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Review: taking Lyrica and Morphine Sulfate together

Summary: drug interactions are reported among people who take Lyrica and Morphine Sulfate together.

This review analyzes the effectiveness and drug interactions between Lyrica and Morphine Sulfate. It is created by eHealthMe based on reports of 2,529 people who take the same drugs from FDA and social media, and is updated regularly.

 

 

 

 

You are not alone: join a mobile support group for people who take Lyrica and Morphine Sulfate >>>

What are the drugs

Lyrica has active ingredients of pregabalin. It is often used in fibromyalgia. (latest outcomes from 66,581 Lyrica users)

Morphine sulfate has active ingredients of morphine sulfate. It is often used in pain. (latest outcomes from 19,049 Morphine sulfate users)

On Dec, 31, 2014: 2,528 people who take Lyrica, Morphine Sulfate are studied

Lyrica, Morphine Sulfate outcomes

Drug combinations in study:
- Lyrica (pregabalin)
- Morphine Sulfate (morphine sulfate)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Lyrica is effective16.67%
(1 of 6 people)
14.29%
(3 of 21 people)
42.86%
(3 of 7 people)
20.00%
(2 of 10 people)
33.33%
(6 of 18 people)
18.18%
(2 of 11 people)
0.00%
(0 of 1 people)
0.00%
(0 of 1 people)
Morphine Sulfate is effective50.00%
(6 of 12 people)
15.79%
(3 of 19 people)
71.43%
(5 of 7 people)
16.67%
(1 of 6 people)
52.94%
(9 of 17 people)
22.22%
(2 of 9 people)
50.00%
(2 of 4 people)
33.33%
(1 of 3 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
SomnolencePainFallBack PainDepressionDry MouthOxygen Saturation DecreasedPain
Confusional StateRenal Failure AcuteDrug IneffectiveSuicide AttemptDrug DependenceBlood Cholesterol IncreasedRenal FailureAnxiety
DizzinessConfusional StateOedema PeripheralPainNauseaCerebrovascular AccidentNauseaDyspnoea
Renal Failure AcuteDrug IneffectiveHypoaesthesiaSomnolencePainPainful EjaculationHyperhidrosisBack Pain
DehydrationSomnolenceSpeech DisorderCerebrovascular AccidentConstipationFemur FractureDehydrationNausea
PyrexiaDizzinessCardiac FailureFluid RetentionUnresponsive To StimuliNeuropathic PainDepressed Level Of ConsciousnessPyrexia
PainSepsisDyspnoeaMyocarditisOedema PeripheralSleep TerrorNeurofibromatosis-1Dizziness
NauseaOedema PeripheralPyrexiaPathological GamblingConvulsionObsessive-compulsive DisorderOedema Peripheral
Oedema PeripheralRespiratory FailureSepsisObesityDental CariesCompulsive ShoppingArthralgia
AstheniaDyspnoeaRenal Failure AcutePulmonary HypertensionRhabdomyolysisSleep WalkingSomnolence

Drug effectiveness by gender :

FemaleMale
Lyrica is effective24.00%
(12 of 50 people)
20.00%
(5 of 25 people)
Morphine Sulfate is effective39.22%
(20 of 51 people)
34.62%
(9 of 26 people)

Most common drug interactions by gender * :

FemaleMale
PainPain
AnxietyDyspnoea
NauseaAnxiety
DizzinessBack Pain
FallAsthenia
DyspnoeaConfusional State
Back PainPyrexia
PyrexiaArthralgia
SomnolenceOedema Peripheral
ArthralgiaAnaemia

Drug effectiveness by age :

0-12-910-1920-2930-3940-4950-5960+
Lyrica is effectiven/an/an/a30.00%
(3 of 10 people)
12.90%
(4 of 31 people)
14.29%
(4 of 28 people)
9.43%
(5 of 53 people)
5.00%
(1 of 20 people)
Morphine Sulfate is effectiven/an/an/a40.00%
(4 of 10 people)
30.00%
(9 of 30 people)
17.24%
(5 of 29 people)
12.96%
(7 of 54 people)
12.12%
(4 of 33 people)

