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Review: taking Lexapro and Topamax together

Summary: drug interactions are reported among people who take Lexapro and Topamax together.

This review analyzes the effectiveness and drug interactions between Lexapro and Topamax. It is created by eHealthMe based on reports of 1,411 people who take the same drugs from FDA and social media, and is updated regularly.





You are not alone: join a mobile support group for people who take Lexapro and Topamax >>>

What are the drugs

Lexapro has active ingredients of escitalopram oxalate. It is often used in depression. (latest outcomes from 39,446 Lexapro users)

Topamax has active ingredients of topiramate. It is often used in migraine. (latest outcomes from 24,599 Topamax users)

On Jan, 26, 2015: 1,411 people who take Lexapro, Topamax are studied

Lexapro, Topamax outcomes

Drug combinations in study:
- Lexapro (escitalopram oxalate)
- Topamax (topiramate)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Lexapro is effective33.33%
(2 of 6 people)
(3 of 17 people)
(3 of 11 people)
(5 of 14 people)
(14 of 32 people)
(11 of 17 people)
(4 of 8 people)
(0 of 2 people)
Topamax is effective20.00%
(1 of 5 people)
(10 of 22 people)
(5 of 15 people)
(4 of 12 people)
(11 of 25 people)
(10 of 16 people)
(4 of 6 people)
(1 of 2 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Hepatitis CholestaticDepressionDrug ToxicityConvulsionDeep Vein ThrombosisEmotional DistressBreast Cancer FemaleDiabetes Mellitus
OverdoseSuicidal IdeationSomnolenceAnxietyAnxietyCleft Lip And PalateAkathisiaPain
LeukopeniaNauseaGrowth RetardationType 2 Diabetes MellitusDepressionEmotional DisorderExhaustion, Fatigue, Lethargy, Tiredness, WearinessNausea
Grand Mal ConvulsionDizzinessHypospadiasDepressionDizzinessPatent Ductus ArteriosusSleepyDepression
SomnolenceType 2 Diabetes MellitusSuicide AttemptObesityDiarrhoeaMalocclusionMemory ImpairmentWeight Increased
FatigueTremorThrombocytopeniaPainAbdominal DiscomfortSleep Apnoea SyndromeImpairment Of SpeechHeadache
NauseaGrand Mal ConvulsionConfusional StateSleep Apnoea SyndromeAbdominal PainDevelopmental DelayEnuresisAnxiety
Vision BlurredLeukopeniaDyspnoeaAcute Respiratory FailureAbdominal Pain UpperNasal Septum DeviationShort-term Memory LossType 2 Diabetes Mellitus
HeadacheVomitingComplications Of Transplanted KidneyVomitingPain In ExtremityEnlarged ClitorisDizziness

Drug effectiveness by gender :

Lexapro is effective42.55%
(40 of 94 people)
(2 of 13 people)
Topamax is effective46.15%
(42 of 91 people)
(4 of 12 people)

Most common drug interactions by gender * :

PainDiabetes Mellitus
Diabetes MellitusSuicidal Ideation
NauseaType 2 Diabetes Mellitus
Type 2 Diabetes MellitusOverdose
Weight IncreasedDepression
HeadacheWeight Increased
Back PainVomiting

Drug effectiveness by age :

Lexapro is effectiven/an/a0.00%
(0 of 6 people)
(8 of 54 people)
(9 of 41 people)
(12 of 48 people)
(11 of 19 people)
(2 of 4 people)
Topamax is effectiven/an/a33.33%
(3 of 9 people)
(11 of 60 people)
(16 of 39 people)
(10 of 48 people)
(6 of 16 people)
(0 of 4 people)

Most common drug interactions by age * :

