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Review: taking Lamotrigine and Benadryl together

Summary: drug interactions are reported among people who take Lamotrigine and Benadryl together.

This review analyzes the effectiveness and drug interactions between Lamotrigine and Benadryl. It is created by eHealthMe based on reports of 469 people who take the same drugs from FDA and social media, and is updated regularly.

 

 

 

 

You are not alone: join a mobile support group for people who take Lamotrigine and Benadryl >>>

What are the drugs

Lamotrigine has active ingredients of lamotrigine. It is often used in bipolar disorder. (latest outcomes from 15,828 Lamotrigine users)

Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in allergies. (latest outcomes from 29,395 Benadryl users)

On Feb, 17, 2015: 469 people who take Lamotrigine, Benadryl are studied

Lamotrigine, Benadryl outcomes

Drug combinations in study:
- Lamotrigine (lamotrigine)
- Benadryl (diphenhydramine hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Lamotrigine is effective16.67%
(1 of 6 people)
0.00%
(0 of 11 people)
0.00%
(0 of 3 people)
37.50%
(3 of 8 people)
50.00%
(7 of 14 people)
83.33%
(5 of 6 people)
33.33%
(1 of 3 people)
100.00%
(1 of 1 people)
Benadryl is effective33.33%
(5 of 15 people)
44.44%
(4 of 9 people)
57.14%
(4 of 7 people)
18.18%
(2 of 11 people)
50.00%
(2 of 4 people)
0.00%
(0 of 1 people)
n/a66.67%
(2 of 3 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
RashRashRashDizzinessVomitingHivesConfusionRash
Engraftment SyndromeUrticariaDepressionOxygen Saturation DecreasedAbdominal DiscomfortSneezingForgetfulnessNausea
Blood Bilirubin IncreasedAstheniaPruritusHeart Rate IrregularFaeces DiscolouredRash PustularLower Blood PressurePruritus
Renal Failure AcuteDepressionHallucination, VisualWeight GainWeight DecreasedDrowsinessConvulsion
PyrexiaVision BlurredFeeling AbnormalNumbness And TinglingAbdominal PainHeadacheConfusional State
InsomniaRhabdomyolysisPainHallucinationCholesterosisDizzinessTremor
Stevens-johnson SyndromePruritusDiarrhoeaHeadacheBiliary DyskinesiaPetechiaePain
MalaiseExcessive Eye BlinkingBlisterCystitisDeep Vein ThrombosisHeart Rate IrregularDepression
DizzinessAbasiaTardive DyskinesiaSneezingPain In ExtremityOxygen Saturation DecreasedHeadache
HeadacheTremorRash PustularHivesTremorNumbness And TinglingVomiting

Drug effectiveness by gender :

FemaleMale
Lamotrigine is effective29.27%
(12 of 41 people)
54.55%
(6 of 11 people)
Benadryl is effective36.59%
(15 of 41 people)
44.44%
(4 of 9 people)

Most common drug interactions by gender * :

FemaleMale
RashCompleted Suicide
NauseaRash
PruritusWeight Increased
ConvulsionPneumonia
PainVomiting
HeadacheRenal Failure Acute
Confusional StateDyspepsia
DepressionIncontinence
TremorMania
Back PainGait Disturbance

Drug effectiveness by age :

0-12-910-1920-2930-3940-4950-5960+
Lamotrigine is effectiven/an/a0.00%
(0 of 5 people)
4.00%
(1 of 25 people)
17.86%
(5 of 28 people)
20.83%
(5 of 24 people)
28.57%
(6 of 21 people)
20.00%
(1 of 5 people)
Benadryl is effectiven/an/a0.00%
(0 of 4 people)
4.17%
(1 of 24 people)
18.52%
(5 of 27 people)
29.17%
(7 of 24 people)
19.05%
(4 of 21 people)
40.00%
(2 of 5 people)

Most common drug interactions by age * :

0-12-910-1920-2930-3940-4950-5960+
n/aPetit Mal EpilepsySuicidal IdeationRashConvulsionRashRashSwelling
Weight IncreasedCompleted SuicideRashPruritusDepressionDelirium
AkathisiaSuicidal IdeationVomitingHeadachePainConfusional State
ExcoriationAstheniaLoss Of ConsciousnessComaFallPyrexia
PyrexiaDepressionType 2 Diabetes MellitusMental DisorderTremorPain In Extremity
Vision BlurredNauseaHeadacheNauseaMeningitis AsepticNeck Pain
RashConvulsionDevice Related InfectionConfusional StateWeight IncreasedNeuropathy Peripheral
Gait DisturbanceFeeling AbnormalCompleted SuicideTremorWeight DecreasedBack Pain
Decreased AppetiteAbdominal PainDizzinessCompleted SuicideMood SwingsConjunctivitis
Feeling GuiltyRenal Failure AcuteAnxietyDizzinessFatigueNausea

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Get connected: join our support group of Lamotrigine and Benadryl on

Do you take Lamotrigine and Benadryl?