Most common drug interactions by age * :

0-12-910-1920-2930-3940-4950-5960+
n/aSepsisBalance DisorderPainPainPainPainPain
ArthralgiaMulti-organ FailureUrinary Tract InfectionNauseaAnxietyAnxietyConfusional State
Bone PainBrain OedemaNauseaAbdominal PainDyspnoeaDyspnoeaAnxiety
Tumour Lysis SyndromeDisseminated Intravascular CoagulationVomitingArthralgiaBack PainPyrexiaSomnolence
Respiratory FailureArthralgiaHypertensionFatiguePneumoniaBone DisorderDehydration
PneumoniaDrug Rash With Eosinophilia And Systemic SymptomsInfluenza Like IllnessOedema PeripheralConfusional StateHypoaesthesiaBack Pain
Renal FailureRashPyrexiaWeight DecreasedFatigueBack PainFall
Disease ProgressionPyrexiaAbdominal Pain UpperDysuriaDepressionOsteonecrosis Of JawDyspnoea
NeutropeniaGeneral Physical Health DeteriorationCardiac Failure CongestiveHodgkin's DiseaseDeathArthralgiaAsthenia
BradycardiaFallDyspnoeaIntervertebral Disc ProtrusionInsomniaOsteoarthritisOsteoarthritis

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Lyrica and Morphine Sulfate?

You are not alone! Join a related mobile support group:
- support group for people who take Lyrica and Morphine Sulfate
- support group for people who take Lyrica
- support group for people who take Morphine Sulfate

Recent conversations of related support groups:

  • Support group for people who take Lyrica
    I have gained about 35 pounds, and I have the cognitive effects listed in the prescribing information--problems with thinking and concentration." I've been off Lyrica once, and the side effects went away, but I couldn't get out of bed in the morning

Can you answer these questions (Ask a question):

  • Does lyrica cause neutropenia and if it does, how long does it take to subside after stopping the drug?
    The patient is a 28 year old female who has been involved in a horrific car accident back in February 7th 2014. She had bilateral femural fracture along with fractured right tibia and fibula in addition to right humerus. However, to make it short, after treatment, the outcome was not acceptable with various complications. The patient is scheduled for another surgery, however, her CBC shows neutropenia (3.4).
  • Does morphine cause mouth ulcerations
    one month after beginning the drug morphine I developed mouth ulcerations on my mouth palate. My mouth and face has developed soreness and painful pressure.
  • Can i take a steroid while taking xarelto (1 answer)
    I took prednisone for constant cough. had 3rd surgery on back one year ago. Had to patch spinal cord. Got blood clots. Had pulmonary embolism. Now have severe bronchitis. I know the prednisone will take care of cough, but what else?
  • How much do i decrease at a time, and how long should the decrease last. lyrica, and symbalta
    After the extreme weight gain. The dizziness. The exhaustion all the time. Nausea consistently before, during and after eating. Extreme lower back pain. Leg pain, cramping, and jerking. Now her oxygen levels are from 82-95 tops with the bi-pap. She finally wants to quit taking Lyrica, cymbalta, forteo, and all the prescription stomach meds she has to take because she's on them. I am figuring lowering 25 mgs at a time and staying there for 28 days with the Lyrica. She's been on Lyrica and cymbalta for 5-1/2 years. Any help would be greatly appreciated. I know with the severity of her problems she will not make it another three years. The confusion she's in approximately 70% of the time I'm going to lose her. She woke up and was totally confused while I was in the restroom for a couple minutes and I wound up rushing her to the hospital where she died in my arms before bringing her back three times because she took 17-15 mg oxycodone thinking they were her night pills. The reason I'm going into so much detail is to show the severity. Every doctor I've spoken with has said 25-50 mgs for two weeks is the norm. I told her doctor when he bumped her from 75 to 150 she wouldn't be able to take it. I am absolutely positive her body will go through major withdrawals and I can't have that happen. Thank you for taking the time to read everything I've written.
  • Is osteoarthrisis caused by drinking alcohol
    Chronic pain in spine, right hip, right hand, swollen joints in both hands, swollen knees.