Drug Exposure During PregnancySedationDepressionPainDepressionType 2 Diabetes MellitusNauseaAnxiety
Feeding Disorder NeonatalFeeding Disorder NeonatalSuicide AttemptDyspnoeaDiabetes MellitusDiabetes MellitusDepressionTooth Disorder
Drug Exposure Via Breast MilkDrug Exposure Via Breast MilkConvulsionAbdominal PainType 2 Diabetes MellitusBack PainDiabetes MellitusImpaired Healing
Uterine LeiomyomaAnxietyHeadacheHeadacheDepressionWeight IncreasedRib Fracture
Urinary Tract InfectionManiaUrinary Tract InfectionAnxietyPainBack PainIntracranial Aneurysm
Type 2 Diabetes MellitusAffective DisorderAbdominal Pain UpperNauseaNeuropathy PeripheralConvulsionCardiac Arrest
Suicidal IdeationDizzinessWeight IncreasedPainWeight IncreasedAnxietyPain
Weight IncreasedAggressionDiabetes MellitusSuicidal IdeationObesityCondition AggravatedColitis
SedationBradycardiaDizzinessConvulsionNauseaDrug IneffectiveOnychomycosis
Neonatal OversedationDrug Rash With Eosinophilia And Systemic SymptomsSuicidal IdeationWeight IncreasedConvulsionType 2 Diabetes MellitusUterine Disorder

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Lexapro and Topamax?

You are not alone! Join a related mobile support group:
- support group for people who take Lexapro and Topamax
- support group for people who take Lexapro
- support group for people who take Topamax

Can you answer these questions (Ask a question):

  • Nose bleeds after meningioma surgery(post 11 months)
    I have been experiencing bloody nose, 3 in the last week. 2014 I had a meningioma removed, never experienced any bloody noses until now, I know it is dry because of winter, but there us no warning, it lasts for 20 min then it is gone no dizziness, I do have vertigo- slight case
  • Is it possible to suddenly form ulcers after 20 years of tegretol usage
    have been using tegretol and Topamax for over 20 years and only now starting to get severe mouth ulcers
  • I have quit smoking about 4 wks ago. i'm having nightmares for the 5 days. my question is do the nightmares taper off or do they never stop?
    I've been on lexapro for 7 yrs. This is the only med that works for me I've tired lots of diff meds for my anxiety/depression and the all made me nuts or want to die. Even the generic gave me nightmare so I stopped that one. I literally have little to no stress in my life either. So lexapro is the best for me. Anyway I'm getting healthy working out and I quit smoking about 4 wks ago. The nightmares have been going on all wk. They are stressing me out blah. When are these crazy stressful dreams gonna stop? Or at least tapper off?
  • What can i take for a headache when i am on lexapro (1 answer)
    lexapro started only a week ago, feel tightness in jaw and headache, sleeplessness, not sure if lexapro is good for me if i cannot ever take an aspirin or tylenol for sleep.
  • Can nuvigil (vs adderall) be used simultaneously to help wean off 60mg/day of adderall? (1 answer)
    I have been on Adderall 30mg 2x daily for years!! I've had it lowered to 20mg, I've TRIED to go months without it (when not working) however I feel I've built up a tolerance level to the point that it's not as effective as it once was. My personal life has detoured WAY past anything an ADHD medication can possibly help as far as focusing on NEEDED tasks etc. I end up feeling wrapped up in what I'm doing at the moment that my anxiety increases due to all that I haven't been able to accomplish. I take various medications for various reasons, depression, anxiety, bulimia etc., and for the most part the doses have varied based on circumstances and current need at said time of prescription.. MY FAMILY HAS A HISTORY OF HEART DISEASE, And realizing that I'm already on the highest Adderall dosage scares me (and THEN as I think about it, it makes my heart race!). I've also noticed increased muscle spasms as well as extreme and intense pressure on my jaw (TMJ). MY QUESTION IS: does anyone have any experience LOWERING their Adderall dosage AND adding Nuvigil? The research I've done to date gives me impression that it could help balance out the more extreme effects of Adderall (60mg/day) but that the nuvigil would or could potentially help with the EXTREME exhaustion I feel as Adderall wears off. Some days I just crash, some days I sleep fine and others no matter how hard I tryyyy, I just CAN'T fall asleep, therefore making the next day worse! IDEALLY I'D LIKE TO BE MED FREE, right now I need them, but am hoping maybe I can speak with my doctor to lower Adderall and add Nuvigil to help wean me off the amphetamines as well as lower dosage intake. YES, a lot of the anxiety, sleeplessness and depression are related to current circumstances in my life, however, where I am is not where I want to be or where I'm headed.. Life is a journey, and all my meds have become a part of a journey I never thought I'd find myself taking. I don't want life/meds to define me, or create a me I no longer recognize, because scarily enough that seems to be a common pattern. As I overcome each and every daily obstacle, I also don't want to be "hooked" on my meds or needing "more" to wake up/sleep/function.. I'd like to work on finding a solution towards weaning off my meds NOW, and work my way off slowly, primarily the Adderall. I'm hoping by suggesting to my doctor and showing him my research he may agree (IF ITS EVEN A LOGICAL COMBO, CLEARLY IM NOT A DOCTOR) nuvigil could help me. I've already started taking less of my anti depressants, trazadone and xanax without discussing with doc because he is always busy.. My next appt I want to go in fully prepared with a plan and an overall goal to REDUCE my Adderall dose, but overall, I'm clueless!!! I have no idea what other meds other than nuvigil "could" potentially help if at all. I could be entirely wrong, Anyone with any experience using one vs other or both simultaneously, or anyone with constructive input, PLEASE COMMENT/SHARE!!

