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Review: taking Lamotrigine and Benadryl together

Summary: drug interactions are reported among people who take Lamotrigine and Benadryl together.

This review analyzes the effectiveness and drug interactions between Lamotrigine and Benadryl. It is created by eHealthMe based on reports of 469 people who take the same drugs from FDA and social media, and is updated regularly.


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On Mar, 20, 2015: 469 people who take Lamotrigine, Benadryl are studied

Lamotrigine, Benadryl outcomes

Drug combinations in study:
- Lamotrigine (lamotrigine)
- Benadryl (diphenhydramine hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Lamotrigine is effective16.67%
(1 of 6 people)
(0 of 11 people)
(0 of 3 people)
(3 of 8 people)
(7 of 14 people)
(5 of 6 people)
(1 of 3 people)
(1 of 1 people)
Benadryl is effective33.33%
(5 of 15 people)
(4 of 9 people)
(4 of 7 people)
(2 of 11 people)
(2 of 4 people)
(0 of 1 people)
(2 of 3 people)

Drug effectiveness by gender :

Lamotrigine is effective29.27%
(12 of 41 people)
(6 of 11 people)
Benadryl is effective36.59%
(15 of 41 people)
(4 of 9 people)

Drug effectiveness by age :

Lamotrigine is effectiven/an/a0.00%
(0 of 5 people)
(1 of 25 people)
(5 of 28 people)
(5 of 24 people)
(6 of 21 people)
(1 of 5 people)
Benadryl is effectiven/an/a0.00%
(0 of 4 people)
(1 of 24 people)
(5 of 27 people)
(7 of 24 people)
(4 of 21 people)
(2 of 5 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Engraftment SyndromeUrticariaDepressionOxygen Saturation DecreasedAbdominal DiscomfortSneezingForgetfulnessNausea
Blood Bilirubin IncreasedAstheniaPruritusHeart Rate IrregularFaeces DiscolouredRash PustularLower Blood PressurePruritus
Renal Failure AcuteDepressionHallucination, VisualWeight GainWeight DecreasedDrowsinessConvulsion
PyrexiaVision BlurredFeeling AbnormalNumbness And TinglingAbdominal PainHeadacheConfusional State
Stevens-johnson SyndromePruritusDiarrhoeaHeadacheBiliary DyskinesiaPetechiaePain
MalaiseExcessive Eye BlinkingBlisterCystitisDeep Vein ThrombosisHeart Rate IrregularDepression
DizzinessAbasiaTardive DyskinesiaSneezingPain In ExtremityOxygen Saturation DecreasedHeadache
HeadacheTremorRash PustularHivesTremorNumbness And TinglingVomiting

Most common drug interactions by gender * :

RashCompleted Suicide
PruritusWeight Increased
HeadacheRenal Failure Acute
Confusional StateDyspepsia
Back PainGait Disturbance

Most common drug interactions by age * :

n/aPetit Mal EpilepsySuicidal IdeationRashConvulsionRashRashSwelling
Weight IncreasedCompleted SuicideRashPruritusDepressionDelirium
AkathisiaSuicidal IdeationVomitingHeadachePainConfusional State
ExcoriationAstheniaLoss Of ConsciousnessComaFallPyrexia
PyrexiaDepressionType 2 Diabetes MellitusMental DisorderTremorPain In Extremity
Vision BlurredNauseaHeadacheNauseaMeningitis AsepticNeck Pain
RashConvulsionDevice Related InfectionConfusional StateWeight IncreasedNeuropathy Peripheral
Gait DisturbanceFeeling AbnormalCompleted SuicideTremorWeight DecreasedBack Pain
Decreased AppetiteAbdominal PainDizzinessCompleted SuicideMood SwingsConjunctivitis
Feeling GuiltyRenal Failure AcuteAnxietyDizzinessFatigueNausea

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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- support group for people who take Benadryl
- support group for people who take Lamotrigine

Recent related drug studies (Check your drugs):

Complete drug side effects:

On eHealthMe, Lamotrigine (lamotrigine) is often used to treat bipolar disorder. Benadryl (diphenhydramine hydrochloride) is often used to treat allergies. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.


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