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Review: Keppra and Benadryl





Summary: drug interactions are reported among people who take Keppra and Benadryl together.

This review analyzes the effectiveness and drug interactions between Keppra and Benadryl. It is created by eHealthMe based on reports of 278 people who take the same drugs from FDA and social media, and is updated regularly.

You are not alone: join a mobile support group for people who take Keppra and Benadryl >>>

What are the drugs

Keppra has active ingredients of levetiracetam. It is often used in epilepsy. (latest outcomes from Keppra 21,210 users)

Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in allergies. (latest outcomes from Benadryl 29,367 users)

On Nov, 28, 2014: 278 people who take Keppra, Benadryl are studied

Keppra, Benadryl outcomes

Drug combinations in study:
- Keppra (levetiracetam)
- Benadryl (diphenhydramine hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Keppra is effective33.33%
(1 of 3 people)
0.00%
(0 of 2 people)
100.00%
(1 of 1 people)
n/a50.00%
(1 of 2 people)
n/an/an/a
Benadryl is effective0.00%
(0 of 3 people)
0.00%
(0 of 1 people)
n/a0.00%
(0 of 1 people)
n/a50.00%
(1 of 2 people)
n/an/a

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Blood Bilirubin IncreasedToxic Epidermal NecrolysisDizzinessn/an/aDizzinessn/aConvulsion
Renal Failure AcuteSeizure AnoxicNausea
ConvulsionHeadache
FatigueVomiting
Red Blood Cell Sedimentation Rate IncreasedDiarrhoea
Gamma-glutamyltransferase IncreasedAnaemia
Brain OedemaPyrexia
Transferrin Saturation DecreasedDyspnoea
High Density Lipoprotein DecreasedPneumonia
Mean Platelet Volume DecreasedTremor

Drug effectiveness by gender :

FemaleMale
Keppra is effective25.00%
(1 of 4 people)
50.00%
(2 of 4 people)
Benadryl is effective0.00%
(0 of 4 people)
33.33%
(1 of 3 people)

Most common drug interactions by gender * :

FemaleMale
NauseaConvulsion
ConvulsionDyspnoea
HeadacheAnaemia
VomitingNeutropenia
AstheniaVomiting
DepressionThrombocytopenia
DiarrhoeaRenal Failure Acute
AnxietyMental Status Changes
Pain In ExtremityNausea
SyncopeHypotension

Drug effectiveness by age :

0-12-910-1920-2930-3940-4950-5960+
Keppra is effectiven/a0.00%
(0 of 2 people)
0.00%
(0 of 1 people)
100.00%
(2 of 2 people)
0.00%
(0 of 3 people)
100.00%
(1 of 1 people)
n/an/a
Benadryl is effectiven/a0.00%
(0 of 2 people)
0.00%
(0 of 1 people)
100.00%
(1 of 1 people)
0.00%
(0 of 3 people)
0.00%
(0 of 1 people)
n/an/a

Most common drug interactions by age * :

0-12-910-1920-2930-3940-4950-5960+
n/aDehydrationBlood Bilirubin IncreasedHeadacheConvulsionFatigueNauseaConvulsion
HaematocheziaConvulsionVomitingAlanine Aminotransferase IncreasedNauseaPyrexiaNausea
Diarrhoea HaemorrhagicHeadacheNauseaBlood Bilirubin IncreasedFallConvulsionAnaemia
Haemoglobin DecreasedRenal Failure AcuteDiarrhoeaSerum Ferritin IncreasedConvulsionTremorMental Status Changes
Gastrointestinal Mucosal ExfoliationEngraftment SyndromeConvulsionBlood Creatine Phosphokinase IncreasedNeutropeniaOxygen Saturation DecreasedLoss Of Consciousness
Bacillus InfectionNeutropeniaMalaiseDeep Vein ThrombosisDyspnoeaHypersensitivityUnresponsive To Stimuli
Ulcer HaemorrhageBlood Alkaline Phosphatase IncreasedUterine Contractions During PregnancyHigh Density Lipoprotein DecreasedGastrooesophageal Reflux DiseaseDizzinessAsthenia
HypokalaemiaAlanine Aminotransferase IncreasedDyspepsiaThyroxine Free DecreasedWeight IncreasedOesophageal InfectionRenal Failure Chronic
Disease ProgressionFallSubarachnoid HaemorrhageMean Platelet Volume DecreasedPneumoniaPancytopeniaPneumonia
Pneumatosis IntestinalisHypoxiaCerebrovascular AccidentBlood Glucose IncreasedDeep Vein ThrombosisLymphopeniaAnxiety

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Keppra and Benadryl?

