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Review: taking Klonopin and Vyvanse together

Summary: drug interactions are reported among people who take Klonopin and Vyvanse together.

This review analyzes the effectiveness and drug interactions between Klonopin and Vyvanse. It is created by eHealthMe based on reports of 296 people who take the same drugs from FDA and social media, and is updated regularly.


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On Mar, 27, 2015: 296 people who take Klonopin, Vyvanse are studied

Klonopin, Vyvanse outcomes

Drug combinations in study:
- Klonopin (clonazepam)
- Vyvanse (lisdexamfetamine dimesylate)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Klonopin is effective60.00%
(6 of 10 people)
(13 of 28 people)
(12 of 25 people)
(14 of 29 people)
(19 of 37 people)
(13 of 19 people)
(4 of 6 people)
(2 of 2 people)
Vyvanse is effective45.45%
(10 of 22 people)
(17 of 36 people)
(16 of 34 people)
(17 of 28 people)
(22 of 28 people)
(2 of 3 people)
(0 of 1 people)
(2 of 3 people)

Drug effectiveness by gender :

Klonopin is effective55.88%
(57 of 102 people)
(26 of 54 people)
Vyvanse is effective53.92%
(55 of 102 people)
(31 of 53 people)

Drug effectiveness by age :

Klonopin is effectiven/an/a36.36%
(8 of 22 people)
(31 of 98 people)
(22 of 134 people)
(12 of 43 people)
(7 of 30 people)
(3 of 6 people)
Vyvanse is effectiven/an/a40.91%
(9 of 22 people)
(25 of 98 people)
(24 of 135 people)
(17 of 42 people)
(8 of 30 people)
(3 of 7 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
AnxietyNauseaWeight GainInsomniaDepressionWeight GainNutrition - InadequateDrug Ineffective
Drug IneffectiveDizzinessFatigueAnxietyItchingLoss Of LibidoItching - Burning EyesDepression
TremorCondition AggravatedRestless Legs SyndromeConstipationTremorItchingMemory ImpairmentNausea
Therapeutic Response UnexpectedSuicidal IdeationPostnasal DripHeadacheBone And Joint PainAnxiety AggravatedAppetite - IncreasedAnxiety
Abdominal PainSerotonin SyndromeNumbness And TinglingPainAnxietyAppetite - IncreasedAnxiety AggravatedFatigue
HeadacheAnxietySleeping DifficultyIrritabilityEuphoric MoodSkin RashMood SwingsVomiting
NauseaDepressionAnxiety AggravatedDry MouthFatigueItching - Burning EyesItchingPain
FatigueIrritabilityBlue VisionFatigueGerdNutrition - InadequateSkin RashDrug Effect Decreased
SomnolenceMuscle CrampsAgitated DepressionSerotonin SyndromeInsomnia ExacerbatedConstipationNystagmusOverdose
AnorexiaDisturbance In AttentionBone And Joint PainNauseaPain In ExtremityHoarsenessDepressionIntentional Overdose

Most common drug interactions by gender * :

NauseaDrug Ineffective
AnxietyIntentional Overdose
Drug IneffectiveDepression
VomitingDrug Effect Decreased
HeadacheLoss Of Libido
AstheniaSerotonin Syndrome

Most common drug interactions by age * :

n/an/aConvulsionNauseaDizzinessDepressionDrug IneffectiveBalance Disorder
InsomniaMalaiseNauseaIrritabilityFatigueWrist Fracture
IrritabilityAbdominal Pain UpperIll-defined DisorderCondition AggravatedDepressionMusculoskeletal Disorder
Feeling AbnormalInsomniaVomitingVision BlurredNauseaUpper Limb Fracture
TicDepressionAsthmaDrug Effect DecreasedPainLower Limb Fracture
FatiguePeroneal Nerve PalsyGastric BypassNauseaAbdominal PainMultiple Fractures
AnorexiaDehydrationPsoriatic ArthropathyDry MouthAstheniaInfection
Chest DiscomfortCompartment SyndromeSkin IrritationDisturbance In AttentionGait DisturbanceSpinal Fracture
Vision BlurredRectal UlcerSwellingFatigueAnxietyLimb Crushing Injury

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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- support group for people who take Klonopin
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Recent related drug studies (Check your drugs):

Complete drug side effects:

On eHealthMe, Klonopin (clonazepam) is often used to treat stress and anxiety. Vyvanse (lisdexamfetamine dimesylate) is often used to treat attention deficit hyperactivity disorder. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

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