More questions for: Lyrica, Morphine Sulfate

You may be interested at these reviews (Write a review):

  • Blood sugar level while taking veltrex
    I been taking Veltrex for a viral infection in my eye for 3 days and today my blood sugar was 448.My normal blood sugar runs around 146.
  • Leg pain especially near knees after taking lyrica
    Had to stop taking Lyrica due to joint pain in both legs. Difficult to get up from sitting position to stand. Ache in knee's can't relax to sleep. Motrin and vicodin not helping with pain. Also have applied muscle cream not working for pain. Have been off the lyrica for 3 months with no let up in pain. Did not have this pain before taking lyrica.
  • 3 strong drugs together against neuropathic pain
    Neuropathic pain debuted when I was 24, now I'm 50. Received diagnosed with Ehler-Danlos syndrome (EDS), joint hypermobility type, when I was 35 years old. So it can take some time to get a diagnose. And as EDS-patient I do not belong to any clinic. Orthopedics says that EDS is not orthopedic, rheumatology says that EDS is not an autoimmune disease, GPs say that EDS is too difficult, and so on. Sooner or later we all end up at Psychiatry, even if we are not depressed.

    The first kind of pain I got when I was 24 came from low back, but I experienced as pelvic pain and leg pain. It was clearly a neuropathic pain, but it took years to find out. Later it was treated by a pain clinic with cortisone around the genitofemoral nerves (both sides). Since this treatment didn't result in lasting freedom from pain, the pain clinic started to give me RF (radio frequency) treatment. This made the pain disappeared after one year, and I was 80% free from it between 2002 and 2014, 12 years. The pain doctors said pain could return after 10 years.

    The other kind of neuropathic pain started 2003 with intense stomach pain. During 6 months I could hardly eat nothing due to nausea and vomiting. After this 6 months, stomach pain changed to almost unbearable pain in upper back.
    What happened 2003, and what all the doctors missed, was that the right lowest ribs slid up over the sternum. This rib dislocation is till there today, but now with a lot of cartilage formed around the rib where it is stuck in the lower end of the sternum. The dislocation is clearly visible on X-ray. This has greatly affected the thoracic spine. I have a scoliosis which I had not before 2003. And I still have severe pain in the thoracic spine.

    It was initially treated with morphine daily, and later with Durogesic (fentanyl), but this didn't help much. 2005 I was hospitalized because I had too much pain to take care of myself and my hygiene. After some months the doctors started to give me clonazepam because the muscles along the spine was in a chronic seizures. Clonazepam helped, but I could still have a lot of pain in two vertebrae in the thoracic spine. It felt as if someone drilled into the vertebrae without anesthesia. After a few months, doctors also prescribed me methadone. Then the pain disappeared almost completely. Since 2006, I have eaten clonazepam and methadone every day, and I need to sleep in an armchair to not get more pain because of moving during sleep.

    There are side effects. After 1,5 years with clonazepam and methadone I started to have panic attacks. Or rather one long panic attack which didn't stop before I got treatment with amitryptilin and pregabalin (Lyrica). These 2 medicines stopped the panic disorder completely after some hours, and the panic was then gone. Then I got side effects of these 2 medicines, amitryptilin & Lyrica, too. I gained a lot of weight (from 83 to 148 kg) and got much water (edema) in both my legs under the knees and in both feet. The feet could swallow to the double size. 2012 I stopped with amitryptilin and started to loose weight again (in Aug 2014 below 80 kg) and get less water in my legs. Today I eat as little medicines I can, but I have to take methadone, clonazepam and Lyrica every day, twice. If I try to take away one of these 3 medicines, I got pain problems at once. Lyrica is the most painful one to take away. In Sept-Dec 2013 I lowered Lyrica from 300 mg daily, to 150, then to 75 and finally 0 mg. The pain I had was extremely difficult to handle. It didn't help to take more methadone or anything else. I have checked on Internet and found that many people got pain from quitting with Lyrica. Most people start eating it again. So did I. But 2006 and 2007 it was enough to treat the pain with methadone and clonazepam, I got the Lyrica against anxiety not pain. But today I take Lyrica against pain.

