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Review: Lyrica and Lisinopril





Summary: drug interactions are reported among people who take Lyrica and Lisinopril together.

This review analyzes the effectiveness and drug interactions between Lyrica and Lisinopril. It is created by eHealthMe based on reports of 2,823 people who take the same drugs from FDA and social media, and is updated regularly.

You are not alone: join a mobile support group for people who take Lyrica and Lisinopril >>>

What are the drugs

Lyrica has active ingredients of pregabalin. It is often used in fibromyalgia. (latest outcomes from Lyrica 66,558 users)

Lisinopril has active ingredients of lisinopril. It is often used in high blood pressure. (view latest outcomes from 99,129 users)

On Dec, 1, 2014: 2,823 people who take Lyrica, Lisinopril are studied

Lyrica, Lisinopril outcomes

Drug combinations in study:
- Lyrica (pregabalin)
- Lisinopril (lisinopril)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Lyrica is effective20.00%
(2 of 10 people)
28.00%
(7 of 25 people)
22.22%
(2 of 9 people)
38.46%
(5 of 13 people)
29.41%
(5 of 17 people)
25.00%
(1 of 4 people)
100.00%
(1 of 1 people)
0.00%
(0 of 1 people)
Lisinopril is effective0.00%
(0 of 2 people)
83.33%
(5 of 6 people)
71.43%
(5 of 7 people)
63.64%
(7 of 11 people)
56.52%
(13 of 23 people)
80.00%
(20 of 25 people)
100.00%
(5 of 5 people)
0.00%
(0 of 1 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
PainPainMalaisePainDrug IneffectivePainWithdrawal SyndromePain
SomnolenceOedema PeripheralRenal FailureDrug IneffectivePainFibromyalgiaMalaiseDyspnoea
DizzinessPain In ExtremityDizzinessWeight DecreasedSeptic ShockHypertensionPainOedema Peripheral
Oedema PeripheralMalaiseDrug IneffectiveDepressionMulti-organ FailureRenal DisorderErectile DysfunctionDrug Ineffective
TremorDyspnoeaWeight IncreasedTremorHypoaesthesiaGait DisturbanceSimvastatinAnxiety
Drug IneffectiveHeadacheVitamin B1 IncreasedOedema PeripheralNeutropeniaSarcoidosisDepressionNausea
HeadacheDepressionPainSomnolenceDizzinessSwelling Of FingersSleepiness - During The DayFatigue
Vision BlurredWeight IncreasedOedema PeripheralVisual ImpairmentMobility DecreasedJoint DislocationCarcinoembryonic Antigen IncreasedPain In Extremity
FatigueDizzinessHeadacheWeight IncreasedInsomniaConfusional StateAspartate Aminotransferase IncreasedDizziness
FallVisual ImpairmentFatigueLethargyPharyngeal OedemaSleep Apnoea SyndromeGoutWeight Increased

Drug effectiveness by gender :

FemaleMale
Lyrica is effective37.50%
(15 of 40 people)
20.00%
(8 of 40 people)
Lisinopril is effective74.36%
(29 of 39 people)
63.41%
(26 of 41 people)

Most common drug interactions by gender * :

FemaleMale
PainPain
NauseaOedema Peripheral
DyspnoeaDrug Ineffective
AnxietyFatigue
DizzinessAnxiety
AstheniaPain In Extremity
Back PainDyspnoea
FatigueWeight Increased
Drug IneffectiveHypertension
Pain In ExtremityFall

Drug effectiveness by age :

0-12-910-1920-2930-3940-4950-5960+
Lyrica is effectiven/an/an/a0.00%
(0 of 2 people)
0.00%
(0 of 12 people)
15.79%
(3 of 19 people)
11.32%
(6 of 53 people)
25.00%
(14 of 56 people)
Lisinopril is effectiven/an/an/a50.00%
(1 of 2 people)
44.44%
(4 of 9 people)
52.63%
(10 of 19 people)
39.62%
(21 of 53 people)
33.93%
(19 of 56 people)

Most common drug interactions by age * :

