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Review: taking Lyrica and Mirtazapine together

Summary: drug interactions are reported among people who take Lyrica and Mirtazapine together.

This review analyzes the effectiveness and drug interactions between Lyrica and Mirtazapine. It is created by eHealthMe based on reports of 906 people who take the same drugs from FDA and social media, and is updated regularly.


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On Mar, 31, 2015: 906 people who take Lyrica, Mirtazapine are studied

Lyrica, Mirtazapine outcomes

Drug combinations in study:
- Lyrica (pregabalin)
- Mirtazapine (mirtazapine)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Lyrica is effective60.00%
(3 of 5 people)
(3 of 8 people)
(2 of 8 people)
(0 of 1 people)
(0 of 6 people)
(1 of 3 people)
Mirtazapine is effective0.00%
(0 of 2 people)
(4 of 9 people)
(2 of 7 people)
(0 of 5 people)
(3 of 5 people)
(1 of 3 people)
(1 of 2 people)

Drug effectiveness by gender :

Lyrica is effective23.53%
(4 of 17 people)
(5 of 14 people)
Mirtazapine is effective27.78%
(5 of 18 people)
(6 of 15 people)

Drug effectiveness by age :

Lyrica is effectiven/an/an/a6.67%
(1 of 15 people)
(2 of 13 people)
(2 of 9 people)
(2 of 13 people)
(2 of 10 people)
Mirtazapine is effectiven/an/an/a20.00%
(3 of 15 people)
(4 of 13 people)
(2 of 13 people)
(1 of 14 people)
(1 of 10 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
DyskinesiaWeight IncreasedWeight IncreasedLower Respiratory Tract InfectionFatigueRestless Legs Syndromen/aPain
DizzinessOedema PeripheralDyspnoeaInfluenza Like IllnessChillsWeight DecreasedAnxiety
Grand Mal ConvulsionPolypCognitive DisorderWeight IncreasedDehydrationBack PainDyspnoea
DystoniaDyspnoeaDrug IneffectiveUrinary Tract InfectionMalaiseLimb DiscomfortOedema Peripheral
ConvulsionLocal SwellingRenal Failure AcuteFractureHypertensionParaesthesiaNausea
Oculogyric CrisisSuicidal IdeationFatigueHallucinationDiarrhoeaMusculoskeletal PainFatigue
TremorHepatitisDehydrationFallVomitingVomitingPain In Extremity
AnxietySwelling FaceVomitingHeart Rate IncreasedBalance DisorderVitamin D DecreasedPyrexia
Feeling AbnormalBack PainAstheniaSomnolenceSlow SpeechAbdominal PainBack Pain
Oedema PeripheralMalaiseSuicidal IdeationBalance DisorderDizzinessPancytopeniaDizziness

Most common drug interactions by gender * :

Oedema PeripheralNausea
Back PainPyrexia
Pain In ExtremityDyspnoea
NauseaDecreased Appetite

Most common drug interactions by age * :

n/an/aHypokalaemiaDyskinesiaGait DisturbancePainDyspnoeaDizziness
Suicide AttemptDystoniaWeight IncreasedCompleted SuicidePainNausea
HypocalcaemiaGrand Mal ConvulsionNauseaDyspnoeaAnxietyPain
Extrapyramidal DisorderOculogyric CrisisAtaxiaOedema PeripheralBack PainAnxiety
Multiple Drug OverdoseConvulsionPainDrug IneffectiveOedema PeripheralPain In Extremity
VomitingPyrexiaAnxietyDepressionStaphylococcal InfectionDyspnoea
PoisoningDyspnoeaMuscle TwitchingFatigueInjuryVomiting
Hepatic Enzyme IncreasedChest DiscomfortTremorWeight IncreasedUrinary Tract InfectionArthralgia
MydriasisAbnormal DreamsEnuresisAnxietyIntervertebral Disc ProtrusionDiarrhoea

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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Do you take Lyrica and Mirtazapine?




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- support group for people who take Lyrica
- support group for people who take Mirtazapine

Recent related drug studies (Check your drugs):

Complete drug side effects:

On eHealthMe, Lyrica (pregabalin) is often used to treat fibromyalgia. Mirtazapine (mirtazapine) is often used to treat depression. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.


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