You are not alone! Join a related mobile support group:
- support group for people who take Keppra and Benadryl
- support group for people who take Benadryl
- support group for people who take Keppra

Can you answer these questions (Ask a question):

More questions for: Benadryl, Keppra

You may be interested at these reviews (Write a review):

  • Dyphenhydramine and headaches horrible going one almost 24 hours a day for 4 weeks and cant get them to stop, now looking for cause . think its the dyphenhydramine im taking to help me sleep .
    have been taking 3 dyphenhydramine for some time to help me sleep , just in last few weeks began having severe headache almost all the time.. cant get it to go away. just found out it can cause headache and am going to lower my intake to one per night and see if my headaches get better. am taking migrane meds and that hasnt helped a bit so think its not migranes im having. some other reason.
  • Nightmare on benadryl
    After 5 nights without sleep and not having past bad dreams, the last 2 night's taking walfrin sub, for benadryl has terrified THE WORST OF WORST dream in my 55 years. Peaceful start of a dream then seeing myself or family,friends get slottard.crazy thing is I don't watch scary movies or the news. I think I'm going to pass on this meds, and pass out next time :) thank you,God bless
  • Benadryl completed suicide 50 year old
    My mother comitted suicide by taking a bottle of Benadryl. She also had been drinking, she had taken xanax and drank beer, she also took 300 Benadryl pills and started having seizures and went to the hospital was brain dead and her heart stopped the next morning.
  • Had nms in 2005, will trileptal increase chance of recurrence?
    In 2005 I had NMS, which was not detected by my drs for 4 months. I'd been on Lexapro & Seroquel for 2 yrs, but was weaned from Lexapro & placed on Lamictal 3/05. Began getting low-grade fevers, which I was told were not caused by the Lamictal. I quit taking it anyway, fevers (along with uncontrollable shivering) continued & got higher. By 5/05 my temps were reaching 105 deg F. Husband said I became combative, refused to go to hospital. Early June/05 he came home to find me wrapped in blankets, with a temp over 105 F. He tried to place me in a tub of cold water, said I was rigid & screamed when he tried to move me. I was in the tub, speaking "in tongues" (his description, I have no memory of this). He called 911, took me to hospital. I woke, no idea where I was or why. After a lumbar puncture & 2 days in ICU I went home. The fevers continued...2 weeks later he came home to find me wrapped in sheets, towels, blankets, with the heat on full (it was in the 90's outside) he called ambulance again. I awoke to find myself under an ice blanket with nurses pushing large vials of dantrolene into both arms, several liters. Another LP, a stint in ICU...this time they told me it was NMS. The dr who dxd me said he was surprised I was alive, & not a vegetable, as my temp had peaked at 109 deg F. I suffered brain damage; short-term memory loss, brain can't control my body temp, my blood pressure went up. An arteriogram showed completely healthy heart & arteries, no plaque at all. I lost all body fat as well as some muscle mass. The fevers continued even after stopping the Seroquel. I visited my PCP for a checkup in 9/05, temp was normal. I started shuddering, my temp went up a full degree every 5 minutes. PCP admitted me to ER, my heart rate was over 272 B/M; they stopped my heart 3 times to "reset" it, which didn't work. I spent 3 days in hospital. Several months later my P doc tried me on Lamictal alone; I got Stevens-Johnson syndrome. I stopped the drug as soon as the signs appeared. I've been untreated, except for Neurontin & Primidone, until my manic episodes became unlivable. 3 weeks ago I went 8 days with no sleep, became psychotic. My P doc gave me Trileptal, which has evened my moods, but I've been getting low-grade fevers (highest was 103.6). Would having had NMS in the past make me more prone to falling to it again with the Trileptal? It's the only new med I've taken in over a year.
  • Seizure patient was on depakote for 16 years now on keppra 1500 mg.
    I am 28 years old and been off depakote for 5 months. I started keppra to control my seizure disorder, which works great. But for the past year I have developed osteoarthritis in my thoracic, si joints, and lumbar. I get alot of muscle hypersensitivity and pain. Can any of this be due to long term effects of seizure meds?

More reviews for: Benadryl, Keppra

Comments from related studies:

  • From this study (10 months ago):

  • Leg jerking as I fall asleep after taking 50 mg Benadryl

    Reply

  • From this study (4 years ago):

  • seizures, rapid heart rate, hypotention, hypertention , sepsis, confusion, lethargic

    Reply

Complete drug side effects:

On eHealthMe, Keppra (levetiracetam) is often used to treat epilepsy. Benadryl (diphenhydramine hydrochloride) is often used to treat allergies. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

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You may report adverse side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

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