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Review: taking Klonopin and Melatonin together

Summary: drug interactions are reported among people who take Klonopin and Melatonin together.

This review analyzes the effectiveness and drug interactions between Klonopin and Melatonin. It is created by eHealthMe based on reports of 234 people who take the same drugs from FDA and social media, and is updated regularly.


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On Apr, 12, 2015: 234 people who take Klonopin, Melatonin are studied

Klonopin, Melatonin outcomes

Drug combinations in study:
- Klonopin (clonazepam)
- Melatonin (melatonin)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Klonopin is effective100.00%
(1 of 1 people)
(2 of 8 people)
(3 of 4 people)
(4 of 5 people)
(2 of 6 people)
(7 of 9 people)
(4 of 5 people)
Melatonin is effective0.00%
(0 of 1 people)
(1 of 2 people)
(3 of 5 people)
(3 of 12 people)
(5 of 11 people)
(2 of 4 people)
(0 of 1 people)

Drug effectiveness by gender :

Klonopin is effective56.67%
(17 of 30 people)
(6 of 8 people)
Melatonin is effective33.33%
(10 of 30 people)
(4 of 6 people)

Drug effectiveness by age :

Klonopin is effectiven/an/a50.00%
(2 of 4 people)
(1 of 28 people)
(3 of 12 people)
(2 of 34 people)
(8 of 15 people)
(7 of 16 people)
Melatonin is effectiven/an/a50.00%
(2 of 4 people)
(1 of 31 people)
(1 of 12 people)
(3 of 34 people)
(6 of 15 people)
(1 of 11 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Accidental ExposureInflammationFatigueInsomniaDepressionDry SkinVision BlurredFatigue
IncontinenceArthritisSeromaKnee PainPseudoporphyriaItchinessMovement - UncoordinatedDrug Ineffective
LethargyPseudoporphyriaBack PainArthritisMuscle PainSupraventricular TachycardiaNausea
Confusional StateDepressionThoughts - CloudyConstipationWeaknessDark Circles Under EyesInsomnia
Depressed Level Of ConsciousnessAnxietyTmj DisordersFacial PainEaracheSkin Blushing/flushingPain
Interstitial Lung DiseaseFacial Nerve PalsyExcessive Sexual FantasiesMemory LossBone And Joint PainHeadache NosPain In Extremity
InflammationMemory LossDark Circles Under EyesFatigue - ChronicSweating - ExcessiveTeeth Grinding And ClenchingAnxiety
Drug Rash With Eosinophilia And Systemic SymptomsFatigue - ChronicShoulder PainAnxietyMuscle SpasmsDiarrhoeaFall
Rash MorbilliformConstipationFeeling Of DespairFacial Nerve PalsyIrritable Bowel Syndrome AggravatedAortic Valve StenosisDizziness
EnanthemaFacial PainHypoactive Sexual DesireInflammationHearing LossNightmares - RepeatedChest Pain

Most common drug interactions by gender * :

Drug IneffectiveMyelodysplastic Syndrome
Pain In ExtremityAnxiety
InsomniaDrug Ineffective
Influenza Like IllnessAgitation
Chest PainFall
HeadacheCondition Aggravated

Most common drug interactions by age * :

PyrexiaHypertoniaConvulsionHepatorenal SyndromePainFatigueInsomniaFall
PneumoniaConvulsionAnticonvulsant Drug Level DecreasedRash ErythematousOedema PeripheralNauseaConfusional StateInfluenza Like Illness
SomnolenceMuscle RigidityDeathSeptic ShockSwelling FaceAnxietyIncontinenceFatigue
GastroenteritisStatus EpilepticusDepressed Level Of ConsciousnessCoagulopathyFatigueConstipationLethargyArthralgia
CoughSomnolenceAcute Prerenal FailureCoughDrug IneffectiveUnresponsive To StimuliDrug Ineffective
Feeling ColdAsphyxiaTherapeutic Agent ToxicitySinusitisWeight IncreasedDrug IneffectiveVisual Impairment
Respiratory Tract CongestionMental Status ChangesHigh Density Lipoprotein IncreasedDecreased AppetiteVomitingAccidental ExposureFibrocystic Breast Disease
Aspartate Aminotransferase IncreasedRestlessnessTonsillitisAbdominal PainAnxietyBreast Cancer In Situ
Gamma-glutamyltransferase IncreasedDepressed MoodOvarian CystParaesthesiaRestlessnessOsteopenia
Lightheadedness - FaintingInsomniaHeadacheJoint SprainSomnolencePain In Extremity

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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- support group for people who take Klonopin
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Recent related drug studies (Check your drugs):

Complete drug side effects:

On eHealthMe, Klonopin (clonazepam) is often used to treat stress and anxiety. Melatonin (melatonin) is often used to treat insomnia. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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