    Beside weight gain and leg edema, clonazepam and Lyrica significantly affect the sexual desire. And Lyrica alone makes it almost impossible to ejaculate. All four drugs together (clonazepam, methadone, amitryptiline and Lyrica), make one forget all about sex life. You don't even miss it. When I stopped with amitryptiline and lowered Lyrica (still taking clonazepam and methadone), I could suddenly easily get erections again, feel desire, but not getting orgasms. This is quite difficult to deal with.

    The pain pattern is greatly affected, by pain and by the medicines. So is the mood. I get something which feels like heavy depression, especially if I take the medicines late that day. I should take a medicine like methadone 3 times a day, because the effects of the tablet lasts around 8 hours. But I take them every 12 hours, to have a low consumption in case doctors prescribe them too late (which happens, and then it's good to have a spouse going to the pharmacy buying them for you, because you have too much pain to go yourself).

    Since methadone is also used for treating heroine addicts, medical staff treat you with disrespect when they see that it says "methadone" in your health record. I need to show a certificate that says that I deal with chronic neuropathic pain, that I never have had problems with drug addiction, to get normal respect.

    I wanted to share this because I think I am alone in the world with these medicines in combination against neuropathic pain caused by hypermobile joints, joint dislocation and muscle spasms. After trying almost everything else, including surgery cutting nerves, methadone, clonazepam and Lyrica seems to be the only way to kill my pain. But it's a life where you always is questioned, because of the use of methadone. I can guarantee that everybody in the world should accept these medicines if they had experienced the unbearable pain I had in upper back before they started to give me clonazepam and methadone.
  • Prostatitis and prostate cancer acceleration due to anaesthetics
    Caught Chlamydia in 1978. Interestingly, the partnered girl's sister worked in an aviary; and I found out later that Chlamydia originates from handling birdshit and birds are the carriers. Chlamydia was undiagnosed at the time, so it was listed under 'Non-specific urethritis'. Chlamydia wasn't named until about 8 years later. I was given tetracycline and told to stay off alcohol and sex. Yeah, really?

    I was 24; highly sexed, and in night clubs and pubs most nights. I laid off the alcohol and after two weeks, I was good. The laying off sex, I understood, because of contamination of others (condoms were little used in 1978 in the singles arena); so I masturbated one night... and that caused me immense in my prostate, and pain and suffering for the rest of my life.

    The ejaculation was extremely painful, and chronic prostatitis started. I was on and off medication for two years. I got light-sensitivity, which means in sunlight, I came out in burning rashes. I became allergic to tetracycline.

    The message? Consultants are generally poor at communicating what not to do, and why not. Lay off sex he said. All he had to say was no sex, no masturbation; or you may suffer for the rest of your life. That would have done it.

    No-one has been able to help me with this chronic prostatitis. In the early years it would come and go, but as the years have gone on, it has become more frequent, and now it is constant.

    Four years ago I went in for major foot surgery, and flat-lined. I was in intensive care for 2 days, on a morphine drip for the pain.
    When I awoke, I knew immediately I was suffering with my prostate. It was aching badly and I was urinating frequently. The nurses were amazed with how many 'bottles' I filled in such a short time.
    For the next few months, I was in agony. I have tried every possible drug going, as well as prostate massage and the indignancy of a urethragram whilst female students were watching.

    In November 2011 I went to see another consultant, who suggested a biopsy. I was diagnosed with prostate cancer. After much research, I now know that my diet and lifestyle, coupled with inflammation of the prostate with prostatitis, has caused prostate cancer. Yes, there is a direct relationship between prostatitis and prostate cancer.

