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Review: Klonopin and Ondansetron





Summary: drug interactions are reported among people who take Klonopin and Ondansetron together.

This review analyzes the effectiveness and drug interactions between Klonopin and Ondansetron. It is created by eHealthMe based on reports of 821 people who take the same drugs from FDA and social media, and is updated regularly.

You are not alone: join a mobile support group for people who take Klonopin and Ondansetron >>>

What are the drugs

Klonopin has active ingredients of clonazepam. It is often used in stress and anxiety. (latest outcomes from Klonopin 31,277 users)

Ondansetron has active ingredients of ondansetron. It is often used in nausea. (latest outcomes from Ondansetron 3,025 users)

On Nov, 25, 2014: 821 people who take Klonopin, Ondansetron are studied

Klonopin, Ondansetron outcomes

Drug combinations in study:
- Klonopin (clonazepam)
- Ondansetron (ondansetron)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Klonopin is effectiven/an/a100.00%
(1 of 1 people)
25.00%
(1 of 4 people)
66.67%
(2 of 3 people)
100.00%
(1 of 1 people)
n/an/a
Ondansetron is effective100.00%
(1 of 1 people)
n/a33.33%
(1 of 3 people)
0.00%
(0 of 2 people)
0.00%
(0 of 2 people)
n/an/an/a

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Acute Respiratory Distress SyndromePruritusIntervertebral Disc ProtrusionDepressionPainDehydrationn/aPain
ArrhythmiaIleusMetastases To KidneyObsessive-compulsive Personality DisorderCholecystitis ChronicHypotensionAnxiety
Renal ImpairmentSkin DisorderSpinal FracturePathological GamblingPancreatitisNeutropeniaNausea
Hepatic Function AbnormalToxic Epidermal NecrolysisMetastases To BoneSuicidal IdeationSphincter Of Oddi DysfunctionDiarrhoeaDyspnoea
Gastrointestinal HaemorrhageMucous Membrane DisorderMetastases To GallbladderHypersexualityGallbladder DisorderPain In ExtremityVomiting
Loss Of ConsciousnessRash Maculo-papularAdenocarcinomaEmotional DistressAbdominal Pain UpperPlatelet Count DecreasedDiarrhoea
HyponatraemiaHepatocellular DamageMetastases To Central Nervous SystemFoetal Exposure During PregnancyInjuryWhite Blood Cell Count DecreasedPyrexia
Myocardial InfarctionConjunctivitisMetastases To LiverSudden Infant Death SyndromeCholelithiasisHaematocrit DecreasedBack Pain
AnaemiaClostridial InfectionTerminal StateHeadacheChest TightnessHaemoglobin DecreasedFatigue
PneumoniaDiarrhoeaChemotherapyVertigoDry MouthBlood Creatinine IncreasedChest Pain

Drug effectiveness by gender :

FemaleMale
Klonopin is effective62.50%
(5 of 8 people)
0.00%
(0 of 1 people)
Ondansetron is effective28.57%
(2 of 7 people)
0.00%
(0 of 1 people)

Most common drug interactions by gender * :

FemaleMale
PainAnxiety
NauseaPain
AnxietyDyspnoea
FatiguePneumonia
VomitingAnaemia
DiarrhoeaPyrexia
Chest PainSepsis
DyspnoeaDizziness
Back PainHeadache
DepressionNausea

Drug effectiveness by age :

0-12-910-1920-2930-3940-4950-5960+
Klonopin is effectiven/an/a0.00%
(0 of 1 people)
33.33%
(1 of 3 people)
28.57%
(2 of 7 people)
40.00%
(2 of 5 people)
n/an/a
Ondansetron is effectiven/an/a0.00%
(0 of 1 people)
0.00%
(0 of 2 people)
10.00%
(1 of 10 people)
20.00%
(1 of 5 people)
n/an/a

Most common drug interactions by age * :

