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Review: Flexeril and Tramadol

This review analyzes the effectiveness and drug interactions between Flexeril and Tramadol. It is created by eHealthMe based on reports of 2,674 people who take the same drugs from FDA and social media, and is updated regularly.

Stay connected: join a mobile support group for people who take Flexeril and Tramadol >>>

What are the drugs

Flexeril (latest outcomes from 16,398 users) has active ingredients of cyclobenzaprine hydrochloride. It is often used in muscle spasms.

Tramadol (latest outcomes from 41,355 users) has active ingredients of tramadol hydrochloride. It is often used in pain.

On Jul, 14, 2014: 2,674 people who take Flexeril, Tramadol are studied

Flexeril, Tramadol outcomes

Drug combinations in study:
- Flexeril (cyclobenzaprine hydrochloride)
- Tramadol (tramadol hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Flexeril is effective18.18%
(6 of 33 people)
10.34%
(3 of 29 people)
8.33%
(1 of 12 people)
31.25%
(10 of 32 people)
35.14%
(13 of 37 people)
27.27%
(3 of 11 people)
83.33%
(5 of 6 people)
50.00%
(2 of 4 people)
Tramadol is effective20.69%
(6 of 29 people)
22.58%
(7 of 31 people)
5.88%
(1 of 17 people)
19.35%
(6 of 31 people)
38.46%
(15 of 39 people)
41.67%
(5 of 12 people)
57.14%
(4 of 7 people)
25.00%
(1 of 4 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Myocardial InfarctionPainAcute Myocardial InfarctionDepressionDepressionPainAbnormal DreamsPain
NauseaParaesthesiaTherapeutic Response DecreasedPainAnxietyAnxietyAnxietyNausea
Deep Vein ThrombosisSyncopeInfluenzaInsomniaSuicidal IdeationEmotional DistressDepressionDepression
Completed SuicideAnxietyIntervertebral Disc ProtrusionAbnormal BehaviourLoss Of ConsciousnessCyanosisPhysiologic Ovarian CystsBack Pain
AnxietyFrequent HeadachesIntervertebral Disc DegenerationMyocardial InfarctionBipolar DisorderGallbladder DisorderFunctional Ovarian CystsAnxiety
PainDrug IneffectiveRoad Traffic AccidentRenal Failure AcuteConvulsionPeripheral IschaemiaKnee PainArthralgia
DizzinessDetoxificationDepressionFrequent HeadachesNauseaDepressionMiddle InsomniaHeadache
Blood Cholesterol IncreasedCompleted SuicidePalpitationsDeep Vein ThrombosisPainCholecystitis ChronicSuicidal IdeationFatigue
DyspnoeaPeripheral IschaemiaRenal Failure AcuteJoint SwellingPulmonary EmbolismPancreatitisLoss Of ConsciousnessFall
Heart Rate IncreasedDizzinessConvulsionLower Extremity MassAggressionSphincter Of Oddi DysfunctionHeart PoundingDyspnoea

Drug effectiveness by gender :

FemaleMale
Flexeril is effective27.42%
(34 of 124 people)
22.50%
(9 of 40 people)
Tramadol is effective28.46%
(37 of 130 people)
20.00%
(8 of 40 people)

Most common drug interactions by gender * :

FemaleMale
PainAnxiety
NauseaPain
HeadacheBack Pain
ArthralgiaDepression
FatigueNausea
DepressionPain In Extremity
AnxietyDyspnoea
Back PainInsomnia
FallMyocardial Infarction
DyspnoeaFatigue

Drug effectiveness by age :

0-12-910-1920-2930-3940-4950-5960+
Flexeril is effectiven/an/a0.00%
(0 of 1 people)
12.82%
(5 of 39 people)
15.53%
(16 of 103 people)
14.52%
(9 of 62 people)
10.42%
(5 of 48 people)
33.33%
(8 of 24 people)
Tramadol is effectiven/an/a0.00%
(0 of 1 people)
12.20%
(5 of 41 people)
12.00%
(12 of 100 people)
14.75%
(9 of 61 people)
20.75%
(11 of 53 people)
33.33%
(8 of 24 people)

Most common drug interactions by age * :

0-12-910-1920-2930-3940-4950-5960+
DeathSomnolencePainPainPainPainPainBack Pain
Foetal Exposure During PregnancyMultiple Drug Overdose AccidentalCholecystitis ChronicConvulsionDepressionBack PainNauseaPain
Diabetes MellitusLethargyDeep Vein ThrombosisInjuryHeadacheDepressionHeadachePain In Extremity
LethargyAccidental Drug Intake By ChildAbdominal Pain UpperDizzinessAnxietyNauseaAnxietyFall
Accidental Drug Intake By ChildCholelithiasisNauseaNauseaArthralgiaFatigueHeadache
Cardio-respiratory ArrestNauseaInsomniaArthralgiaFatigueFallOsteoarthritis
ComaDiarrhoeaLoss Of ConsciousnessDyspnoeaDyspnoeaArthralgiaAnxiety
ConvulsionGallbladder DisorderVomitingDizzinessPain In ExtremityDiarrhoeaFatigue
ApnoeaPancreatitisDeep Vein ThrombosisDrug DependenceAnxietyCoughDyspnoea
SomnolenceMultiple Drug OverdoseHypertensionChest PainBack PainArthralgia

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

You can also:

Comments from related studies:

  • From this study (2 weeks ago):

  • Pacemaker due to 3 rd degree AV Block
    Intraocular lenses due to cataracts
    Celiac disease use gluten free diet

    Reply

  • From this study (1 month ago):

  • I see a pain doctor once a month. They do a drug screen to see if you take you're meds, and if there's any meds you should not be taking. I did produce very little urine, approx. 1tsp-1tbl, but the nurse said she had a reading. it showed positive for Nuycnta in my system. I did not take anything than my prescribed drugs. I didn't even know what type of drug it was, so I am very curios to know why I tested positive for it.

    Reply

  • From this study (2 months ago):

  • The abnormal dreams & mild hallucinations came only after starting the methylprednisolone a few days ago. They happen primarily when I am sleeping. I woke up last night with very unusual dreams & head/brain pain, and was quite concerned. I had taken 1 methylprednisolone & 1 cymbalta before bed. Earlier in the day, I had taken 2 methylprednisolone & 2 tramadol before a nap, and had similar, though not as severe issues. Trying to figure out what the interaction problem is. I did not take the muscle relaxant (cyclopenzaprine) before bed since I started the cortico steroid pack.

    Reply

    britsarmymom on Apr, 26, 2014:

    Mother just survived near brush with respiratory arrest. Hallucinated at night on Tramadol, argumentative with RN who reported her to MD. He planned to ADD Seroquel 25 mg to Tramadol, Neurontin, Remeron and Ativan in rehab facility. She declined Tramadol and Seroquel and was still so sedated her pulse ox went down to 84 with long periods of apnea and need for constant obs with frequent rousing for airway. MAJOR struggle with RN to get 02 and MD agreed to no more Tramodol at night and absolutely no Seroquel. How many elderly are lost this way?

    Reply

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More reviews for: Flexeril, Tramadol

Complete drug side effects:

On eHealthMe, Flexeril (cyclobenzaprine hydrochloride) is often used to treat muscle spasms. Tramadol (tramadol hydrochloride) is often used to treat pain. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

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