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Review: Lyrica and Levothyroxine





Summary: drug interactions are reported among people who take Lyrica and Levothyroxine together.

This review analyzes the effectiveness and drug interactions between Lyrica and Levothyroxine. It is created by eHealthMe based on reports of 4,860 people who take the same drugs from FDA and social media, and is updated regularly.

You are not alone: join a mobile support group for people who take Lyrica and Levothyroxine >>>

What are the drugs

Lyrica has active ingredients of pregabalin. It is often used in fibromyalgia. (latest outcomes from Lyrica 66,558 users)

Levothyroxine sodium has active ingredients of levothyroxine sodium. It is often used in hypothyroidism. (latest outcomes from Levothyroxine sodium 70,120 users)

On Dec, 8, 2014: 4,860 people who take Lyrica, Levothyroxine Sodium are studied

Lyrica, Levothyroxine Sodium outcomes

Drug combinations in study:
- Lyrica (pregabalin)
- Levothyroxine Sodium (levothyroxine sodium)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Lyrica is effective0.00%
(0 of 13 people)
34.38%
(11 of 32 people)
34.62%
(9 of 26 people)
37.04%
(10 of 27 people)
48.57%
(17 of 35 people)
44.44%
(8 of 18 people)
75.00%
(3 of 4 people)
0.00%
(0 of 2 people)
Levothyroxine Sodium is effective75.00%
(3 of 4 people)
50.00%
(4 of 8 people)
50.00%
(3 of 6 people)
38.89%
(7 of 18 people)
62.50%
(20 of 32 people)
71.43%
(20 of 28 people)
73.02%
(46 of 63 people)
n/a

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
DizzinessWeight IncreasedDrug IneffectiveWeight IncreasedDrug IneffectiveNauseaMigrainePain
Drug IneffectivePainWeight IncreasedDizzinessWeight IncreasedMalaiseDizzinessDizziness
PainOedema PeripheralSwellingPainGait DisturbanceBurning SensationDry Eyes AggravatedNausea
Vision BlurredDrug IneffectiveVision BlurredFallBalance DisorderPainUrinary RetentionDrug Ineffective
Oedema PeripheralSomnolenceFallVision BlurredDizzinessMuscle SpasmsMemory ImpairmentOedema Peripheral
FatiguePain In ExtremityDizzinessMemory ImpairmentFatigueDiarrhoeaConfusionFatigue
Gait DisturbanceDizzinessPainFatiguePainImpulsive BehaviourAnxiety AggravatedWeight Increased
Feeling AbnormalGait DisturbanceGait DisturbanceSomnolenceHypoaesthesiaFallNauseaDyspnoea
FallHeadacheMyalgiaDyspnoeaFibromyalgiaIrritabilityDry MouthFall
SomnolenceInsomniaDisorientationDrug IneffectiveFeeling AbnormalDry SkinAnxietySomnolence

Drug effectiveness by gender :

FemaleMale
Lyrica is effective37.88%
(50 of 132 people)
32.00%
(8 of 25 people)
Levothyroxine Sodium is effective62.41%
(83 of 133 people)
76.92%
(20 of 26 people)

Most common drug interactions by gender * :

FemaleMale
PainPain
DizzinessDizziness
NauseaDrug Ineffective
FatigueOedema Peripheral
Drug IneffectiveRenal Failure Acute
Oedema PeripheralNausea
Weight IncreasedDyspnoea
FallFall
DyspnoeaFatigue
SomnolenceBack Pain

Drug effectiveness by age :

0-12-910-1920-2930-3940-4950-5960+
Lyrica is effectiven/an/a0.00%
(0 of 1 people)
7.14%
(1 of 14 people)
21.43%
(6 of 28 people)
11.54%
(12 of 104 people)
17.54%
(20 of 114 people)
22.62%
(19 of 84 people)
Levothyroxine Sodium is effectiven/an/a100.00%
(1 of 1 people)
14.29%
(2 of 14 people)
33.33%
(11 of 33 people)
24.71%
(21 of 85 people)
31.90%
(37 of 116 people)
35.23%
(31 of 88 people)