0-12-910-1920-2930-3940-4950-5960+
Myopathyn/aSyncopeInsomniaHeadachePainPainPain
Renal Failure AcuteMuscle SpasmsInfluenza Like IllnessPainWeight IncreasedHypoaesthesiaDizziness
RhabdomyolysisDyspnoeaUrinary Tract InfectionDizzinessAnxietyAnxietyDrug Ineffective
Metabolic DisorderBronchitisDrug IneffectiveFibromyalgiaDyspnoeaOedema Peripheral
Iron Deficiency AnaemiaFatigueChest PainFatigueBack PainFall
DyspnoeaCardiac Failure CongestiveAnxietyDepressionParaesthesiaNausea
GoutChest DiscomfortDepressionNauseaHeadacheFatigue
Blood Urine PresentTuberculin Test PositiveDyspnoeaBack PainOedema PeripheralDyspnoea
HypertensionDiabetes MellitusOedema PeripheralDrug IneffectiveAnxiety
Intracardiac ThrombusFatigueDyspnoeaPain In ExtremityDiarrhoea

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Lyrica and Lisinopril?

You are not alone! Join a related mobile support group:
- support group for people who take Lyrica and Lisinopril
- support group for people who take Lisinopril
- support group for people who take Lyrica

Recent conversations of related support groups:

  • Support group for people who take Lyrica
    I have gained about 35 pounds, and I have the cognitive effects listed in the prescribing information--problems with thinking and concentration." I've been off Lyrica once, and the side effects went away, but I couldn't get out of bed in the morning

Can you answer these questions (Ask a question):

  • I am on 2 x daily rifampin and 4 x daily cephalixin 500mg and and awake exhausted after 8-9 hours sleep and the fatigue is unbelievable all day every day, is this "normal" or should i investigate ore (1 answer)
    Had total knee replacement 11/12, bad from the start, knee swollen/hot/painful/unstable for most of 2 years before a mechanically successful Revision that found a loose patella and both ends of the prostheses loose. In spite of 10-12 aspirations and almost as many samples sent to labs for testing the result was always "no growth after a week". Following the revision, 10 days after, surgeons office called and says yes you have a staph E infection. Immediate therapy with 6 weeks of 3 X day IV PLUS 2 x per day oral Rifampin.
    IV over but now on the 2 X day Rifampin PLUS 4 X day 500mg cephalexin and the fatigue is unbelievable. Wake up exhausted after 8 hours sleep, daily hour plus mid afternoon naps.
  • Can the drug cellcept be used to treat pityriasis rosea
    Been diagnosed as Pityriasis Rosea. Dark patchy circles all over upper body and back. Condition has worsen, lasting over 5 months with outbreaks now on face and on scalp in hair. Some are painful raw blistery. Spreading on buttocks and a few on legs. Have tried several medications. Some have helped but none have cured. It is showing no signs of letting up. Dr has now prescribed Cellcept. Is this a safe drug for treatment for Pityriasis Rosea?
  • Any information on deaths from taking lyica and high doses of alprazolam (1 answer)
    My Mother was a healthy 89 yr old with no healt issues, she was put on anxiety medicine, which she took regularly. She was also taking Lyric and had just started her Macular degeneration shots. She was prone to bladder infections and we went to the dr. for that, labs showed high calcium, within one week I had to take her to the emergency room, within one day she was on oxygen, within three days she was in the ICU intubated and unresponsive. She remained in ICU for 4 days had renal failure and died two days later.
  • Plendil and pad interaction with arteries
    I'm currently taking 10 MG of Plendil with 20MG of Lisinopril. I've developed PAD a couple of years ago. I used to take 40MG of Lisinopril but since retiring my blood pressure had calmed down. My doctor reduced my Lisinopril to 20MG and kept the Plendil at 10MG. I was wondering is I should go back to the 40MG Lisinopril and discontinue the Plendil. I'm confused about the effects that Plendil has on my arteries. Does Plendil dialate the arteries ? If so, then wouldn't it be better that I stop the Plendil to reduce the pain of my PAD ?
  • Is pregabalin aggravate the symptoms of bph?
    I am having BPH. for foot pain doctor prescribes Pregabalin. that night the symptoms of BPH worsens. Is it due to Pregabalin? pl.write.

