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Review: taking Gabapentin and Benadryl together

Summary: drug interactions are reported among people who take Gabapentin and Benadryl together.

This review analyzes the effectiveness and drug interactions between Gabapentin and Benadryl. It is created by eHealthMe based on reports of 1,927 people who take the same drugs from FDA and social media, and is updated regularly.

 

 

 

 

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What are the drugs

Gabapentin has active ingredients of gabapentin. It is often used in neuralgia. (latest outcomes from 39,609 Gabapentin users)

Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in allergies. (latest outcomes from 29,393 Benadryl users)

On Feb, 25, 2015: 1,926 people who take Gabapentin, Benadryl are studied

Gabapentin, Benadryl outcomes

Drug combinations in study:
- Gabapentin (gabapentin)
- Benadryl (diphenhydramine hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Gabapentin is effective40.00%
(2 of 5 people)
30.00%
(3 of 10 people)
33.33%
(2 of 6 people)
33.33%
(3 of 9 people)
25.00%
(3 of 12 people)
80.00%
(4 of 5 people)
50.00%
(1 of 2 people)
0.00%
(0 of 2 people)
Benadryl is effective16.67%
(2 of 12 people)
16.67%
(1 of 6 people)
100.00%
(4 of 4 people)
50.00%
(3 of 6 people)
66.67%
(4 of 6 people)
71.43%
(5 of 7 people)
83.33%
(5 of 6 people)
50.00%
(1 of 2 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
HypotensionPneumonitisAppendicitisComaConfusional StateDrug IneffectiveNeck TightnessPain
FatigueHypernatraemiaDiabetic NeuropathyDrug IneffectiveOliguriaSleep DisorderPalpitationsAnxiety
Pain In ExtremityPneumonia Respiratory Syncytial ViralDiabetic FootHepatic FailureHepatic FailureHepatitis CLightheadednessNausea
Aspartate Aminotransferase IncreasedAcute Respiratory Distress SyndromeDiabetes Mellitus Inadequate ControlSuicide AttemptMultiple Drug OverdoseInfluenzaMuscle SpasmsArthralgia
Renal Failure AcuteHypotensionBlood Cholesterol IncreasedOliguriaComaHaemorrhoidsBack Pain
Deep Vein ThrombosisBlood Bilirubin IncreasedGlucose Tolerance ImpairedAmnesiaSuicide AttemptFeeling AbnormalPain In Extremity
Platelet Count DecreasedBreast CancerObesityAppendicitisBlood Creatinine IncreasedIrritabilityDyspnoea
DehydrationDuodenal Ulcer PerforationRoad Traffic AccidentBlood Creatinine IncreasedHypoglycaemiaHepatitis BAnaemia
Alanine Aminotransferase IncreasedRespiratory FailureNephrogenic Fibrosing DermopathyHypoglycaemiaAmnesiaPneumoniaVomiting
AnaemiaInterstitial Lung DiseaseHypoxiaMultiple Drug OverdoseDrug IneffectiveWeight DecreasedOsteonecrosis Of Jaw

Drug effectiveness by gender :

FemaleMale
Gabapentin is effective31.43%
(11 of 35 people)
46.67%
(7 of 15 people)
Benadryl is effective54.29%
(19 of 35 people)
42.86%
(6 of 14 people)

Most common drug interactions by gender * :

FemaleMale
PainPain
ArthralgiaAnxiety
AnxietyNausea
NauseaPain In Extremity
DyspnoeaBack Pain
Pain In ExtremityDepression
Back PainArthralgia
AnaemiaVomiting
Osteonecrosis Of JawHeadache
FatigueAnaemia

Drug effectiveness by age :

0-12-910-1920-2930-3940-4950-5960+
Gabapentin is effectiven/an/an/a22.22%
(2 of 9 people)
10.00%
(3 of 30 people)
16.67%
(3 of 18 people)
37.50%
(6 of 16 people)
18.18%
(4 of 22 people)
Benadryl is effectiven/an/an/a20.00%
(2 of 10 people)
23.33%
(7 of 30 people)
25.00%
(4 of 16 people)
40.00%
(6 of 15 people)
30.00%
(6 of 20 people)

Most common drug interactions by age * :

