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Review: Imitrex and Benadryl





Summary: drug interactions are reported among people who take Imitrex and Benadryl together.

This review analyzes the effectiveness and drug interactions between Imitrex and Benadryl. It is created by eHealthMe based on reports of 181 people who take the same drugs from FDA and social media, and is updated regularly.

You are not alone: join a mobile support group for people who take Imitrex and Benadryl >>>

What are the drugs

Imitrex has active ingredients of sumatriptan succinate. It is often used in migraine. (latest outcomes from Imitrex 5,981 users)

Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in allergies. (view latest outcomes from 29,367 users)

On Nov, 25, 2014: 180 people who take Imitrex, Benadryl are studied

Imitrex, Benadryl outcomes

Drug combinations in study:
- Imitrex (sumatriptan succinate)
- Benadryl (diphenhydramine hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Imitrex is effective50.00%
(1 of 2 people)
100.00%
(1 of 1 people)
n/a100.00%
(1 of 1 people)
50.00%
(1 of 2 people)
100.00%
(1 of 1 people)
100.00%
(1 of 1 people)
0.00%
(0 of 1 people)
Benadryl is effective50.00%
(1 of 2 people)
n/a100.00%
(1 of 1 people)
0.00%
(0 of 1 people)
66.67%
(2 of 3 people)
n/a50.00%
(1 of 2 people)
n/a

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Painn/an/aSleepyJoint PainGeneral Physical Health DeteriorationAbdominal Pain LowerNausea
Renal FailureTremorOedema PeripheralPain In Extremity
Pain In ExtremityAbdominal Pain LowerInjuryDiarrhoea
InjuryEmotional DistressVomiting
DystoniaDeep Vein ThrombosisOedema Peripheral
Drug IneffectiveChest PainInjury
Pharyngeal HypoaesthesiaPain In ExtremityDeep Vein Thrombosis
Accidental ExposureRespiration AbnormalAbdominal Pain
Esophageal Stricture - BenignPulmonary EmbolismBlood Alkaline Phosphatase Increased
ColitisDyspnoea ExertionalAnaemia

Drug effectiveness by gender :

FemaleMale
Imitrex is effective62.50%
(5 of 8 people)
100.00%
(1 of 1 people)
Benadryl is effective50.00%
(4 of 8 people)
100.00%
(1 of 1 people)

Most common drug interactions by gender * :

FemaleMale
NauseaMemory Impairment
Pain In ExtremityTherapeutic Response Unexpected
DiarrhoeaCognitive Disorder
VomitingDepression
Oedema PeripheralInjury
Deep Vein ThrombosisSomnolence
ArthralgiaMusculoskeletal Discomfort
AstheniaConversion Disorder
InjuryDystonia
MigrainePain In Extremity

Drug effectiveness by age :

0-12-910-1920-2930-3940-4950-5960+
Imitrex is effectiven/an/an/a0.00%
(0 of 2 people)
16.67%
(2 of 12 people)
66.67%
(2 of 3 people)
100.00%
(1 of 1 people)
100.00%
(1 of 1 people)
Benadryl is effectiven/an/an/a50.00%
(1 of 2 people)
8.33%
(1 of 12 people)
33.33%
(1 of 3 people)
100.00%
(1 of 1 people)
100.00%
(1 of 1 people)

Most common drug interactions by age * :

0-12-910-1920-2930-3940-4950-5960+
n/an/aDiarrhoeaPain In ExtremityMigrainePain In ExtremityNauseaPulmonary Oedema
DizzinessPeripheral ColdnessMuscle SpasmsMusculoskeletal DiscomfortPain In ExtremityPleural Effusion
LymphadenitisSkin DiscolourationHypersensitivityChest PainVomitingRash
PainHypoaesthesiaBlood Pressure IncreasedDiarrhoeaInjuryMulti-organ Failure
VomitingMuscular WeaknessNauseaDyspnoea ExertionalAnaemiaSupraventricular Tachycardia
PhotophobiaPulmonary EmbolismInjection Site PainPainArthralgiaAtrial Fibrillation
HeadacheMigraineVomitingOropharyngeal PainAstheniaDysphagia
Musculoskeletal StiffnessDeep Vein ThrombosisCholelithiasisNauseaPurulent DischargeConfusional State
Epstein-barr Virus InfectionCrohn's DiseaseDyspepsiaInjuryAbdominal PainFall
DysphoniaAscitesPruritusCoughHypoaesthesiaMetabolic Acidosis

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Imitrex and Benadryl?

