Review: Ibuprofen and Pregabalin
Summary: drug interactions are reported among people who take Ibuprofen and Pregabalin together.
This review analyzes the effectiveness and drug interactions between Ibuprofen and Pregabalin. It is created by eHealthMe based on reports of 2,197 people who take the same drugs from FDA and social media, and is updated regularly.
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Ibuprofen has active ingredients of ibuprofen. It is often used in pain. (latest outcomes from Ibuprofen 61,602 users) Pregabalin has active ingredients of pregabalin. It is often used in fibromyalgia. (latest outcomes from Pregabalin 4,476 users)
What are the drugs
Ibuprofen has active ingredients of ibuprofen. It is often used in pain. (latest outcomes from Ibuprofen 61,602 users)
Pregabalin has active ingredients of pregabalin. It is often used in fibromyalgia. (latest outcomes from Pregabalin 4,476 users)
On Nov, 25, 2014: 2,197 people who take Ibuprofen, Pregabalin are studied
Drug combinations in study:
- Ibuprofen (ibuprofen)
- Pregabalin (pregabalin)
Drug effectiveness over time :
|< 1 month||1 - 6 months||6 - 12 months||1 - 2 years||2 - 5 years||5 - 10 years||10+ years||not specified|
|Ibuprofen is effective||33.33%|
(2 of 6 people)
(1 of 6 people)
(2 of 9 people)
(1 of 6 people)
(1 of 4 people)
(2 of 7 people)
(5 of 14 people)
(1 of 1 people)
|Pregabalin is effective||10.00%|
(1 of 10 people)
(1 of 7 people)
(2 of 5 people)
(6 of 13 people)
(6 of 12 people)
(2 of 3 people)
(0 of 1 people)
Most common drug interactions over time * :
|< 1 month||1 - 6 months||6 - 12 months||1 - 2 years||2 - 5 years||5 - 10 years||10+ years||not specified|
|Dizziness||Pain||Renal Failure Acute||Dizziness||Pain||Lymphocytosis||Muscle Twitching||Pain|
|Drug Ineffective||Nausea||Hyperkalaemia||Vision Blurred||Depression||Chronic Leukaemia||Muscle Spasticity||Anxiety|
|Somnolence||Confusional State||Convulsion||Pain||Gallbladder Non-functioning||Lymphocytic Leukaemia||Euphoric Mood||Fatigue|
|Pain||Vision Blurred||Apathy||Insomnia||Weight Decreased||Pain||Tearfulness||Dizziness|
|Nausea||Dizziness||Paralysis||Somnolence||Balance Disorder||Aggression||Tired Eyes||Nausea|
|Vision Blurred||Fatigue||Loss Of Consciousness||Visual Impairment||Gastric Perforation||Gait Disturbance||Nausea||Drug Ineffective|
|Dry Mouth||Malaise||Disorientation||Myalgia||Cholecystitis Chronic||Fibromyalgia||Tremor||Dyspnoea|
|Oedema Peripheral||Oedema Peripheral||Vision Blurred||General Physical Health Deterioration||Feeling Abnormal||Headache||Headache||Vision Blurred|
|Feeling Abnormal||Fall||Haematemesis||Arthralgia||Mental Impairment||Chronic Lymphocytic Leukaemia||Vision Blurred||Back Pain|
|Weight Increased||Somnolence||Dyspnoea||Drug Ineffective||Fall||Suicide Attempt||Depression||Weight Increased|
Drug effectiveness by gender :
|Ibuprofen is effective||30.95%|
(13 of 42 people)
(2 of 11 people)
|Pregabalin is effective||39.02%|
(16 of 41 people)
(2 of 10 people)
Most common drug interactions by gender * :
|Injury||Intervertebral Disc Degeneration|
|Oedema Peripheral||Osteonecrosis Of Jaw|
Drug effectiveness by age :
|Ibuprofen is effective||n/a||n/a||n/a||25.00%|
(2 of 8 people)
(1 of 24 people)
(8 of 35 people)
(2 of 18 people)
(2 of 8 people)
|Pregabalin is effective||n/a||n/a||n/a||25.00%|
(2 of 8 people)
(2 of 25 people)
(7 of 34 people)
(5 of 18 people)
(2 of 7 people)
Most common drug interactions by age * :
|n/a||n/a||Paraesthesia||Loss Of Consciousness||Pain||Pain||Pain||Pain|
|Heart Rate Increased||Hypoaesthesia||Nausea||Depression||Anxiety||Dyspnoea|
