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Review: Lyrica and Mirtazapine

This review analyzes the effectiveness and drug interactions between Lyrica and Mirtazapine. It is created by eHealthMe based on reports of 902 people who take the same drugs from FDA and social media, and is updated regularly.

Stay connected: get help anytime and anywhere for people who take Lyrica and Mirtazapine >>>

What are the drugs

Lyrica (latest outcomes from 66,459 users) has active ingredients of pregabalin. It is often used in fibromyalgia.

Mirtazapine (latest outcomes from 17,884 users) has active ingredients of mirtazapine. It is often used in depression.

On Jul, 16, 2014: 902 people who take Lyrica, Mirtazapine are studied

Lyrica, Mirtazapine outcomes

Drug combinations in study:
- Lyrica (pregabalin)
- Mirtazapine (mirtazapine)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Lyrica is effective60.00%
(3 of 5 people)
33.33%
(2 of 6 people)
28.57%
(2 of 7 people)
0.00%
(0 of 1 people)
0.00%
(0 of 5 people)
33.33%
(1 of 3 people)
n/an/a
Mirtazapine is effective0.00%
(0 of 2 people)
44.44%
(4 of 9 people)
33.33%
(2 of 6 people)
0.00%
(0 of 3 people)
75.00%
(3 of 4 people)
33.33%
(1 of 3 people)
50.00%
(1 of 2 people)
n/a

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
DyskinesiaWeight IncreasedWeight IncreasedLower Respiratory Tract InfectionDiarrhoeaRestless Legs Syndromen/aPain
DizzinessOedema PeripheralCognitive DisorderInfluenza Like IllnessChillsWeight DecreasedAnxiety
Grand Mal ConvulsionPolypAstheniaWeight IncreasedFatigueBack PainDyspnoea
DystoniaDyspnoeaDehydrationUrinary Tract InfectionVomitingLimb DiscomfortOedema Peripheral
ConvulsionSuicidal IdeationVomitingFractureColitisParaesthesiaNausea
Oculogyric CrisisSwelling FaceDrug IneffectiveHallucinationBalance DisorderMusculoskeletal PainFatigue
TremorLocal SwellingDyspnoeaFallSlow SpeechVomitingPain In Extremity
AnxietyHepatitisSuicidal IdeationSomnolenceDizzinessVitamin D DecreasedPyrexia
Feeling AbnormalHeadacheRenal Failure AcuteHeart Rate IncreasedDehydrationAbdominal PainBack Pain
Oedema PeripheralMalaiseDepressionBalance DisorderMalaisePancytopeniaDizziness

Drug effectiveness by gender :

FemaleMale
Lyrica is effective25.00%
(4 of 16 people)
36.36%
(4 of 11 people)
Mirtazapine is effective29.41%
(5 of 17 people)
50.00%
(6 of 12 people)

Most common drug interactions by gender * :

FemaleMale
PainPain
DyspnoeaAnxiety
AnxietyFatigue
Oedema PeripheralNausea
Back PainPyrexia
Pain In ExtremityDyspnoea
DizzinessPneumonia
ArthralgiaVomiting
NauseaDecreased Appetite
FatigueDepression

Drug effectiveness by age :

0-12-910-1920-2930-3940-4950-5960+
Lyrica is effectiven/an/an/a10.00%
(1 of 10 people)
18.18%
(2 of 11 people)
22.22%
(2 of 9 people)
15.38%
(2 of 13 people)
20.00%
(1 of 5 people)
Mirtazapine is effectiven/an/an/a30.00%
(3 of 10 people)
36.36%
(4 of 11 people)
15.38%
(2 of 13 people)
7.14%
(1 of 14 people)
20.00%
(1 of 5 people)

Most common drug interactions by age * :

