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Review: Lyrica and Morphine Sulfate





Summary: drug interactions are reported among people who take Lyrica and Morphine Sulfate together.

This review analyzes the effectiveness and drug interactions between Lyrica and Morphine Sulfate. It is created by eHealthMe based on reports of 2,529 people who take the same drugs from FDA and social media, and is updated regularly.

You are not alone: join a mobile support group for people who take Lyrica and Morphine Sulfate >>>

What are the drugs

Lyrica has active ingredients of pregabalin. It is often used in fibromyalgia. (latest outcomes from Lyrica 66,558 users)

Morphine sulfate has active ingredients of morphine sulfate. It is often used in pain. (latest outcomes from Morphine sulfate 19,045 users)

On Nov, 28, 2014: 2,528 people who take Lyrica, Morphine Sulfate are studied

Lyrica, Morphine Sulfate outcomes

Drug combinations in study:
- Lyrica (pregabalin)
- Morphine Sulfate (morphine sulfate)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Lyrica is effective16.67%
(1 of 6 people)
14.29%
(3 of 21 people)
42.86%
(3 of 7 people)
20.00%
(2 of 10 people)
33.33%
(6 of 18 people)
18.18%
(2 of 11 people)
0.00%
(0 of 1 people)
0.00%
(0 of 1 people)
Morphine Sulfate is effective50.00%
(6 of 12 people)
15.79%
(3 of 19 people)
71.43%
(5 of 7 people)
16.67%
(1 of 6 people)
52.94%
(9 of 17 people)
22.22%
(2 of 9 people)
50.00%
(2 of 4 people)
33.33%
(1 of 3 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
SomnolencePainFallBack PainDepressionDry MouthOxygen Saturation DecreasedPain
Confusional StateRenal Failure AcuteDrug IneffectiveSuicide AttemptDrug DependenceBlood Cholesterol IncreasedRenal FailureAnxiety
DizzinessConfusional StateOedema PeripheralPainNauseaCerebrovascular AccidentNauseaDyspnoea
Renal Failure AcuteDrug IneffectiveHypoaesthesiaSomnolencePainPainful EjaculationHyperhidrosisBack Pain
DehydrationSomnolenceSpeech DisorderCerebrovascular AccidentConstipationFemur FractureDehydrationNausea
PyrexiaDizzinessCardiac FailureFluid RetentionUnresponsive To StimuliNeuropathic PainDepressed Level Of ConsciousnessPyrexia
PainSepsisDyspnoeaMyocarditisOedema PeripheralSleep TerrorNeurofibromatosis-1Dizziness
NauseaOedema PeripheralPyrexiaPathological GamblingConvulsionObsessive-compulsive DisorderOedema Peripheral
Oedema PeripheralRespiratory FailureSepsisObesityDental CariesCompulsive ShoppingArthralgia
AstheniaDyspnoeaRenal Failure AcutePulmonary HypertensionRhabdomyolysisSleep WalkingSomnolence

Drug effectiveness by gender :

FemaleMale
Lyrica is effective24.00%
(12 of 50 people)
20.00%
(5 of 25 people)
Morphine Sulfate is effective39.22%
(20 of 51 people)
34.62%
(9 of 26 people)

Most common drug interactions by gender * :

FemaleMale
PainPain
AnxietyDyspnoea
NauseaAnxiety
DizzinessBack Pain
FallAsthenia
DyspnoeaConfusional State
Back PainPyrexia
PyrexiaArthralgia
SomnolenceOedema Peripheral
ArthralgiaAnaemia

Drug effectiveness by age :

0-12-910-1920-2930-3940-4950-5960+
Lyrica is effectiven/an/an/a30.00%
(3 of 10 people)
12.90%
(4 of 31 people)
14.29%
(4 of 28 people)
9.43%
(5 of 53 people)
5.00%
(1 of 20 people)
Morphine Sulfate is effectiven/an/an/a40.00%
(4 of 10 people)
30.00%
(9 of 30 people)
17.24%
(5 of 29 people)
12.96%
(7 of 54 people)
12.12%
(4 of 33 people)

Most common drug interactions by age * :

