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Review: taking Lexapro and Seroquel Xr together

Summary: drug interactions are reported among people who take Lexapro and Seroquel Xr together.

This review analyzes the effectiveness and drug interactions between Lexapro and Seroquel Xr. It is created by eHealthMe based on reports of 4,151 people who take the same drugs from FDA and social media, and is updated regularly.





You are not alone: join a mobile support group for people who take Lexapro and Seroquel Xr >>>

What are the drugs

Lexapro has active ingredients of escitalopram oxalate. It is often used in depression. (latest outcomes from 39,466 Lexapro users)

Seroquel xr has active ingredients of quetiapine fumarate. It is often used in bipolar disorder. (latest outcomes from 9,521 Seroquel xr users)

On Feb, 10, 2015: 4,151 people who take Lexapro, Seroquel Xr are studied

Lexapro, Seroquel Xr outcomes

Drug combinations in study:
- Lexapro (escitalopram oxalate)
- Seroquel Xr (quetiapine fumarate)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Lexapro is effective16.67%
(3 of 18 people)
(11 of 32 people)
(10 of 23 people)
(7 of 29 people)
(13 of 37 people)
(6 of 16 people)
(1 of 10 people)
(0 of 2 people)
Seroquel Xr is effective16.00%
(4 of 25 people)
(11 of 31 people)
(10 of 20 people)
(17 of 36 people)
(20 of 30 people)
(11 of 17 people)
(1 of 4 people)
(1 of 2 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Type 2 Diabetes MellitusType 2 Diabetes MellitusType 2 Diabetes MellitusType 2 Diabetes MellitusType 2 Diabetes MellitusType 2 Diabetes MellitusDizzinessDiabetes Mellitus
Suicidal IdeationDiabetes MellitusDiabetes MellitusDiabetes MellitusDiabetes MellitusDiabetes MellitusType 2 Diabetes MellitusType 2 Diabetes Mellitus
SomnolenceInsomniaObesityObesitySuicidal IdeationBlood Cholesterol IncreasedDiabetes MellitusWeight Increased
ConvulsionDiabetes Mellitus Inadequate ControlWeight IncreasedBlood Cholesterol IncreasedDepressionObesityAstheniaDepression
DepressionBlood Cholesterol IncreasedDiabetes Mellitus Inadequate ControlHyperglycaemiaBlood Cholesterol IncreasedHyperlipidaemiaSomnolenceBlood Cholesterol Increased
AgitationSuicide AttemptInsomniaPancreatitisPancreatitisDiabetes Mellitus Inadequate ControlBlood Cholesterol IncreasedAnxiety
Suicide AttemptHeadacheDiabetic KetoacidosisAnxietyObesityNeuropathy PeripheralDehydrationSuicidal Ideation
Blood Cholesterol IncreasedType 1 Diabetes MellitusSuicidal IdeationDepressionSuicide AttemptSuicidal IdeationCholelithiasisPancreatitis
OverdoseWeight IncreasedDepressionWeight IncreasedInsomniaBlood Triglycerides IncreasedUrinary Tract InfectionInsomnia
Diabetes MellitusOverdoseBlood Cholesterol IncreasedDiabetes Mellitus Inadequate ControlWeight IncreasedHeadacheHypercholesterolaemiaDiabetes Mellitus Inadequate Control

Drug effectiveness by gender :

Lexapro is effective37.50%
(39 of 104 people)
(12 of 63 people)
Seroquel Xr is effective46.60%
(48 of 103 people)
(27 of 62 people)

Most common drug interactions by gender * :

Diabetes MellitusDiabetes Mellitus
Type 2 Diabetes MellitusType 2 Diabetes Mellitus
DepressionSuicidal Ideation
Weight IncreasedAnxiety
Blood Cholesterol IncreasedDepression
PancreatitisBlood Cholesterol Increased
ObesityWeight Increased
Diabetes Mellitus Inadequate ControlSuicide Attempt