You are not alone! Join a related mobile support group:
- support group for people who take Imitrex and Benadryl
- support group for people who take Benadryl
- support group for people who take Imitrex

Can you answer these questions (Ask a question):

More questions for: Benadryl, Imitrex

You may be interested at these reviews (Write a review):

  • Dyphenhydramine and headaches horrible going one almost 24 hours a day for 4 weeks and cant get them to stop, now looking for cause . think its the dyphenhydramine im taking to help me sleep .
    have been taking 3 dyphenhydramine for some time to help me sleep , just in last few weeks began having severe headache almost all the time.. cant get it to go away. just found out it can cause headache and am going to lower my intake to one per night and see if my headaches get better. am taking migrane meds and that hasnt helped a bit so think its not migranes im having. some other reason.
  • Nightmare on benadryl
    After 5 nights without sleep and not having past bad dreams, the last 2 night's taking walfrin sub, for benadryl has terrified THE WORST OF WORST dream in my 55 years. Peaceful start of a dream then seeing myself or family,friends get slottard.crazy thing is I don't watch scary movies or the news. I think I'm going to pass on this meds, and pass out next time :) thank you,God bless
  • Benadryl completed suicide 50 year old
    My mother comitted suicide by taking a bottle of Benadryl. She also had been drinking, she had taken xanax and drank beer, she also took 300 Benadryl pills and started having seizures and went to the hospital was brain dead and her heart stopped the next morning.
  • Imetrix verses butalb/acet/caffeine
    I have taken both Imitrex and Butalb/acet/caffeine and I have to say that Imitrex works far better than the other one! The substitute I was given for Imitrex doesn't even touch my migraine pain.
  • Had nms in 2005, will trileptal increase chance of recurrence?
    In 2005 I had NMS, which was not detected by my drs for 4 months. I'd been on Lexapro & Seroquel for 2 yrs, but was weaned from Lexapro & placed on Lamictal 3/05. Began getting low-grade fevers, which I was told were not caused by the Lamictal. I quit taking it anyway, fevers (along with uncontrollable shivering) continued & got higher. By 5/05 my temps were reaching 105 deg F. Husband said I became combative, refused to go to hospital. Early June/05 he came home to find me wrapped in blankets, with a temp over 105 F. He tried to place me in a tub of cold water, said I was rigid & screamed when he tried to move me. I was in the tub, speaking "in tongues" (his description, I have no memory of this). He called 911, took me to hospital. I woke, no idea where I was or why. After a lumbar puncture & 2 days in ICU I went home. The fevers continued...2 weeks later he came home to find me wrapped in sheets, towels, blankets, with the heat on full (it was in the 90's outside) he called ambulance again. I awoke to find myself under an ice blanket with nurses pushing large vials of dantrolene into both arms, several liters. Another LP, a stint in ICU...this time they told me it was NMS. The dr who dxd me said he was surprised I was alive, & not a vegetable, as my temp had peaked at 109 deg F. I suffered brain damage; short-term memory loss, brain can't control my body temp, my blood pressure went up. An arteriogram showed completely healthy heart & arteries, no plaque at all. I lost all body fat as well as some muscle mass. The fevers continued even after stopping the Seroquel. I visited my PCP for a checkup in 9/05, temp was normal. I started shuddering, my temp went up a full degree every 5 minutes. PCP admitted me to ER, my heart rate was over 272 B/M; they stopped my heart 3 times to "reset" it, which didn't work. I spent 3 days in hospital. Several months later my P doc tried me on Lamictal alone; I got Stevens-Johnson syndrome. I stopped the drug as soon as the signs appeared. I've been untreated, except for Neurontin & Primidone, until my manic episodes became unlivable. 3 weeks ago I went 8 days with no sleep, became psychotic. My P doc gave me Trileptal, which has evened my moods, but I've been getting low-grade fevers (highest was 103.6). Would having had NMS in the past make me more prone to falling to it again with the Trileptal? It's the only new med I've taken in over a year.

More reviews for: Benadryl, Imitrex

Comments from related studies:

  • From this study (9 months ago):

  • 5/325 every 4 hours as needed. 0-4 per day. Would like to stop taking this drug as my eye pressure has increased. Only take it if the pain is 10+++. Looking for Orthopedic Surgeon to fix the bulging disks.

    Reply

Complete drug side effects:

On eHealthMe, Imitrex (sumatriptan succinate) is often used to treat migraine. Benadryl (diphenhydramine hydrochloride) is often used to treat allergies. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

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You may report adverse side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

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