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Review: taking Klonopin and Effexor Xr together

Summary: drug interactions are reported among people who take Klonopin and Effexor Xr together.

This review analyzes the effectiveness and drug interactions between Klonopin and Effexor Xr. It is created by eHealthMe based on reports of 5,172 people who take the same drugs from FDA and social media, and is updated regularly.


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On Apr, 12, 2015: 5,172 people who take Klonopin, Effexor Xr are studied

Klonopin, Effexor Xr outcomes

Drug combinations in study:
- Klonopin (clonazepam)
- Effexor Xr (venlafaxine hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Klonopin is effective21.05%
(4 of 19 people)
(17 of 34 people)
(16 of 30 people)
(17 of 43 people)
(31 of 61 people)
(23 of 46 people)
(21 of 33 people)
(1 of 3 people)
Effexor Xr is effective11.11%
(2 of 18 people)
(9 of 33 people)
(6 of 28 people)
(8 of 35 people)
(29 of 54 people)
(21 of 62 people)
(18 of 35 people)
(0 of 3 people)

Drug effectiveness by gender :

Klonopin is effective48.95%
(93 of 190 people)
(37 of 79 people)
Effexor Xr is effective34.22%
(64 of 187 people)
(29 of 80 people)

Drug effectiveness by age :

Klonopin is effectiven/an/a50.00%
(4 of 8 people)
(11 of 47 people)
(31 of 90 people)
(47 of 123 people)
(25 of 102 people)
(12 of 68 people)
Effexor Xr is effectiven/an/a20.00%
(2 of 10 people)
(7 of 46 people)
(18 of 90 people)
(35 of 136 people)
(16 of 100 people)
(15 of 70 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Drug Withdrawal SyndromeAnxietyDrug Withdrawal SyndromeDepressionDepressionAnxietyDrug IneffectiveDepression
Suicidal IdeationPainNauseaDrug IneffectiveSuicidal IdeationInsomniaBack InjuryNausea
NauseaSuicidal IdeationAnxietyEmotional DistressType 2 Diabetes MellitusDepressionDrug Withdrawal SyndromeAnxiety
AnxietyNauseaHeadachePainSuicide AttemptPulmonary EmbolismInsomniaPain
HeadacheDrug Withdrawal SyndromeDizzinessSuicidal IdeationAnxietyWeight IncreasedAccident At WorkHeadache
Drug IneffectiveSuicide AttemptFatigueSuicide AttemptDrug Withdrawal SyndromeDrug Withdrawal SyndromeAnxietyDiabetes Mellitus
Completed SuicideWeight DecreasedVision BlurredAnxietyInsomniaDiabetes MellitusDry MouthFatigue
Suicide AttemptDepressionSuicidal IdeationHeadacheDiarrhoeaWithdrawal SyndromeCoronary Artery DiseaseWeight Increased
Feeling AbnormalDrug IneffectiveTinnitusInjuryVomitingFatigueTardive DyskinesiaSuicidal Ideation
PainConvulsionInfluenza Like IllnessCerebrovascular AccidentSepsisPainPneumoniaInsomnia

Most common drug interactions by gender * :

DepressionDiabetes Mellitus
HeadacheType 2 Diabetes Mellitus
FatigueSuicidal Ideation
InsomniaWeight Increased
Weight IncreasedFatigue
Suicidal IdeationDrug Ineffective
DizzinessBack Pain

Most common drug interactions by age * :

Premature BabyPyrexiaSuicidal IdeationSuicide AttemptDiabetes MellitusNauseaDepressionPain
SwellingSerotonin SyndromeDepressionSuicidal IdeationNauseaDiabetes MellitusPainDepression
Weight IncreasedPhotophobiaWeight IncreasedNauseaDepressionHeadacheAnxietyFall
Ill-defined DisorderPalpitationsAngerAnxietyType 2 Diabetes MellitusPainInsomniaAnxiety
StomatitisHeadache NosAggressionDepressionAnxietyDepressionHeadacheNausea
AnorexiaNeck TightnessAgitationCompleted SuicideSuicidal IdeationType 2 Diabetes MellitusNauseaFatigue
Gastrointestinal MalformationSelf-injurious IdeationOverdoseSuicide AttemptAnxietyFatigueDrug Ineffective
Maternal Drugs Affecting FoetusPainType 2 Diabetes MellitusWeight IncreasedFatigueDizzinessDizziness
MeningoceleDiabetes MellitusDrug Withdrawal SyndromeHeadacheWeight IncreasedDiabetes MellitusHeadache
Drug Withdrawal Syndrome NeonatalPyrexiaFatigueDizzinessSuicidal IdeationType 2 Diabetes MellitusInsomnia

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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- support group for people who take Effexor Xr
- support group for people who take Klonopin

Recent related drug studies (Check your drugs):

Complete drug side effects:

On eHealthMe, Klonopin (clonazepam) is often used to treat stress and anxiety. Effexor Xr (venlafaxine hydrochloride) is often used to treat depression. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

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