    I am now beating it, without drugs and without surgery. I have changed my diet to a vegan diet, no sugar, very little alcohol, and a lot of supplementation.

    In December 2013, I went in for more foot surgery. I was unaware about the morphine at this time, so didn't consider it being a problem. I talk to the anaesthetist, who wanted me to have an epidural (injection in the spine to numb my lower body). At no point did he talk to me about my prostate history.
    In recovery, I sensed a problem as soon as the anaesthetic began to wear off. It was like my prostate and testicles wanted to explode. I knew I was going to have problems. My intuition reminded me of three years ago with the morphine, so I asked the surgeon if he knew of these complications with morphine, but he didn't.

    I spoke to the head of the post-operative ward and asked her if she had any experience of post-operative patients who suffered with prostatitis after surgery, and she confirmed she had. So here was a nurse who knew of the problems, but the surgeon and anaesthetist didn't. This is typical in the health service... the lack of sharing.

    Not only did I suffer with the chronic prostatitis (and still am 11 month later) I was incontinent. It took 6 months of 4-times daily legal exercises to get back control of my bladder.
    For me, morphine has a dire effect on my prostate.

    Bear in mind that your prostate is designed to eliminate toxins, so it is flooded with morphine. I will do my best to ensure I check for morphine in any drugs or anaesthetics in future.

    My first PSA level was 18, 3 ears ago. I brought it down to 13.5, then 10.4, 10.3, 10.9, 11.3, 14.3 and after the last surgery it spiked at 17.5. As a result, I have gone back to a stricter, greener raw diet to bring it down again.

    Oh, and anther tip; you need to get your vitamin D3 blood count above 200n/mols (UK measure) to have any chance of not getting prostate cancer. Mine was 32 when I was diagnosed. Today it is over 200, from supplementation of 10000 ius a day. Minimum in the UK, recommended by scientists, is 75n/mols, and it's too low. OK if you have a great immune system, but not if you want to fight prostate cancer and prostatitis.

    Black African males in the Northern US states and in Europe have twice as much risk, due to lack of sunlight. Sunlight on skin promotes vitamin D3, which is essential for the immune system and production of calcium.

    Black African males need more sunlight to produce the same amount of vitamin D3 as a caucasian male. Also, any male who is bald and fat has a higher risk, so a Black African, obese bald male, has an extremely high risk of prostate cancer, unless they get their immune system in order.

    The main way to fight all this, is on a clean, raw vegetable diet, pure water, no alcohol, sugar, processed or refined food, no meat, no dairy, no vegetable oil, no exceptions, and some breath-taking regular exercise. Just like we did 100 years ago. Go figure! Look at chronic disease studies of 100 years ago. 85% of all disease was from infection. Today 85% is from chronic disease.

    Your prostate eliminates toxins, and today, we are overloading it. Remove the toxins (and the stress and anxiety) and things will improve. It's a hard road; but with it is you want to be healthier and live longer.

    Good luck.
    Glenn.
  • Nexium improves my constipation
    Started taking Nexium 1 week ago and I noticed improvement with my chronic constipation.

More reviews for: Lyrica, Morphine Sulfate

Comments from related studies:

  • From this study (4 months ago):

  • Thick uncomfortable ejaculations. Sometimes "chunks" of semen exit my penis durning bowel movements. Ejaculations look like gobs of tiny little round, very thick balls of semen making up large chunks of ejaculate...

    Reply

  • From this study (9 months ago):

  • Possible connection with any of this or combination that may have contributed to recent Kidney Infections and Nephrolithiasis

    Reply

  • From this study (9 months ago):

  • Extremely thick, chunky like semen. Making it painful to ejaculate. Occasionally semen will come out during bowel movements in glob like increments. Ejaculations appear to be made up of small oblong jelly like balls, mixed together with semi vascular fluid.

    Reply

Post a new comment    OR    Read more comments

Complete drug side effects:

On eHealthMe, Lyrica (pregabalin) is often used to treat fibromyalgia. Morphine Sulfate (morphine sulfate) is often used to treat pain. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

   

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