0-12-910-1920-2930-3940-4950-5960+
n/aConvulsionPancreatitisNauseaPainAbdominal PainPainPain
Drug Level Below TherapeuticPainBronchitisNauseaAnxietyNauseaAnxiety
Abdominal PainCholecystitis ChronicVomitingAnxietyNauseaDiarrhoeaPyrexia
Abnormal BehaviourDehydrationHeadacheChest PainDyspnoeaPneumoniaAnaemia
Urinary Tract InfectionSphincter Of Oddi DysfunctionFatigueHeadachePainFallUrinary Tract Infection
Respiratory FailureGallbladder DisorderDyspnoeaFatigueChest PainDehydrationOsteonecrosis Of Jaw
Pulmonary HaemorrhageNauseaUpper Respiratory Tract InfectionAstheniaBack PainVomitingAsthenia
Febrile Bone Marrow AplasiaVomitingInsomniaDepressionHypotensionHypotensionBone Disorder
Mucosal InflammationWeight DecreasedSinusitisDyspnoeaAbdominal Pain UpperAnxietySpinal Osteoarthritis
Premature BabyShockPainConstipationVomitingHypoxiaArthralgia

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Klonopin and Ondansetron?

You are not alone! Join a related mobile support group:
- support group for people who take Klonopin and Ondansetron
- support group for people who take Klonopin
- support group for people who take Ondansetron

Can you answer these questions (Ask a question):

  • Can my eye twitch be because of lexapro?
    So I have had symptoms of anxiety and depression due to a lot of stressors and disasters that happened in my life over the past two years. As my anxiety got worse after a breast biopsy, I started freaking out and thinking I may have MS because my sister has MS. So I went to my GP and she decided my symptoms do not follow the symptoms of MS or any similar problem and it should most likely be anxiety. She put me on Lexapro and Clonazepam. At first I was very hesitant to take medication but as my symptoms got worse I decided to give it a try. I was on Lexopro 5 mg for about two months and then I went to 10 mg, and I would take 1 or 2 Clonazepam a day. And this all started 5 months ago. And things seemed to be working just fine.Until about two months ago I started having this freaking annoying eye twitch on my upper left eyelid. I have had eye twitches before but they always go away after a couple of days or a week top. This one has been lasting for 2 months now and seems to be just getting worse. I went to the GP and my eye doctor and they still found no cause and said it's probably stress and anxiety. I have not been overly stressed and I get plenty of sleep, 10 hrs or more! and I stopped taking caffeine and alcohol after the twitch started. Any idea? Could it be because of medication? I also need to add I have had thumb twitching and severe spasms in my muscles around my right thumb starting in May (before taking any medication).
  • Why would doctor prescribe meclizine when otc med available? stronger?
    Gastric bypass. After years found should not be prescribed extended release medications-- they do not work because stomach (duodenum) releases enzymes and acids to release XR. Suffer from GAD, MAD, PTSD, ADHD, Insomnia. I've driven away my best friend-- I'm tired of life-- alone.
  • Does klonopin counteract phentermine?
    does klonopin counteract phentermine? i have taken phentermine before while not taking any other medications and it really worked for me but not its not working and i think my klonopin is counteracting it.
  • What is the current treatment for larangospasm?
    For two years I have been fighting with larangospasm. I have been hospitalized twice and treated with prednisone as well as nebulizers with albuterol. I had botox injections into my vocal cords last July 2013 and have a straw hanging around my neck for straw breathing. The last "attack" lasted one hour last week and I get approximately two a week now. With the botox injection I could not talk or drink water without it being thickened for six weeks. Is there any other alternative that I can try?
  • Anyone else develop facial swelling during clonazepam withdrawal and not recover from it several years later?
    Weaned off of clonazepam 10 years ago. Body went into severe withdrawal: Hair loss/ thinning, swelling through T-zone portion of my face, excessively oily face and hair, stiff painful joints. Hair and face have never completely recovered although have days/weeks symptoms are milder, buy only worsening again.

    So fed up. It has affected my confidence and self-esteem. I can't believe I am still living with this 10 years after discontinuing clonazepam.

More questions for: Klonopin, Ondansetron

You may be interested at these reviews (Write a review):

  • A life of depression and fatigue
    1) Family history of depression, 2) Diagnosed depression 1964-not treated until 1973, 3) Worked in medical field 35 years, 4) Emergency on-call 24/7, 5) Hospital 15 times major depression, 6) Tried nearly all MAOI, TCA, SSRI, SNRI, and ECT. 7) 100% Disability in 1998 for depression. Now at age 70 I have dysthymia, chronic fatigue, COPD, and PTSD. My recommendation to younger people - do not over stress,
    do not smoke, avoid horrific or traumatic situations and try to find some enjoyment in life. If you have symptoms like mine seek early treatment put balance in your life. The often heard recommendations - get plenty of sleep, eat properly, learn to relax and avoid bad habits should not be ignored, they are critical to good physical and mental health.
  • 3 strong drugs together against neuropathic pain
    Neuropathic pain debuted when I was 24, now I'm 50. Received diagnosed with Ehler-Danlos syndrome (EDS), joint hypermobility type, when I was 35 years old. So it can take some time to get a diagnose. And as EDS-patient I do not belong to any clinic. Orthopedics says that EDS is not orthopedic, rheumatology says that EDS is not an autoimmune disease, GPs say that EDS is too difficult, and so on. Sooner or later we all end up at Psychiatry, even if we are not depressed.