|Device Related Infection||Convulsion||Fatigue||Injury||Nausea||Vision Blurred|
|Pyrexia||Injury||Intervertebral Disc Protrusion||Back Pain||Depression||Back Pain|
|Chills||Abdominal Pain||Dizziness||Fatigue||Drug Ineffective||Osteoarthritis|
|Pain||Nausea||Injury||Weight Increased||Dyspnoea||Oedema Peripheral|
|Weight Increased||Pyrexia||Headache||Intervertebral Disc Protrusion||Somnolence||Fall|
|Pain In Extremity||Gallbladder Disorder||Hodgkin's Disease||Dizziness||Diarrhoea||Dizziness|
|Staphylococcal Bacteraemia||Paralysis||Abdominal Pain||Spinal Osteoarthritis||Insomnia||Nausea|
* Some reports may have incomplete information.
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- support group for people who take Pregabalin
Can you answer these questions (Ask a question):
- Is it safe to take demerol while taking tramadol hydrochloride and hydroxychloroquine (1 answer)
I am experiencing acute, debilitating pain due to the Chikungunya virus, which has reintroduced all of the previous painful symptoms I have,ongoing and in the past, from Fibromyalgia, Arthritis, tendonitis and severe headaches. It's in its 38th day and I am basically crippled from neck to feet. Have to sleep propped up as arms throb with pain when horizontal. The only thing that has subdued the pain slightly are Oxycocet and Ibuprofen, but the pain never goes away. My hands and feet are so inflammed it's difficult to perform even the smallest tasks of personal hygiene and housekeeping. I have difficulty controlling my bladder and often don't make it to the washroom in time. Just started on Demerol today so will no longer take the Oxycocet, but am concerned of the interactions with Demerol, Hydroxychloroquine and Tramadol Hydrochloride extended release tablets that I take daily for the Fibromyalgia and Arthritis. I have dealt with a great deal of pain through the years, but I now have the pain of every serious illness I have had in my lifetime, all at the same time. I honestly didn't think a person could deal with this much pain at once. I have tried and am still taking several vitamins and herbal supplements as well as drinking tons of water and eating really well. Lots of berries, dark vegetables, apples, yogurt and minimal meat. Taking turmeric, papaya leaf, ginger, cinnamon and boswellia for the inflammation. Taking minimal wheat products, sugar and no alcohol. Also, drinking green, fennel and nettle tea daily. I know this is a lot of information, but I really need help and wonder if anyone has any suggestions! Thanking you in advance!!!
- Any information on deaths from taking lyica and high doses of alprazolam
My Mother was a healthy 89 yr old with no healt issues, she was put on anxiety medicine, which she took regularly. She was also taking Lyric and had just started her Macular degeneration shots. She was prone to bladder infections and we went to the dr. for that, labs showed high calcium, within one week I had to take her to the emergency room, within one day she was on oxygen, within three days she was in the ICU intubated and unresponsive. She remained in ICU for 4 days had renal failure and died two days later.
- Is pregabalin aggravate the symptoms of bph?
I am having BPH. for foot pain doctor prescribes Pregabalin. that night the symptoms of BPH worsens. Is it due to Pregabalin? pl.write.
- Is ibuprofen safe to use if i have retinitis pigmentosa?
I have bulging disc pain that I use Ibuprofen for. I can be pain free for weeks/months and take nothing. When I have a flair up I can take up to 8x200mg per day. I have heard this may affect my RP. Can you advise?
