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Review: Klonopin and Wellbutrin





Summary: drug interactions are reported among people who take Klonopin and Wellbutrin together.

This review analyzes the effectiveness and drug interactions between Klonopin and Wellbutrin. It is created by eHealthMe based on reports of 5,505 people who take the same drugs from FDA and social media, and is updated regularly.

You are not alone: join a mobile support group for people who take Klonopin and Wellbutrin >>>

What are the drugs

Klonopin has active ingredients of clonazepam. It is often used in stress and anxiety. (latest outcomes from Klonopin 31,277 users)

Wellbutrin has active ingredients of bupropion hydrochloride. It is often used in depression. (latest outcomes from Wellbutrin 54,972 users)

On Nov, 29, 2014: 5,503 people who take Klonopin, Wellbutrin are studied

Klonopin, Wellbutrin outcomes

Drug combinations in study:
- Klonopin (clonazepam)
- Wellbutrin (bupropion hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Klonopin is effective31.82%
(14 of 44 people)
46.51%
(40 of 86 people)
47.46%
(28 of 59 people)
50.68%
(37 of 73 people)
52.54%
(62 of 118 people)
64.79%
(46 of 71 people)
74.63%
(50 of 67 people)
57.14%
(4 of 7 people)
Wellbutrin is effective18.37%
(9 of 49 people)
19.51%
(16 of 82 people)
31.34%
(21 of 67 people)
35.29%
(24 of 68 people)
32.08%
(34 of 106 people)
53.01%
(44 of 83 people)
51.92%
(27 of 52 people)
25.00%
(1 of 4 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
AnxietyDepressionNauseaAnxietyType 2 Diabetes MellitusDepressionPainDepression
DizzinessDrug Exposure During PregnancyType 2 Diabetes MellitusNauseaDiabetes MellitusAnxietyInsomniaAnxiety
Drug IneffectiveDilatation VentricularBack PainType 2 Diabetes MellitusSuicide AttemptDizzinessChest PainNausea
DepressionCardiomegalyHeadacheHeadacheWeight IncreasedPainDry MouthDrug Ineffective
NauseaVentricular Septal DefectAbdominal DiscomfortDepressionDepressionNauseaDepressionWeight Increased
InsomniaCongenital AnomalyAbdominal Pain UpperGastric UlcerFatigueSuicide AttemptPancreatitisPain
PainTruncus Arteriosus PersistentGallbladder InjuryEmotional DistressPulmonary EmbolismIntentional OverdoseFatigueDiabetes Mellitus
ConvulsionBundle Branch Block RightVomitingPainPainIrritabilityPanic AttackFatigue
Suicidal IdeationAnxietyBiliary DyskinesiaCardiac ArrestAnxietyVision BlurredAnxietyInsomnia
DiarrhoeaAortic StenosisDepressionFatigueHeadacheAngerTardive DyskinesiaDizziness

Drug effectiveness by gender :

FemaleMale
Klonopin is effective54.42%
(197 of 362 people)
51.53%
(84 of 163 people)
Wellbutrin is effective33.33%
(117 of 351 people)
36.88%
(59 of 160 people)

Most common drug interactions by gender * :

FemaleMale
DepressionDepression
NauseaDiabetes Mellitus
AnxietyDrug Ineffective
PainAnxiety
Weight IncreasedType 2 Diabetes Mellitus
Drug IneffectiveFatigue
HeadacheWeight Increased
InsomniaSuicidal Ideation
DizzinessInsomnia
FatigueNausea

Drug effectiveness by age :

0-12-910-1920-2930-3940-4950-5960+
Klonopin is effective100.00%
(1 of 1 people)
n/a20.00%
(1 of 5 people)
30.47%
(39 of 128 people)
33.80%
(72 of 213 people)
30.24%
(75 of 248 people)
36.59%
(60 of 164 people)
31.13%
(33 of 106 people)
Wellbutrin is effective0.00%
(0 of 1 people)
n/a50.00%
(3 of 6 people)
18.40%
(23 of 125 people)
16.06%
(35 of 218 people)
19.75%
(48 of 243 people)
27.50%
(44 of 160 people)
22.33%
(23 of 103 people)

Most common drug interactions by age * :