You are not alone! Join a related mobile support group:
- support group for people who take Lamotrigine and Benadryl
- support group for people who take Benadryl
- support group for people who take Lamotrigine

Recent conversations of related support groups:

Can you answer these questions (Ask a question):

More questions for: Benadryl, Lamotrigine

You may be interested at these reviews (Write a review):

  • Diphenhydramine and mental acuity
    For at least 10 years, I have taken diphenhydramine 50 mg. at bedtime for insomnia and allergies. The results have been that I sleep well with no hangover or any cognitive impairment. If I experience vertigo from allergies, I may take an additional 50 mg. but never exceeding 100 mg in a 24 hour period.

    After reading the report regarding an Alzheimer's study finding that after taking as little as 4mg diphenhydramine daily for more than 3 years, dementia rates were high.

    I stopped the diphenhydramine one night. I experienced symptoms of deep brain pulsating pain and severe insomnia. After 4 hours, I took 50 mg diphenhydramine and slept very well. The next night I took 37.5 mg. diphenhydramine, slept very well. However, some of my tasks require layers of mental challenges in which I became slower.

    My question is how did the study recipients obtain 4 mg doses of diphenhydramine when the standard over-the-counter (OTC) availability in tablets is 25 mg? How reliable is the information submitted from the study subjects? What manufacturer's diphendramine was used, or were there several?

    I felt sharper mentally when on 50 mg daily than so far on 37.5 mg.
  • Lamotrigine severe rash
    I started taking 100mg of Teva-Lamotrigine Nov 22 once daily. I got a refill on Dec 5 that was Mylan-Lamotrigine. Two days later I woke up with an odd hot feeling rash all over my body and severe fatigue. I went back to bed 1/2 hour later after taking my regular Wellbutrin and the Lamotrigine. I woke up late morning. It got progressively worse during the day and I had a headache,fever and chills. I took the anti-histimine Aerius later that day which didn't help. The next day I went to a walk in clinic and they said it wasn't the Lamotrigine and thought it was a virus and did a throat swab. The fever and chills went away after a few days but I still have the rash. Finally after a week I saw a doctor that agreed it was the drug and I am now on the second week of Prednisone steroid treatment and prescription Reactin which is helping slowly. I have reported it to the Mylan drug company.
  • Sinuses and lamictal
    Have been having painful problems with sinuses, focal seizures have increased along with lapses of consciousness. Had the doctor take blood levels. They are normal, but feeling like this is not. Am wondering if the strange weather isn't a factor - as there is a constant fluctuation of the air pressure. Has anyone had similar problems. Would love to hear from you
  • The zoloft/vyvanse concoction ruined my life.
    I started taking these drugs about two months ago. I am diagnosed ADHD by a psychiatrist. I received these medications from a doctor whom I know and is married to a friend my wife. She, the doctor, gave them to me from her personal medications in a plastic baggy. I was given loose instructions for taking these on a piece of paper. I was never given the paperwork with warning signs. 10 days after starting these medications, I attacked my wife and am now separated. I am barred from seeing her and my daughter by means of a Victims Protective Order. I am a normally nonviolent person. Most who know me call me a peacemaker...a pacifist. I am still horrified by the events of that night. 15 seconds changed my life forever. I hope and pray my story helps others. Don't be naïve, as I was, when given medications. Ask questions.
  • A life of depression and fatigue (1 response)
    1) Family history of depression, 2) Diagnosed depression 1964-not treated until 1973, 3) Worked in medical field 35 years, 4) Emergency on-call 24/7, 5) Hospital 15 times major depression, 6) Tried nearly all MAOI, TCA, SSRI, SNRI, and ECT. 7) 100% Disability in 1998 for depression. Now at age 70 I have dysthymia, chronic fatigue, COPD, and PTSD. My recommendation to younger people - do not over stress,
    do not smoke, avoid horrific or traumatic situations and try to find some enjoyment in life. If you have symptoms like mine seek early treatment put balance in your life. The often heard recommendations - get plenty of sleep, eat properly, learn to relax and avoid bad habits should not be ignored, they are critical to good physical and mental health.

More reviews for: Benadryl, Lamotrigine

Comments from related studies:

  • From this study (4 months ago):

  • I have dizzinws, forgetfulness and memory loss

    Reply

  • From this study (9 months ago):

  • Itching in extremeties with no rash apparent. Eyes watery and burning. Twitching is in left eyelid. Itching started 8 days ago. Lotion does not help much. Diphenhydramine does not help much.

    Reply

  • From this study (1 year ago):

  • Ovarian cysts

    Reply

Post a new comment    OR    Read more comments

Complete drug side effects:

On eHealthMe, Lamotrigine (lamotrigine) is often used to treat bipolar disorder. Benadryl (diphenhydramine hydrochloride) is often used to treat allergies. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

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