0-12-910-1920-2930-3940-4950-5960+
n/aSepsisBalance DisorderPainPainPainPainPain
ArthralgiaMulti-organ FailureUrinary Tract InfectionNauseaAnxietyAnxietyConfusional State
Bone PainBrain OedemaNauseaAbdominal PainDyspnoeaDyspnoeaAnxiety
Tumour Lysis SyndromeDisseminated Intravascular CoagulationVomitingArthralgiaBack PainPyrexiaSomnolence
Respiratory FailureArthralgiaHypertensionFatiguePneumoniaBone DisorderDehydration
PneumoniaDrug Rash With Eosinophilia And Systemic SymptomsInfluenza Like IllnessOedema PeripheralConfusional StateHypoaesthesiaBack Pain
Renal FailureRashPyrexiaWeight DecreasedFatigueBack PainFall
Disease ProgressionPyrexiaAbdominal Pain UpperDysuriaDepressionOsteonecrosis Of JawDyspnoea
NeutropeniaGeneral Physical Health DeteriorationCardiac Failure CongestiveHodgkin's DiseaseDeathArthralgiaAsthenia
BradycardiaFallDyspnoeaIntervertebral Disc ProtrusionInsomniaOsteoarthritisOsteoarthritis

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Lyrica and Morphine Sulfate?

You are not alone! Join a related mobile support group:
- support group for people who take Lyrica and Morphine Sulfate
- support group for people who take Lyrica
- support group for people who take Morphine Sulfate

Recent conversations of related support groups:

  • Support group for people who take Lyrica
    I have gained about 35 pounds, and I have the cognitive effects listed in the prescribing information--problems with thinking and concentration." I've been off Lyrica once, and the side effects went away, but I couldn't get out of bed in the morning

Can you answer these questions (Ask a question):

  • Is osteoarthrisis caused by drinking alcohol
    Chronic pain in spine, right hip, right hand, swollen joints in both hands, swollen knees.
  • Any information on deaths from taking lyica and high doses of alprazolam (1 answer)
    My Mother was a healthy 89 yr old with no healt issues, she was put on anxiety medicine, which she took regularly. She was also taking Lyric and had just started her Macular degeneration shots. She was prone to bladder infections and we went to the dr. for that, labs showed high calcium, within one week I had to take her to the emergency room, within one day she was on oxygen, within three days she was in the ICU intubated and unresponsive. She remained in ICU for 4 days had renal failure and died two days later.
  • Is pregabalin aggravate the symptoms of bph?
    I am having BPH. for foot pain doctor prescribes Pregabalin. that night the symptoms of BPH worsens. Is it due to Pregabalin? pl.write.
  • Is vomiting all liquids common while taking morphine
    I Recently started taking 6mg of Hydro-Morphine per day for pain. Every time i take the drug i vomit up any liquids I drink. i fell just fine without anything in my stomach but as soon as i eat or drink I instantly become nauseated and vomit everything. It is hard not to drink because the drug is making me very thirsty. So i try to drink and my body rejects it over and over again.. this goes on for hours (3-5)because i am sooo thirsty that I can not stop drinking.
  • Can mrsa cause chronic intestinal pseudo obstruction?
    I had a small bowel obstruction caused by adhesions from an appendectomy carried out 20yrs previously and had grumbling pain ever since but been labelled a malingerer by my family GP until one day at work when I started with terrible tummy ache and sickness like I'd never known, fetching up bile with force. I hated going to hospital after yrs of being called a moaner but after a day of rolling round in pain, temperature of 103 an dehydration, my Mammy insisted we go and I was seen straight away - to my shock I was in theatre within 3hrs with a serious obstruction.
    I never really recovered... The obstruction returned after 2 days and a portion of necrotic bowel was removed, then further fever and cellulitis then MRSA and deaths door.... Isolation in high dependency (intensive care) wound break down, ventilated and all related issues that come with that - chest infection, pneumonia, bed sores. Total time in hospital 8 months. Negative pressure dressing on laparotomy wound, colostomy, picc, 4 rounds of vancomycin, minor flirt with heart failure (just water related) an eventually everything healed. Had a large incisional hernia to repair and some corrective work to the horrific scarring but then the neuropathy started plus problems eating, spewing up after any solid food, more than a few forks, diarrhoea and sickness or constipation nausea and pain driving me mad, tried all manner of drugs, nerve blocks, physio, floating tank, acupuncture, opiates, non opiates, spinal cord stimulation, an now a consultant just had a 'eureka' moment and said were you treated with vancomycin when you had MRSA? If so I'm pretty sure you have chronic intestinal pseudo obstruction and is 90% sure but wants to take a muscle biopsy to be certain. I've had so much surgery and bad news in the last 10yrs I'm terrified of germs, hospital acquired bugs and anaesthetics, is there any other way? Or can I have this test done awake - conscious sedation? I had it before during spinal cord surgery so I know what's involved and it's better than GA as I know what's going on, who is doing what to me etc...
    Does anyone with a medical background know about this ailment/disease? Does it sound feasible that MRSA or it's treatment could have caused this? I was surgically debrided up to every other day when the vac pac/negative pressure machine and dressings were changed and the doctors told me I lost a great deal of tissue and had a lot of nerve damage due to the infection.
    Any patient perspectives on this illness would also be very much valued in helping me make a decision, moving forward. If all this is going to accomplish is to attach a label to the pain but not actually change anything, after fighting it for 10yrs now, avoiding hospital as much as I can, I really can't see the point of exploratory surgerys and biopsys now when it is known that I have this propensity towards adhesions and a new wound means a potentially new adhesion growth site.
    If it helps, the appendectomy happened when I was 10yrs old, the MRSA when I was 30 and I am now 40.
    Beat Wishes.