More questions for: Lisinopril, Lyrica

You may be interested at these reviews (Write a review):

  • Avoid lisinopril or any ace inhibitor
    This was the only drug I was taking other than low-dose aspirin 3x/week.
    Within 2 days I began coughing, as though something was deep in my lungs; became long severe coughing fits than threw out my back, sore all over. Then began runny nose, exhaustion, occasional mild chest pain. Not connecting the dots, after a month of this I returned to my dr., who prescribed an antibiotic and inhaler, saying I had asthma! After a week starting feeling worse, sore throat and sore lungs from coughing, in bed from exhaustion.
    After reading on-line about identical symptoms from LISINOPRIL, I immediately stopped it; now, 2 weeks later I am beginning to feel better -- cough much better. I am hoping I will be one of the lucky ones who does not have the cough continue. By the way, this drug reduced my bp from 140/100 to 110/80 BUT I'd rather have high bp than take this poison.
    Now I learn than many deaths have resulted from use of Lisinopril. Had this drug caused my death, no one would know my story as I have no relatives to tell it; am assuming many unreported have died and of course are not able to go on-line and tell their story post-death!
    All I can do is ask WHY is this drug allowed to be sold -- even stranger, in my case the drugstore is giving this poison away at no charge -- a first; but WHY?
  • Leg pain especially near knees after taking lyrica
    Had to stop taking Lyrica due to joint pain in both legs. Difficult to get up from sitting position to stand. Ache in knee's can't relax to sleep. Motrin and vicodin not helping with pain. Also have applied muscle cream not working for pain. Have been off the lyrica for 3 months with no let up in pain. Did not have this pain before taking lyrica.
  • Experience with morphine and xanax
    I take MS contin for back pain, and xanax for anxiety. I was in the heart unit, and they decided to give me my morphine through the central line because I was having a lot of pain. The nurse pushed it in really slow, and afterword they asked me if I wanted my xanax, and I took it as well. 1 mg. I don't know how much morphine they gave me, but i began to hallucinate. I thought was dying..I remember trying to talk but the words wouldn't come out. I thought the nurse was asking me if I believed in Christ, and I said yes I love the Lord. At some point I was sure I had died, but I was calm and peaceful..there were several nurses in the room and I thought omg.. they've been keeping the secret of what happens when you die. I told them I was leaving because I wanted to go out in the hall, I was sure my deceased mother was out there looking for me, so I tried to remove my IV to get out of bed. They stopped me and I remember the nurse saying no its not your time. And I woke up the next morning.
  • Lipitor weight loss/ lisinipril ed issue (1 response)
    40 mg Lipitor for two months caused 8 pounds weight loss,thoughts of losing my mind ,racing heart rate,mental confusion,emergency visits twice,never in my life have gone to hospital by ambulance..5'11 178 BM 17 ,faithful gym rat ,all test ruled out physical issues,informed doctor, he didn't feel Lipitor was the cause,I stopped Lipitor 3 weeks later not losing weight ,bad dreams gone,feeling like myself again,hoping to regain the weight in time,Lisinpril 10 mg started two years ago ,has issues but did not connect until recently,3 months after taking started to have problems in the bedroom,only within the last 5 months did it occur to me was that was the cause of my sexual performance...had all test done testosterone ,blood work and all came back normal,stopped taking Lisinpril for 4 days a my manhood returned to normal!! Just spoke with doctor and says that shouldn't be????? Really ,he has since written me a new BP prescription,recent BP readings have been normal and will not take until BP rises....eating better ,with supplements ,,why Doctors don't believe the patient is incredulous ,thanks to sites like this people need to really question the health care their getting .....
  • 3 strong drugs together against neuropathic pain
    Neuropathic pain debuted when I was 24, now I'm 50. Received diagnosed with Ehler-Danlos syndrome (EDS), joint hypermobility type, when I was 35 years old. So it can take some time to get a diagnose. And as EDS-patient I do not belong to any clinic. Orthopedics says that EDS is not orthopedic, rheumatology says that EDS is not an autoimmune disease, GPs say that EDS is too difficult, and so on. Sooner or later we all end up at Psychiatry, even if we are not depressed.

    The first kind of pain I got when I was 24 came from low back, but I experienced as pelvic pain and leg pain. It was clearly a neuropathic pain, but it took years to find out. Later it was treated by a pain clinic with cortisone around the genitofemoral nerves (both sides). Since this treatment didn't result in lasting freedom from pain, the pain clinic started to give me RF (radio frequency) treatment. This made the pain disappeared after one year, and I was 80% free from it between 2002 and 2014, 12 years. The pain doctors said pain could return after 10 years.

    The other kind of neuropathic pain started 2003 with intense stomach pain. During 6 months I could hardly eat nothing due to nausea and vomiting. After this 6 months, stomach pain changed to almost unbearable pain in upper back.
    What happened 2003, and what all the doctors missed, was that the right lowest ribs slid up over the sternum. This rib dislocation is till there today, but now with a lot of cartilage formed around the rib where it is stuck in the lower end of the sternum. The dislocation is clearly visible on X-ray. This has greatly affected the thoracic spine. I have a scoliosis which I had not before 2003. And I still have severe pain in the thoracic spine.