0-12-910-1920-2930-3940-4950-5960+
n/an/aHypokalaemiaGrand Mal ConvulsionGait DisturbancePainDyspnoeaDizziness
Suicide AttemptDyskinesiaWeight IncreasedCompleted SuicidePainNausea
HypocalcaemiaOculogyric CrisisNauseaDyspnoeaAnxietyPain
Extrapyramidal DisorderDystoniaAtaxiaOedema PeripheralBack PainAnxiety
Multiple Drug OverdoseConvulsionEnuresisDrug IneffectiveOedema PeripheralPain In Extremity
VomitingPyrexiaMuscle TwitchingDepressionStaphylococcal InfectionDyspnoea
PoisoningDyspnoeaTremorFatigueInjuryVomiting
Hepatic Enzyme IncreasedSuicidal IdeationAnxietyWeight IncreasedUrinary Tract InfectionArthralgia
MydriasisNauseaPainAnxietyIntervertebral Disc ProtrusionDiarrhoea
DyskinesiaChest DiscomfortDysarthriaAstheniaHypoaesthesiaFatigue

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

You can also:

Get connected! Join a mobile support group:
- group for people who take Lyrica and Mirtazapine
- group for people who take Lyrica
- group for people who take Mirtazapine

Comments from related studies:

  • From this study (2 years ago):

  • Need more information about the drugs I am taking. I have so many Dr.'s working on my case that I fear major drug interactio. Myathesia gravis Is getting worse. My double vision is becoming an issue. I can no longer watch more than an hour of t.v. a day. Nod off alot.

    Reply

    Sue Lang on Nov, 10, 2012:

    Your best ally right now is your pharmacist! Have him look up all the drugs you are taking, and ask about interactions. His computer should be able to flag if there any. Then go to a neurologist. Forget everyone else. See a neurologist as this is his/her field.
    Good luck, and if you need someone to "talk" to, you have my e-mail up there. You may use it.
    Sue

    Reply

    Neal on Dec, 8, 2012:

    Hi I am a 31 year old male who suffers from Bi Polar. Following a raised white blood cell count (lithium) extreme lethargy (quitiapine) and an ineffective anti-depressant (citalopram) a complete overhaul of my meds was under taken (correctly and slowly)
    I am currently taking lamotragine ( now been on 100mg for over a month) and have recently and gradually ended the citalopram and gradually put on Mertazapine to a dose of 30mg over the course of 2.5 weeks (1 week at 15mg and 1.5 weeks so far at 30mg)
    I have recently, over the last 2 -3 days, been experiencing symptoms of lhemerits sign and following an all night stay in A&E I have been told that I have this and it is most likely caused by the Mertazapine. apparently this is extremely rare but it does happen.

    Reply

    Oops3 on Dec, 8, 2012:

    First I would get off the Lyrica,and that is not easy to do. It messed up my mind so badly, that now that I'm off it, people are saying "" welcome back"! I guess I should mention my antidepressant failed, rheumatologist decided he wasn't prescribing them anymore to anyone, and long story short, ended up putting myself into mental ward from a sudden panic attack. Did the Lyrica help cause it, I don't know. But being off it is a godsend.

    Reply

  • From this study (4 years ago):

  • The Lamotrigine seems to be helping with the depression but the lethary/drowsiness seems to be cancelling out the effectiveness of the medication. I don't know whether it is the lamotrigine thats causing the drowsiness or the combination of the medication I'm taking. My psychiatrist thinks it may be the other meds and has suggested reducing and then stopping the Mirtazepine. Any constructive feedback would be gratefully received.

    Reply

  • From this study (4 years ago):

  • I have both parents as Dr.'s but they are not involved in my medication or medical issues. I don't know how to quit Benzodiazepines and I wish I knew how all these med's interact.

    Reply

    Natalie on Jun, 7, 2010:

    Be careful pulling yourself off of benzo's without your dr.'s knowledge. These drugs can have a rebound detox. It can be fatal. Best of luck!

    Reply

Can you answer these questions (what is this?):

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Complete drug side effects:

On eHealthMe, Lyrica (pregabalin) is often used to treat fibromyalgia. Mirtazapine (mirtazapine) is often used to treat depression. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

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