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Review: taking Imuran and Enbrel together

Summary: drug interactions are reported among people who take Imuran and Enbrel together.

This review analyzes the effectiveness and drug interactions between Imuran and Enbrel. It is created by eHealthMe based on reports of 455 people who take the same drugs from FDA and social media, and is updated regularly.





You are not alone: join a mobile support group for people who take Imuran and Enbrel >>>

What are the drugs

Imuran has active ingredients of azathioprine. It is often used in crohn's disease. (latest outcomes from 9,814 Imuran users)

Enbrel has active ingredients of etanercept. It is often used in rheumatoid arthritis. (latest outcomes from 175,547 Enbrel users)

On Feb, 5, 2015: 455 people who take Imuran, Enbrel are studied

Imuran, Enbrel outcomes

Drug combinations in study:
- Imuran (azathioprine)
- Enbrel (etanercept)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Imuran is effective0.00%
(0 of 1 people)
(1 of 2 people)
Enbrel is effectiven/an/a0.00%
(0 of 1 people)
(0 of 1 people)
(0 of 1 people)
(2 of 2 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
PsoriasisFailure To ThrivePyrexiaFailure To ThriveRed Blood Cell Sedimentation Rate IncreasedUrinary Tract InfectionHaemorrhoidsDiarrhoea
PainSquamous Cell Carcinoma Of SkinEyelid DisorderCondition AggravatedArthritisMalaiseAnal FistulaPain
InflammationLeukopeniaEyelid PtosisRenal Failure ChronicRenal Failure ChronicAtrial FibrillationDiffuse Large B-cell LymphomaInjection Site Pain
Rheumatoid ArthritisImpaired HealingDiplopiaArthritisArthralgiaInterstitial Lung DiseaseCardiomyopathyNausea
SyncopeDyspnoeaVomitingArthralgiaMycobacterium Avium Complex InfectionNauseaAnal UlcerPyrexia
Uterine InfectionSystemic Lupus ErythematosusJoint SwellingSystemic Lupus ErythematosusConvulsionEndometrial Cancer Stage ISalivary Gland NeoplasmFatigue
Pulmonary OedemaNeutropeniaArthritisMycobacterium Avium Complex InfectionOvarian Epithelial CancerKnee ArthroplastyInterstitial Lung DiseaseSepsis
Respiratory Tract InfectionOvarian Epithelial CancerOcular MyastheniaConvulsionHaemangiomaPain In ExtremityLung NeoplasmOedema Peripheral
Haemoglobin DecreasedCutaneous VasculitisPainDiverticulitisRheumatoid ArthritisSkin AtrophySinusitis
HypotensionSyncopeActivities Of Daily Living ImpairedImpaired HealingLung ConsolidationCardiac Failure CongestiveAnaemia

Drug effectiveness by gender :

Imuran is effective50.00%
(1 of 2 people)
(0 of 1 people)
Enbrel is effective50.00%
(2 of 4 people)
(0 of 1 people)

Most common drug interactions by gender * :

Injection Site PainFailure To Thrive
NauseaCondition Aggravated
FatigueInjection Site Haematoma
ArthralgiaErectile Dysfunction
Oedema PeripheralDizziness

Drug effectiveness by age :

Imuran is effectiven/an/an/an/a33.33%
(1 of 3 people)
(0 of 1 people)
(0 of 1 people)
Enbrel is effectiven/an/an/an/a33.33%
(1 of 3 people)
(0 of 1 people)
(1 of 2 people)
(0 of 1 people)

Most common drug interactions by age * :

n/aParvovirus B19 Serology PositivePyrexiaTransient Ischaemic AttackPyrexiaArthritisPainInjection Site Pain
Parvovirus InfectionConvulsionFuruncleHeadacheArthralgiaDiarrhoeaArthralgia
White Blood Cell Count DecreasedMycobacterium Avium Complex InfectionImmunodeficiencyLeukopeniaPainStomatitisDyspnoea
ImmunosuppressionHistiocytosis HaematophagicInjection Site WarmthGranulocytopeniaNauseaTooth AbscessNausea
Histiocytosis HaematophagicHepatorenal FailureRash GeneralisedHypertensionPyrexiaOedema PeripheralRash
Blood Urea IncreasedPneumocystis Jiroveci InfectionInjection Site SwellingJoint SwellingRenal Failure ChronicSwellingRheumatoid Arthritis
Fibrin D Dimer IncreasedLung ConsolidationInjection Site PruritusTachycardiaSquamous Cell Carcinoma Of SkinRenal FailureCondition Aggravated
Haematocrit DecreasedJuvenile ArthritisHypoaesthesia OralRespiratory Tract InfectionRed Blood Cell Sedimentation Rate IncreasedFoot FractureInjection Site Erythema
Haemoglobin DecreasedDisseminated Intravascular CoagulationSpeech DisorderCystitisActivities Of Daily Living ImpairedGastrooesophageal Reflux DiseaseFall
Activated Partial Thromboplastin Time ProlongedHaemangiomaInjection Site ErythemaDiarrhoeaUrinary Tract InfectionExostosisPsoriasis

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Get connected: join our support group of Imuran and Enbrel on

Do you take Imuran and Enbrel?

