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Review: taking Klonopin and Vicodin together

Summary: drug interactions are reported among people who take Klonopin and Vicodin together.

This review analyzes the effectiveness and drug interactions between Klonopin and Vicodin. It is created by eHealthMe based on reports of 5,035 people who take the same drugs from FDA and social media, and is updated regularly.


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On Mar, 6, 2015: 5,035 people who take Klonopin, Vicodin are studied

Klonopin, Vicodin outcomes

Drug combinations in study:
- Klonopin (clonazepam)
- Vicodin (acetaminophen; hydrocodone bitartrate)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Klonopin is effective54.29%
(19 of 35 people)
(29 of 50 people)
(12 of 34 people)
(17 of 44 people)
(21 of 56 people)
(27 of 46 people)
(9 of 17 people)
(0 of 1 people)
Vicodin is effective41.30%
(19 of 46 people)
(19 of 43 people)
(10 of 24 people)
(20 of 47 people)
(27 of 65 people)
(15 of 32 people)
(7 of 17 people)
(1 of 1 people)

Drug effectiveness by gender :

Klonopin is effective47.55%
(97 of 204 people)
(36 of 78 people)
Vicodin is effective43.50%
(87 of 200 people)
(31 of 75 people)

Drug effectiveness by age :

Klonopin is effectiven/an/a100.00%
(1 of 1 people)
(24 of 83 people)
(38 of 140 people)
(31 of 145 people)
(33 of 135 people)
(6 of 39 people)
Vicodin is effectiven/an/a100.00%
(2 of 2 people)
(19 of 86 people)
(30 of 142 people)
(28 of 135 people)
(31 of 135 people)
(8 of 39 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
AnxietyPainNauseaEmotional DistressDepressionAnxietyHeadachePain
DepressionStress FracturePain In ExtremityDepressionAnxietyDepressionDepressionAnxiety
Drug IneffectiveBone Density DecreasedBack PainCerebrovascular AccidentPainNeck PainShort-term Memory LossNausea
NauseaRib FracturePainHeadacheOsteomyelitisHeadacheSleep Disorder Due To General Medical Condition, Insomnia TypeDepression
PainHip FractureHydronephrosisAnxietyOedema PeripheralSuicide AttemptBrain Scan AbnormalHeadache
Gallbladder DisorderOsteopeniaPyelonephritisInjuryOesophageal DisorderDeep Vein ThrombosisConstipationBack Pain
Heart Rate IncreasedDeep Vein ThrombosisMuscle SpasmsNeuropathyGastrooesophageal Reflux DiseaseIntentional OverdoseDry MouthDyspnoea
Decreased AppetiteDizzinessNephrolithiasisCardiomyopathyCellulitisLoss Of ConsciousnessTemperature Regulation DisorderFall
Cholecystitis ChronicDepressionHaematemesisPathological GamblingAcquired Oesophageal WebPulmonary EmbolismHigh Blood PressureFatigue
Abdominal PainPulmonary EmbolismCholecystitis ChronicAortic Valve IncompetenceBack PainPainMental DisorderInsomnia

Most common drug interactions by gender * :

NauseaBack Pain
Back PainNausea

Most common drug interactions by age * :

Type 2 Diabetes MellitusCardio-respiratory ArrestCholecystitis ChronicPainHeadachePainPainPain
Diabetes MellitusOtitis MediaPainNauseaAnxietyAnxietyDyspnoeaBack Pain
PancreatitisAccidental ExposureGallbladder DisorderAnxietyNauseaDepressionAnxietyAnxiety
Blood Cholesterol IncreasedPneumoniaNauseaCompleted SuicideDepressionNauseaDepressionFall
LymphomaCardiac ArrestDiarrhoeaHeadachePainHeadacheHeadacheNausea
PneumoniaRespiratory ArrestVomitingVomitingDyspnoeaBack PainBack PainDizziness
GastritisPainBack PainInsomniaDiabetes MellitusDrug IneffectiveNauseaAsthenia
ObesitySkin InfectionGallbladder InjuryBronchitisCompleted SuicideCompleted SuicideFallPneumonia
Systemic Lupus ErythematosusApnoeaPain In ExtremityDyspnoeaDrug DependenceFatigueInsomniaArthralgia
Deep Vein ThrombosisUnresponsive To StimuliTraumatic Lung InjuryInjuryChest PainVomitingDiarrhoeaDyspnoea

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Klonopin and Vicodin?




You are not alone! Join a related support group:
- support group for people who take Klonopin
- support group for people who take Vicodin

Recent related drug studies (Check your drugs):

Complete drug side effects:

On eHealthMe, Klonopin (clonazepam) is often used to treat stress and anxiety. Vicodin (acetaminophen; hydrocodone bitartrate) is often used to treat pain. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.


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