- Propranolo & pregabalin - do they produce heart troubles? my meds mix has
Being on zopiclone 75mg (sleep med) gave me terrible poly/firbomyalgia, which I was then prescrbed pregabalin to aleviate pains and anxiety, and the propranolo to help with the same. On day one of propranolo I had a medium heart attack like event, within 24hrs had a large attack and became hospitalised. But vital signs and chest xray, blood tests, then showed 'normal'. But since then have had several more (almost one or more a month) heart attacklike events, hospitalisation, etc, but still being told all 'normal'. But now I've met someone who has told me they had similar heart issues and were told professionally for years his vital signs were normal : he now has a tripple-heart-bypass. I keep being told the angina like symtoms I have are anxiety realted - "only". But when I look at the professional descriptions and illustrations of angina, and similar, I see I could have written and drawn those from my own experiences. Hellish! No where to turn to. So I'm stopping the meds now one by one in careful withdrawl - docs don't like it - but I'm convinced my meds are slowly degrading my overall health as they build up into a toxic soup in me. I started this withdrawly after I discovered that - officially - Pregabalin (a calcium ?minimiser) and Propranolol (a beta blocker) should not be taken together in case they cause heart malfunctions... shame my doctors didn't know that.... before they let me take them for 8 months!!!!!!
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- Leg pain especially near knees after taking lyrica
Had to stop taking Lyrica due to joint pain in both legs. Difficult to get up from sitting position to stand. Ache in knee's can't relax to sleep. Motrin and vicodin not helping with pain. Also have applied muscle cream not working for pain. Have been off the lyrica for 3 months with no let up in pain. Did not have this pain before taking lyrica.
- 3 strong drugs together against neuropathic pain
Neuropathic pain debuted when I was 24, now I'm 50. Received diagnosed with Ehler-Danlos syndrome (EDS), joint hypermobility type, when I was 35 years old. So it can take some time to get a diagnose. And as EDS-patient I do not belong to any clinic. Orthopedics says that EDS is not orthopedic, rheumatology says that EDS is not an autoimmune disease, GPs say that EDS is too difficult, and so on. Sooner or later we all end up at Psychiatry, even if we are not depressed.
The first kind of pain I got when I was 24 came from low back, but I experienced as pelvic pain and leg pain. It was clearly a neuropathic pain, but it took years to find out. Later it was treated by a pain clinic with cortisone around the genitofemoral nerves (both sides). Since this treatment didn't result in lasting freedom from pain, the pain clinic started to give me RF (radio frequency) treatment. This made the pain disappeared after one year, and I was 80% free from it between 2002 and 2014, 12 years. The pain doctors said pain could return after 10 years.
The other kind of neuropathic pain started 2003 with intense stomach pain. During 6 months I could hardly eat nothing due to nausea and vomiting. After this 6 months, stomach pain changed to almost unbearable pain in upper back.
What happened 2003, and what all the doctors missed, was that the right lowest ribs slid up over the sternum. This rib dislocation is till there today, but now with a lot of cartilage formed around the rib where it is stuck in the lower end of the sternum. The dislocation is clearly visible on X-ray. This has greatly affected the thoracic spine. I have a scoliosis which I had not before 2003. And I still have severe pain in the thoracic spine.
It was initially treated with morphine daily, and later with Durogesic (fentanyl), but this didn't help much. 2005 I was hospitalized because I had too much pain to take care of myself and my hygiene. After some months the doctors started to give me clonazepam because the muscles along the spine was in a chronic seizures. Clonazepam helped, but I could still have a lot of pain in two vertebrae in the thoracic spine. It felt as if someone drilled into the vertebrae without anesthesia. After a few months, doctors also prescribed me methadone. Then the pain disappeared almost completely. Since 2006, I have eaten clonazepam and methadone every day, and I need to sleep in an armchair to not get more pain because of moving during sleep.
