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Review: Lyrica and Keppra





Summary: drug interactions are reported among people who take Lyrica and Keppra together.

This review analyzes the effectiveness and drug interactions between Lyrica and Keppra. It is created by eHealthMe based on reports of 680 people who take the same drugs from FDA and social media, and is updated regularly.

You are not alone: join a mobile support group for people who take Lyrica and Keppra >>>

What are the drugs

Lyrica has active ingredients of pregabalin. It is often used in fibromyalgia. (latest outcomes from Lyrica 66,567 users)

Keppra has active ingredients of levetiracetam. It is often used in epilepsy. (latest outcomes from Keppra 21,214 users)

On Nov, 29, 2014: 680 people who take Lyrica, Keppra are studied

Lyrica, Keppra outcomes

Drug combinations in study:
- Lyrica (pregabalin)
- Keppra (levetiracetam)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Lyrica is effectiven/a50.00%
(1 of 2 people)
0.00%
(0 of 2 people)
25.00%
(1 of 4 people)
60.00%
(3 of 5 people)
0.00%
(0 of 1 people)
0.00%
(0 of 1 people)
n/a
Keppra is effective100.00%
(1 of 1 people)
66.67%
(2 of 3 people)
0.00%
(0 of 1 people)
66.67%
(2 of 3 people)
40.00%
(2 of 5 people)
0.00%
(0 of 1 people)
50.00%
(1 of 2 people)
n/a

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
ConvulsionConvulsionConvulsionFatigueConvulsionSeizuresCoughConvulsion
SomnolenceDizzinessDisturbance In AttentionConvulsionAdrenal InsufficiencyPulmonary Venous ThrombosisFatigue
Feeling AbnormalInsomniaEye IrritationDepression SuicidalInsomniaBrain InjuryDizziness
DizzinessPruritusDry MouthDepressionVisual Acuity ReducedSupraventricular TachycardiaSomnolence
Balance DisorderDepressionLow Density Lipoprotein IncreasedAuraOptic AtrophyKidney StonesDrug Ineffective
Gait DisturbanceT-cell LymphomaSimple Partial SeizuresSedationBalance DisorderWeight Increased
NauseaSuicidal IdeationNervous System DisorderParanoiaHeadachesFall
Suicide AttemptEpilepsyAtaxiaRespiratory Tract CongestionLoss Of Sensation, Numbness And Tingling, Paresthesias, Sensory Loss, Tingling And NumbnessGrand Mal Convulsion
Disturbance In AttentionHeadacheConfusional StateAnxietyDrug IneffectiveEpilepsy
AstheniaRashCondition AggravatedCoordination AbnormalVisual Field DefectVision Blurred

Drug effectiveness by gender :

FemaleMale
Lyrica is effective25.00%
(3 of 12 people)
66.67%
(2 of 3 people)
Keppra is effective46.15%
(6 of 13 people)
66.67%
(2 of 3 people)

Most common drug interactions by gender * :

FemaleMale
ConvulsionConvulsion
FatigueSomnolence
DizzinessFatigue
SomnolenceAggression
Weight IncreasedDrug Ineffective
Drug IneffectiveDizziness
Vision BlurredOedema Peripheral
Memory ImpairmentConfusional State
FallGait Disturbance
EpilepsyGrand Mal Convulsion

Drug effectiveness by age :

0-12-910-1920-2930-3940-4950-5960+
Lyrica is effectiven/an/an/a0.00%
(0 of 3 people)
20.00%
(1 of 5 people)
11.11%
(2 of 18 people)
11.76%
(2 of 17 people)
0.00%
(0 of 1 people)
Keppra is effectiven/an/an/a0.00%
(0 of 3 people)
60.00%
(3 of 5 people)
10.53%
(2 of 19 people)
17.65%
(3 of 17 people)
0.00%
(0 of 1 people)

Most common drug interactions by age * :

