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Review: taking Klonopin and Wellbutrin together

Summary: drug interactions are reported among people who take Klonopin and Wellbutrin together.

This review analyzes the effectiveness and drug interactions between Klonopin and Wellbutrin. It is created by eHealthMe based on reports of 5,519 people who take the same drugs from FDA and social media, and is updated regularly.


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On Apr, 1, 2015: 5,517 people who take Klonopin, Wellbutrin are studied

Klonopin, Wellbutrin outcomes

Drug combinations in study:
- Klonopin (clonazepam)
- Wellbutrin (bupropion hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Klonopin is effective31.82%
(14 of 44 people)
(40 of 88 people)
(28 of 60 people)
(37 of 73 people)
(65 of 124 people)
(47 of 73 people)
(51 of 69 people)
(5 of 8 people)
Wellbutrin is effective17.65%
(9 of 51 people)
(17 of 84 people)
(22 of 68 people)
(24 of 71 people)
(35 of 109 people)
(45 of 85 people)
(27 of 52 people)
(2 of 5 people)

Drug effectiveness by gender :

Klonopin is effective53.62%
(200 of 373 people)
(87 of 166 people)
Wellbutrin is effective33.43%
(121 of 362 people)
(60 of 163 people)

Drug effectiveness by age :

Klonopin is effective100.00%
(1 of 1 people)
(1 of 5 people)
(39 of 128 people)
(74 of 219 people)
(77 of 251 people)
(61 of 188 people)
(34 of 109 people)
Wellbutrin is effective0.00%
(0 of 1 people)
(3 of 6 people)
(23 of 125 people)
(38 of 224 people)
(49 of 246 people)
(45 of 184 people)
(23 of 106 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
AnxietyDepressionNauseaAnxietyType 2 Diabetes MellitusDepressionPainDepression
DizzinessDrug Exposure During PregnancyType 2 Diabetes MellitusNauseaSuicide AttemptAnxietyDry MouthAnxiety
DepressionCongenital AnomalyBack PainType 2 Diabetes MellitusDiabetes MellitusDizzinessDepressionNausea
Drug IneffectiveCardiomegalyHeadacheHeadacheWeight IncreasedNauseaChest PainDrug Ineffective
NauseaVentricular Septal DefectAbdominal DiscomfortDepressionDepressionPainInsomniaWeight Increased
InsomniaDilatation VentricularAbdominal Pain UpperGastric UlcerFatigueIntentional OverdoseFatiguePain
ConvulsionTruncus Arteriosus PersistentGallbladder InjuryEmotional DistressPulmonary EmbolismSuicide AttemptType 2 Diabetes MellitusDiabetes Mellitus
PainBundle Branch Block RightVomitingCardiac ArrestAnxietyVision BlurredAnxietyFatigue
Suicidal IdeationAnxietyBiliary DyskinesiaPainHeadacheIrritabilityPancreatitisInsomnia
FallAortic StenosisDepressionFatiguePainFatigueTardive DyskinesiaDizziness

Most common drug interactions by gender * :

NauseaDiabetes Mellitus
AnxietyDrug Ineffective
Weight IncreasedType 2 Diabetes Mellitus
Drug IneffectiveFatigue
HeadacheWeight Increased
DizzinessSuicidal Ideation

Most common drug interactions by age * :

Diabetes MellitusSpeech DisorderNauseaCompleted SuicideDiabetes MellitusDepressionDepressionDrug Ineffective
Weight IncreasedLaryngomalaciaSomnolenceDepressionNauseaNauseaAnxietyNausea
Type 2 Diabetes MellitusDysphagiaVomitingSuicidal IdeationType 2 Diabetes MellitusAnxietyFallDizziness
PollakiuriaDrug Exposure During PregnancyBack PainWeight IncreasedDepressionDiabetes MellitusNauseaFatigue
Major DepressionMaternal Drugs Affecting FoetusGallbladder InjuryGrand Mal ConvulsionCompleted SuicideFatiguePainHeadache
HyperglycaemiaHeadacheAbdominal DiscomfortSuicide AttemptWeight IncreasedDizzinessHeadacheAsthenia
InjuryWeight DecreasedBiliary DyskinesiaDrug IneffectiveAnxietyPainFatigueDepression
Suicidal IdeationDizzinessAbdominal Pain UpperConvulsionPainType 2 Diabetes MellitusInsomniaInsomnia
Jaundice NosLethargyDiabetes MellitusDrug IneffectiveWeight IncreasedWeight IncreasedWeight Increased
Maternal Drugs Affecting FoetusElectrocardiogram Qrs Complex ProlongedType 2 Diabetes MellitusSuicidal IdeationSuicidal IdeationDiabetes MellitusAnxiety

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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Recent related drug studies (Check your drugs):

Complete drug side effects:

On eHealthMe, Klonopin (clonazepam) is often used to treat stress and anxiety. Wellbutrin (bupropion hydrochloride) is often used to treat depression. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

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