Most common drug interactions by age * :

0-12-910-1920-2930-3940-4950-5960+
n/aLethargyMuscle TwitchingAbdominal PainPainPainPainPain
Depressed Level Of ConsciousnessPapilloedemaNauseaNauseaOedema PeripheralNauseaDizziness
Muscle SpasmsBack PainFatigueDepressionFatigueDrug Ineffective
Visual DisturbanceVomitingArthralgiaBack PainOedema PeripheralFall
MigrainePyrexiaAbdominal PainNauseaWeight IncreasedFatigue
Condition AggravatedWeight DecreasedIntervertebral Disc ProtrusionWeight IncreasedSomnolenceNausea
Visual Field DefectParaesthesiaHeadacheAnxietyDrug IneffectiveOedema Peripheral
Wisdom Teeth RemovalPainDizzinessConvulsionDyspnoeaDyspnoea
Procedural PainInjuryHodgkin's DiseaseDizzinessDizzinessDiarrhoea
AcneLoss Of ConsciousnessDecreased AppetiteDyspnoeaAstheniaWeight Increased

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Lyrica and Levothyroxine?

You are not alone! Join a related mobile support group:
- support group for people who take Lyrica and Levothyroxine
- support group for people who take Levothyroxine Sodium
- support group for people who take Lyrica

Recent conversations of related support groups:

  • Support group for people who take Levothyroxine Sodium
    Here is some data, @CDaugherty: http://www.ehealthme.com/ds/levothyroxine+sodium/muscle+atrophy Can anyone in the group speak to this?
  • Support group for people who take Lyrica
    I have gained about 35 pounds, and I have the cognitive effects listed in the prescribing information--problems with thinking and concentration." I've been off Lyrica once, and the side effects went away, but I couldn't get out of bed in the morning

Can you answer these questions (Ask a question):

More questions for: Levothyroxine Sodium, Lyrica

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    Neuropathic pain debuted when I was 24, now I'm 50. Received diagnosed with Ehler-Danlos syndrome (EDS), joint hypermobility type, when I was 35 years old. So it can take some time to get a diagnose. And as EDS-patient I do not belong to any clinic. Orthopedics says that EDS is not orthopedic, rheumatology says that EDS is not an autoimmune disease, GPs say that EDS is too difficult, and so on. Sooner or later we all end up at Psychiatry, even if we are not depressed.

    The first kind of pain I got when I was 24 came from low back, but I experienced as pelvic pain and leg pain. It was clearly a neuropathic pain, but it took years to find out. Later it was treated by a pain clinic with cortisone around the genitofemoral nerves (both sides). Since this treatment didn't result in lasting freedom from pain, the pain clinic started to give me RF (radio frequency) treatment. This made the pain disappeared after one year, and I was 80% free from it between 2002 and 2014, 12 years. The pain doctors said pain could return after 10 years.

    The other kind of neuropathic pain started 2003 with intense stomach pain. During 6 months I could hardly eat nothing due to nausea and vomiting. After this 6 months, stomach pain changed to almost unbearable pain in upper back.
    What happened 2003, and what all the doctors missed, was that the right lowest ribs slid up over the sternum. This rib dislocation is till there today, but now with a lot of cartilage formed around the rib where it is stuck in the lower end of the sternum. The dislocation is clearly visible on X-ray. This has greatly affected the thoracic spine. I have a scoliosis which I had not before 2003. And I still have severe pain in the thoracic spine.

    It was initially treated with morphine daily, and later with Durogesic (fentanyl), but this didn't help much. 2005 I was hospitalized because I had too much pain to take care of myself and my hygiene. After some months the doctors started to give me clonazepam because the muscles along the spine was in a chronic seizures. Clonazepam helped, but I could still have a lot of pain in two vertebrae in the thoracic spine. It felt as if someone drilled into the vertebrae without anesthesia. After a few months, doctors also prescribed me methadone. Then the pain disappeared almost completely. Since 2006, I have eaten clonazepam and methadone every day, and I need to sleep in an armchair to not get more pain because of moving during sleep.