0-12-910-1920-2930-3940-4950-5960+
n/aMetabolic AcidosisConvulsionConvulsionConvulsionConvulsionConvulsionConvulsion
Calculus UrinaryBack PainCondition AggravatedWeight IncreasedSomnolenceEpilepsyFatigue
ConvulsionCervical Vertebral FracturePyrexiaDizzinessAtaxiaFatigueGrand Mal Convulsion
Haemodynamic InstabilityAggressionDrug Exposure During PregnancyCardiac ArrestFatigueGrand Mal ConvulsionHallucination
Drug IneffectivePsychotic DisorderEpilepsyVision BlurredDrug IneffectiveFallPancreatitis
Acidosis HyperchloraemicMemory ImpairmentPneumoniaMemory ImpairmentTremorSomnolenceDrug Ineffective
Abnormal BehaviourSedationFatigueImmune Reconstitution SyndromeWeight IncreasedAbdominal Distension
Drug Effect DecreasedBrain InjuryLoss Of ConsciousnessProgressive Multifocal LeukoencephalopathyDrug IneffectiveDysuria
ParanoiaPoisoningFallBack PainMemory ImpairmentConfusional State
Grand Mal ConvulsionConfusional StateOptic AtrophyDizzinessDyspnoeaSomnolence

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Lyrica and Keppra?

You are not alone! Join a related mobile support group:
- support group for people who take Lyrica and Keppra
- support group for people who take Keppra
- support group for people who take Lyrica

Recent conversations of related support groups:

  • Support group for people who take Lyrica
    I have gained about 35 pounds, and I have the cognitive effects listed in the prescribing information--problems with thinking and concentration." I've been off Lyrica once, and the side effects went away, but I couldn't get out of bed in the morning

Can you answer these questions (Ask a question):

  • Any information on deaths from taking lyica and high doses of alprazolam (1 answer)
    My Mother was a healthy 89 yr old with no healt issues, she was put on anxiety medicine, which she took regularly. She was also taking Lyric and had just started her Macular degeneration shots. She was prone to bladder infections and we went to the dr. for that, labs showed high calcium, within one week I had to take her to the emergency room, within one day she was on oxygen, within three days she was in the ICU intubated and unresponsive. She remained in ICU for 4 days had renal failure and died two days later.
  • Is pregabalin aggravate the symptoms of bph?
    I am having BPH. for foot pain doctor prescribes Pregabalin. that night the symptoms of BPH worsens. Is it due to Pregabalin? pl.write.
  • Propranolo & pregabalin - do they produce heart troubles? my meds mix has
    Being on zopiclone 75mg (sleep med) gave me terrible poly/firbomyalgia, which I was then prescrbed pregabalin to aleviate pains and anxiety, and the propranolo to help with the same. On day one of propranolo I had a medium heart attack like event, within 24hrs had a large attack and became hospitalised. But vital signs and chest xray, blood tests, then showed 'normal'. But since then have had several more (almost one or more a month) heart attacklike events, hospitalisation, etc, but still being told all 'normal'. But now I've met someone who has told me they had similar heart issues and were told professionally for years his vital signs were normal : he now has a tripple-heart-bypass. I keep being told the angina like symtoms I have are anxiety realted - "only". But when I look at the professional descriptions and illustrations of angina, and similar, I see I could have written and drawn those from my own experiences. Hellish! No where to turn to. So I'm stopping the meds now one by one in careful withdrawl - docs don't like it - but I'm convinced my meds are slowly degrading my overall health as they build up into a toxic soup in me. I started this withdrawly after I discovered that - officially - Pregabalin (a calcium ?minimiser) and Propranolol (a beta blocker) should not be taken together in case they cause heart malfunctions... shame my doctors didn't know that.... before they let me take them for 8 months!!!!!!
  • I have an enlarged liver...could i use buprenorphine?
    I want to know if i can take buprenorphine with an enlarged liver
  • Can droopy eyelid be caused by a bump and/or pregabalin?
    Had a bad bump on my forehead a couple of weeks ago and my whole face went black. Mostly better now but Im let with a badly drooping eyelid (right) which the doctors tell me will go away. No sign of that at the moment but Ive read that pregabalin (which I take in small doses, can cause this. It is so bad and looks so different to the other eye (which is still tight enough to put makeup on) that unless I can find a better solution, I'll have to get it fixed cosmetically. Is two weeks a short time to expect it to be gone? Cheers