0-12-910-1920-2930-3940-4950-5960+
Diabetes MellitusSpeech DisorderNauseaCompleted SuicideDiabetes MellitusDepressionDepressionDrug Ineffective
Weight IncreasedLaryngomalaciaSomnolenceDepressionNauseaNauseaAnxietyNausea
Type 2 Diabetes MellitusDysphagiaVomitingSuicidal IdeationType 2 Diabetes MellitusAnxietyFallDizziness
PollakiuriaDrug Exposure During PregnancyBack PainWeight IncreasedDepressionDiabetes MellitusNauseaFatigue
Major DepressionMaternal Drugs Affecting FoetusGallbladder InjuryGrand Mal ConvulsionCompleted SuicideFatiguePainHeadache
HyperglycaemiaHeadacheAbdominal DiscomfortSuicide AttemptWeight IncreasedDizzinessHeadacheAsthenia
InjuryWeight DecreasedBiliary DyskinesiaDrug IneffectiveAnxietyPainFatigueInsomnia
Suicidal IdeationDizzinessAbdominal Pain UpperConvulsionPainType 2 Diabetes MellitusInsomniaDepression
Jaundice NosLethargyDiabetes MellitusDrug IneffectiveWeight IncreasedWeight IncreasedWeight Increased
Maternal Drugs Affecting FoetusElectrocardiogram Qrs Complex ProlongedType 2 Diabetes MellitusInsomniaSuicidal IdeationDiabetes MellitusAnxiety

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Klonopin and Wellbutrin?

You are not alone! Join a related mobile support group:
- support group for people who take Klonopin and Wellbutrin
- support group for people who take Klonopin
- support group for people who take Wellbutrin

Can you answer these questions (Ask a question):

  • I had bladder cancer and my doctor put me on metformin should i get off this
    I do not want to take this metformin if it may cause my bladder cancer to come badk
  • I am on 2 x daily rifampin and 4 x daily cephalixin 500mg and and awake exhausted after 8-9 hours sleep and the fatigue is unbelievable all day every day, is this "normal" or should i investigate ore (1 answer)
    Had total knee replacement 11/12, bad from the start, knee swollen/hot/painful/unstable for most of 2 years before a mechanically successful Revision that found a loose patella and both ends of the prostheses loose. In spite of 10-12 aspirations and almost as many samples sent to labs for testing the result was always "no growth after a week". Following the revision, 10 days after, surgeons office called and says yes you have a staph E infection. Immediate therapy with 6 weeks of 3 X day IV PLUS 2 x per day oral Rifampin.
    IV over but now on the 2 X day Rifampin PLUS 4 X day 500mg cephalexin and the fatigue is unbelievable. Wake up exhausted after 8 hours sleep, daily hour plus mid afternoon naps.
  • Has anyone been helped by taking lexapro and wellbutrin? (1 answer)
    I am the mom of a 22 year old who is trying to get through college and can't seem to find the right meds for depression. She is taking Lexapro and I am wondering if adding Wellbutrin will help.
  • Can my eye twitch be because of lexapro?
    So I have had symptoms of anxiety and depression due to a lot of stressors and disasters that happened in my life over the past two years. As my anxiety got worse after a breast biopsy, I started freaking out and thinking I may have MS because my sister has MS. So I went to my GP and she decided my symptoms do not follow the symptoms of MS or any similar problem and it should most likely be anxiety. She put me on Lexapro and Clonazepam. At first I was very hesitant to take medication but as my symptoms got worse I decided to give it a try. I was on Lexopro 5 mg for about two months and then I went to 10 mg, and I would take 1 or 2 Clonazepam a day. And this all started 5 months ago. And things seemed to be working just fine.Until about two months ago I started having this freaking annoying eye twitch on my upper left eyelid. I have had eye twitches before but they always go away after a couple of days or a week top. This one has been lasting for 2 months now and seems to be just getting worse. I went to the GP and my eye doctor and they still found no cause and said it's probably stress and anxiety. I have not been overly stressed and I get plenty of sleep, 10 hrs or more! and I stopped taking caffeine and alcohol after the twitch started. Any idea? Could it be because of medication? I also need to add I have had thumb twitching and severe spasms in my muscles around my right thumb starting in May (before taking any medication).
  • Why would doctor prescribe meclizine when otc med available? stronger?
    Gastric bypass. After years found should not be prescribed extended release medications-- they do not work because stomach (duodenum) releases enzymes and acids to release XR. Suffer from GAD, MAD, PTSD, ADHD, Insomnia. I've driven away my best friend-- I'm tired of life-- alone.