More questions for: Lyrica, Morphine Sulfate

You may be interested at these reviews (Write a review):

  • Leg pain especially near knees after taking lyrica
    Had to stop taking Lyrica due to joint pain in both legs. Difficult to get up from sitting position to stand. Ache in knee's can't relax to sleep. Motrin and vicodin not helping with pain. Also have applied muscle cream not working for pain. Have been off the lyrica for 3 months with no let up in pain. Did not have this pain before taking lyrica.
  • 3 strong drugs together against neuropathic pain
    Neuropathic pain debuted when I was 24, now I'm 50. Received diagnosed with Ehler-Danlos syndrome (EDS), joint hypermobility type, when I was 35 years old. So it can take some time to get a diagnose. And as EDS-patient I do not belong to any clinic. Orthopedics says that EDS is not orthopedic, rheumatology says that EDS is not an autoimmune disease, GPs say that EDS is too difficult, and so on. Sooner or later we all end up at Psychiatry, even if we are not depressed.

    The first kind of pain I got when I was 24 came from low back, but I experienced as pelvic pain and leg pain. It was clearly a neuropathic pain, but it took years to find out. Later it was treated by a pain clinic with cortisone around the genitofemoral nerves (both sides). Since this treatment didn't result in lasting freedom from pain, the pain clinic started to give me RF (radio frequency) treatment. This made the pain disappeared after one year, and I was 80% free from it between 2002 and 2014, 12 years. The pain doctors said pain could return after 10 years.

    The other kind of neuropathic pain started 2003 with intense stomach pain. During 6 months I could hardly eat nothing due to nausea and vomiting. After this 6 months, stomach pain changed to almost unbearable pain in upper back.
    What happened 2003, and what all the doctors missed, was that the right lowest ribs slid up over the sternum. This rib dislocation is till there today, but now with a lot of cartilage formed around the rib where it is stuck in the lower end of the sternum. The dislocation is clearly visible on X-ray. This has greatly affected the thoracic spine. I have a scoliosis which I had not before 2003. And I still have severe pain in the thoracic spine.

    It was initially treated with morphine daily, and later with Durogesic (fentanyl), but this didn't help much. 2005 I was hospitalized because I had too much pain to take care of myself and my hygiene. After some months the doctors started to give me clonazepam because the muscles along the spine was in a chronic seizures. Clonazepam helped, but I could still have a lot of pain in two vertebrae in the thoracic spine. It felt as if someone drilled into the vertebrae without anesthesia. After a few months, doctors also prescribed me methadone. Then the pain disappeared almost completely. Since 2006, I have eaten clonazepam and methadone every day, and I need to sleep in an armchair to not get more pain because of moving during sleep.

    There are side effects. After 1,5 years with clonazepam and methadone I started to have panic attacks. Or rather one long panic attack which didn't stop before I got treatment with amitryptilin and pregabalin (Lyrica). These 2 medicines stopped the panic disorder completely after some hours, and the panic was then gone. Then I got side effects of these 2 medicines, amitryptilin & Lyrica, too. I gained a lot of weight (from 83 to 148 kg) and got much water (edema) in both my legs under the knees and in both feet. The feet could swallow to the double size. 2012 I stopped with amitryptilin and started to loose weight again (in Aug 2014 below 80 kg) and get less water in my legs. Today I eat as little medicines I can, but I have to take methadone, clonazepam and Lyrica every day, twice. If I try to take away one of these 3 medicines, I got pain problems at once. Lyrica is the most painful one to take away. In Sept-Dec 2013 I lowered Lyrica from 300 mg daily, to 150, then to 75 and finally 0 mg. The pain I had was extremely difficult to handle. It didn't help to take more methadone or anything else. I have checked on Internet and found that many people got pain from quitting with Lyrica. Most people start eating it again. So did I. But 2006 and 2007 it was enough to treat the pain with methadone and clonazepam, I got the Lyrica against anxiety not pain. But today I take Lyrica against pain.