More questions for: Lexapro, Topamax

You may be interested at these reviews (Write a review):

  • Tourette's syndrome caused by lexapro
    After two months on lexapro, Tourette's syndrome started and has continued for 18 months, increasing in intensity and frequency. After one month off the Lexapro, the Tourette's syndrome has stopped completely.
  • Escitalopram /narcolepsy
    Began taking escitalopram one month ago. Having narcoleptic type sleep incidents as well as unwanted suicidal thoughts. Legs and arms also go out. Sleeping up to thirteen or more hours per day.
  • Urea urine increased while taking topamax
    I was on Topamax to lose weight. It worked for me, I lost weight but my blood urea increased. I have to stop taking it.
  • Massive aggression within first 4 days at 50mg (1 response)
    am only taking 50mg and have only been taking it for 4 days(this is the evening of the 4th day)as a preventative for migraine headaches that I have suffered from from 16 years. I have had pins and needles in my hands and feet as well as spontaneous crying fits since day 2 and Major aggression since yesterday. With normally an insurmountable amount of patience with my 1 year old son, I outright yelled at him last night. This is unacceptable. I have never felt such quick and sudden rage over nothing before, well, over anything before.
  • Lexapro and memory loss
    I actually have no idea what other medicine I was on the week I took Lexapro, it was back at the end of February 2014 right before I checked myself into the psych hospital. I formed no memory for a whole week just because of one drug! My friends and family tell me what happened that week and I have called them a liar because there is no recall from that week! I have been on psychiatric drugs for over 14 years and have never had such a horrible reaction as I did with Lexapro! The side effects do not include this reaction, but I didn't sleep at all that week or so I am told and there is just nothing, not even a little memory. Take this as you will I am not saying everyone gets this side effect I am just saying it is not impossible. I learned a lesson I don't remember, but will never take Lexapro again! It was dangerous for me!

More reviews for: Lexapro, Topamax

Comments from related studies:

  • From this study (1 week ago):

  • Had 3 alcoholic drinks. Blacked out. No memory.


  • From this study (3 months ago):

  • doc moc on Apr, 25, 2013:

    BREAK down FOOL!


    Rhs on Oct, 13, 2012:

    Get your medical records
    and consult w/your doctor


Post a new comment    OR    Read more comments

Complete drug side effects:

On eHealthMe, Lexapro (escitalopram oxalate) is often used to treat depression. Topamax (topiramate) is often used to treat migraine. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.


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