More questions for: Keppra, Lyrica

You may be interested at these reviews (Write a review):

  • Leg pain especially near knees after taking lyrica
    Had to stop taking Lyrica due to joint pain in both legs. Difficult to get up from sitting position to stand. Ache in knee's can't relax to sleep. Motrin and vicodin not helping with pain. Also have applied muscle cream not working for pain. Have been off the lyrica for 3 months with no let up in pain. Did not have this pain before taking lyrica.
  • 3 strong drugs together against neuropathic pain
    Neuropathic pain debuted when I was 24, now I'm 50. Received diagnosed with Ehler-Danlos syndrome (EDS), joint hypermobility type, when I was 35 years old. So it can take some time to get a diagnose. And as EDS-patient I do not belong to any clinic. Orthopedics says that EDS is not orthopedic, rheumatology says that EDS is not an autoimmune disease, GPs say that EDS is too difficult, and so on. Sooner or later we all end up at Psychiatry, even if we are not depressed.

    The first kind of pain I got when I was 24 came from low back, but I experienced as pelvic pain and leg pain. It was clearly a neuropathic pain, but it took years to find out. Later it was treated by a pain clinic with cortisone around the genitofemoral nerves (both sides). Since this treatment didn't result in lasting freedom from pain, the pain clinic started to give me RF (radio frequency) treatment. This made the pain disappeared after one year, and I was 80% free from it between 2002 and 2014, 12 years. The pain doctors said pain could return after 10 years.

    The other kind of neuropathic pain started 2003 with intense stomach pain. During 6 months I could hardly eat nothing due to nausea and vomiting. After this 6 months, stomach pain changed to almost unbearable pain in upper back.
    What happened 2003, and what all the doctors missed, was that the right lowest ribs slid up over the sternum. This rib dislocation is till there today, but now with a lot of cartilage formed around the rib where it is stuck in the lower end of the sternum. The dislocation is clearly visible on X-ray. This has greatly affected the thoracic spine. I have a scoliosis which I had not before 2003. And I still have severe pain in the thoracic spine.

    It was initially treated with morphine daily, and later with Durogesic (fentanyl), but this didn't help much. 2005 I was hospitalized because I had too much pain to take care of myself and my hygiene. After some months the doctors started to give me clonazepam because the muscles along the spine was in a chronic seizures. Clonazepam helped, but I could still have a lot of pain in two vertebrae in the thoracic spine. It felt as if someone drilled into the vertebrae without anesthesia. After a few months, doctors also prescribed me methadone. Then the pain disappeared almost completely. Since 2006, I have eaten clonazepam and methadone every day, and I need to sleep in an armchair to not get more pain because of moving during sleep.

    There are side effects. After 1,5 years with clonazepam and methadone I started to have panic attacks. Or rather one long panic attack which didn't stop before I got treatment with amitryptilin and pregabalin (Lyrica). These 2 medicines stopped the panic disorder completely after some hours, and the panic was then gone. Then I got side effects of these 2 medicines, amitryptilin & Lyrica, too. I gained a lot of weight (from 83 to 148 kg) and got much water (edema) in both my legs under the knees and in both feet. The feet could swallow to the double size. 2012 I stopped with amitryptilin and started to loose weight again (in Aug 2014 below 80 kg) and get less water in my legs. Today I eat as little medicines I can, but I have to take methadone, clonazepam and Lyrica every day, twice. If I try to take away one of these 3 medicines, I got pain problems at once. Lyrica is the most painful one to take away. In Sept-Dec 2013 I lowered Lyrica from 300 mg daily, to 150, then to 75 and finally 0 mg. The pain I had was extremely difficult to handle. It didn't help to take more methadone or anything else. I have checked on Internet and found that many people got pain from quitting with Lyrica. Most people start eating it again. So did I. But 2006 and 2007 it was enough to treat the pain with methadone and clonazepam, I got the Lyrica against anxiety not pain. But today I take Lyrica against pain.