There are side effects. After 1,5 years with clonazepam and methadone I started to have panic attacks. Or rather one long panic attack which didn't stop before I got treatment with amitryptilin and pregabalin (Lyrica). These 2 medicines stopped the panic disorder completely after some hours, and the panic was then gone. Then I got side effects of these 2 medicines, amitryptilin & Lyrica, too. I gained a lot of weight (from 83 to 148 kg) and got much water (edema) in both my legs under the knees and in both feet. The feet could swallow to the double size. 2012 I stopped with amitryptilin and started to loose weight again (in Aug 2014 below 80 kg) and get less water in my legs. Today I eat as little medicines I can, but I have to take methadone, clonazepam and Lyrica every day, twice. If I try to take away one of these 3 medicines, I got pain problems at once. Lyrica is the most painful one to take away. In Sept-Dec 2013 I lowered Lyrica from 300 mg daily, to 150, then to 75 and finally 0 mg. The pain I had was extremely difficult to handle. It didn't help to take more methadone or anything else. I have checked on Internet and found that many people got pain from quitting with Lyrica. Most people start eating it again. So did I. But 2006 and 2007 it was enough to treat the pain with methadone and clonazepam, I got the Lyrica against anxiety not pain. But today I take Lyrica against pain.
Beside weight gain and leg edema, clonazepam and Lyrica significantly affect the sexual desire. And Lyrica alone makes it almost impossible to ejaculate. All four drugs together (clonazepam, methadone, amitryptiline and Lyrica), make one forget all about sex life. You don't even miss it. When I stopped with amitryptiline and lowered Lyrica (still taking clonazepam and methadone), I could suddenly easily get erections again, feel desire, but not getting orgasms. This is quite difficult to deal with.
The pain pattern is greatly affected, by pain and by the medicines. So is the mood. I get something which feels like heavy depression, especially if I take the medicines late that day. I should take a medicine like methadone 3 times a day, because the effects of the tablet lasts around 8 hours. But I take them every 12 hours, to have a low consumption in case doctors prescribe them too late (which happens, and then it's good to have a spouse going to the pharmacy buying them for you, because you have too much pain to go yourself).
Since methadone is also used for treating heroine addicts, medical staff treat you with disrespect when they see that it says "methadone" in your health record. I need to show a certificate that says that I deal with chronic neuropathic pain, that I never have had problems with drug addiction, to get normal respect.
I wanted to share this because I think I am alone in the world with these medicines in combination against neuropathic pain caused by hypermobile joints, joint dislocation and muscle spasms. After trying almost everything else, including surgery cutting nerves, methadone, clonazepam and Lyrica seems to be the only way to kill my pain. But it's a life where you always is questioned, because of the use of methadone. I can guarantee that everybody in the world should accept these medicines if they had experienced the unbearable pain I had in upper back before they started to give me clonazepam and methadone.
- Nexium improves my constipation
Started taking Nexium 1 week ago and I noticed improvement with my chronic constipation.
- Nightmare on lyrica st.
r.knee revision 3rd.and last time due from Mersa infection and blood clot left me 1 1/2 shorter on r. Leg. Lost a lot of nerves in foot lower r. Leg.bulging disc was from falling from knee revision and for 9 months had no knee and on crutches.had lots of falls and blew out lower back. Put me on lyrica 2 weeks ago now up to 120 mg.With perks 4 times a day. The title says it all when trying to sleep :( my dream hands down beat any horror movies and directors. 2 hours of sleep per night and overly beat down :(.the only 2 good things I have going,my since of silliness and the Lord :) I guess family also.so far not much help with meds but willingly and pos, that both will work, the Lord :) thanks and God bless
- Lyrica varied widely
I was prescribed Lyrica for treatment of chronic pain. It was ineffective, but it knocked out the symptoms of interstitial. However, it also caused rapid weight gain (I went from 110 to 130 lbs. in just a few weeks) and my ankles started to swell. The pain doctor advised me to discontinue the drug, but the urologist suggested lowering the dose. I did, and the swelling went down. I weighed myself daily and watched what I ate, and my weight returned to normal within a month. Subsequently, I continued taking the lower dose and had no further problems. Then I developed severe spinal stenosis, and my dosage of Lyrica was increased to six 75 capsules daily, in addition to 480 mg of morphine sulphate. I tolerated the Lyrica well. After surgery, however, my ankles began to swell again, and although I didn't have a problem with weight gain, I developed a bright red rash from ankles to knees. I dropped the dosage of Lyrica to 50 mg twice daily, and had no further side effects. The rash simply disappeared, with no damage to the skin. Following the surgery, I was able to titrate off morphine completely. I continue to take Lyrica twice daily. It doesn't seem to affect pain (I still ache a bit, as I have degenerative changes in all joints) but it does dampen peripheral neuropathy, which I experience both in my toes and balls of my feet. It also dampens the neuropathy in my forehead, where I had four surgeries to remove a malignant melanoma. I have had no side effects other than those mentioned, and find it interesting the I could tolerate a high dosage of Lyrica prior to surgery, but after surgery could not, and that adverse side effects varied not only with the dosage but with my own physical condition. I don't find it to be highly effective in treating neuropathy, but it does still the tingling enough to let me sleep and take my mind off the condition.
