Drug interactions between Lyrica and Mirtazapine
This is a real world study of Lyrica and Mirtazapine drug interactions. The study is created by eHealthMe based on 835 reports from FDA.
Do you have chronic disease and take multiple drugs? eHealthMe can monitor your drugs and notify you when there are serious drug reactions detected. Our original studies have been used on premier medical publications. The monitor will be personalized to your gender and age. Start now
What are the drugs
Lyrica has active ingredients of pregabalin. It is used in fibromyalgia, pain, neuralgia, peripheral neuropathy, neuropathy peripheral, neuropathic pain.
Mirtazapine has active ingredients of mirtazapine. It is used in depression, stress and anxiety, sleep disorder, insomnia, generalized anxiety disorder, depressed mood.
On Apr, 27, 2013: 835 people who reported to have interactions when taking Mirtazapine, Lyrica are studied
Drug combinations in study:
- Mirtazapine (mirtazapine)
- Lyrica (pregabalin)
Most common interactions experienced by people in the use of Mirtazapine, Lyrica:
(click on each outcome to view in-depth analysis, incl. how people recovered)| Interaction | Number of reports | |
| 1 | Anxiety | 222 |
| 2 | Dyspnoea | 216 |
| 3 | Pyrexia | 146 |
| 4 | Pain | 132 |
| 5 | Fatigue | 93 |
| 6 | Oedema Peripheral | 92 |
| 7 | Nausea | 87 |
| 8 | Dizziness | 81 |
| 9 | Pain In Extremity | 73 |
| 10 | Back Pain | 70 |
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Most common interactions experienced by people in long term use of Mirtazapine, Lyrica:
(click on each outcome to view in-depth analysis, incl. how people recovered)| Interaction | Number of reports | |
| 1 | Hallucination | 6 |
| 2 | Restless Legs Syndrome | 6 |
| 3 | Somnolence | 6 |
| 4 | Lower Respiratory Tract Infection | 4 |
| 5 | Urinary Tract Infection | 4 |
| 6 | Influenza Like Illness | 4 |
| 7 | Weight Increased | 4 |
| 8 | Walking Aid User | 3 |
| 9 | Heart Rate Increased | 3 |
| 10 | Fall | 3 |
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Top conditions involved for these people * :
- Depression
- Pain
- Anxiety
- Fibromyalgia
- Neuralgia
Top co-used drugs for these people * :
- Remeron
- Seroquel
- Neurontin
- Ambien
- Aspirin
* Approximation only. Some reports may have incomplete information.
How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.
Next: personalize this study to your gender and age
You can also:
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- post a comment or see what 7 people said
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- still have questions? Check any related studies below
Side effects in real world:
On eHealthMe, Lyrica (pregabalin) is often used to treat fibromyalgia. Mirtazapine (mirtazapine) is often used to treat depression. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.
What is the drug used for and how effective is it:
Other drugs that are used to treat the same conditions:
Comments from related studies:
From this study (6 months ago):
From this study (3 years ago):
From this study (3 years ago):
Need more information about the drugs I am taking. I have so many Dr.'s working on my case that I fear major drug interactio. Myathesia gravis Is getting worse. My double vision is becoming an issue. I can no longer watch more than an hour of t.v. a day. Nod off alot.
Oops3 on Dec, 8, 2012:
First I would get off the Lyrica,and that is not easy to do. It messed up my mind so badly, that now that I'm off it, people are saying "" welcome back"! I guess I should mention my antidepressant failed, rheumatologist decided he wasn't prescribing them anymore to anyone, and long story short, ended up putting myself into mental ward from a sudden panic attack. Did the Lyrica help cause it, I don't know. But being off it is a godsend.
Neal on Dec, 8, 2012:
Hi I am a 31 year old male who suffers from Bi Polar. Following a raised white blood cell count (lithium) extreme lethargy (quitiapine) and an ineffective anti-depressant (citalopram) a complete overhaul of my meds was under taken (correctly and slowly)
I am currently taking lamotragine ( now been on 100mg for over a month) and have recently and gradually ended the citalopram and gradually put on Mertazapine to a dose of 30mg over the course of 2.5 weeks (1 week at 15mg and 1.5 weeks so far at 30mg)
I have recently, over the last 2 -3 days, been experiencing symptoms of lhemerits sign and following an all night stay in A&E I have been told that I have this and it is most likely caused by the Mertazapine. apparently this is extremely rare but it does happen.
Sue Lang on Nov, 10, 2012:
Your best ally right now is your pharmacist! Have him look up all the drugs you are taking, and ask about interactions. His computer should be able to flag if there any. Then go to a neurologist. Forget everyone else. See a neurologist as this is his/her field.
Good luck, and if you need someone to "talk" to, you have my e-mail up there. You may use it.
Sue
The Lamotrigine seems to be helping with the depression but the lethary/drowsiness seems to be cancelling out the effectiveness of the medication. I don't know whether it is the lamotrigine thats causing the drowsiness or the combination of the medication I'm taking. My psychiatrist thinks it may be the other meds and has suggested reducing and then stopping the Mirtazepine. Any constructive feedback would be gratefully received.
I have both parents as Dr.'s but they are not involved in my medication or medical issues. I don't know how to quit Benzodiazepines and I wish I knew how all these med's interact.
Natalie on Jun, 7, 2010:
Be careful pulling yourself off of benzo's without your dr.'s knowledge. These drugs can have a rebound detox. It can be fatal. Best of luck!
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