    Beside weight gain and leg edema, clonazepam and Lyrica significantly affect the sexual desire. And Lyrica alone makes it almost impossible to ejaculate. All four drugs together (clonazepam, methadone, amitryptiline and Lyrica), make one forget all about sex life. You don't even miss it. When I stopped with amitryptiline and lowered Lyrica (still taking clonazepam and methadone), I could suddenly easily get erections again, feel desire, but not getting orgasms. This is quite difficult to deal with.

    The pain pattern is greatly affected, by pain and by the medicines. So is the mood. I get something which feels like heavy depression, especially if I take the medicines late that day. I should take a medicine like methadone 3 times a day, because the effects of the tablet lasts around 8 hours. But I take them every 12 hours, to have a low consumption in case doctors prescribe them too late (which happens, and then it's good to have a spouse going to the pharmacy buying them for you, because you have too much pain to go yourself).

    Since methadone is also used for treating heroine addicts, medical staff treat you with disrespect when they see that it says "methadone" in your health record. I need to show a certificate that says that I deal with chronic neuropathic pain, that I never have had problems with drug addiction, to get normal respect.

    I wanted to share this because I think I am alone in the world with these medicines in combination against neuropathic pain caused by hypermobile joints, joint dislocation and muscle spasms. After trying almost everything else, including surgery cutting nerves, methadone, clonazepam and Lyrica seems to be the only way to kill my pain. But it's a life where you always is questioned, because of the use of methadone. I can guarantee that everybody in the world should accept these medicines if they had experienced the unbearable pain I had in upper back before they started to give me clonazepam and methadone.
  • Prostatitis and prostate cancer acceleration due to anaesthetics
    Caught Chlamydia in 1978. Interestingly, the partnered girl's sister worked in an aviary; and I found out later that Chlamydia originates from handling birdshit and birds are the carriers. Chlamydia was undiagnosed at the time, so it was listed under 'Non-specific urethritis'. Chlamydia wasn't named until about 8 years later. I was given tetracycline and told to stay off alcohol and sex. Yeah, really?

    I was 24; highly sexed, and in night clubs and pubs most nights. I laid off the alcohol and after two weeks, I was good. The laying off sex, I understood, because of contamination of others (condoms were little used in 1978 in the singles arena); so I masturbated one night... and that caused me immense in my prostate, and pain and suffering for the rest of my life.

    The ejaculation was extremely painful, and chronic prostatitis started. I was on and off medication for two years. I got light-sensitivity, which means in sunlight, I came out in burning rashes. I became allergic to tetracycline.

    The message? Consultants are generally poor at communicating what not to do, and why not. Lay off sex he said. All he had to say was no sex, no masturbation; or you may suffer for the rest of your life. That would have done it.

    No-one has been able to help me with this chronic prostatitis. In the early years it would come and go, but as the years have gone on, it has become more frequent, and now it is constant.

    Four years ago I went in for major foot surgery, and flat-lined. I was in intensive care for 2 days, on a morphine drip for the pain.
    When I awoke, I knew immediately I was suffering with my prostate. It was aching badly and I was urinating frequently. The nurses were amazed with how many 'bottles' I filled in such a short time.
    For the next few months, I was in agony. I have tried every possible drug going, as well as prostate massage and the indignancy of a urethragram whilst female students were watching.

    In November 2011 I went to see another consultant, who suggested a biopsy. I was diagnosed with prostate cancer. After much research, I now know that my diet and lifestyle, coupled with inflammation of the prostate with prostatitis, has caused prostate cancer. Yes, there is a direct relationship between prostatitis and prostate cancer.

    I am now beating it, without drugs and without surgery. I have changed my diet to a vegan diet, no sugar, very little alcohol, and a lot of supplementation.

