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Review: taking Lexapro and Topamax together

Summary: drug interactions are reported among people who take Lexapro and Topamax together.

This review analyzes the effectiveness and drug interactions between Lexapro and Topamax. It is created by eHealthMe based on reports of 1,414 people who take the same drugs from FDA and social media, and is updated regularly.


You are not alone: join a support group for people who take Lexapro and Topamax >>>

On Mar, 28, 2015: 1,414 people who take Lexapro, Topamax are studied

Lexapro, Topamax outcomes

Drug combinations in study:
- Lexapro (escitalopram oxalate)
- Topamax (topiramate)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Lexapro is effective33.33%
(2 of 6 people)
(3 of 17 people)
(3 of 11 people)
(5 of 15 people)
(14 of 32 people)
(11 of 17 people)
(4 of 10 people)
(0 of 2 people)
Topamax is effective20.00%
(1 of 5 people)
(10 of 22 people)
(5 of 15 people)
(4 of 14 people)
(11 of 25 people)
(10 of 16 people)
(5 of 7 people)
(1 of 2 people)

Drug effectiveness by gender :

Lexapro is effective41.67%
(40 of 96 people)
(2 of 14 people)
Topamax is effective46.24%
(43 of 93 people)
(4 of 13 people)

Drug effectiveness by age :

Lexapro is effectiven/an/a0.00%
(0 of 6 people)
(8 of 54 people)
(9 of 42 people)
(12 of 49 people)
(11 of 20 people)
(2 of 4 people)
Topamax is effectiven/an/a33.33%
(3 of 9 people)
(11 of 60 people)
(16 of 40 people)
(11 of 49 people)
(6 of 17 people)
(0 of 4 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Hepatitis CholestaticDepressionDrug ToxicityConvulsionDeep Vein ThrombosisEmotional DistressTeeth Grinding And ClenchingDiabetes Mellitus
OverdoseSuicidal IdeationSomnolenceType 2 Diabetes MellitusAnxietyCleft Lip And PalateFolliculitisPain
LeukopeniaNauseaGrowth RetardationDepressionDepressionEmotional DisorderBreast Cancer FemaleNausea
Grand Mal ConvulsionDizzinessHypospadiasAnxietyDizzinessPatent Ductus ArteriosusExhaustion, Fatigue, Lethargy, Tiredness, WearinessDepression
SomnolenceType 2 Diabetes MellitusSuicide AttemptPainDiarrhoeaMalocclusionSleepyWeight Increased
FatigueTremorThrombocytopeniaAcute Respiratory FailureAbdominal DiscomfortSleep Apnoea SyndromeAkathisiaHeadache
NauseaGrand Mal ConvulsionConfusional StateObesityAbdominal PainDevelopmental DelayMemory ImpairmentAnxiety
Vision BlurredLeukopeniaDyspnoeaNauseaAbdominal Pain UpperNasal Septum DeviationEnuresisType 2 Diabetes Mellitus
HeadacheVomitingComplications Of Transplanted KidneyVomitingPain In ExtremityEnlarged ClitorisShort-term Memory LossDizziness
FallOverdoseAnaemiaSleep Apnoea SyndromeNauseaDyspnoeaImpairment Of SpeechFatigue

Most common drug interactions by gender * :

PainDiabetes Mellitus
Diabetes MellitusSuicidal Ideation
NauseaType 2 Diabetes Mellitus
Type 2 Diabetes MellitusOverdose
Weight IncreasedAnxiety
HeadacheWeight Increased
Back PainVomiting

Most common drug interactions by age * :

Drug Exposure During PregnancySedationDepressionPainDepressionType 2 Diabetes MellitusNauseaAnxiety
Feeding Disorder NeonatalFeeding Disorder NeonatalSuicide AttemptDyspnoeaDiabetes MellitusDiabetes MellitusDepressionTooth Disorder
Drug Exposure Via Breast MilkDrug Exposure Via Breast MilkConvulsionAbdominal PainType 2 Diabetes MellitusBack PainDiabetes MellitusImpaired Healing
Uterine LeiomyomaAnxietyHeadacheHeadacheDepressionWeight IncreasedRib Fracture
Urinary Tract InfectionManiaUrinary Tract InfectionAnxietyNeuropathy PeripheralBack PainIntracranial Aneurysm
Type 2 Diabetes MellitusAffective DisorderAbdominal Pain UpperPainPainConvulsionCardiac Arrest
Suicidal IdeationDizzinessWeight IncreasedNauseaWeight IncreasedDrug IneffectivePain
Weight IncreasedAggressionDiabetes MellitusSuicidal IdeationObesityAnxietyColitis
SedationBradycardiaDizzinessConvulsionConvulsionCondition AggravatedOnychomycosis
Neonatal OversedationDrug Rash With Eosinophilia And Systemic SymptomsSuicidal IdeationDyspnoeaNauseaType 2 Diabetes MellitusUterine Disorder

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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- support group for people who take Lexapro
- support group for people who take Topamax

Recent related drug studies (Check your drugs):

Complete drug side effects:

On eHealthMe, Lexapro (escitalopram oxalate) is often used to treat depression. Topamax (topiramate) is often used to treat migraine. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.


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