0-12-910-1920-2930-3940-4950-5960+
Orthostatic HypotensionGastrointestinal Mucosal ExfoliationNephrogenic Systemic FibrosisPainPainPainPainFall
StillbirthHaematocheziaPainDyspnoeaAnxietyAnxietyAnxietyFatigue
Umbilical Cord Around NeckDiarrhoea HaemorrhagicPain In ExtremityNauseaHeadacheBack PainPain In ExtremityAnaemia
Urinary Tract InfectionUlcer HaemorrhageCardiac ArrestLung DisorderPyrexiaDiarrhoeaNauseaPain
Type 2 Diabetes MellitusPneumatosis IntestinalisHypotensionLymphadenopathyDiarrhoeaHeadacheArthralgiaPain In Extremity
NephrolithiasisMalignant Neoplasm ProgressionPyrexiaTachycardiaVomitingPain In ExtremityInjuryOsteoarthritis
Pericardial EffusionNeuroblastomaMetaplasiaSynovial CystParaesthesiaNauseaHypoaesthesiaNausea
Pulmonary HypertensionContusionSkin IndurationArthralgiaHallucinationArthralgiaDyspnoeaDyspnoea
SepsisSkin TightnessNeuropathy PeripheralDyspnoeaVomitingOsteoarthritisBack Pain
Chest PainPulmonary FibrosisOral HerpesSuicidal IdeationAnaemiaEmotional DistressOsteonecrosis Of Jaw

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Get connected: join our support group of Gabapentin and Benadryl on

Do you take Gabapentin and Benadryl?

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- support group for people who take Gabapentin and Benadryl
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Can you answer these questions (Ask a question):

More questions for: Benadryl, Gabapentin

You may be interested at these reviews (Write a review):

  • Fibromyalgia, rsd, interstitial cystitis, lupus
    I have suffered chronic autoimmune conditions for over 20 years. Started out as fibromyalgia, for over a decade. Under a lot of stressors, 8 yrs ago, acquired more autoimmune conditions such as: Interstital Cystitis (IC), sjorgren's syndrome (chronic dry eye..sometimes testing + & sometimes -), RSD in right upper extremity (following cervical fusion surgery), then Lupus (sometimes + & - on bloodwork). Many MDs made me feel as if it was "in my head" b/c of all stressors in life @ the time. An Alternative Medicine/Internal Medicine MD believed in me, as well as a great endrocrinologist...HOPE was FINALLY FOUND & RESULTS GOTTEN. Acupuncture, LDN (Low Dose Naltrexone), eliminating sugar, all sugar substitutes (replacing ONLY with ORGANIC stevia), eating non-GMO foods (basically no prepacked foods that has no more than 7 "ingredients" you have no idea what they are!), eating fresh fruit/veggies, only grass fed/organic meats, fish from U.S. I SLOWLY integrated diet changes, as had great difficulty changing my diet. I was a sugarholic! Especially when stressed! Eliminating sugar, however, proved to be most immediate pain reliever. Next...LOW DOSE NALTREXONE!! (lowdosenaltrexone.org most helpful explaining & finding MDs to prescribe it..Another HUGE hurdle until the 2 MDs listed above suggested, rx'd & maintaining me on after 1 yr!) CANNOT SAY ENOUGH ABOUT LDN.. HAVE TO HAVE PATIENCE..longer have had condition(s), longer to see results! It has allowed me to have a participating life..has it cured all conditions..no..has improved quality of life..TREMENDOUSLY!! My MDs both believe RSD (in presence of other autoimmune condition(s) is basically an autonomic nervous system autoimmune disease (your nervous system NEVER stops firing! Thereby creating: severe pain, swelling, redness, skin changes, burning sensation, etc., we experience). Acupuncture helped SIGNIFICANTLY regulate the autonomic nervous system, reducing severe RSD pain..did it require alot of acupuncture? Yes..to keep "resetting" nervous system response..UNTIL LDN therapy & now require 4x's/yr for acupuncture. ALWAYS make sure an acupuncturist is an MD &/or REGISTERED as a CERTIFIED acupuncturist (google it). The diet changes were the "cherry on top of the sundae" (see, the sugarholic is still there & have to work at it everyday! BUT results in biggest pain reduction of ALL autoimmune condition symptoms..then, no dairy (except organic aged cheese, ie. Kefir, blue cheese, feta, etc), increase fresh fruits/veggies..eliminate GMO foods (google it!), etc. My husband & I both lost jobs (mine from my health..his from downsizing in company! We were on VERY limited budget. IT CAN BE DONE: buy frozen organic (or non organic if cannot afford..still changing to good eating!) fruits & veggies if too expensive for fresh..or, organic vegetable/fruit powders with organic almond or coconut milk w/chia seeds, flavored w/frozen fruit & stevia..organic pea, hemp, whey protein pwders full of amino acids are affordable on vitacost.com & look @'it as a trip to grocery store or a run to fast food (even fast food meal costs more than the powders. Etc made in smoothies!) GOOD reading & I hope I have helped change just 1 person's pain & made their lives more liveable, functional & enjoyable! I was in bed for 2 yrs! I thought i'd NEVER enjoy anything in life again..it's still a struggle @ times...but..without excruciating pain in EVERY part of my body! If u can do ONLY 1 change..do the LDN! It's $10 a month from Skip's Pharmacy in Boca Raton, FL! They ship all over there world! It's cheap & WORKS!! They are great people as well! God Bless
  • Vasculitis caused by gabapentin
    i also take but didnt have such symptom till recent; however, such could be due to gabapentin 1800 mg/d.
    also was suing at the time topamac 100 mg amitriptyline 50 mg, metoprolol 25 mg HCTZ 25 mg,Proventil inh etc.,OTC Tylenol aspirin and vitamins. Been on gabapentin about 15 months but on other meds more than 5 yrs. on and off.

