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Review: taking Herceptin and Letrozole together

Summary: drug interactions are reported among people who take Herceptin and Letrozole together.

This review analyzes the effectiveness and drug interactions between Herceptin and Letrozole. It is created by eHealthMe based on reports of 532 people who take the same drugs from FDA and social media, and is updated regularly.





You are not alone: join a mobile support group for people who take Herceptin and Letrozole >>>

What are the drugs

Herceptin has active ingredients of trastuzumab. It is often used in breast cancer. (latest outcomes from 10,452 Herceptin users)

Letrozole has active ingredients of letrozole. It is often used in breast cancer. (latest outcomes from 1,842 Letrozole users)

On Feb, 26, 2015: 532 people who take Herceptin, Letrozole are studied

Herceptin, Letrozole outcomes

Drug combinations in study:
- Herceptin (trastuzumab)
- Letrozole (letrozole)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Herceptin is effectiven/an/a0.00%
(0 of 1 people)
(1 of 1 people)
(1 of 1 people)
Letrozole is effectiven/an/a50.00%
(1 of 2 people)
(1 of 1 people)

Drug effectiveness by gender :

Herceptin is effective66.67%
(2 of 3 people)
Letrozole is effective66.67%
(2 of 3 people)

Drug effectiveness by age :

Herceptin is effectiven/an/an/an/an/a100.00%
(2 of 2 people)
(0 of 1 people)
Letrozole is effectiven/an/an/an/an/a100.00%
(2 of 2 people)
(0 of 1 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
PruritusArthralgiaPyrexiaDyspnoeaOsteomyelitisNeoplasm Malignantn/aPain
FatigueAlopeciaChest PainPleural EffusionSwellingHepatic LesionOsteonecrosis Of Jaw
CoughRash PruriticDyspnoeaDecreased AppetiteErythemaMalignant Peritoneal NeoplasmAnaemia
ErythemaRadiation PneumonitisCoughDisease ProgressionPainBlood Alkaline Phosphatase IncreasedAnxiety
Infusion Related ReactionPyrexiaOsteomyelitisAcneMetastases To LungBlood Lactate Dehydrogenase IncreasedOsteomyelitis
Rash ErythematousLiver AbscessAlopeciaDrug EruptionPleural EffusionGamma-glutamyltransferase IncreasedBone Disorder
Tumour Lysis SyndromeDyspnoeaPurulent DischargeTachycardiaDysphagiaJaundicePleural Effusion
Interstitial Lung DiseaseMalignant Pleural EffusionGingival PainMetastases To LiverCapillary Leak SyndromeRash PruriticPrimary Sequestrum
Metastases To Central Nervous SystemBlood Urea IncreasedInflammationHypertensionExostosisNeuropathy PeripheralTooth Disorder
Nephropathy ToxicOsteonecrosisDental CariesOrthopnoeaFamily StressHepatitis CholestaticFatigue

Most common drug interactions by gender * :

Osteonecrosis Of Jaw
Bone Disorder
Primary Sequestrum
Metastases To Bone
Pain In Jaw

Most common drug interactions by age * :

n/an/an/an/aBreast Cancer FemaleBone DisorderAnxietyAlopecia
Biopsy Breast AbnormalAnxietyPainFatigue
AnaemiaAnaemiaOsteonecrosis Of JawOsteonecrosis
Intervertebral Disc ProtrusionPainOsteomyelitisArthralgia
OsteopeniaOsteonecrosis Of JawAnaemiaPyrexia
Ovarian CystTooth ExtractionMetastases To BonePain In Extremity
ConjunctivitisInjuryGait DisturbancePain
AlopeciaTooth DisorderInflammationPrimary Sequestrum
AcneOsteomyelitisBack PainMetastases To Central Nervous System
Eyelid OedemaPain In JawImpaired HealingRash Pruritic

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Herceptin and Letrozole?