Comments from related studies:
From this study (2 months ago):
Elavil, 25mg @ night stopped an 11 month chronic headache after a head injury, I sustained 1 1/2 years ago.
Additionally, Neurologist prescribed 100 mg Lyrica for chronic back/nerve pain from moderate/severe spinal injuries, sustained 20+ years earlier. (Crushed/cracked verabrae and 3 intervertebral disc bulges)
I had been using Ibuprofen daily in moderate to heavy dosage for the last 20+ years. (800+ mg daily B/4 and then continually after recent head injury)
I was advised to stop/reduce use of Motrin to 1/2 month or less. It is still the best pain relief but have reduced to PRN, perhaps 200 mg alternate days.
Since treatment with Lyrica I've noticed reduced nerve pain and stopped using Elavil for sake of not feeling so "wrecked" in the mornings. I have also developed a severe sleep apnoea, treated unsuccessfully via CPAP device which is unbearable to use. I have subsequently suffered with depression/mood disorder for 20+ years and am currently un-treated for this long-standing vulnerability which came back with a vengence after the head-injury. I feel irregularity to my heart beat by the end of the day. I feel suicidal and violently angry.
Squidly on Oct, 25, 2014:
Found this because I have similar symptoms- brain injury 2005, 12 herniated discs with osteophytes, migraines, seizures and the like. 1. The Motrin is an easy fix. Swap it out for Mobic (Meloxicam). I replaced 1600mg/day for 12mg Mobic and it's easier on the stomach. 2. The Evril and Lyrica taken together causes dizziness. Get a different antidepressant or swap the Lyrica for Neurontin (gabapentin). I had to because I couldn't stand up without passing out. 3. The B/4 I'm stumped on as its not approved for use in the United States but I know it can help with seizures but a friend of mine tells me it makes her sick. 4. Waking up at night. No where in your medication is a pain reliever or muscle relaxer for your back. An anti-inflammatory like Ibuprofen will not cut it when you lay on it. Get both, whether low level like Flexoril and Hydrocodone, or if needed Soma and Methadone. Something is needed to relieve the pain on your back which, can also cause the headaches. 5. Anger - A head injury can cause an inability to control ones emotions, even reacting inappropriately (wrong emotion or too much emotion) in circumstances. If this is the case, treat yourself as a toddler and try to relearn how to react (counting to 10, timeouts) and informing loved ones this is going on. Another thing is that you may have Marijuana rage. This is something I thought was untrue until my brother-in-law stabbed his wife's hand with a fork for being near him while smoking with his buddies. Just as there are angry drunks, there are angry pot heads and TBI can change how you react.
dutchgirlsamm on Aug, 30, 2014:
Lyrics is known to cause suicidal thoughts and aggression...its called an adverse reaction.
Complete drug side effects:
On eHealthMe, Ibuprofen (ibuprofen) is often used to treat pain. Pregabalin (pregabalin) is often used to treat fibromyalgia. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.
What is the drug used for and how effective is it:
- Ibuprofen is used in:
- Pregabalin is used in:
Other drugs that are used to treat the same conditions:
- Ibuprofen alternatives:
- Pregabalin alternatives:
NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
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