Drug effectiveness by age :

Lexapro is effective0.00%
(0 of 1 people)
(3 of 35 people)
(13 of 48 people)
(12 of 65 people)
(11 of 54 people)
(8 of 50 people)
(4 of 30 people)
Seroquel Xr is effective100.00%
(1 of 1 people)
(4 of 34 people)
(14 of 50 people)
(19 of 65 people)
(18 of 53 people)
(14 of 49 people)
(5 of 31 people)

Most common drug interactions by age * :

Diabetes MellitusSuicidal IdeationWeight IncreasedDiabetes MellitusDiabetes MellitusDiabetes MellitusDiabetes MellitusAnxiety
PancreatitisDiarrhoeaSuicidal IdeationType 2 Diabetes MellitusType 2 Diabetes MellitusType 2 Diabetes MellitusType 2 Diabetes MellitusDepression
Suicidal IdeationMood SwingsDiabetes MellitusWeight IncreasedWeight IncreasedBlood Cholesterol IncreasedBlood Cholesterol IncreasedConfusional State
Ovarian CystAbnormal BehaviourSomnolenceHeadacheBlood Cholesterol IncreasedDiabetes Mellitus Inadequate ControlAnxietySuicidal Ideation
Suicide AttemptTicManiaDyspnoeaObesityNeuropathy PeripheralDepressionDiabetes Mellitus
Type 2 Diabetes MellitusSuicide AttemptBipolar DisorderInsomniaDiabetes Mellitus Inadequate ControlWeight IncreasedInsomniaDiarrhoea
Extrapyramidal DisorderAnxietyDepressionAbdominal PainDepressionPancreatitisNauseaPain
Intentional OverdoseAngerGallbladder DisorderVomitingSuicidal IdeationObesityHyperglycaemiaWeight Decreased
DepressionCryingDiabetic KetoacidosisDizzinessPancreatitisDepressionWeight IncreasedFall
Gastrointestinal HaemorrhageAggressionFatigueSuicidal IdeationDiabetic NeuropathyHyperlipidaemiaPancreatitisType 2 Diabetes Mellitus

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Lexapro and Seroquel Xr?

You are not alone! Join a related mobile support group:
- support group for people who take Lexapro and Seroquel Xr
- support group for people who take Lexapro
- support group for people who take Seroquel Xr

Can you answer these questions (Ask a question):

  • I am on nexplanon as well as lexapro. why do i start my period everytime i start taking it.
    I was put on Lexpro(escitalopram) about 6 months ago and I was scared to take the medicine I would take it about 2 days and I would start my period so I stopped. I began taking it again cause I feel like I need to stick it out and see what happens and I was not a 100% sure it was the Lexapro starting my periods cause I am on nexplanon as well. so my periods are almost not existent.I have been taking lexpro for about 4 days now and I started to bleed again. Is this something I need to be alarmed about? Do they have some type of horrible unknown reaction. I just want to hear some good news cause I want to stick with the Lexapro to see if it helps me at all. Thanks for your time.
  • Nose bleeds after meningioma surgery(post 11 months)
    I have been experiencing bloody nose, 3 in the last week. 2014 I had a meningioma removed, never experienced any bloody noses until now, I know it is dry because of winter, but there us no warning, it lasts for 20 min then it is gone no dizziness, I do have vertigo- slight case
  • I tested positive for methadone, i have never taken this drug (1 answer)
    I tested positive for methadone, I have never taken this drug. My Dr said I had to have taken it because it was there and that a false positive is out of the question. Could my meds cause methadone to show up on a urine drug test
  • I have quit smoking about 4 wks ago. i'm having nightmares for the 5 days. my question is do the nightmares taper off or do they never stop?
    I've been on lexapro for 7 yrs. This is the only med that works for me I've tired lots of diff meds for my anxiety/depression and the all made me nuts or want to die. Even the generic gave me nightmare so I stopped that one. I literally have little to no stress in my life either. So lexapro is the best for me. Anyway I'm getting healthy working out and I quit smoking about 4 wks ago. The nightmares have been going on all wk. They are stressing me out blah. When are these crazy stressful dreams gonna stop? Or at least tapper off?
  • What can i take for a headache when i am on lexapro (1 answer)
    lexapro started only a week ago, feel tightness in jaw and headache, sleeplessness, not sure if lexapro is good for me if i cannot ever take an aspirin or tylenol for sleep.