You are not alone! Join a related mobile support group:
- support group for people who take Herceptin and Letrozole
- support group for people who take Herceptin
- support group for people who take Letrozole

Recent conversations of related support groups:

Can you answer these questions (Ask a question):

  • Plantar fasciitis and femara
    HELP!!! I have been on femara for 12 months, and at about 4 months I started getting plantar fasciitis. I now have plantar fasciitis in both feet and it is so painful that I am contemplating using a wheel chair. I cry daily from the pain, and sometimes wish I would just die. I was taking ibuprofen to help, but my onc had me stop due to liver issues. Is there anyone out there that can give me any advice or suggestions? I truly wish that I had just left the cancer alone, as my quality of life is so poor now that I see very little value in it.
  • Does femara affect crp results?
    Does femara affect the results of the C Reactive Protein test? I have been on it for two years and have side effects of joint pain and hot flashes with nausea.
  • Should a 66-year-old with paroxysmal atrial tachycardia (pat) take herceptin for 6 months instread of 12 months?
    My concern is the potential for cardiac damage from taking Herceptin. The research on Herceptin for highly HER2 positive breast cancer seems less than clear that 12 months of treatment has truly significant benefit over 6 months. With a pre-existing heart condition of PAT (rx metoprolol) and also high blood pressure (rx losartan) would it be more prudent to limit the Herceptin to 6 mos?
  • I have severe bone pain and am taking femara. even when i am not on the drug, the bone pain does not go away. is it possible that the femara is triggering internal herpes outbreaks causing this pain?
    For the past eight months, I have been experiencing severe bone pain, not joint pain, but bone pain that causes me to feel the marrow in my bones is smoldering. I have tremendous amounts of fatigue in addition to genital herpes. I am only taking Femara, Vitamin D and Calcium per the Oncologist orders. I have had a bone scan for cancer a few months ago and my primary care MD told me bone cancer would not cause this type of overall pain.

    I have gone off the Femara for a few weeks at time to see if the pain would subside. It does not. Recently, I began to think that since my herpes outbreaks are triggered by certain foods, especially nuts, maybe an ingredient in the Femara is triggering the more systemic Herpes outbreak. I have never been a person to have headaches, only when I have herpes outbreaks, and now I have severe and frequent headaches. Could there be a connection?

    I have read that Femara can cause bone pain on its own, but this is so over the top from the blogs I have read, something else must be going on. Thanks to anyone who has any information regarding people who have had Herpes outbreaks for years and now are taking Femara.

    I have taken other hormone inhibitors with many side effects for previous breast cancer, which is why my Oncologist chose Femara this time around. Mary
  • Does anyone else have my weight gain problem?
    I have been taking Femara for 3 years, and constantly gain weight. I watch my diet, go to the gym 3 times a week, cycle whenever the weather allows. I´ve just came off a 4 weeks strikt diet and have lost nothing. I didn´t want to get on the scale, as I could feel on my clothes that nothing has changed. I´m desperate, but don´t want to come off the medivation.

    Anyone out there with the same problem? Any hints on what I can do?

    Thank you, Eileen

More questions for: Herceptin, Letrozole

You may be interested at these reviews (Write a review):

  • Bone pain whilst taking letrozole
    Before having breast cancer I walked 10 miles a week, and did a 40 min exercise
    routine. Having had a lumpectomy followed by 15 radiation treatments, and then
    prescribed letrozole for 10 years, I can no longer do my 40 min exercise routine, nor the power walking that I have done for so many years.
    I suffer severe bone pain and fatigue.
    I have come off the medication (3 wks now) after taking letrozole for 6mths.
    I can no longer tolerate the awful side affects, and Im just hoping the cancer
    does not come back.
  • Tinnitus with letrozole
    Sudden onset of ringing in the ears after two weeks on Letrozole 2.5mgs

More reviews for: Herceptin, Letrozole

Comments from related studies:

  • From this study (6 months ago):

  • Also take a liver tonic, kidney tonic, dandelion, Vitamin B, Calcium tablet, vitamin E, vitamin, multivitamin, fish oil, curcumin and selenium. Drink green tea and dandelion tea and liver detox tea.


Complete drug side effects:

On eHealthMe, Herceptin (trastuzumab) is often used to treat breast cancer. Letrozole (letrozole) is often used to treat breast cancer. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.


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