    The first kind of pain I got when I was 24 came from low back, but I experienced as pelvic pain and leg pain. It was clearly a neuropathic pain, but it took years to find out. Later it was treated by a pain clinic with cortisone around the genitofemoral nerves (both sides). Since this treatment didn't result in lasting freedom from pain, the pain clinic started to give me RF (radio frequency) treatment. This made the pain disappeared after one year, and I was 80% free from it between 2002 and 2014, 12 years. The pain doctors said pain could return after 10 years.

    The other kind of neuropathic pain started 2003 with intense stomach pain. During 6 months I could hardly eat nothing due to nausea and vomiting. After this 6 months, stomach pain changed to almost unbearable pain in upper back.
    What happened 2003, and what all the doctors missed, was that the right lowest ribs slid up over the sternum. This rib dislocation is till there today, but now with a lot of cartilage formed around the rib where it is stuck in the lower end of the sternum. The dislocation is clearly visible on X-ray. This has greatly affected the thoracic spine. I have a scoliosis which I had not before 2003. And I still have severe pain in the thoracic spine.

    It was initially treated with morphine daily, and later with Durogesic (fentanyl), but this didn't help much. 2005 I was hospitalized because I had too much pain to take care of myself and my hygiene. After some months the doctors started to give me clonazepam because the muscles along the spine was in a chronic seizures. Clonazepam helped, but I could still have a lot of pain in two vertebrae in the thoracic spine. It felt as if someone drilled into the vertebrae without anesthesia. After a few months, doctors also prescribed me methadone. Then the pain disappeared almost completely. Since 2006, I have eaten clonazepam and methadone every day, and I need to sleep in an armchair to not get more pain because of moving during sleep.

    There are side effects. After 1,5 years with clonazepam and methadone I started to have panic attacks. Or rather one long panic attack which didn't stop before I got treatment with amitryptilin and pregabalin (Lyrica). These 2 medicines stopped the panic disorder completely after some hours, and the panic was then gone. Then I got side effects of these 2 medicines, amitryptilin & Lyrica, too. I gained a lot of weight (from 83 to 148 kg) and got much water (edema) in both my legs under the knees and in both feet. The feet could swallow to the double size. 2012 I stopped with amitryptilin and started to loose weight again (in Aug 2014 below 80 kg) and get less water in my legs. Today I eat as little medicines I can, but I have to take methadone, clonazepam and Lyrica every day, twice. If I try to take away one of these 3 medicines, I got pain problems at once. Lyrica is the most painful one to take away. In Sept-Dec 2013 I lowered Lyrica from 300 mg daily, to 150, then to 75 and finally 0 mg. The pain I had was extremely difficult to handle. It didn't help to take more methadone or anything else. I have checked on Internet and found that many people got pain from quitting with Lyrica. Most people start eating it again. So did I. But 2006 and 2007 it was enough to treat the pain with methadone and clonazepam, I got the Lyrica against anxiety not pain. But today I take Lyrica against pain.

    Beside weight gain and leg edema, clonazepam and Lyrica significantly affect the sexual desire. And Lyrica alone makes it almost impossible to ejaculate. All four drugs together (clonazepam, methadone, amitryptiline and Lyrica), make one forget all about sex life. You don't even miss it. When I stopped with amitryptiline and lowered Lyrica (still taking clonazepam and methadone), I could suddenly easily get erections again, feel desire, but not getting orgasms. This is quite difficult to deal with.

    The pain pattern is greatly affected, by pain and by the medicines. So is the mood. I get something which feels like heavy depression, especially if I take the medicines late that day. I should take a medicine like methadone 3 times a day, because the effects of the tablet lasts around 8 hours. But I take them every 12 hours, to have a low consumption in case doctors prescribe them too late (which happens, and then it's good to have a spouse going to the pharmacy buying them for you, because you have too much pain to go yourself).