    Since more than 10 weeks I developed 1 to 2 inches across reddish areas on feet and ankles not raised , and slightly dotted;total about 4 or 5 on each foot and ankle.,that dont itch or ache, dont seem to grow or subside w any cream like HC. showed to doctor,said to observe.Basic screening tests were neg,but perhaps needs more testing. We discussed possiblility of bites from various things but I doubt that.
  • Sids/benedryl infant stopped breathing
    We are devastated. Our grand daughter was being breastfed and mother only took 1 tablet of Benedryl 25 mg and healthy baby girl died of SIDS following morning. Any information is appreciated.
  • Diphenhydramine and mental acuity
    For at least 10 years, I have taken diphenhydramine 50 mg. at bedtime for insomnia and allergies. The results have been that I sleep well with no hangover or any cognitive impairment. If I experience vertigo from allergies, I may take an additional 50 mg. but never exceeding 100 mg in a 24 hour period.

    After reading the report regarding an Alzheimer's study finding that after taking as little as 4mg diphenhydramine daily for more than 3 years, dementia rates were high.

    I stopped the diphenhydramine one night. I experienced symptoms of deep brain pulsating pain and severe insomnia. After 4 hours, I took 50 mg diphenhydramine and slept very well. The next night I took 37.5 mg. diphenhydramine, slept very well. However, some of my tasks require layers of mental challenges in which I became slower.

    My question is how did the study recipients obtain 4 mg doses of diphenhydramine when the standard over-the-counter (OTC) availability in tablets is 25 mg? How reliable is the information submitted from the study subjects? What manufacturer's diphendramine was used, or were there several?

    I felt sharper mentally when on 50 mg daily than so far on 37.5 mg.
  • Roaring in the ears from tramadol (taken with dexamethasone)
    It seems the roaring in my right ear happens more around taking the tramadol (2-3/day). Of course, I have a (5) day regiment of dexamethasone at (2/day) so maybe there's a connection. This was prescribed by my GP ( highly regarded) for severe lower back bulging disc pain and down left leg. Also prescribed tizanidine for muscle spasms and gabapentin for, maybe nerve swelling? Both at 2/day but I take less of these two.

    Back pain much better but have the roaring in right ear and can't sleep much. Also doing the Dr recommended exercises daily. Will follow up with chiropractic if this doesn't get me there.

    This is a chronic condition, maybe 20 years, no specific injury, just an accumulation of doing dumb things in my youth.

More reviews for: Benadryl, Gabapentin

Comments from related studies:

  • From this study (11 months ago):

  • Been I'll for 9 months. Just recently found pneumonia. Can't afford dermatologist and do for doesn't know what the hives are. You can write with your finger on my skin and it will show up.

    Reply

  • From this study (1 year ago):

  • I've lost 70 lbs in two years, 40 lbs. in the past year. I am having significant atrophy in my legs, specifically my right leg. As a 52 year old man, I cannot walk normally nor can I walk up stairs.

    Reply

  • From this study (1 year ago):

  • To ER with new onset pressure/tightness in throat/neck up to my ears. Have a paraesophageal hiatal hernia. Cardiac work up negative. New bradycardia, low of mid 50's) with this episode. Normal HR is 80's +/- 10.

    Reply

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Complete drug side effects:

On eHealthMe, Gabapentin (gabapentin) is often used to treat neuralgia. Benadryl (diphenhydramine hydrochloride) is often used to treat allergies. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

   

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