnancyMultiple Drug Overdose AccidentalCholecystitis ChronicConvulsionDepressionBack PainNauseaPain
Diabetes MellitusLethargyDeep Vein ThrombosisInjuryHeadacheDepressionHeadachePain In Extremity
LethargyAccidental Drug Intake By ChildAbdominal Pain UpperDizzinessAnxietyNauseaAnxietyFall
Accidental Drug Intake By ChildCholelithiasisNauseaNauseaArthralgiaFatigueHeadache
Cardio-respiratory ArrestNauseaInsomniaArthralgiaFatigueFallAnxiety
ComaDiarrhoeaLoss Of ConsciousnessDyspnoeaDyspnoeaArthralgiaOsteoarthritis
ConvulsionGallbladder DisorderVomitingDizzinessPain In ExtremityDiarrhoeaFatigue
ApnoeaPancreatitisDeep Vein ThrombosisDrug DependenceAnxietyCoughDyspnoea
SomnolenceMultiple Drug OverdoseHypertensionChest PainBack PainArthralgia

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Flexeril and Tramadol?

You are not alone! Join a related mobile support group:
- support group for people who take Flexeril and Tramadol
- support group for people who take Flexeril
- support group for people who take Tramadol

Can you answer these questions (Ask a question):

  • Is it safe to take demerol while taking tramadol hydrochloride and hydroxychloroquine (2 answers)
    I am experiencing acute, debilitating pain due to the Chikungunya virus, which has reintroduced all of the previous painful symptoms I have,ongoing and in the past, from Fibromyalgia, Arthritis, tendonitis and severe headaches. It's in its 38th day and I am basically crippled from neck to feet. Have to sleep propped up as arms throb with pain when horizontal. The only thing that has subdued the pain slightly are Oxycocet and Ibuprofen, but the pain never goes away. My hands and feet are so inflammed it's difficult to perform even the smallest tasks of personal hygiene and housekeeping. I have difficulty controlling my bladder and often don't make it to the washroom in time. Just started on Demerol today so will no longer take the Oxycocet, but am concerned of the interactions with Demerol, Hydroxychloroquine and Tramadol Hydrochloride extended release tablets that I take daily for the Fibromyalgia and Arthritis. I have dealt with a great deal of pain through the years, but I now have the pain of every serious illness I have had in my lifetime, all at the same time. I honestly didn't think a person could deal with this much pain at once. I have tried and am still taking several vitamins and herbal supplements as well as drinking tons of water and eating really well. Lots of berries, dark vegetables, apples, yogurt and minimal meat. Taking turmeric, papaya leaf, ginger, cinnamon and boswellia for the inflammation. Taking minimal wheat products, sugar and no alcohol. Also, drinking green, fennel and nettle tea daily. I know this is a lot of information, but I really need help and wonder if anyone has any suggestions! Thanking you in advance!!!
  • Does anyone experience heart palpitations causedby their acid reflux ?
    I have had acid reflux/Gerd for 4 years + Was not believed that symptoms were real for a while as had no heartburn and a diagnosis of Fibromyalgia which even now some medics think is imaginary...it's NOT!!! Following a demeester score of 45 ( very high confirmation of acid reflux) and discovery of a large hiatal hernia, ( a classic physical cause of acid reflux) I had hernia repair operation and LINX anti reflux surgery. Throughout the four years a major symptom of my acid reflux were heart palpatations. They started at the same time I started with reflux and cleared up after the surgery. I have been reflux free palpitation free and antacid free for four months. then I was put on Gabapentin for back spasm and the reflux returned along with the palpitations. Medics keep insisting this is just anxiety yet eat a food that gives me reflux also starts the palps which is the indicator of the reflux as I do not have heartburn. Comes on when relaxing and eating watching tv ( no anxiety present) and when I am sleeping peacefully ( no anxiety present) my heart wakes me up and fires off into tachycardia. Recently a doctor has said it is now known that acid reflux irritates the nerves in the solar plexus area and that triggers the palps. Anyone else experienced this? Are there any studies on it at all? Thanks all.
  • I have been having a horrible reaction to tramadol now from the er doctor. what do i do now for pain . i've tried the shots made things even worse. so many trials it's hurts 2 try to gr better ? (3 answers)
    Tramadol so been making me so sick from the ER doctor 2 c my doctor if I can hold on. It's a shame ! So many things they keep trying . It's pain not the knew in thing of treating fibromyalgia. Disk problems nerve sciatic. Anxiety u wouldn't believe. I've talked to the FDA