More questions for: Klonopin, Wellbutrin

You may be interested at these reviews (Write a review):

  • Panic after using flonase
    I was diagnosed with nasal polyps and put on Flonase (a steroid nose spray). It worked well to dry up post-nasal drip but I ended up with a bad case of panic and fear. I had overcome episodes of these nervous disorders but the Flonase brought it all back. I still suffer from panic even though I stopped the Flonase months ago. I had a bad attack on a bridge and also inside a grocery store. Personnel had to take me to the store office to calm me down. I am nearly agoraphobic now. I do go out alone but try to avoid after-dark. My life has been turned into daily dread of another attack. To think that I was more than ten years FREE of panic until I took the Flonase makes me feel so regretful that I ever took that stuff. It should be banned as there is enough evidence to do so from many people who now suffer debilitating and recurring panic.
  • Intrsoccular pressure increase associated with wellbutrin
    I was given a prescription for Wellbutrin in approximately 1998. I had has my ocular pressure checked a year prior to this and it was okay. At the time, I only needed to wear reading glasses, common in people over 45. I took the drug at the full prescribed dosage for two weeks. Immediately prior to the narrow angle glaucoma episode, my vision had actually seemed to improve. For one day, prior, I could read without reading glasses. The following night, I was watching tv, and things suddenly became foggy. It was actually as if a fog had enveloped the room. I could not see anything except to discern between light and dark areas. I had to have emergency laser surgery the next morning. I mentioned to the doctor that Iwas taking Wellbutrin to stop smoking, and asked if it could have caused the ocular pressure increase. he consulted the PDR, and said there was no mention of it causing increases in ocular pressure. One year later my primary care doctor again insisted that I stop smoking, and again I mentioned that I thought it might increase ocular pressure. She told me to take a half dose, I did, and I took it one week, at which time I again experienced another episode of narrow angle glaucoma. When I go to the doctor's office my pressure in my left eye was 72, and 68 in my right eye. I was then referred on a triage basis to another doctor. I spent the rest of the day in his office having drops administered every fifteen minutes(extremely painful). I had extensive laser surgery the next morning.It required over fifty shots from the laser machine into each eye, (also extremely painful). I had lost considerable peripheral AND CENTRAL VISION in my left eye, and a good deal in my right. As a result of having to have such extensive laser surgery I also had cataracts that began at 50% maturity. I was advised by the surgeon that I should wait to have the cataracts removed "until my vision and quality of life was so poor that I was ready to commit suicide" because having the cataracts removed would cause the pressure in my eyes to become very difficult to control, and that more than likely I would end up being black blind. I would never use Wellbutrin under any circumstances, and I always check to make sure that any new meds I may be put on don't have anything to do with an increase in ocular pressure. If they do, I refuse to take them. The surgeon said he was surprised that I didn't lose more vision than I did, and I am grateful that I didn't, and that he was a good surgen. He wrote an article concerning this case for a medical journal since he said he had been seeing a recent increase of narrow angle glaucoma.
  • Librium 25mg and wellbutrin 300mg for >1 month
    I've been taking librium twice daily, morning and night, for about 3 months now along with wellbutrin XL in the morning. I've basically had the mood of "I don't care" and a great boost in confidence.
  • A life of depression and fatigue
    1) Family history of depression, 2) Diagnosed depression 1964-not treated until 1973, 3) Worked in medical field 35 years, 4) Emergency on-call 24/7, 5) Hospital 15 times major depression, 6) Tried nearly all MAOI, TCA, SSRI, SNRI, and ECT. 7) 100% Disability in 1998 for depression. Now at age 70 I have dysthymia, chronic fatigue, COPD, and PTSD. My recommendation to younger people - do not over stress,
    do not smoke, avoid horrific or traumatic situations and try to find some enjoyment in life. If you have symptoms like mine seek early treatment put balance in your life. The often heard recommendations - get plenty of sleep, eat properly, learn to relax and avoid bad habits should not be ignored, they are critical to good physical and mental health.
  • 3 strong drugs together against neuropathic pain
    Neuropathic pain debuted when I was 24, now I'm 50. Received diagnosed with Ehler-Danlos syndrome (EDS), joint hypermobility type, when I was 35 years old. So it can take some time to get a diagnose. And as EDS-patient I do not belong to any clinic. Orthopedics says that EDS is not orthopedic, rheumatology says that EDS is not an autoimmune disease, GPs say that EDS is too difficult, and so on. Sooner or later we all end up at Psychiatry, even if we are not depressed.

    The first kind of pain I got when I was 24 came from low back, but I experienced as pelvic pain and leg pain. It was clearly a neuropathic pain, but it took years to find out. Later it was treated by a pain clinic with cortisone around the genitofemoral nerves (both sides). Since this treatment didn't result in lasting freedom from pain, the pain clinic started to give me RF (radio frequency) treatment. This made the pain disappeared after one year, and I was 80% free from it between 2002 and 2014, 12 years. The pain doctors said pain could return after 10 years.