    It was initially treated with morphine daily, and later with Durogesic (fentanyl), but this didn't help much. 2005 I was hospitalized because I had too much pain to take care of myself and my hygiene. After some months the doctors started to give me clonazepam because the muscles along the spine was in a chronic seizures. Clonazepam helped, but I could still have a lot of pain in two vertebrae in the thoracic spine. It felt as if someone drilled into the vertebrae without anesthesia. After a few months, doctors also prescribed me methadone. Then the pain disappeared almost completely. Since 2006, I have eaten clonazepam and methadone every day, and I need to sleep in an armchair to not get more pain because of moving during sleep.

    There are side effects. After 1,5 years with clonazepam and methadone I started to have panic attacks. Or rather one long panic attack which didn't stop before I got treatment with amitryptilin and pregabalin (Lyrica). These 2 medicines stopped the panic disorder completely after some hours, and the panic was then gone. Then I got side effects of these 2 medicines, amitryptilin & Lyrica, too. I gained a lot of weight (from 83 to 148 kg) and got much water (edema) in both my legs under the knees and in both feet. The feet could swallow to the double size. 2012 I stopped with amitryptilin and started to loose weight again (in Aug 2014 below 80 kg) and get less water in my legs. Today I eat as little medicines I can, but I have to take methadone, clonazepam and Lyrica every day, twice. If I try to take away one of these 3 medicines, I got pain problems at once. Lyrica is the most painful one to take away. In Sept-Dec 2013 I lowered Lyrica from 300 mg daily, to 150, then to 75 and finally 0 mg. The pain I had was extremely difficult to handle. It didn't help to take more methadone or anything else. I have checked on Internet and found that many people got pain from quitting with Lyrica. Most people start eating it again. So did I. But 2006 and 2007 it was enough to treat the pain with methadone and clonazepam, I got the Lyrica against anxiety not pain. But today I take Lyrica against pain.

    Beside weight gain and leg edema, clonazepam and Lyrica significantly affect the sexual desire. And Lyrica alone makes it almost impossible to ejaculate. All four drugs together (clonazepam, methadone, amitryptiline and Lyrica), make one forget all about sex life. You don't even miss it. When I stopped with amitryptiline and lowered Lyrica (still taking clonazepam and methadone), I could suddenly easily get erections again, feel desire, but not getting orgasms. This is quite difficult to deal with.

    The pain pattern is greatly affected, by pain and by the medicines. So is the mood. I get something which feels like heavy depression, especially if I take the medicines late that day. I should take a medicine like methadone 3 times a day, because the effects of the tablet lasts around 8 hours. But I take them every 12 hours, to have a low consumption in case doctors prescribe them too late (which happens, and then it's good to have a spouse going to the pharmacy buying them for you, because you have too much pain to go yourself).

    Since methadone is also used for treating heroine addicts, medical staff treat you with disrespect when they see that it says "methadone" in your health record. I need to show a certificate that says that I deal with chronic neuropathic pain, that I never have had problems with drug addiction, to get normal respect.

    I wanted to share this because I think I am alone in the world with these medicines in combination against neuropathic pain caused by hypermobile joints, joint dislocation and muscle spasms. After trying almost everything else, including surgery cutting nerves, methadone, clonazepam and Lyrica seems to be the only way to kill my pain. But it's a life where you always is questioned, because of the use of methadone. I can guarantee that everybody in the world should accept these medicines if they had experienced the unbearable pain I had in upper back before they started to give me clonazepam and methadone.

More reviews for: Lisinopril, Lyrica

Comments from related studies:

  • From this study (2 days ago):

  • I am normally stable minded, but sometimes I curse more than usual while on drugs, it seems involuntary. There is not a direct etiology for this, it just happens. I suffer with fibromyalgia, lupus. diabetes and RLS. The pain is sometimes is so severe that I am rendered useless. I am a songwriter but my interest has dwindled IE: No energy to write.

    Reply

  • From this study (6 months ago):

  • Switched from gabapentin to lyrica to ease effects of low white blood cell count.

    Reply

  • From this study (7 months ago):

  • can any of these meds cause trigeminal neuralgia?

    Reply

Post a new comment    OR    Read more comments

Complete drug side effects:

On eHealthMe, Lyrica (pregabalin) is often used to treat fibromyalgia. Lisinopril (lisinopril) is often used to treat high blood pressure. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

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