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Review: taking Imodium and Promethazine together

Summary: drug interactions are reported among people who take Imodium and Promethazine together. This review analyzes the effectiveness and drug interactions between Imodium and Promethazine. It is created by eHealthMe based on reports of 475 people who take the same drugs from FDA and social media, and is updated regularly.

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What are the drugs

Imodium has active ingredients of loperamide hydrochloride. It is often used in diarrhea. (latest outcomes from 10,175 Imodium users)

Promethazine has active ingredients of promethazine hydrochloride. It is often used in nausea. (latest outcomes from 1,222 Promethazine users)

On May, 12, 2015: 475 people who take Imodium, Promethazine are studied

Imodium, Promethazine outcomes

Drug combinations in study:
- Imodium (loperamide hydrochloride)
- Promethazine (promethazine hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Imodium is effective50.00%
(2 of 4 people)
(1 of 1 people)
(0 of 1 people)
Promethazine is effective100.00%
(4 of 4 people)
(1 of 1 people)
(0 of 1 people)

Drug effectiveness by gender :

Imodium is effective60.00%
(3 of 5 people)
(0 of 1 people)
Promethazine is effective80.00%
(4 of 5 people)
(1 of 1 people)

Drug effectiveness by age :

Imodium is effectiven/an/an/a25.00%
(1 of 4 people)
(1 of 1 people)
(1 of 24 people)
Promethazine is effectiven/an/an/a75.00%
(3 of 4 people)
(1 of 1 people)
(1 of 24 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Cardiac Failure CongestiveSinus TachycardiaConfusional Staten/aSkin Burning SensationSkin Burning Sensationn/aDiarrhoea
Interstitial Lung DiseaseSpinal OsteoarthritisDiarrheaDiarrheaNausea
Respiratory FailureRashHeadacheHeadacheVomiting
AnaemiaUterine LeiomyomaLethargyLethargyDehydration
NauseaMyositisAnxiety, Apprehension, Feeling Uptight, Jitters, Stress, Stress And Anxiety, TensionAnxiety, Apprehension, Feeling Uptight, Jitters, Stress, Stress And Anxiety, TensionPain
Renal Tubular NecrosisDiarrhoeaConstipationConstipationDepression
VomitingDiabetes MellitusPancreatitis AggravatedPancreatitis AggravatedAbdominal Pain
GastroenteritisHeart Rate IncreasedNauseaNauseaPneumonia
MyositisCondition AggravatedNausea AggravatedNausea AggravatedFatigue
Gastrointestinal HaemorrhageJoint SwellingChronic SinusitisChronic SinusitisAnxiety

Most common drug interactions by gender * :

VomitingAbdominal Pain
DehydrationChest Pain
Urinary Tract InfectionGastrointestinal Haemorrhage

Most common drug interactions by age * :

n/aFoetal Exposure During PregnancyChillsCholecystitis ChronicNauseaNauseaPneumoniaDiarrhoea
Premature BabyCatheter Related InfectionAnxietyFatigueDehydrationCardiac Failure CongestiveNausea
Blood Potassium DecreasedPainChest PainDyspnoeaNauseaFall
PyrexiaGallbladder DisorderHeadacheDiarrhoeaRenal Failure AcuteVomiting
Abdominal DistensionMental DisorderInsomniaDepressionVomitingDehydration
HyperlipidaemiaDeep Vein ThrombosisDiarrhoeaAbdominal PainPainHypotension
AnxietyEmotional DistressAbdominal PainDiabetes MellitusGeneral Physical Health DeteriorationAnaemia
Diabetes MellitusPulmonary EmbolismDepressionInsomniaDehydrationAnxiety
Emotional DistressIrritable Bowel SyndromeDisturbance In AttentionUrinary Tract InfectionAnxietyPain

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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Do you take Imodium and Promethazine?


You are not alone! Join a related support group:
- support group for people who take Imodium
- support group for people who take Promethazine

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Complete drug side effects:

On eHealthMe, Imodium (loperamide hydrochloride) is often used to treat diarrhea. Promethazine (promethazine hydrochloride) is often used to treat nausea. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.


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