You are not alone! Join a related mobile support group:
- support group for people who take Imuran and Enbrel
- support group for people who take Enbrel
- support group for people who take Imuran

Can you answer these questions (Ask a question):

More questions for: Enbrel, Imuran

You may be interested at these reviews (Write a review):

  • Enbrel related to higher cholesterol levels and trigly
    On enbrel 150mg per week. Have high cholesterol and trigly levels. Taking provastatin, trilipix, and lovaza to conteract high levels. Experience much gastro disburance and naseau. Have heart disease now and two stents in my RCA as it was 100% blocked on year ago. Also taking effient, norvasc, and metpropol. Taking coq10 supplement, zantac, and culturelle. If off enbrel gastro problems clear. There is a definite negative increase when on enbrel. There is a definite increase side effect when on enbrel and statins/acid lowering trigly meds. Let's see some research on this. Need enbrel to walk and get partial clearing of skin. 10 year battle now between drugs. Thinking of humira now as i see studies have shown impoved arterial sclorosis events. Help!!!!
  • Having leg cramps after 2 years on enbrel
    Started having leg cramps after using Enbrel for almsot 2 years. They start the day I give the injection and have lasted 1-3 days waking me several time in the middle of the night.
  • Hair loss with enbrel
    I have been on Enbrel for 4 months and started seeing significant hair thinning at the second month of treatments (50 mg once per week). My Rhuematologist suggested 800 mcg of folic acid. I am still losing hair although I am feeling so much better.
  • Etanercept and irritability
    I have been on Etanercept for 8 years for Psoriasis. Previous to this I was on
    Methotrexate, Cyclosporine, Retinodes and ACTH injections.Since being on 25mg twice a week I have been 98% clear.The only side effect to date is "Irritability" which lasts about 24hrs.
    This Drug has been my saving grace.
  • Humira: my experience
    I have had some form of arthritis probably since birth. My father and maternal grandfather had some form of arthritis. I began to realize pain in both ankles if I stood or walked too long.

    I began taking many NSAIDs when I was around 22. I've done gold, prednisone (twice), plaquenil, butazoidin, sulfasalazine, etc. My best results came with methotrexate after I got cellulitis in my knee (scratch it while kayaking in the summer, fiberglass boat). It dropped my sed rate from over 100 to 35 or so within a few months. I continued with MTX from 1977 to 2000 when my MD suggested Enbrel and stopping MTX. That was a VERY bad decision. Enbrel appeared to mask the disease for a few years. I had my left MCP replaced in 2004, my right heel debrided in 2010, and both my TMJs replaced in 2012. I strongly believe that if I had kept with the MTX it would have delayed those changes. Additionally, in 2011 I was in a bus crash returning from RAGBRAI. I got knocked out from three to six minutes. I had a nasty concussion that lasted 2+ years. Towards the end of the third year post accident I started exercising more aggressively. After doing several 40, 50, and 60 miles rides, I took a leisurely 50 mile ride around Boston at night. Two days later I had a spinal edema. So much for biking and other active sports! :-(

    I have continued with MTX. Late 2013 my MD increased my MTX to .8/week. I had been taking .6/week. I stopped taking Enbrel and switched to Humira in early 2014. I took it for a few months before my doc and I realized it was not doing any better than Enbrel. I tried Humira for three months but it did not seem to work any better than Enbrel. In early June I stopped Humira and waited a few weeks before I started Otezla. I stopped Oterzla on 9/15/14 because it made me depressed and allowed my morning stiffness to get much worse.

    I started prednisone again from the start of July. By mid-August I told my MD that I was screaming louder than I ever had; my dog was very startled. I stopped it gradually over the next two weeks. Meanwhile, the Otezla made me feel awful.

    My MD is going to get me onto another injectable that I take monthly. I forget its name.

More reviews for: Enbrel, Imuran

Comments from related studies:

  • From this study (3 weeks ago):

  • I am currently experiencing constant muscle contractions in my abdomen and jerking movements in my neck and midsection. My neck will pull back by itself... Or while I'm standing I'll involuntarily bend over. I'm also having balance issues. I feel very unstable walking and am experiencing some tremors.


Complete drug side effects:

On eHealthMe, Imuran (azathioprine) is often used to treat crohn's disease. Enbrel (etanercept) is often used to treat rheumatoid arthritis. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.


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