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Review: taking Lexapro and Depakote together

Summary: drug interactions are reported among people who take Lexapro and Depakote together.

This review analyzes the effectiveness and drug interactions between Lexapro and Depakote. It is created by eHealthMe based on reports of 1,248 people who take the same drugs from FDA and social media, and is updated regularly.


You are not alone: join a support group for people who take Lexapro and Depakote >>>

On Apr, 6, 2015: 1,248 people who take Lexapro, Depakote are studied

Lexapro, Depakote outcomes

Drug combinations in study:
- Lexapro (escitalopram oxalate)
- Depakote (divalproex sodium)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Lexapro is effective0.00%
(0 of 4 people)
(1 of 8 people)
(1 of 7 people)
(3 of 6 people)
(3 of 12 people)
(1 of 2 people)
(5 of 6 people)
(0 of 1 people)
Depakote is effective40.00%
(4 of 10 people)
(2 of 10 people)
(1 of 3 people)
(3 of 4 people)
(5 of 10 people)
(1 of 1 people)
(4 of 7 people)
(1 of 1 people)

Drug effectiveness by gender :

Lexapro is effective35.48%
(11 of 31 people)
(3 of 15 people)
Depakote is effective41.38%
(12 of 29 people)
(9 of 17 people)

Drug effectiveness by age :

Lexapro is effectiven/an/a7.69%
(1 of 13 people)
(2 of 8 people)
(5 of 19 people)
(2 of 14 people)
(2 of 10 people)
(2 of 6 people)
Depakote is effectiven/an/a7.14%
(1 of 14 people)
(6 of 10 people)
(6 of 19 people)
(4 of 13 people)
(1 of 10 people)
(3 of 7 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
DyspnoeaPancreatitisAnxietyType 2 Diabetes MellitusType 2 Diabetes MellitusSuicidal IdeationWeight IncreasedDiabetes Mellitus
ConvulsionConvulsionOverdoseObesityConvulsionDepressionObesityType 2 Diabetes Mellitus
Suicide AttemptType 2 Diabetes MellitusFatigueWeight IncreasedPainNeuropathy PeripheralThrombosisWeight Increased
Cerebrovascular AccidentDiabetes Mellitus Inadequate ControlWeight IncreasedNeuropathy PeripheralHypoglycaemiaType 2 Diabetes MellitusType 2 Diabetes MellitusDepression
Suicidal IdeationDepressionPain In ExtremityDiabetes MellitusNauseaLethargyBreast MassSuicidal Ideation
Eosinophilic PneumoniaBlood Triglycerides IncreasedDepressionOverdoseDiabetic NeuropathySomnolencePerirectal AbscessAnxiety
DepressionBlood Cholesterol IncreasedChest PainBlood Cholesterol IncreasedObesityTremorAnticoagulation Drug Level Above TherapeuticTremor
ComaPyrexiaNeutrophil Count IncreasedCardiac DisorderVomitingDiabetes MellitusHeadacheBlood Cholesterol Increased
AnxietyDyskinesiaUrinary IncontinenceBreast MassBlood Cholesterol IncreasedHerniaDiabetes Mellitus Inadequate ControlFatigue
Breast CystDiabetic GastroparesisMalaiseThrombosisMental Status ChangesHepatic Enzyme IncreasedSomnolenceDiarrhoea

Most common drug interactions by gender * :

Type 2 Diabetes MellitusType 2 Diabetes Mellitus
Diabetes MellitusDiabetes Mellitus
Weight IncreasedAnxiety
Suicidal IdeationTremor
Blood Cholesterol IncreasedSuicidal Ideation
NauseaWeight Increased
ConvulsionDrug Ineffective

Most common drug interactions by age * :

Type 2 Diabetes MellitusSomnolenceDiarrhoeaDiabetes MellitusType 2 Diabetes MellitusType 2 Diabetes MellitusDiabetes MellitusSuicidal Ideation
Suicidal IdeationHaematocritDizzinessWeight IncreasedDiabetes MellitusDiabetes MellitusType 2 Diabetes MellitusDry Mouth
Pyoderma GangrenosumFallSuicidal IdeationSuicidal IdeationObesityAnxietyDepressionFall
Pelvic PainDrug ToxicityAggressionDyspnoeaBlood Cholesterol IncreasedBlood Cholesterol IncreasedFatigueDecreased Appetite
Urinary Tract InfectionDizzinessVomitingType 2 Diabetes MellitusWeight IncreasedDiabetic NeuropathyPainDiarrhoea
Uterine LeiomyomaHeadacheWeight IncreasedSuicide AttemptBlood Triglycerides IncreasedBack PainSomnolenceTremor
Oculoauriculovertebral DysplasiaRadius FractureDiabetes MellitusInsomniaDiabetes Mellitus Inadequate ControlDiabetes Mellitus Inadequate ControlAnxietyDrug Ineffective
Drug Exposure During PregnancyPlatelet CountAbdominal PainAgitationNauseaDyspnoeaDizzinessDepression
PancreatitisDisorientationCondition AggravatedPost-traumatic Stress DisorderChest PainConvulsionTremorMuscle Twitching
Weight IncreasedPsychomotor HyperactivityHyperhidrosisDizzinessSuicidal IdeationNeuropathy PeripheralWeight DecreasedNightmare

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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Do you take Lexapro and Depakote?




You are not alone! Join a related support group:
- support group for people who take Depakote
- support group for people who take Lexapro

Recent related drug studies (Check your drugs):

Complete drug side effects:

On eHealthMe, Lexapro (escitalopram oxalate) is often used to treat depression. Depakote (divalproex sodium) is often used to treat bipolar disorder. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.


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