    There are side effects. After 1,5 years with clonazepam and methadone I started to have panic attacks. Or rather one long panic attack which didn't stop before I got treatment with amitryptilin and pregabalin (Lyrica). These 2 medicines stopped the panic disorder completely after some hours, and the panic was then gone. Then I got side effects of these 2 medicines, amitryptilin & Lyrica, too. I gained a lot of weight (from 83 to 148 kg) and got much water (edema) in both my legs under the knees and in both feet. The feet could swallow to the double size. 2012 I stopped with amitryptilin and started to loose weight again (in Aug 2014 below 80 kg) and get less water in my legs. Today I eat as little medicines I can, but I have to take methadone, clonazepam and Lyrica every day, twice. If I try to take away one of these 3 medicines, I got pain problems at once. Lyrica is the most painful one to take away. In Sept-Dec 2013 I lowered Lyrica from 300 mg daily, to 150, then to 75 and finally 0 mg. The pain I had was extremely difficult to handle. It didn't help to take more methadone or anything else. I have checked on Internet and found that many people got pain from quitting with Lyrica. Most people start eating it again. So did I. But 2006 and 2007 it was enough to treat the pain with methadone and clonazepam, I got the Lyrica against anxiety not pain. But today I take Lyrica against pain.

    Beside weight gain and leg edema, clonazepam and Lyrica significantly affect the sexual desire. And Lyrica alone makes it almost impossible to ejaculate. All four drugs together (clonazepam, methadone, amitryptiline and Lyrica), make one forget all about sex life. You don't even miss it. When I stopped with amitryptiline and lowered Lyrica (still taking clonazepam and methadone), I could suddenly easily get erections again, feel desire, but not getting orgasms. This is quite difficult to deal with.

    The pain pattern is greatly affected, by pain and by the medicines. So is the mood. I get something which feels like heavy depression, especially if I take the medicines late that day. I should take a medicine like methadone 3 times a day, because the effects of the tablet lasts around 8 hours. But I take them every 12 hours, to have a low consumption in case doctors prescribe them too late (which happens, and then it's good to have a spouse going to the pharmacy buying them for you, because you have too much pain to go yourself).

    Since methadone is also used for treating heroine addicts, medical staff treat you with disrespect when they see that it says "methadone" in your health record. I need to show a certificate that says that I deal with chronic neuropathic pain, that I never have had problems with drug addiction, to get normal respect.

    I wanted to share this because I think I am alone in the world with these medicines in combination against neuropathic pain caused by hypermobile joints, joint dislocation and muscle spasms. After trying almost everything else, including surgery cutting nerves, methadone, clonazepam and Lyrica seems to be the only way to kill my pain. But it's a life where you always is questioned, because of the use of methadone. I can guarantee that everybody in the world should accept these medicines if they had experienced the unbearable pain I had in upper back before they started to give me clonazepam and methadone.
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More reviews for: Levothyroxine Sodium, Lyrica

Comments from related studies:

  • From this study (2 weeks ago):

  • All this occurred when I started taking the Lipitor. I'm waiting on a phone call from my doctor.

    Reply

  • From this study (6 months ago):

  • I have had crohns disease since 1990 and was diagnosed with ulcerative colitis 3 years ago. I have osteoarthritis, fibromyalga, hypothyroid since 1980. I just recently started experiencing lightheadedness, dizziness, headaches,feeling faint and feeling as if i was going to be sick to my stomach all at the same time about 2 weeks ago. I am under a little stress, my cousin just passed away. I am also on 30 mg's of prednisone and have been since the end of April 2014

    Reply

  • From this study (7 months ago):

  • Following moderate whiplash injury in a road traffic accident three years ago, symptoms of pain, exhaustion, IBS, headache, nausea have continued and my quality of life consists of work and recovering.

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Complete drug side effects:

On eHealthMe, Lyrica (pregabalin) is often used to treat fibromyalgia. Levothyroxine Sodium (levothyroxine sodium) is often used to treat hypothyroidism. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

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