    Since methadone is also used for treating heroine addicts, medical staff treat you with disrespect when they see that it says "methadone" in your health record. I need to show a certificate that says that I deal with chronic neuropathic pain, that I never have had problems with drug addiction, to get normal respect.

    I wanted to share this because I think I am alone in the world with these medicines in combination against neuropathic pain caused by hypermobile joints, joint dislocation and muscle spasms. After trying almost everything else, including surgery cutting nerves, methadone, clonazepam and Lyrica seems to be the only way to kill my pain. But it's a life where you always is questioned, because of the use of methadone. I can guarantee that everybody in the world should accept these medicines if they had experienced the unbearable pain I had in upper back before they started to give me clonazepam and methadone.
  • Had nms in 2005, will trileptal increase chance of recurrence?
    In 2005 I had NMS, which was not detected by my drs for 4 months. I'd been on Lexapro & Seroquel for 2 yrs, but was weaned from Lexapro & placed on Lamictal 3/05. Began getting low-grade fevers, which I was told were not caused by the Lamictal. I quit taking it anyway, fevers (along with uncontrollable shivering) continued & got higher. By 5/05 my temps were reaching 105 deg F. Husband said I became combative, refused to go to hospital. Early June/05 he came home to find me wrapped in blankets, with a temp over 105 F. He tried to place me in a tub of cold water, said I was rigid & screamed when he tried to move me. I was in the tub, speaking "in tongues" (his description, I have no memory of this). He called 911, took me to hospital. I woke, no idea where I was or why. After a lumbar puncture & 2 days in ICU I went home. The fevers continued...2 weeks later he came home to find me wrapped in sheets, towels, blankets, with the heat on full (it was in the 90's outside) he called ambulance again. I awoke to find myself under an ice blanket with nurses pushing large vials of dantrolene into both arms, several liters. Another LP, a stint in ICU...this time they told me it was NMS. The dr who dxd me said he was surprised I was alive, & not a vegetable, as my temp had peaked at 109 deg F. I suffered brain damage; short-term memory loss, brain can't control my body temp, my blood pressure went up. An arteriogram showed completely healthy heart & arteries, no plaque at all. I lost all body fat as well as some muscle mass. The fevers continued even after stopping the Seroquel. I visited my PCP for a checkup in 9/05, temp was normal. I started shuddering, my temp went up a full degree every 5 minutes. PCP admitted me to ER, my heart rate was over 272 B/M; they stopped my heart 3 times to "reset" it, which didn't work. I spent 3 days in hospital. Several months later my P doc tried me on Lamictal alone; I got Stevens-Johnson syndrome. I stopped the drug as soon as the signs appeared. I've been untreated, except for Neurontin & Primidone, until my manic episodes became unlivable. 3 weeks ago I went 8 days with no sleep, became psychotic. My P doc gave me Trileptal, which has evened my moods, but I've been getting low-grade fevers (highest was 103.6). Would having had NMS in the past make me more prone to falling to it again with the Trileptal? It's the only new med I've taken in over a year.
  • Sepsis hallucinations misdiagnosed
    I was admitted to the hospital at 10 p.m., with a total bowel blockage caused by scar-tissue adhesions. I had first gone to the ER at 3 a.m. that morning, but the ER doc misdiagnosed my condition as constipation. I was in extreme pain and also too weak to tell my husband when he first came home that I needed to return to the ER. By the time I returned, I became violently nauseated, and vomited repeatedly. Then a gastro-nasal tube was forced down my nose and into my stomach. I began hallucinating at approximately 5 p.m. the following day. I did not realize I was hallucinating, and thought my experiences were real. Some were quite coherent, such as believing there was a book sitting on table at home with a photo on the front showing a sculpture in white marble of a woman's hands holding the Bible, with barbed wire wrapped around her hands. I thought the sculpture had won the Nobel prize, and the book was the biography of the sculptor, whose mother had gone to extraordinary lengths to keep him safe from the Nazis. Some may actually have occurred during dreams, and were wildly improbable, but I don't recall ever going to sleep. At one point, I thought I was at a rest stop on the NJ turnpike, and saw the Nobel-winning sculptor there, working on a wood sculpture. The sculptor turned out to be the maintenance man on the hospital floor. I pulled out the naso-gastral tube three times, but was unaware that I had done so, although I do remember believing that I was buried beneath peat moss and feeling suffocated as I clawed my way out. I also thought I was at a party being given by a law firm which had sold its building to a school for gifted children, but I (also a lawyer) had been deposited there by my nurse and her boyfriend, who were supposed to have taken