    In December 2013, I went in for more foot surgery. I was unaware about the morphine at this time, so didn't consider it being a problem. I talk to the anaesthetist, who wanted me to have an epidural (injection in the spine to numb my lower body). At no point did he talk to me about my prostate history.
    In recovery, I sensed a problem as soon as the anaesthetic began to wear off. It was like my prostate and testicles wanted to explode. I knew I was going to have problems. My intuition reminded me of three years ago with the morphine, so I asked the surgeon if he knew of these complications with morphine, but he didn't.

    I spoke to the head of the post-operative ward and asked her if she had any experience of post-operative patients who suffered with prostatitis after surgery, and she confirmed she had. So here was a nurse who knew of the problems, but the surgeon and anaesthetist didn't. This is typical in the health service... the lack of sharing.

    Not only did I suffer with the chronic prostatitis (and still am 11 month later) I was incontinent. It took 6 months of 4-times daily legal exercises to get back control of my bladder.
    For me, morphine has a dire effect on my prostate.

    Bear in mind that your prostate is designed to eliminate toxins, so it is flooded with morphine. I will do my best to ensure I check for morphine in any drugs or anaesthetics in future.

    My first PSA level was 18, 3 ears ago. I brought it down to 13.5, then 10.4, 10.3, 10.9, 11.3, 14.3 and after the last surgery it spiked at 17.5. As a result, I have gone back to a stricter, greener raw diet to bring it down again.

    Oh, and anther tip; you need to get your vitamin D3 blood count above 200n/mols (UK measure) to have any chance of not getting prostate cancer. Mine was 32 when I was diagnosed. Today it is over 200, from supplementation of 10000 ius a day. Minimum in the UK, recommended by scientists, is 75n/mols, and it's too low. OK if you have a great immune system, but not if you want to fight prostate cancer and prostatitis.

    Black African males in the Northern US states and in Europe have twice as much risk, due to lack of sunlight. Sunlight on skin promotes vitamin D3, which is essential for the immune system and production of calcium.

    Black African males need more sunlight to produce the same amount of vitamin D3 as a caucasian male. Also, any male who is bald and fat has a higher risk, so a Black African, obese bald male, has an extremely high risk of prostate cancer, unless they get their immune system in order.

    The main way to fight all this, is on a clean, raw vegetable diet, pure water, no alcohol, sugar, processed or refined food, no meat, no dairy, no vegetable oil, no exceptions, and some breath-taking regular exercise. Just like we did 100 years ago. Go figure! Look at chronic disease studies of 100 years ago. 85% of all disease was from infection. Today 85% is from chronic disease.

    Your prostate eliminates toxins, and today, we are overloading it. Remove the toxins (and the stress and anxiety) and things will improve. It's a hard road; but with it is you want to be healthier and live longer.

    Good luck.
    Glenn.
  • Nexium improves my constipation
    Started taking Nexium 1 week ago and I noticed improvement with my chronic constipation.
  • Nightmare on lyrica st.
    r.knee revision 3rd.and last time due from Mersa infection and blood clot left me 1 1/2 shorter on r. Leg. Lost a lot of nerves in foot lower r. Leg.bulging disc was from falling from knee revision and for 9 months had no knee and on crutches.had lots of falls and blew out lower back. Put me on lyrica 2 weeks ago now up to 120 mg.With perks 4 times a day. The title says it all when trying to sleep :( my dream hands down beat any horror movies and directors. 2 hours of sleep per night and overly beat down :(.the only 2 good things I have going,my since of silliness and the Lord :) I guess family also.so far not much help with meds but willingly and pos, that both will work, the Lord :) thanks and God bless

More reviews for: Lyrica, Morphine Sulfate

Comments from related studies:

  • From this study (3 months ago):

  • Thick uncomfortable ejaculations. Sometimes "chunks" of semen exit my penis durning bowel movements. Ejaculations look like gobs of tiny little round, very thick balls of semen making up large chunks of ejaculate...

    Reply

  • From this study (7 months ago):

  • Possible connection with any of this or combination that may have contributed to recent Kidney Infections and Nephrolithiasis

    Reply

  • From this study (8 months ago):

  • Extremely thick, chunky like semen. Making it painful to ejaculate. Occasionally semen will come out during bowel movements in glob like increments. Ejaculations appear to be made up of small oblong jelly like balls, mixed together with semi vascular fluid.

    Reply

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Complete drug side effects:

On eHealthMe, Lyrica (pregabalin) is often used to treat fibromyalgia. Morphine Sulfate (morphine sulfate) is often used to treat pain. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

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