    The other kind of neuropathic pain started 2003 with intense stomach pain. During 6 months I could hardly eat nothing due to nausea and vomiting. After this 6 months, stomach pain changed to almost unbearable pain in upper back.
    What happened 2003, and what all the doctors missed, was that the right lowest ribs slid up over the sternum. This rib dislocation is till there today, but now with a lot of cartilage formed around the rib where it is stuck in the lower end of the sternum. The dislocation is clearly visible on X-ray. This has greatly affected the thoracic spine. I have a scoliosis which I had not before 2003. And I still have severe pain in the thoracic spine.

    It was initially treated with morphine daily, and later with Durogesic (fentanyl), but this didn't help much. 2005 I was hospitalized because I had too much pain to take care of myself and my hygiene. After some months the doctors started to give me clonazepam because the muscles along the spine was in a chronic seizures. Clonazepam helped, but I could still have a lot of pain in two vertebrae in the thoracic spine. It felt as if someone drilled into the vertebrae without anesthesia. After a few months, doctors also prescribed me methadone. Then the pain disappeared almost completely. Since 2006, I have eaten clonazepam and methadone every day, and I need to sleep in an armchair to not get more pain because of moving during sleep.

    There are side effects. After 1,5 years with clonazepam and methadone I started to have panic attacks. Or rather one long panic attack which didn't stop before I got treatment with amitryptilin and pregabalin (Lyrica). These 2 medicines stopped the panic disorder completely after some hours, and the panic was then gone. Then I got side effects of these 2 medicines, amitryptilin & Lyrica, too. I gained a lot of weight (from 83 to 148 kg) and got much water (edema) in both my legs under the knees and in both feet. The feet could swallow to the double size. 2012 I stopped with amitryptilin and started to loose weight again (in Aug 2014 below 80 kg) and get less water in my legs. Today I eat as little medicines I can, but I have to take methadone, clonazepam and Lyrica every day, twice. If I try to take away one of these 3 medicines, I got pain problems at once. Lyrica is the most painful one to take away. In Sept-Dec 2013 I lowered Lyrica from 300 mg daily, to 150, then to 75 and finally 0 mg. The pain I had was extremely difficult to handle. It didn't help to take more methadone or anything else. I have checked on Internet and found that many people got pain from quitting with Lyrica. Most people start eating it again. So did I. But 2006 and 2007 it was enough to treat the pain with methadone and clonazepam, I got the Lyrica against anxiety not pain. But today I take Lyrica against pain.

    Beside weight gain and leg edema, clonazepam and Lyrica significantly affect the sexual desire. And Lyrica alone makes it almost impossible to ejaculate. All four drugs together (clonazepam, methadone, amitryptiline and Lyrica), make one forget all about sex life. You don't even miss it. When I stopped with amitryptiline and lowered Lyrica (still taking clonazepam and methadone), I could suddenly easily get erections again, feel desire, but not getting orgasms. This is quite difficult to deal with.

    The pain pattern is greatly affected, by pain and by the medicines. So is the mood. I get something which feels like heavy depression, especially if I take the medicines late that day. I should take a medicine like methadone 3 times a day, because the effects of the tablet lasts around 8 hours. But I take them every 12 hours, to have a low consumption in case doctors prescribe them too late (which happens, and then it's good to have a spouse going to the pharmacy buying them for you, because you have too much pain to go yourself).

    Since methadone is also used for treating heroine addicts, medical staff treat you with disrespect when they see that it says "methadone" in your health record. I need to show a certificate that says that I deal with chronic neuropathic pain, that I never have had problems with drug addiction, to get normal respect.

    I wanted to share this because I think I am alone in the world with these medicines in combination against neuropathic pain caused by hypermobile joints, joint dislocation and muscle spasms. After trying almost everything else, including surgery cutting nerves, methadone, clonazepam and Lyrica seems to be the only way to kill my pain. But it's a life where you always is questioned, because of the use of methadone. I can guarantee that everybody in the world should accept these medicines if they had experienced the unbearable pain I had in upper back before they started to give me clonazepam and methadone.

More reviews for: Klonopin, Wellbutrin

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Complete drug side effects:

On eHealthMe, Klonopin (clonazepam) is often used to treat stress and anxiety. Wellbutrin (bupropion hydrochloride) is often used to treat depression. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

   

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