More questions for: Lexapro, Seroquel Xr

You may be interested at these reviews (Write a review):

  • Tourette's syndrome caused by lexapro
    After two months on lexapro, Tourette's syndrome started and has continued for 18 months, increasing in intensity and frequency. After one month off the Lexapro, the Tourette's syndrome has stopped completely.
  • Terrible excessive sweating from hydrochlorothiazide
    I guess I fit the profile of who gets excessive sweating from HCTZ. I am a 65 year old female and suffered from excessive sweating for two years. With just very little exertion, I would pour sweat from the top of my head. It would run into my face and all over my hair. My hair would be ringing wet. I had heavy perspiration in the groin area and down my back also. I had to change clothing 2-3 times a day and wash up or shower that many times also. The doctor tried changing my Cymbalta and put me on Wellbutrin instead. It did absolutely no good. I went off the wellbutrin and back onto the Cymbalta. I did some research and saw that HCTZ could cause excessive sweating. Both my doctor and my pharmacist said that they had never heard of that. I went off the HCTZ, and my sweating stopped almost immediately. My doctor and my pharmacist were very surprised. I'm one of those people who frequently have different reactions to drugs than are typical. If you're having excessive perspiration and are on HCTZ, try going off of it. It just may be the culprit!
  • Escitalopram /narcolepsy
    Began taking escitalopram one month ago. Having narcoleptic type sleep incidents as well as unwanted suicidal thoughts. Legs and arms also go out. Sleeping up to thirteen or more hours per day.
  • Bipolar patient extremely violent on seraquel
    I have been diagnosed bipolar for over 10 years. 3 years ago I was taken off of topamax and my seraquel was upped to 300 mg from 100 because I was pregnant. I was very violent! Punching, breaking stuff, in jail, in the psych ward. Yes pregnancy and bipolar are not a perfect combination. I too thought it was the hormones. My husband and split several times over me punching him. We moved to a state cross country so there was no more family drama. Nothing worked! Over the last 3 years my life has been hell! I happen to run out of my seroquel (tg) it took 2 weeks to arrive. In that time my body went thru horrible withdrawals. I vowed I wouldn't take it any longer. I've been seraquel free for 2 months. I'm now on gabapentin and proud to say I have no anger issues! Not 1 punch has
    been thrown. I feel like a totally different person.
  • Seroquel and iron deficiency?
    I've been taking Seroquel for about four year, I have been having symptoms similar to hypothyroidism, and just found out I have an iron deficiency. The doctor said my platelets are smaller than average, and it is possible that my grandmother is anemic. But in trying to study Seroquel I kept finding things that made me wonder if Seroquel could be linked to iron deficiency.

More reviews for: Lexapro, Seroquel Xr

Comments from related studies:

  • From this study (2 weeks ago):

  • seroquel had negative effects, induced panic attacks
    used marijuana recreationally for a year, stopped after a come-down induced panic-like thoughts for the first time since childhood


  • From this study (3 months ago):

  • doc moc on Apr, 25, 2013:

    BREAK down FOOL!


    Rhs on Oct, 13, 2012:

    Get your medical records
    and consult w/your doctor


Post a new comment    OR    Read more comments

Complete drug side effects:

On eHealthMe, Lexapro (escitalopram oxalate) is often used to treat depression. Seroquel Xr (quetiapine fumarate) is often used to treat bipolar disorder. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.


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