    I don't feel safe at all anymore and want to get better . My family gets so upset and we all have lives to live but mine has been on hold 4-5yrs. Just to do the simple things then I have to rest. It's sad . I've always been active . And watch out for Savella !! My god all I would like is to fel better. I can't believe all the things I've read about tramadol it makes me mad that an ER doctor gave it to me first and I told doctors and pain management It wsnt helping. Can't sleep anger horrible thoughts.please I can't do those shots they made things even worse and they don't help me.
  • Can nuvigil (vs adderall) be used simultaneously to help wean off 60mg/day of adderall? (1 answer)
    I have been on Adderall 30mg 2x daily for years!! I've had it lowered to 20mg, I've TRIED to go months without it (when not working) however I feel I've built up a tolerance level to the point that it's not as effective as it once was. My personal life has detoured WAY past anything an ADHD medication can possibly help as far as focusing on NEEDED tasks etc. I end up feeling wrapped up in what I'm doing at the moment that my anxiety increases due to all that I haven't been able to accomplish. I take various medications for various reasons, depression, anxiety, bulimia etc., and for the most part the doses have varied based on circumstances and current need at said time of prescription.. MY FAMILY HAS A HISTORY OF HEART DISEASE, And realizing that I'm already on the highest Adderall dosage scares me (and THEN as I think about it, it makes my heart race!). I've also noticed increased muscle spasms as well as extreme and intense pressure on my jaw (TMJ). MY QUESTION IS: does anyone have any experience LOWERING their Adderall dosage AND adding Nuvigil? The research I've done to date gives me impression that it could help balance out the more extreme effects of Adderall (60mg/day) but that the nuvigil would or could potentially help with the EXTREME exhaustion I feel as Adderall wears off. Some days I just crash, some days I sleep fine and others no matter how hard I tryyyy, I just CAN'T fall asleep, therefore making the next day worse! IDEALLY I'D LIKE TO BE MED FREE, right now I need them, but am hoping maybe I can speak with my doctor to lower Adderall and add Nuvigil to help wean me off the amphetamines as well as lower dosage intake. YES, a lot of the anxiety, sleeplessness and depression are related to current circumstances in my life, however, where I am is not where I want to be or where I'm headed.. Life is a journey, and all my meds have become a part of a journey I never thought I'd find myself taking. I don't want life/meds to define me, or create a me I no longer recognize, because scarily enough that seems to be a common pattern. As I overcome each and every daily obstacle, I also don't want to be "hooked" on my meds or needing "more" to wake up/sleep/function.. I'd like to work on finding a solution towards weaning off my meds NOW, and work my way off slowly, primarily the Adderall. I'm hoping by suggesting to my doctor and showing him my research he may agree (IF ITS EVEN A LOGICAL COMBO, CLEARLY IM NOT A DOCTOR) nuvigil could help me. I've already started taking less of my anti depressants, trazadone and xanax without discussing with doc because he is always busy.. My next appt I want to go in fully prepared with a plan and an overall goal to REDUCE my Adderall dose, but overall, I'm clueless!!! I have no idea what other meds other than nuvigil "could" potentially help if at all. I could be entirely wrong, Anyone with any experience using one vs other or both simultaneously, or anyone with constructive input, PLEASE COMMENT/SHARE!!
  • Can you loose weight while taking hydroxyzine?
    Hydroxyzine has been my life saver but I have noticed a gradual increase in weight. My blood pressure has also gone up. I don't have the increased hunger but what scares me is I am not eating more than I normally do. I do not eat breakfast. I have a Glucerna at lunch and then dinner, protein potatoes/rice and veggies, sometimes pasta nothing huge and a snack at night. Maybe a small bowl of ice cream but not every night. I do not drink soda, lots of water and with dinner a large glass of apple juice. I have noticed every year I put on a little bit more weight. I was tested for my thyroid and it is normal. I haven't started an avid work out program. Doing high intense impact will not work due to my IC. I would like to try power walking. Anyone else experience any of these issues?