me to the OR. Some scenes from a book I had been reading made their way into my delusions, which were so real to me that I actually called some of the people involved later on and asked if the events had really happened. The hallucinations began before surgery and continued afterward. When I awoke from anesthesia, I thought the hospital staff was painting the doors to my upstairs bathroom, a project I'd been involved with before the blockage struck. I asked them how they knew what colors to use. They thought I was joking, and confirmed that they had gotten the colors right. Finally a neurologist was summoned, and I told her I was on the passenger ramp at La Guardia airport (instead of in a hospital in NC), and that I'd been born in Havana, Cuba (instead of Baltimore, MD.) I believed myself to be a member of the ruling party in Cuba (pre-Castro) and during an outdoor ceremony, an earthquake had struck, causing ancient monuments to come tumbling down. Later, I was bobbing in harbor waters near a huge ocean liner, with plastic bottles and other detritus floating by. The foregoing are only a small sample of the multitude of hallucinations. Occasionally, I was only an observer of astonishing events, but usually I was a participant. I recognized my husband and friends, but told them about many of these events, believing they had happened. The neurologist diagnosed clonazepam withdrawal. My other doctors later said this was unlikely, as I took clonazepam in small amounts on an erratic schedule, and was not dependent on the drug, although my prescription called for 3 mg. daily. Physician friends said my symptoms were more likely the result of sepsis. I did contract a urinary-tract infection from the catheter, and was being given antibiotics. Additionally, the nature of my underlying condition, and the delay in diagnosis and treatment, may have contributed to the sepsis. Hallucinations occur in only a very small percentage of sepsis sufferers, and in only a small percentage of those withdrawing suddenly from clonazepam. However, I do fit the profile of those who do experience hallucinations with sepsis, being female and aged 62 at the time of this description. After the three-day period, I returned to normal, although believing that my hallucinations had been real persisted for some days afterward. I recovered quickly from the surgery, although the pain persisted for a while, and I was walking easily (dragging my IV with me) through the hospital halls. This was the ONLY symptom I had. Not all the hallucinations were unpleasant -- in fact, they were highly interesting -- but they were incredibly complex. I still remember all the details, better than I remember what actually happened yesterday. Except for the urinary-tract infection, I had no other adverse effects from hospitalization -- no fever, chills, nausea, sweating, headaches, trembling or anything of that kind. The bowel blockage and the surgery were of course not fun, but in a way the hallucinations were fascinating. My own feeling, and that of the doctors who know me and my medical issues, is that my experiences were caused by sepsis, not clonazepam withdrawal, and the antibiotics I was given are probably what saved me.
  • Psychosis, weight loss and topamax (1 response)
    I had a brain hemorrhage in my occipital lobe. It left me with with a partial seizure disorder. The seizures would interrupt my ability to see. I was trying different anti-seizure medication and they all made me more tired and more depressed. My neurologist decided to try topamax. On topamax I began to feel more energetic and started losing weight. For the first time in years I woke up in the morning feeling zippy. I started feeling euphoric sometimes. I started to feel like I was glowing with life. I became so energetic I was like someone in a manic state. My temper got shorter and I began to hallucinate. I started to see angels and/or feel their presence. I live in a big city and there are a lot of people who are pretty mean here and I decided I wasn't going to let any of them push me around. I wasn't diplomatic anymore with anyone. Basically everyone thought I had gone crazy and I guess I had.
    My psychiatrist saw me and told my neurologist to "Get Her Off The Topamax!" After I stopped taking it and was more my normal tired self, my psychiatrist told me that I had been psychotic and that I had scared him. Unfortunately, after I stopped taking topamax I gained back the 30 pounds I had lost and none of my new clothes fit me. My doctors told me that they had never seen Topamax affect anyone the way it had affected me. They said it usually makes people more sedated. Hopefully, sharing my experience with Topamax will be helpful to someone.

More reviews for: Klonopin, Ondansetron

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Complete drug side effects:

On eHealthMe, Klonopin (clonazepam) is often used to treat stress and anxiety. Ondansetron (ondansetron) is often used to treat nausea. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

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You may report adverse side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

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