    Beside weight gain and leg edema, clonazepam and Lyrica significantly affect the sexual desire. And Lyrica alone makes it almost impossible to ejaculate. All four drugs together (clonazepam, methadone, amitryptiline and Lyrica), make one forget all about sex life. You don't even miss it. When I stopped with amitryptiline and lowered Lyrica (still taking clonazepam and methadone), I could suddenly easily get erections again, feel desire, but not getting orgasms. This is quite difficult to deal with.

    The pain pattern is greatly affected, by pain and by the medicines. So is the mood. I get something which feels like heavy depression, especially if I take the medicines late that day. I should take a medicine like methadone 3 times a day, because the effects of the tablet lasts around 8 hours. But I take them every 12 hours, to have a low consumption in case doctors prescribe them too late (which happens, and then it's good to have a spouse going to the pharmacy buying them for you, because you have too much pain to go yourself).

    Since methadone is also used for treating heroine addicts, medical staff treat you with disrespect when they see that it says "methadone" in your health record. I need to show a certificate that says that I deal with chronic neuropathic pain, that I never have had problems with drug addiction, to get normal respect.

    I wanted to share this because I think I am alone in the world with these medicines in combination against neuropathic pain caused by hypermobile joints, joint dislocation and muscle spasms. After trying almost everything else, including surgery cutting nerves, methadone, clonazepam and Lyrica seems to be the only way to kill my pain. But it's a life where you always is questioned, because of the use of methadone. I can guarantee that everybody in the world should accept these medicines if they had experienced the unbearable pain I had in upper back before they started to give me clonazepam and methadone.
  • Nexium improves my constipation
    Started taking Nexium 1 week ago and I noticed improvement with my chronic constipation.
  • Nightmare on lyrica st.
    r.knee revision 3rd.and last time due from Mersa infection and blood clot left me 1 1/2 shorter on r. Leg. Lost a lot of nerves in foot lower r. Leg.bulging disc was from falling from knee revision and for 9 months had no knee and on crutches.had lots of falls and blew out lower back. Put me on lyrica 2 weeks ago now up to 120 mg.With perks 4 times a day. The title says it all when trying to sleep :( my dream hands down beat any horror movies and directors. 2 hours of sleep per night and overly beat down :(.the only 2 good things I have going,my since of silliness and the Lord :) I guess family also.so far not much help with meds but willingly and pos, that both will work, the Lord :) thanks and God bless
  • Seizure patient was on depakote for 16 years now on keppra 1500 mg.
    I am 28 years old and been off depakote for 5 months. I started keppra to control my seizure disorder, which works great. But for the past year I have developed osteoarthritis in my thoracic, si joints, and lumbar. I get alot of muscle hypersensitivity and pain. Can any of this be due to long term effects of seizure meds?

More reviews for: Keppra, Lyrica

Comments from related studies:

  • From this study (1 year ago):

  • I am trying to find out if taking Lyrica has caused me to develop a chronic cough or if it is just allergies

    Reply

  • From this study (2 years ago):

  • Over past 2 months have been increasing Keppra to present dose of 2000 miligrams daily. Low Sodium level detected 2 weeks ago, at 130. Dilantin is 600 miligrams daily.

    Reply

  • From this study (3 years ago):

  • i am on multiple meds after total removal of para and thyroid glands

    Reply

    june turner 256557 9964 on Apr, 17, 2012:

    i still have seizures most everday, pain from fibromyalgia, numbness in left arm hand ,leg and shoulder, need help on diagnosis and help. i have reactions to light ,heat, cold,sound, and numerous others due to this...

    Reply

Post a new comment    OR    Read more comments

Complete drug side effects:

On eHealthMe, Lyrica (pregabalin) is often used to treat fibromyalgia. Keppra (levetiracetam) is often used to treat epilepsy. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

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