More questions for: Flexeril, Tramadol

You may be interested at these reviews (Write a review):

  • No noticeable effects
    No noticeable effects when used together. Tramadol dose 50-100 mg's four times a day.
  • I wish i had never taken ambien
    Ambien was prescribed after my sleep study showed severe sleep latency and awakening. In the five hours I slept I woke 85 times and had only 5 minutes of deep sleep. However, the doctors couldn't make a recommendation because they could detect no cause for the poor sleep pattern. My doctor offered Ambien and since I had obviously needed the help sleeping I took it. For the next 10 years I suffered incredible depression. For example I remember laying in bed staring at the ceiling with tears rolling into my ears but I was too tired to wipe them away and realizing that I wanted to die so badly but there was no way I could have done anything about it. The worst effects were the loss of consciousness and the verbal abuse that I heaped on my husband and son. An example of each : I actually had sex with my husband that I could not remember amd hundreds of other actions and discussions. My husband started asking every morning what I remembered of the night before. He could usually tell when I was Ambien-awake (his name for it) he said my eyes would get glassy and my voice cadence would be off. Unfortunately my oldest son was going from infant to 8 years old at this time and any ifraction or even without provocation I would scream horrible things in his face. I don't remember much of it but what I do remember causes me enormous regret. He went from a happy and active toddler to a terrified amd anxious pre-teen. We are still working through the effects of this behavior. Finally, after a surprise pregnancy (see example above) My baby was placed in NICU and I stayed at the Ronald McDonald House and my son and husband visited when they could. Somehow my Ambien prescription was stopped and so I began going through withdrawal but I had no idea what was going on. My vision became so blurred thqt I couldn't identify items unless they were very large and then only by colors. When I visited my son those several days in the NICU I couldn't walk straight and would try to aim myself toward my goal until I hit a wall and I would correct course. These things didn't bother me at all but the nurses in the NICU were with me nearly the entire day because they were afraid I would have a stroke or who knew. Finally, after discussing these symptoms we decided to gradually stop the medication. Thankfully, i didn't have any withdrawal symptoms then. I did feel like an incredibly heavy and black blanket had been lifted away. Ever since I have had very little trouble with depression despite the continuation of sleep disturbance and pain. On a scale from one to 10 for depression with 10 being committing suicide I think my 10 years on the medicine was probably an 8.5 (I desperately wanted to die) and since stopping the medication I don't think it has gone above a 4 and is usually a 2 or 3. I will spend the rest of my life trying to repair the damage my verbal abuse caused my oldest son and my husband. For 10 years they lived in fear of my rages if I had a bad episode with Ambien.
  • Horrific nightmares taking naproxen
    I've Taking naproxen 500mg twice a day for 3 weeks on a course for 6 months, I've been having horrific dreams worse than horrer movies, the most recent is involving my ex & current partner where I had a psychotic stalker (my ex) switched around because in the dream I dump my partner for my ex, well the things that have been going on in my dreams are scary to the point I've woken up screaming/ crying, body is covered in sweat & it's stopping me from sleeping more, I get around 2 hours sleep a night off them..... I mean dripping, this dream was so horrific I had to post a review which I woke up around 15 mins ago, I have nightmares quiet often but never this bad
  • Burning mouth syndrome
    I went into a local emergency room for a sore throat with pustules and difficulty swallowing, i was given Tramadol for pain through my iv. About 2 days later i woke up with a very blistery tongue, which was mildly painful as the day progressed i felt like i had been eating habanero peppers all day.. Quite painful. No matter what i tried to eat, including popsicles.. It felt as if i was eating habaneros on a stick with a side of glass shards.. Apparently all you can do is wait the darn syndrome out... I still have a blistered tongue 2 weeks later but the pain is still there. Im now on a liquid version of norco, it numbs the pain for a little while, im able to eat and taste some foods again, which is nice and a lot better than a liquid diet.
  • Nexium and feeling cold (1 response)
    I took Nexium (1 40mg capsule) and approximately 45 minutes later, I felt extremely cold. I could not get warm, even though I put on a polartec jacket and sat near a heater.



    I also was extremely nauseated at the same time.



    About 30 minutes after the incident began, it ended. I no longer was cold and I was no longer nauseated.

More reviews for: Flexeril, Tramadol

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Complete drug side effects:

On eHealthMe, Flexeril (cyclobenzaprine hydrochloride) is often used to treat muscle spasms. Tramadol (tramadol hydrochloride) is often used to treat pain. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

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You may report adverse side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

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